Curriculum Vitae

Dr Mymoona Alzouebi

MBChB MRCP DTM&H MSc

FRCR (London UK)

Consultant Clinical

Radiation Oncologist

Personal Statement

I am a senior oncology clinical consultant in a large tertiary cancer referral centre in the NHS serving a population over 1.2 million. I qualified from the Sheffield University, UK in 2004, obtained MRCP in 2007, Masters in Oncology in 2010 and Fellow of Royal College of Radiologist (Clinical Oncology) UK in 2012. I undertook an extensive formal clinical oncology training programme in South Yorkshire and successfully CCT’d in 2014. I have been in my post in the NHS for over 6 years. I have a busy clinical practice covering the breadth of advanced radiotherapy techniques and systemic therapies. My training has been very comprehensive and covered all tumour sites. Currently within the NHS as practices are subspecialised I am an expert in the management of urological malignancies with radiotherapy and chemotherapy and paediatric malignancies with radiotherapy. I am confident this will evolve depending on the post and needs of the department I join.

My aim in joining a developing department at your centre is to take a leadership role in Oncology as well as a clinical post. I believe I have the skills, experience and training to allow me to establish and lead a state of the art oncology facility for patients and a thriving unit based on the latest advances in cancer management.

Appraisal and Feedback

I comply with annual appraisal requirements as per GMC. I have had no complaints in my consultant role. I have excellent 360 feedback from colleagues and very positive reviews from patients. This is anonymised both via our local appraisal and iwantgreatcare.com platform Management and Leadership experience

My leadership roles include

1. Core member of three multi-disciplinary cancer meetings across the network. 2. Lead for Prostate Interventional Fiducial marker service for patients undergoing SABR to treat prostate cancer

3. Lead for Uro-oncology Radiotherapy practice guidelines at Weston Park Hospital– established in accordance with evidence base practice and in line with the Yorkshire Cancer Network. 4. Lead for Paediatric Radiotherapy practice guidelines at Weston Park Hospital– established in accordance with evidence base practice and in line with Childhood Cancer Leukemia Group 5. Co-Lead for Uro-Oncology Peer review of complex radiotherapy plans 6. Designated Medical Supervisor Sheffield Hallam University for Masters in Advanced Medical Prescribing- and lead for education, training and supervision of uro-oncology CNS 7. Developing Establishing radiographer and senior nurse led prostate cancer telephone clinic 8. Principal Investigator and co-investigator for several trials at Clinical Cancer Trials Centre – Weston Park Hospital, Sheffield Teaching Hospital NHS Foundation Trust 9. Led on two separate Patient Support Programmes aimed at improving access to treatment and monitoring via nurse led clinics

10. Organised several educational events within and outside of Post Graduate Medical Education at Weston Park Hospital.

Research experience:

I am a senior Consultant Oncologist in a field that fortunately excels in research. I have led a number of clinical research projects resulting in several peer-review publications and 11 poster presentations.

I maintain Good Clinical Practice certification annually, I regularly attend Research Meetings and submit proposals to the Committee for Clinical Trials and Ethics and Research and Development at our centre.

I successfully completed and published a 5000 word Masters Dissertation in Oncology and awarded a distinction. I am the principal investigator for a national trial (RAIDER) investigating the role of adaptive image guided radiotherapy, SIOP HRMB – High risk medulloblastoma in paediatrics, FarRMS

– Rhabdomyosarcoma in paediatrics, SIOP EPII – Ependymoma in paediatrics. I am co-investigator on several national and international trials in urological malignancies such as STAMPEDE, RADICALS, ADD ASPIRIN and CORE to name a few. I and keep my certification in up to date. I have completed a research Methodologies course. Working in a large tertiary referral centre I have significant experience of recruiting to and managing patients on clinical trials.

Radiotherapy experience:

I have been in my current post as a Consultant Clinical Oncologist for over six years. I am competent and experienced in the assessment, planning, consent and management of patients undergoing radical and palliative radiotherapy. I have good anatomical awareness and radiological diagnostic knowledge necessary for accurate contouring. Currently, my centre uses Aria software for contouring and Rapid Arc and Fixed field IMRT for most disease sites, daily Cone beam CT imaging on set. Also trained and skilled at fiducial marker insertion for prostate SABR treatment – delivered within CORE trial in the UK.

