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Manager Industrial Training

Vasant Nagar, Karnataka, India
May 16, 2020

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Address: *** *, **** ***** **** apartment,

Near Kachanayakanahalli Government school Hennagara main road,

Kachanayakanahalli, Bangalore – 560 105 – INDIA.

Phone: +91-720*******

Email –



JUNIOR MANAGER / ASSOCIATE SCIENTIST, Syngene International, Biocon PArk, bengaluru, india

Responsible in handling multiple projects for multiple clients with high level data integrity and confidentiality. Preparation of project report and update the project manager on the ongoing project. In depth higher knowledge in mammalian cell culture and cell line development. Cell culture assay design and assay execution knowledge as per regulatory requirements/Industry practice and SOPs. Strategic planning execution of various complexities. Experience in scientific documentation of Data, Data analysis and interpretation. Ability to work independently asa well as with team members. Highly focused, versatile, curious, multi-tasking, goal oriented and passionate to make difference.

11/APRIL/2016 – 24/OCTOBER/2019

PROJECT FELLOW, GROW research LABORATORY, narayana nethralaya foundation, bengaluru, india

The proposed research is to investigate the role of molecular signalling pathways in the pathogenesis of pterygium. Pterygium is one of the ocular surface diseases which contributes about 29% of unilateral/bilateral visual impairments in India. The major cause of the disease pathology is due to ultraviolet B rays. The current existing treatment strategy is surgical intervention. But there is always a risk of recurrence of pterygium which is reported to be about 6% to 9%. Stress is mainly associated with inflammation and autophagic-lysosomal pathway to maintain cellular homeostasis, but in pterygium disease, the role of autophagy and its association with inflammation is not studied well. In this project, we will be addressing this knowledge gap. Initial studies involve the examining the levels of autophagic-lysosomal related proteins in pterygium tissues, establishing in vitro disease condition using Chang’s conjunctival cell line (CCL) with UVB stimulation, followed by investigating autophagy dynamics in UVB exposed CCLs, studying the association of inflammation and autophagy in pterygium disease condition and final objective will be to screen for autophagy modulators in primary pterygium cells for developing novel therapeutic strategies.

The other project is to develop novel therapeutic strategies for ocular surface disorders using a turmeric derived compound, tetrahydro curcuminoid in combination with vitamin-D. About over 7 million people with preventable corneal blindness of which over 1 million require a corneal transplant to recover vision. Most of these conditions can be prevented by early detection and management. These conditions include corneal wounds/scarring, adverse refractive surgery complications, infections, keratoconus, Keratitis, trachoma and corneal erosions. Several molecular factors are known to be associated with driving corneal blindness. However, the role of inflammatory and fibrotic signalling under the control of the NFkB and TGFβ pathways have been well documented. In this part of the study, THC and vitamin-D will be employed to regulate the inflammation and fibrosis to maintain cellular homeostasis. The initial objective is to generate the efficacy and cytotoxicity profile of THC and Vitamin-D in different ocular cell types (epithelial, keratocyte, stromal fibroblast, etc) from primary patients and immortalized lines, develop a formulation based on this profile. Signal transduction analysis of the immunomodulation by THC and vitamin-D formulation on ocular cells in vitro and establish the maximum effective dosage by detailed molecular analysis of the TGFβ and TNFα stimulated signalling pathways.

2010 – 2016

RESEARCH SCIENTIST, Biocon ltd, bengaluru, india

Six years of industrial training and process development experience in monoclonal antibody production.

Provide project update, analysis and advice to cross-functional team and senior management

Reviews worksheets and batch records

Contributes to operations of the process development lab, including training of new employees

Project focused on CHO and NS0 cell line-based process development and optimization to produce antibodies meant for preclinical studies employing standard pharma regulations and good manufacturing practices (cGMP)

Leading the inhouse preparation of media, enriched feed and seed expansion for pre-clinical batches.

Actively involved in documentation of batch manufacturing records, EHS training records and analysis reports.

Seed expansion and maintains for all critical pre-clinical batches (Trastuzumab - CANMAB).

Expert in root cause analysis & troubleshooting.


Involved in advising and developing learning management system tool for the organization.

Pro-actively involved in designing curriculum for manufacturing, quality and R&D department under “Mpower” learning program.

2009 – 2010


Trained in various biological assays like Calcium pantothenate assay, Folic acid assay and Vitamin B12 assay with lactobacillus arabinosa, Streptococcus faecalis.

Responsible in area monitoring/Bio-load check of manufacturing units and Microbial Limit Testing of raw materials, online batches and finished products.

Also involved in drug stability study with expiring and expired drugs.




Major subjects: Biotechnology, Immunology, Genetics & molecular biology



Major subjects: Applied Botany, Chemistry & Biotechnology


Molecular biology – protein and gene expression using western blotting and quantitative real-time polymerase chain reaction

Recombinant DNA technology – Plasmid-based cloning and transfection

Flow cytometry – Multiplex bead-based ELISA for cytokine profiling, immune cell phenotyping

Cell culture – Primary cells and cell lines

Proficiency in software application like – ImageJ, Graphpad, Adobe, Foxit, MS word, MS excel, MS PowerPoint.

Histological techniques – Immunofluorescent and immunohistochemical assays

Chromatography (HPLC and UPLC) - IgG estimation and Amino acid estimation

Analytical instrument – Glucose & lactate analyser (YSI), Cedex, Osmometer (gonotec) & BGA analyser.

Bioreactors of various make and scale - Shake flask/T flask to benchtop/in situ Bioreactor, Disposable reactor and Wave Bag bioreactors. (Bioengineering, Sartorius STR, Applikon, GE Wave bag)

Protein purification – Ion Exchange chromatography, Affinity chromatography using AKTA system.


Indo-Australian summit of epithelial to mesenchymal transition (2017)


Awarded travel grant for the poster presentation at ARVO-INDIA 2019


Priyaranjan Pattanaik, PhD

Deputy Research Director, Syngene international

Biocon park, Jigani link road, Bangalore, 560099, India


Arkasubhra Ghosh, PhD

Director, GROW laboratory (Genes, repair and regeneration at ophthalmic workstation)

Narayana Nethralaya Foundation,

3rd Floor, Narayana Nethralaya, Narayana Health City,

#258/A, Bommasandra, Hosur Road, Bangalore, 560 099, India


Nallathambi Jeyabalan, PhD

Senior scientist, GROW laboratory (Genes, repair and regeneration at ophthalmic workstation)

Narayana Nethralaya Foundation,

3rd Floor, Narayana Nethralaya, Narayana Health City,

#258/A, Bommasandra, Hosur Road, Bangalore, 560 099, India


Murgeshwari, PhD

Scientist, Stem cell research,

Narayana Nethralaya Foundation,

3rd Floor, Narayana Nethralaya, Narayana Health City,

#258/A, Bommasandra, Hosur Road, Bangalore, 560 099, India



I declare that all the information above is true to the best of my knowledge.

Naveen Kumar M


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