Formulation chemist

CHENCHEN WANG

***L Misty Woods Circle, Chapel Hill, NC 27514, Cell: 919-***-****, Email: *******@*****.***

HIGHLIGHTS

A dedicated formulation specialist qualified by a strong academic background in pharmaceutics (M.S.) and broad laboratory experience:

* Formulation development (spray drying, lyophilization, wet-milling, dynamic light scattering, SEM, DSC, TGA, TLC, Franz diffusion cell, dissolution test, UV spectrometry, two stage liquid impinger)

* Biological Assays (HPLC, LC-MS, ELISA, MTT Assay)

* Protein expression and purification (plasmid design and preparation, restriction mapping, PCR, Agarose gel electrophoresis, metal affinity resin column, SDS-PAGE, Bradford assays)

* Cell culture, animal handling and surgery

EDUCATION

School of Pharmacy, University of North Carolina, Chapel Hill, NC

Master of Science in Molecular Pharmaceutics, 2009

Thesis title: "Pulmonary Delivery of an Antituberculosis Drug to Treat Mycobacterium tuberculosis."

College of Pharmacy, University of Kentucky, Lexington, KY (GPA: 4.0/ 4.0)

Master of Science in Drug Discovery, 2005

Thesis title: "Carbon-Carbon Bond Cleaving Oxygenases Involved in Biosynthetic Pathways of Anticancer Drugs and Antibiotics."

College of Pharmacy, China Pharmaceutical University, Nanjing, China (GPA: 86%)

Bachelor of Engineering in Pharmaceutics, 1998

Thesis Title: "The Effects of Permeation Enhancers on the Transdermal Delivery System of an Antidiabetic Drug through Rat Skin."

PROFESSIONAL EXPERIENCE

Graduate Research Assistant, University of North Carolina, Chapel Hill, NC, 2007-Present

Advisor: Anthony J Hickey, Ph.D., Professor

* Prepared and characterized microparticles and nanoparticles for pulmonary delivery

* Developed and validated HPLC methods to quantify drug concentrations in biological samples

* Performed pharmacokinetic study of an antituberculosis drug

* Assessed cytotoxicity of drug particles

* Evaluated antituberculosis effects of drug particles using the infected-cell model

* Assisted in efficacy studies of two mucosal vaccines against Hepatitis B and Diphtheria

Summer Intern, Schering-Plough Corporation, Summit, NJ, 2009

Advisors: Pranav Gupta, Ph.D. and Sai Chamarthy, Ph.D.

* Successfully increased dissolution of insoluble APIs by nanoparticle engineering

* Optimized spray drying conditions to generate stabilized nanoparticles for oral delivery

* Spray dried API solutions to prepare drug microparticles for inhalation

Graduate Teaching Assistant, University of North Carolina, Chapel Hill, NC, 2005-2007

* "Pharmaceutical Care Laboratory I & III", "Pharmaceutical Care Laboratory II & IV", "Introduction to Health Systems", "General Pharmacology"

Graduate Research Assistant, University of Kentucky, Lexington, KY, 2003-2005

Advisor: Jurgen Rohr, Ph.D., Professor

* Successfully constructed five protein overexpression systems and purified the soluble proteins

* Successfully crystallized three oxygenases which diffracted to high resolutions using synchrotron radiation

* Performed enzymatic activity assays

* Biosynthesized and purified polyketides

* Assessed bioactivity of polyketides using human cancer cell lines

Graduate Teaching Assistant, University of Kentucky, Lexington, KY, 2002-2003

* "Pharmacological Basis for Therapeutics: Antibiotics", "Pharmacological Basis for Therapeutics: Endocrine Systems", "Non-prescription Pharmaceuticals and Supplies"

Pharmacist, Henan Provincial People's Hospital, Zhengzhou, China, 1998-2002

* Established and managed drug information databases

* Developed pharmaceutical preparations and performed quality control

* Conducted therapeutic drug monitoring (TDM)

* Evaluated bioavailability and bioequivalence of new formulations

Undergraduate Researcher, China Pharmaceutical University, Nanjing, China, 1998

Advisor: Jianping Zhou, Ph.D., Professor

* Designed transdermal drug delivery system and sustained-release drug delivery system

ADDITIONAL RELEVANT TRAINING:

* GMP Basic Training, Schering-Plough Corporation, Summit, NJ, 2009

* Chemical Hygiene Training, Schering-Plough Corporation, Summit, NJ, 2009

* SOP Awareness Training, Schering-Plough Corporation, Summit, NJ, 2009

COMPUTER SKILLS

MS Office, DOE, Sigma Plot, WinNolin, Internet Explorer, Pub Med, EndNote, Adobe, Photoshop, SAS, Image J, MDL ISIS Draw