I am competent at the planning and delivery of SABR treatment to nodal and bone metastasis. Currently I am the Principal Investigator for the RAIDER trial – pioneering adaptive image guided radiotherapy for bladder cancer. In addition I am PI for a number of paediatric radiotherapy trials SIOP HRMB High risk medulloblastoma, FarRMS – Rhabdomyosarcoma and SIOP EPII – Ependymoma In treating Paediatric malignancies I cover all disease sites including primary brain tumours – requiring MR fusion to IMRT craniospinal treatments. I also do plan and prescribe Total Body Irradiation for haematological malignancies.

My extensive formal registrar training covered competencies at all disease sites. I have completed a number of skills workshops within RCR IMRT and brachytherapy courses and the Advanced Radiotherapy Techniques course in addition to Pelvic nodes and prostate bed and dominant intraprostatic tumour boost radiotherapy, more recently the UK SABR consortium Workshop. Furthermore, I am proficient in the management of radiotherapy induced side effects. Systemic therapy experience

As a Clinical Oncologist my clinical practice and training in the UK is unique in that I am dual accredited in the prescription of systemic anti-cancer therapies as well as radiation therapy. I am competent in the use of Tyrosine Kinase Inhibitors, Chemotherapy, Immunotherapy and concurrent chemo-radiation protocols. I assess patients and manage toxicities associated with all systemic therapies and anaphylaxis. I regularly lead the acute oncology ward round of emergency admissions. I am competent and experienced in the management of cytotoxic induced side effects. I have successfully submitted a number of recent drugs to our Drugs and Therapeutic Committee for the provision of advanced systemic therapy to our patients. Training and teaching experience

I take great pride in my teaching roles within my hospital and in association with the Sheffield University Medical School at an undergraduate level. Recently at my centre I was involved in the training of six senior registrars in preparation for the FRCR exam- five of whom passed.

We in Sheffield hold an annual Chemotherapy and Preparatory FRCR course – which attracts delegates nationally and internationally. I have been involved in teaching on both. I am involved in local postgraduate medical education at our centre and have established a number of workshops and training days covering advanced imaging techniques and urological malignancies. Personal Information

Dr Mymoona Alzouebi

DOB 9/6/1981

GMC No. 6102020

Nationality British

Email adk3ga@r.postjobfree.com

adk3ga@r.postjobfree.com

Education and Qualifications

June -July 2018 Coronial Law Diploma, University of Bolton March 2014 GMC - Certificate of Completion of Specialist Training Clinical Oncology - CCT UK

April 2012 FRCR (London UK)

Aug 2008- Aug 2014 Higher Specialist Clinical Oncology Training Programme September 2010 Masters Degree Oncology Distinction - University of Nottingham

June 2007 MRCP (London UK)

April 2007 Diploma in Tropical Medicine, Royal College of Physicians London

June 2004 MBChB University of Sheffield Medical School Distinctions and Awards

Distinction Masters Oncology- University of Nottingham Level 5 and 5 Distinction grade in Phase 1B and 2 – University of Sheffield Medical School Distinction Special Study Module – Refeeding Syndrome post PEG insertion Swann-Morton 2003 Elective Prize

Journal of Medical Ethics - June 2003 Elective Award Present Employment

01/09/2014 -present - Consultant Clinical Oncology Weston Park Hospital

Sheffield Teaching Hospitals NHS Foundation Trust

BMI Thornbury Private Hospital Sheffield

Specialist interest Radiation and Systemic therapy for Urology and Paediatric malignancies

Duties:

Three Multi-Disciplinary Cancer Meetings per week (Paediatric, Local and Central network Uro-Oncology)

Weekly SABR MDT

Three weekly out-patient clinics (new patients, chemotherapy clinics and radiotherapy clinic, post-treatment reviews)

Weekly Radiotherapy Mark-up/Contouring sessions

Weekly Radiotherapy urology and paediatric Peer review

Weekly ward rounds

Principal Investigator of clinical trials (Adaptive Radiotherapy, IMRT, RapidArc)

