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Research Development

Location:
Evanston, Illinois, United States
Posted:
May 21, 2018

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Resume:

Gleb Baida, PhD

**** W **th St #*** Chicago IL 60608 • 312-***-**** • ac5jo3@r.postjobfree.com

Research Scientist

Experienced in developing research projects and bringing them to completion Core Competencies

● Analysis of complex scientific data ● Optimization, troubleshooting, and development of lab protocols

● Experimental design, execution, and interpretation ● Collaborating with colleagues and senior investigators, counseling and training laboratory staff and collaborators in multiple technical and scientific issues, moving projects to completion. ● Oral and written scientific communication skills Technical Expertise

● Advanced molecular and cell biology techniques ● Animal handling and transgenic models ● Tumor models in mice: transplantation of human tumor cells into immune-compromised mice via SC route

● Drug administration via SC, IP, and IV routes. ● In vivo and in vitro assays ● Primary cells and cancer cell lines ● Fluorescence microscopy, FACS, and cell sorting ● Immunological methods of isolation and characterization of basal and stem cells from murine skin ● Cell culture● Quantitative PCR and gene expression analysis ● DNA sequence analysis and bioinformatics ● Gene delivery, lentiviral and retroviral transduction, gene expression and knock-down ● Computer skills, statistical software Research Experience

Planned, prepared, performed and analyzed experiments related to molecular biology and microbiology. Performed literature and nucleic acid sequence searches to investigate, understand, and plan for research projects. Documented experiments and related activities by maintaining an up-to-date laboratory notebook. Presented scientific findings at scientific or professional association meetings and conferences. Worked with a principal investigator to publish work in peer-reviewed scientific journals. Northwestern University 2008 – current

Department of Dermatology, Research Associate

● Identified and validated genes responsible for skin atrophy caused by corticosteroids. Participated in projects aimed at discovering biological compounds and drugs which would decrease side effects of corticosteroids without decreasing their clinical effects. These studies build the foundation for developing safer topical glucocorticoid treatment regimens.

● Investigated small molecule compounds for chemotherapy of hematologic malignancies, as part of a team. We confirmed therapeutic potential of the compounds for treatment of inflammation and cancer.

● My work led to 3 scientific papers in dermatology space. Reported scientific results at international meetings. Tutored and supervised junior lab members, counseled collaborators and team members, which resulted in successful completion of the team projects. My research work critically contributed to funding the laboratory by NIH and other research funds. University of Chicago 2000 – 2008

Departments of Neurology and Medicine, Research Associate

● Authored 4 scientific papers in neuroscience and virology, focusing on a viral model of multiple sclerosis and molecular mechanisms of virus-induced neurological disease. Participated in multiple steps of the projects, from bench work to scientific content preparation. Reported scientific results at international meetings. My work was essential for funding of laboratory by NIH. Education

• PhD (Molecular Biology) Institute of Genetics and Selection of Industrial Microorganisms, State Research Center of Russian Federation, Moscow

• Professional Memberships

• 2016 – current, Society of Investigative Dermatology

• 2014 European Society of Dermatology

• 2004 – 2008, American Society of Microbiology

• 2004 – 2008, Sigma Xi, Scientific Research Society Awards

• 2014, 1st place/500 Euro Award for poster presentation at Dermatoendocrinology Satellite Symposium to the 44th meeting of the European Society for Dermatological Research, Sept. 10-13, Copenhagen, Denmark

Selected Peer-Reviewed Publications

1. Lesovaya E., Agarwal S., Readhead B., Vinokour E., Baida G., Bhalla P., Kirsanov K., Yakubovskaya M., Platanias L.C., Dudley J.T., Budunova I. (2018) Rapamycin modulates glucocorticoid receptor function, blocks atrophogene REDD1, and protects skin from steroid atrophy. J Invest Dermat., Mar 26 [Epub ahead of print].

2. Kishibe M., Baida G., Bhalla P., Lavker R.M., Schlosser B., Iinuma S., Yoshida S., Dudley J.T., Budunova I. (2016) Important role of kallikrein 6 for the development of keratinocyte proliferative resistance to topical glucocorticoids. Oncotarget, 7(43):694**-***** 3. Klopot A., Baida G., Bhalla P., Haegeman G., Budunova I. (2015) Selective activator of the glucocorticoid receptor Compound A dissociates therapeutic and atrophogenic effects of glucocorticoid receptor signaling in skin. J Cancer Prev., 20(4):250-9. 4. Baida G., Bhalla P., Kirsanov K., Lesovaya E., Yakubovskaya M., Yuen K., Guo S., Lavker R.M., Readhead B., Dudley J.T., Budunova I. (2014) REDD1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoids. EMBO Mol Med., 7(1):42-58. 5. Ghadge G., Wollman R., Baida G. et al. (2011) The L-coding region of the DA strain of Theiler's murine encephalomyelitis virus causes dysfunction and death of myelin-synthesizing cells. J Virol., 85(18):9377-84.

6. Stavrou S., Baida G., Viktorova E. et al. (2010) Theiler’s murine encephalomyelitis virus (TMEV) L* amino acid position 93 is important for virus persistence and virus-induced demyelination. J Virol., 84(3):1348-54.

Selected Meeting Presentations

1. Baida G., Yemelyanov A., Bhalla P., Panya A., Brown M. et al. (2016) Topical application of anti- cancer drug Bortezomib stimulates proliferation of follicular cells and induces expression of hair keratins via GATA-3 transcription factor. Society of Investigative Dermatology, May 11-14, Scottsdale, Arizona.

2. Baida G., Bhalla P., Chen H., Shou W., Sanchez E., Budunova I. (2014) Deletion of the glucocorticoid receptor chaperone Fkbp5 unexpectedly prevents development of glucocorticoid- induced cutaneous atrophy via Akt activation. The 44th annual ESDR meeting, September 10-13, Copenhagen, Denmark.

3. Baida G. Bhalla P., Yuen K., Guo S., Lavker R.M. and Budunova I. (2013) Deletion of mTOR inhibitor REDD1 protects CD34+ follicular epithelial stem cells and prevents development of steroid-induced cutaneous atrophy. International Investigative Dermatology Meeting, May 8-11, Edinburgh, Scotland.

4. Baida G., Rundhaug J., Bhalla P., Budunova I. (2012) Role of the glucocorticoid receptor in skin carcinogenesis and stem cell maintenance: Implication for the use of selective GR activators

(SEGRA) as anti-cancer drugs. AACR 103rd Annual Meeting, March 31-Apr 4, Chicago, Illinois.



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