e-mail: email@example.com, firstname.lastname@example.org
A result oriented professional scientist having more than 16 years of rich experience in the filed of ORGANIC SYNTHESIS, Process development of Active Pharmaceuticals Ingredients, Technology transfer, NCE Development, Intermediates and Fine Chemicals
Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits (Bioorganic & Medicinal Chemistry, Volume 20, Issue 9, 1 May 2012, Page 2930-2939)
Isocytosine-based inhibitors of xanthine oxidase: Design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia (Bioorganic & Medicinal Chemistry Letters 22, (2012), 7543-7546)
Lead optimization of isocytosine–derived xanthine oxidase inhibitors (Bioorganic & Medicinal Chemistry Letters 22 (2012))
US7223863 B2 IMPROVED PROCESS FOR THE PREPARATION OF TADALAFIL
WO2010076763 (A2) AN IMPROVED PROCESS FOR THE MANUFACTURE OF SERTRALINE
WO2010084459 (A2) IMPROVED PROCESS FOR PREPARING AN INTERMEDIATE OF SERTRALINE
GR20120100069 PROCESS FOR THE PREPARATION OF BROMOPYRIMIDINE DERIVATIVE
Literature search from Chemical abstracts, JOC, JACS, and Tetrahedrons letters, Chem. Pharm. Bull. JMC, BMC, patents etc
Route evaluation and development of non-infringing synthetic routes of Target molecules
Process Development of APIs and its Polymorphs according to specification by EP, USP etc
Optimisation of Process in terms of operation, time-cycle, inputs and yields to reduce cost and maximize throughput
Process development, process validation, determination of critical process parameters, Scale up etc.
Synthesis, isolation and characterization of impurities, process related impurities etc
Development of robust crystallization procedures for intermediates and final products.
Development of New Chemical Entities and Multi steps synthesis of Organic molecules for clinical trials
Asymmetric synthesis, resolution of recemic compounds, metal catalysed reactions
Development of plant scalable, non-infringing process for APIs of various therapeutic catagories
Evaluation and Characterization of organic molecule by the spectroscopy, chromatography, methods like PMR, CMR, LC-MS, HPLC, XRD, DSC, etc
Handling of various type of chemical reaction from laboratory scale to pilot plant & pilot to commercial scale production (BuLi, LDA, LHMDS etc.).
Ability to perform work under cryogenic conditions (-78 C) and at high pressures
Rapid screening of reactions conditions by utilizing equipment like parallel synthesizer, Julaboo
Good documentation skills, preparation of experimental reports, PDR (Process Development Records), TTD (Technology Transfer Documents) etc
Coordinating with the scientific and regulatory dept. to ensure preparation of dossiers and also satisfy customers with the related queries.
Updation of status and maintenance of Journals, files & records.
Exceptional organization and communication skills, both verbal and written.
The ability to handle multiple priorities in a dynamic and fast paced organization
Ability to interact with customers and multi-functional teams
Ensuring stringent adherence to quality standards, norms & practices, identifying gaps, trouble shootings and taking corrective action
Friedel-Crafts reaction, Pictet-Spengler reaction, Claisen condensation, Claisen-Schmidt reaction, Grignard reaction, Suzuki coupling, Sand-mayer reaction (Cynation), Oxidation, Reduction, Microwave reaction, Reformatsky reaction, mukaiama aldol condensation. Miyaura Ishiyama boration, Suzuki Miyaura coupling, Appel reaction, Finkelstein reaction, Wittig reaction, Horner-emmons reaction, Swern, Dess-Martin reactions etc
Since April 2017 till date with Amneal pharmaceutical pvt Ltd as a Asst. Manager in IPR R&D department
Feb 2010-March 2017 with Adventus Laboratories India Pvt. Ltd (A group company of Pharmathen Pharmaceutical Ltd, Greece) as a Research Scientist in Organic Synthesis department
Aug 2007- Jan 2010 With Piramal Lifescience ltd as a Jr. Research Scientist in Medicinal chemistry department
Jan 2006 - Jun 2007 with Oman Chemicals & Pharmaceuticals LLC. (Sultanate of Oman) as a Research Executive in R&D department
July 2004-Jan 2006 with Bio Arc Solution (Alembic Ltd) as a Research Associates in R&D department
Nov 2003 to July 2004 with Zydus Cadila Healthcare Ltd as a Research Chemist in R&D department
Commenced Career from Aug 2002 to Nov 2003 with Metrochem Industries ltd as a Research Chemist in R&D department
Projects work upon:
Development of Xanthin Oxidase Inhibitor (NCE development for the treatment of Gout)
Voriconaozole, Rosuvastatin, Aripiprazole, Aprepitant
Sertraline Hydrochloride, Irbesartan, Telmisartan,
Losartan, Ramipril, Lisinopril,
Lamotrigine, Tadalafil, Aprepitant
Zonisamide, Ivabradine, Pregabaline
2-ethyl-hexyl-methoxy-cinnamate (For UV protection)
Multistep Synthesis of New Chemical Entities (CRD)
Entacavir (18 step synthesis) plant scale up
D-Penicillamine, Nitazoxanide, Chlordiazepoxide
Basic Knowledge (MS office), Chemistry related software (ISIS, ChemSketch, Chem-draw, NMR, Marvin Sketch) & Internet search
Master of Science – M.Sc. (Organic Chemistry) (June 2000-2002): from Department of Chemistry, Sardar Patel University,
Bachelor of Science – B.Sc. (Chemistry) (June 1997-2000): from V.P. & R.P.T.P. Science College, Sardar Patel University,
Higher Secondary Certificate – H.S.C. Science Stream (March 1997): Gujarat Secondary Education Board,.
Secondary Certificate – S.S.C. (March 1995): Gujarat Secondary Education Board,
Date of Birth : 15th August 1980
Marital Status : Married
Address : 301, Shivani Flats, B/H : Bank of India, Ellorapark, Subhanpura, Vadodara