Active involvement in clinical trials (assessment, consenting and recruitment of patients)

Active participant and regular speaker at Post-graduate medical education events

24 hour consultant on call duties

Audit and Research

Registrar and SHO teaching

Specialist Registrar- Clinical Oncology Training Programme 200*-****-**/08-08/14 Weston Park Hospital, Sheffield Teaching Hospital NHS Foundation Trust

05/14-08/14 Breast and urology

04/13-10/13 Breast, Lung cancer- Dr Hatton

10/12-04/13 Lung, Head & Neck cancers, Lymphoma, Sarcoma- Dr’s Robinson and Murali 04/12-10/12 Breast and Skin cancer- Dr S Ramakrishnan 12/12-04/12 Upper and Lower gastrointestinal cancer- Drs Furniss and Clenton 04/11-05/11 Breast, Head and neck, Skin – Dr O Purohit 10/10-04/11 Urology cancer- Dr's Ferguson and Kirkbride 04/10-10/10 Central Nervous System & Unknown Primary – Dr‘s Bridgewater and Clenton 09/09-04/10 Gynaecology, Colorectal and Paediatrics – Dr Pledge 03/08-09/09 Sarcoma, Head & Neck, Lymphoma and Lung – Dr’s Robinson and Foran 08/08-03/09 Lung Cancer – Dr’s Fisher and Mohanamurali Previous Employment

08/07-08/08 SHO in Respiratory Medicine, Gastroenterology and Dermatology Sheffield Teaching Hospitals

08/06- 08/07 SHO in Care of the Elderly, Respiratory and Cardiology Bassetlaw Hospital

04/06-08/06 SHO in Microbiology, Oncology and Haematology Sheffield Teaching Hospitals

05/05-08/05 PRHO in Colorectal Surgery, Orthopaedics, Nephrology and Diabetes Northern General Hospital

Courses- Conferences -Workshops

Radiotherapy Workshops

UK SABR Consortium & RCR Contouring Workshop Oct 2020 – Virtual meeting Genesiscare SABR credentialing workshop April 2020 – Virtual meeting Royal College of Radiologists RCR Prostate and Pelvic Radiotherapy Workshop Sept 2018, Liverpool Royal College of Radiologists RCR Stereotactic Radiotherapy and CORE trial launch, Sept 2015 London

Royal College of Radiologists RCR NCAT Foundation Course in IMRT for Clinical Oncologists Feb 2013 Royal College of Radiologists RCR Brachytherapy Course - 2 day. Feb 2012 Royal College of Radiologists RCR Advanced Radiation Techniques Course- 2 day. June 2012 Updates in Systemic Anti-Cancer therapies

Update on lines of therapies in Metastatic Renal Cancer Oct 2020 – Virtual meeting for Weston Park Hospital

Merck- Pfizer - North of UK: Virtual Launch of Bavencio (avelumab) + axitinib in advanced Renal Cell Carcinoma (aRCC) – Oct 2020 Virtual meeting

Expert insights into the management decisions of metastatic renal cell carcinoma (mRCC) patients in 2020 during and beyond the COVID-19 crisis

Lymphoma – Management Sept- Oct 2020 – Virtual meeting Pfizer Renal Study day, March 2017, Manchester

Clinical Cancer Chemotherapy Course Jan 2009, Cancer Research Network, Sheffield National Conferences - Urological malignancies

British Uro-Oncology Symposium Sept 2020 – Virtual meeting Prostate Cancer Summit- Janssen London Feb 2020

British Uro-Oncology Symposium Sept 2019, Birmingham Update on Metastatic Renal Cell Cancer – Pfizer Sheffield June 2019 Prostate Cancer Summit- Janssen London Mar 2019

British Uro-Oncology Symposium Sept 2018, Birmingham Bladder Expert Forum, London April 2018

Prostate Cancer Summit, London, Feb 2018

British Uro-Oncology Symposium Sept 2017, Newcastle British Uro-Oncology Symposium Sept 2016, Manchester British Uro-Oncology Symposium Sept 2015, Manchester British Uro-Oncology Symposium Sept 2014, York