HONORS

* Scholar for Tomorrow Fellowship, University of North Carolina, Chapel Hill, 2005-2006

* Kentucky Opportunity Fellowship, University of Kentucky, 2004 - 2005

* China Pharmaceutical University Fellowship, 1994 - 1998

* Tianjin Smith Kcline & French Labs. Ltd., First-Class Scholarship, 1997

* Model Student Honor (awarded to students excellent in academic, moral, and physical qualities), 1994 - 1997

PUBLICATIONS

* Muttil P.; Wang, C.; Hickey, A. J., "Inhaled drug delivery for tuberculosis therapy." Pharm Res 2009, In press.

* Wang, C.; Muttil, P.; Lu, D.; Beltran-Torres, A. A.; Garcia-Contreras, L.; Hickey, A. J., "Screening for potential adjuvants administered by the pulmonary route for tuberculosis." The AAPS Journal 2009, 11(1), 139-47.

* Wang, C.; Gibson, M.; Rohr, J.; Oliveira, M. A., "Crystallization and X-ray diffraction properties of Baeyer-Villiger monooxygenase MtmOIV from the mithramycin biosynthetic pathway in Streptomyces argillaceus." Acta Crystallograph Sect F Struct Biol Cryst Commun. 2005, 61(Pt 11), 1023-6.

* Chen, Y. H.; Wang, C. C.; Greenwell, L.; Rix, U.; Hoffmeister, D.; Vining, L. C.; Rohr, J.; Yang, K. Q., "Functional Analyses of Oxygenases in Jadomycin Biosynthesis and Identification of JadH as a Bifunctional Oxygenase/Dehydrase." J Biol Chem 2005, 280, (23), 22508-14.

* Rix, U.; Wang, C.; Chen, Y.; Lipata, F. M.; Remsing Rix, L. L.; Greenwell, L. M.; Vining, L. C.; Yang, K.; Rohr, J., "The Oxidative Ring Cleavage in Jadomycin Biosynthesis: a Multistep Oxygenation Cascade in a Biosynthetic Black Box." Chembiochem 2005, 6, (5), 838-845.

* Ostash, B.; Rix, U.; Rix, L. L.; Liu, T.; Lombo, F.; Luzhetskyy, A.; Gromyko, O.; Wang, C.; Brana, A. F.; Mendez, C.; Salas, J. A.; Fedorenko, V.; Rohr, J., "Generation of New Landomycins by Combinatorial Biosynthetic Manipulation of the LndGT4 Gene of the Landomycin E Cluster in S. globisporus." Chem Biol 2004, 11, (4), 547-55.

* Wang, D., Zhao, H., Li, G., and Wang, C., "Preparation and Quality Control of Levofloxacin Lactate Vaginal Effervescent Tablets." Chinese Journal of Hospital Pharmacy 2002, 22(4), 250-251.

ABSTRACTS/POSTERS

* Wang, C.; Hickey, A.J., "Preparation of isoxyl particles for pulmonary delivery." Fourth Annual Chapel Hill Drug Conference, May 13-14, 2009, Chapel Hill, NC

* Wang, C.; Gupta, P.; Chamarthy, S.; Ewing, G.; Wan, J.; Monteith, D.; Chambers, D., "Particle engineering of APIs by spray drying for drug delivery." Intern Poster Day, Aug 6, 2009, Schering-Plough Corporation, Summit, NJ

* Wang, C.; Muttil, P.; Lu, D.; Beltran-Torres, A.; Garcia-Contreras, L.; Hickey, A.J., "Preparation, Characterization, and Cellular Response to Microparticles Containing Muramyl Dipeptide and Trehalose Dibehenate." AAPS Annual Meeting and Exposition, Nov 11-15, 2007, San Diego, CA

* Gibson, M.; Nur-e-alam, M.; Wang, C.; Rohr, J., "MtmOIV, a Key Baeyer-Villiger Type Oxygenase of the Mithramycin." 229th American Chemical Society National Meeting & Exposition., Mar 13-17, 2005, San Diego, CA

ACTIVITIES

* Member of the American Association of Pharmaceutical Scientists (AAPS), 2007-2008

* Treasurer of the University of Kentucky Chinese Student and Scholarship Association, 2004

* Member of the Chinese Red Cross, 1998-2002

* Committee member in charge of recreation activities at China Pharmaceutical University, 1995-1998

REFERENCES

Available upon request

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