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Manager Plant

Location:
Kadi, Gujarat, India
Salary:
Negotiable
Posted:
October 12, 2019

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Resume:

Pranay Shah

Mobile: +91-823*******

e-mail: adakpd@r.postjobfree.com, adakpd@r.postjobfree.com

PROFESSIONAL SYNOPSIS

A result oriented professional scientist having more than 16 years of rich experience in the filed of ORGANIC SYNTHESIS, Process development of Active Pharmaceuticals Ingredients, Technology transfer, NCE Development, Intermediates and Fine Chemicals

Article/Patent published

Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits (Bioorganic & Medicinal Chemistry, Volume 20, Issue 9, 1 May 2012, Page 2930-2939)

Isocytosine-based inhibitors of xanthine oxidase: Design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia (Bioorganic & Medicinal Chemistry Letters 22, (2012), 7543-7546)

Lead optimization of isocytosine–derived xanthine oxidase inhibitors (Bioorganic & Medicinal Chemistry Letters 22 (2012))

US7223863 B2 IMPROVED PROCESS FOR THE PREPARATION OF TADALAFIL

WO2010076763 (A2) AN IMPROVED PROCESS FOR THE MANUFACTURE OF SERTRALINE

WO2010084459 (A2) IMPROVED PROCESS FOR PREPARING AN INTERMEDIATE OF SERTRALINE

GR20120100069 PROCESS FOR THE PREPARATION OF BROMOPYRIMIDINE DERIVATIVE

Product Development

Literature search from Chemical abstracts, JOC, JACS, and Tetrahedrons letters, Chem. Pharm. Bull. JMC, BMC, patents etc

Route evaluation and development of non-infringing synthetic routes of Target molecules

Process Development of APIs and its Polymorphs according to specification by EP, USP etc

Optimisation of Process in terms of operation, time-cycle, inputs and yields to reduce cost and maximize throughput

Process development, process validation, determination of critical process parameters, Scale up etc.

Synthesis, isolation and characterization of impurities, process related impurities etc

Development of robust crystallization procedures for intermediates and final products.

Development of New Chemical Entities and Multi steps synthesis of Organic molecules for clinical trials

Asymmetric synthesis, resolution of recemic compounds, metal catalysed reactions

Development of plant scalable, non-infringing process for APIs of various therapeutic catagories

Analytical skills

Evaluation and Characterization of organic molecule by the spectroscopy, chromatography, methods like PMR, CMR, LC-MS, HPLC, XRD, DSC, etc

Handling ability

Handling of various type of chemical reaction from laboratory scale to pilot plant & pilot to commercial scale production (BuLi, LDA, LHMDS etc.).

Ability to perform work under cryogenic conditions (-78 C) and at high pressures

Rapid screening of reactions conditions by utilizing equipment like parallel synthesizer, Julaboo

Documentation

Good documentation skills, preparation of experimental reports, PDR (Process Development Records), TTD (Technology Transfer Documents) etc

Coordinating with the scientific and regulatory dept. to ensure preparation of dossiers and also satisfy customers with the related queries.

Updation of status and maintenance of Journals, files & records.

Management skills

Exceptional organization and communication skills, both verbal and written.

The ability to handle multiple priorities in a dynamic and fast paced organization

Ability to interact with customers and multi-functional teams

Ensuring stringent adherence to quality standards, norms & practices, identifying gaps, trouble shootings and taking corrective action

Organic Reaction

Friedel-Crafts reaction, Pictet-Spengler reaction, Claisen condensation, Claisen-Schmidt reaction, Grignard reaction, Suzuki coupling, Sand-mayer reaction (Cynation), Oxidation, Reduction, Microwave reaction, Reformatsky reaction, mukaiama aldol condensation. Miyaura Ishiyama boration, Suzuki Miyaura coupling, Appel reaction, Finkelstein reaction, Wittig reaction, Horner-emmons reaction, Swern, Dess-Martin reactions etc

CAREER HIGHLIGHTS

Since April 2017 till date with Amneal pharmaceutical pvt Ltd as a Asst. Manager in IPR R&D department

Feb 2010-March 2017 with Adventus Laboratories India Pvt. Ltd (A group company of Pharmathen Pharmaceutical Ltd, Greece) as a Research Scientist in Organic Synthesis department

Aug 2007- Jan 2010 With Piramal Lifescience ltd as a Jr. Research Scientist in Medicinal chemistry department

Jan 2006 - Jun 2007 with Oman Chemicals & Pharmaceuticals LLC. (Sultanate of Oman) as a Research Executive in R&D department

July 2004-Jan 2006 with Bio Arc Solution (Alembic Ltd) as a Research Associates in R&D department

Nov 2003 to July 2004 with Zydus Cadila Healthcare Ltd as a Research Chemist in R&D department

Commenced Career from Aug 2002 to Nov 2003 with Metrochem Industries ltd as a Research Chemist in R&D department

Projects work upon:

Development of Xanthin Oxidase Inhibitor (NCE development for the treatment of Gout)

Voriconaozole, Rosuvastatin, Aripiprazole, Aprepitant

Sertraline Hydrochloride, Irbesartan, Telmisartan,

Losartan, Ramipril, Lisinopril,

Lamotrigine, Tadalafil, Aprepitant

Zonisamide, Ivabradine, Pregabaline

2-ethyl-hexyl-methoxy-cinnamate (For UV protection)

Multistep Synthesis of New Chemical Entities (CRD)

Entacavir (18 step synthesis) plant scale up

D-Penicillamine, Nitazoxanide, Chlordiazepoxide

Computer Skills

Basic Knowledge (MS office), Chemistry related software (ISIS, ChemSketch, Chem-draw, NMR, Marvin Sketch) & Internet search

ACADEMIC CREDENTIALS

Master of Science – M.Sc. (Organic Chemistry) (June 2000-2002): from Department of Chemistry, Sardar Patel University,

Bachelor of Science – B.Sc. (Chemistry) (June 1997-2000): from V.P. & R.P.T.P. Science College, Sardar Patel University,

Higher Secondary Certificate – H.S.C. Science Stream (March 1997): Gujarat Secondary Education Board,.

Secondary Certificate – S.S.C. (March 1995): Gujarat Secondary Education Board,

PERSONAL VITAE

Date of Birth : 15th August 1980

Marital Status : Married

Address : 301, Shivani Flats, B/H : Bank of India, Ellorapark, Subhanpura, Vadodara

Gujarat-India



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