National Conferences – Paediatric malignancies

CCLG Paediatric meeting Jan 2020 Nottingham

CCLG Paediatric Radiotherapy course. June 2017 Oxford CCLG Paediatric Radiotherapy course. June 2015 Manchester Proton therapy course. Jan 2015. Manchester

International Conferences

European Society of Medical Oncology. Sept 2020 – Virtual meeting Genito Urinary ASCO (American Society of Clinical Oncology) – San Francisco Feb 2019 ASCO American Society of Clinical Oncology. June 2015. Chicago European Society of Medical Oncology. Sept 2015. Vienna Educational, Management and CPD Courses

Coronial Law Diploma, University of Bolton July 2018, Good Clinical Practice E-learning Course 2018

Educational Supervisor Trainer Course Jan 2015 Sheffield Quality and Service Improvement course. July 2015. Sheffield Teaching Hospital NHS Foundation Trust

Educational Supervisor Training course. Feb 2015. Sheffield Teaching Hospital NHS Foundation Trust Training the Trainers Course- 3 day. Oct 2013

ALS- Advanced Life Support – Oct 2013

Clinical Governance and Risk Management – 10 week course. Jan 2013 Research Methodology Course – 2 day. Jan 2013

Medical Ethics and Law - 3 day. Nov 2012

Advanced Communication Course – 2 day Oct 2012

Senior Management Course – 3 day. July 2012

Research

10 year cancer centre experience first line therapy for metastatic kidney cancer. Poster presentation at NCRI Nov 2018

A retrospective review and analysis of ten years of prescribing practice at Weston park Hospital for first line metastatic kidney cancer, specifically assessing toxicities and outcomes for Progression free and overall survival.

Are outcomes of adjuvant vaginal vault brachytherapy in endometrial cancer related to the way it is delivered?

MSc Oncology research project - Distinction. Weston Park Hospital 2010. A retrospective analysis of the efficacy, relapse rate, treatment related complications and overall survival of patients with Stage II endometrial adenocarcinoma treated with adjuvant vaginal vault brachytherapy following surgery with focus on the method of treatment delivery and comparing this with available literature.

The results of this study were published in the Journal of Radiotherapy in Practice and presented as a poster at the Royal College of Obstetricians and Gynecologists in London 2010 and orally at the Gyne-oncology study day in 2011.

Primary thyroid lymphoma: The 40 year experience of a UK lymphoma treatment centre. International Journal of Oncology 2012.

A review of the clinical and pathological features of patients with thyroid lymphoma over a 40-year period by the Sheffield Lymphoma Team - one of the largest series conducted in the UK. FDG-PET parameters as predictors for outcome following Stereotactic Ablative Radiotherapy (SABR) Body Radiotherapy for Non-Small Cell Lung Cancer. Presented as a poster at World Lung Cancer Congress, Sydney October 2013 and European Cancer Congress, Amsterdam 2013. Investigation of a range of FDG-PET parameters (Tumour SUVmean, SUVmax, Tumour:Liver SUVmax and SUVmean ratios, Tumour:Mean Blood Pool SUVmax and SUVmean ratios and TLG –Total lesion glycolysis) as predictors for outcomes following SABR in early stage NSCLC. SUVmax was the strongest predictor for outcome.

Refeeding Syndrome after percutaneous endoscopic gastrostomy (PEG) placement. Journal of BAPEN- British Association for Parenteral and Enteral Nutrition Analysis of a range of physical and biochemical parameters pre and post PEG insertion, defining risk factors for the development of Refeeding Syndrome.

Publications

M Alzouebi, R Jones. Outcomes of 10 years prescribing practice for first line metastatic kidney cancer. NCRI 2018

M Alzouebi, JR Goepel, JM Horsman and BW Hancock. Primary thyroid lymphoma: The 40 year experience of a UK lymphoma treatment centre. Int J Oncol 40: 2075-2080, 2012

M Alzouebi, S Pledge and J Martin. Are outcomes of adjuvant vaginal vault brachytherapy in endometrial cancer related to the way it is delivered? Journal of Radiotherapy in Practice. FirstView Article : pp 1-14 Published online: 12 December 2011

M Alzouebi, P Fisher, PJ Woll, MQ Hatton, BH Foran. Audit of adjuvant vinorelbine and cisplatin for patients with resected NSCLC. Lung Cancer 2010;67:S1

M Alzouebi, P Sarrigiannis, M Hadjivassiolou. Acute Polyradiculopathy with renal failure; mind the anion gap – Journal of Neurology, Neurophysiology and Psychiatry Psychiatry 2008;79:842- 844

M Alzouebi. Paediatric Chest Radiographs. StudentBMJ 2005; 13:309-352

M Alzouebi, M McAlindon, DS Sanders. Patients starving before percutaneous endoscopic gastrostomy (PEG) placement may be at risk of refeeding syndrome. BAPEN 2004; 63 (1) Books

Radiotherapy. Essentials of Oncology. M Alzouebi, J Mohanamurali

Non-surgical treatment of breast cancer. The Oxford Textbook of the Fundamentals of Surgery. M Alzouebi, MQF Hatton

Radiotherapy. Manual of head and neck Surgery and Oncology. M Alzouebi. MH Robinson Posters

Poster NCRI 2018. Outcomes of 10 years prescribing practice for first line metastatic kidney cancer.

Poster NCRI 2011. Experience of using sunitinib for the treatment of advanced and/or metastatic renal cell carcinoma in South Yorkshire

Poster and Oral presentation NCRI 2013- FDG-PET parameters as predictors for outcome following Stereotactic Body Radiotherapy (SBRT) for Non Small Cell Lung Cancer

Poster presentation World Lung Cancer Conference 2013- Sydney. FDG-PET parameters as predictors for outcome following Stereotactic Body Radiotherapy (SBRT) for Non Small Cell Lung Cancer

Target Insight Conference Toronto 2013 accepted- PET parameters as predictors for recurrence/metastatses in patients with lung cancer treated with SBRT

Poster presentation BTOG Dublin 2013- Carboplatin/Vinorelbine in advanced/metastatic Non small cell lung cancer

Poster presentation RCOG London Nov 2010 – Endometrial cancer and adjuvant vaginal bracytherapy

Poster presentation UAE Cancer congress accepted October 2010 – Neutropenic sepsis in adjuvant chemotherpay in NSCLCa

Poster presentation BTOG Dublin Jan 2010 – Adjuvant chemotherapy in NSCLCa

Poster presentation RCR London May 2010 - Adjuvant chemotherapy in NSCLCa

Poster presentation DAFNE (Dose Adjustment for Normal Eating in Diabetic patients) UK Diabetes Conference – Birmingham 2006

Audits

Audit of one year of neutropenic sepsis admissions to Weston Park Hospital 2019

Pazopanib and Sunitinib in Advanced renal cell cancer 2018 – ten years on – local practice at Weston Park Hospital

Audit on Carboplatin/Vinorelbine in advanced/metastatic lung cancer Jan 2013

Audit of use of Sunitinib in advanced/metastatic renal cell cancer in Sheffield – April 2011

Use of Carboplatin in poor performance status ovarian and primary peritoneal cancer - September 2010

Use of adjuvant chemotherapy in Non small cell lung cancer in Sheffield - March 2009

Morbidity and Mortality cases 30 days after treatment with capecitabine for colorectal carcinoma - Jan 2009

Thromboprophylaxis in medical patients - May 2008

Management of Bowens Disease and the British Association of Dermatologist Guidelines - Nov 2007

Ovarian Cancer and NICE guidelines at Weston Park Hospital - March 2006

DAFNE (Dose Adjustment for Normal Eating) in Diabetic patients. Retrospective study on the effect of DAFNE on the development of diabetic complications and risk factors for Ischaemic Heart Disease - Aug 2005

Presentations

FRCR VIVA examination Oct 2020

Germ Cell radiotherapy FRCR course July 2019

Renal cancer and first line treatments- Jan 2019

Germ Cell radiotherapy FRCR course July 2018

Specialist Registrar training programme - Urology Update Jun 2018

British Association of urology nurses- Prostate cancer March 2018

Examiner for the Sheffield FRCR course July 2018

Examiner for the Sheffield FRCR course July 2017

RAIDER trial course Sep 2017

Germ Cell radiotherapy FRCR course July 2018

FRCR examinee tale- FRCR course July 2012 and 2013

Enzalutamide in Metastatic prostate cancer 2012

Endometrial cancer and adjuvant brachytherapy – Gynae-Oncology Study day, Sheffield May 2011

Adjuvant Brachytherapy in Endometrial Cancer - Sept 2010

Carboplatin in poor performance status ovarian/PPc cancer patients – Sept 2010

Treatment of recurrent meningioma June 2010

Managing unscheduled interruptions in radical radiotherapy- RCR guidelines October 2009

Use of adjuvant chemotherapy in Non small cell lung cancer in Sheffield (March 2009)

Morbidity and Mortality cases 30 days after treatment with capecitabine for colorectal carcinoma (May 2009) Weston Park Hospital, Sheffield Teaching Hospitals NHS Foundation Trust

A Randomised, Double-Blind, Placebo-Controlled Study to Assess Efficacy and Safety of Alosetron in women with severe Diarrhoea-predominant IBS, Gastroenterology Journal Club

(March 2008)

Management of Bowens Disease, Regional Dermatology Meeting, Rotherham Hospital (Nov 2007)

Infliximab for the treatment of Hidradentitis Suppurativa, Dermatology Journal club meeting, Royal Hallamshire Hospital (October 2007)

Case of Ethylene Glycol induced renal failure and polyradiculopathy, Grand round, Bassetlaw Hospital (June 2007)

Audit on ESBL's, Department of Microbiology, Royal Hallamshire Hospital (Jan 2007)

British Society of Gastroenterologists and the Guidelines on management of Ascites, Journal club meeting, Bassetlaw Hospital (Dec 2006)

Positions Held

Lead for Prostate Interventional Fiducial marker service for patients undergoing SABR to treat prostate cancer

Lead for Uro-oncology Radiotherapy practice guidelines at Weston Park Hospital– established in accordance with evidence base practice and in line with the Yorkshire Cancer Network.

Lead for Paediatric Radiotherapy practice guidelines at Weston Park Hospital– established in accordance with evidence base practice and in line with Childhood Cancer Leukemia Group

Co-Lead for Uro-Oncology Peer review of complex radiotherapy plans

Designated Medical Supervisor Sheffield Hallam University for Masters in Advanced Medical Prescribing- and lead for education, training and supervision of uro-oncology CNS

Developing Establishing radiographer and senior nurse led prostate cancer telephone clinic

Principal Investigator and co-investigator for several trials at Clinical Cancer Trials Centre – Weston Park Hospital, Sheffield Teaching Hospital NHS Foundation Trust

Clinical and Educational Supervisor for Oncology trainee and Cancer Specialist Nurses

Examiner and Lecturer on the Sheffield FRCR II preparatory course 2014- to present

Examiner for Sheffield University Medical School Exams 2012- 2018

Clinical Oncology Clinical and Educational Supervisor for trainees in Clinical Oncology 2014- present

Associate tutor for Royal College of Physicians – Bassetlaw Hospital (Aug 2006-Aug 2007) Teaching

Undergraduate:

OSCE examiner for Sheffield Medical School 2012- 2018 Clinic and ward based teaching of medical students attached to oncology- particular emphasis on medical school exam preparation

Timetabled teaching for students on oncology placements Supervision of students undertaking oncology audit projects Postgraduate:

Co-ordinator of the Oncology trainee Regional Study day Timetabled small group teaching of FY1, FY2 and core medical trainees covering acute oncology, principles of radiotherapy and chemotherapy and specific cancer types Assessor for workplace-based assessments (CEX, DOPs and CBD) Registrar:

Clinical and Educational Supervisor for oncology trainee Lecturer and examiner at FRCR part II Sheffield Course FRCR viva and clinical practice for candidates preparing for examination Regular sessional lead for weekly in-house FRCR teaching Professional Organisations

Member of Medical Defence Union (MDU) and Royal College of Radiologist (RCR) References

Dr S Pledge Dr C Ferguson

Consultant Clinical Oncologist Consultant Clinical Oncologist Broomcross Building Broomcross Building

Weston Park Hospital Weston Park Hospital

Whitham Road Whitham Road

Sheffield S10 2SJ Sheffield S10 2SJ

011**-****** 011**-******

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