Chemist

CURRICULUM VITAE

PERSONAL INFORMATION

Name OLGA A. HENDERSON (MADDEN NAME OLGA HABAROVA)

Address **** ********* ****, *****, ** 92083, USA

Telephone 760-***-****

E-mail ****.*.*********@*****.***

I have received an employment authorization card for work in USA

WORK EXPERIENCE

• Dates 11.01.2010 – 07.03.2012

• Name and address of employer The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA

Department of Chemistry, Scientific Advisor: Professor Edward Roberts.

• Position held Research Associate

• Main activities and responsibilities Design and synthesis of new Oxytocin and Vasopressin receptor positive allosteric modulators, Opioid receptor ligands and Sphingosine Phosphate Receptor agonists. Design, synthesis and description of new small chemical compounds (MW 300-500) that could be used for treatment of patients with Autistic Spectrum Disorders, depression and anxiety. Purification and analysis of obtained compounds using modern equipment for HPLC, NMR (Mercury 300, Av-400, Inova-399, DRX-500), LCMS, IR, work with Biotage equipment. Maintaining, editing and updating of ISIS Data Base.

• Dates 2007 – 2010

• Name and address of employer Latvian Institute of Organic Synthesis, Aizkraukles str. 21, LV-1006, Riga, Latvia

Laboratory of Carbofunctional Compounds

• Position held Scientific Researcher

• Main activities and responsibilities Development of new patent-free anti-cancer agents based on innovative approach for use as pharmacological target zinc containing enzymes. Development of alternative methods for biological screening and analyzing of carbonic anhydrase inhibitors as well as histone deacetylase inhibitors. Teaching and supervising of students. Molecular modeling using HyperChem molecular modeling program pocket.

• Dates 2006 – 2007

• Name and address of employer Latvian Institute of Organic Synthesis, Aizkraukles str. 21, LV-1006, Riga, Latvia

Laboratory of Carbofunctional Compounds

• Position held Research Assistant

• Main activities and responsibilities Design, synthesis, purification and identification of organic chemical compounds. Analyzing of experiments using several pieces of equipment and techniques including; 1H/13C NMR, IR, TLC, HPLC and BiotageTM Column Chromatography. Teaching and controlling students. Preparation of final product certificate for customers.

• Dates 2002 – 2006

• Name and address of employer Latvian Institute of Organic Synthesis, Aizkraukles str. 21, LV-1006, Riga, Latvia

Laboratory of Carbofunctional Compounds

•Position held Laboratory Assistant

• Main activities and responsibilities Synthesis, purification and identification of organic chemical compounds. Distillation and purification of the solvents.

EDUCATION

• Dates 2006 – 2010

• Name of University Faculty of Chemistry, Riga Technical University, Riga, Latvia

Title of qualification Doctor of Science studies in Organic Chemistry (PhD)

• Dates 2004 - 2006

• Name of University Faculty of Chemistry, Latvian University, Riga, Latvia

• Title of qualification Master of Natural Science in Chemistry (MS)

• Dates 2001 – 2004

• Name of University Faculty of Chemistry, Riga Technical University, Riga, Latvia

• Title of qualification Bachelor of Natural Sciences (BS)

AWARDS & HONORS

• Date, location, name of award 2006, Latvian University, for work in Organic Chemistry.

• Date, location, name of award 2006, OlainFarm, for work “Synthesis and investigation of histone deacetylase inhibitors containing quinoline fragment”.

Other skills and abilities

Computer Windows (all versions), MS Office, Photoshop, Internet browsers (Opera, IE, Mozilla Firefox and others), work with databases (Belshtein Crossfire, Science Direct, Sci-Finder, PubMed), special programs (ISIS Draw, ISIS DataBase, ChemBioOffice, ChemWin, NUTS, MestreNova, HyperChem software package) etc..

Mother tongue RUSSIAN

Other languages ENGLISH, LATVIAN

Personal Skills

Ability to decision making in day-to-day shift activities. Good presentation and communication skills. Ability to proper training and guidance to the subordinates. Quick to learn new skills.

PROJECTS

• Date 2009-2010

• Name and address of project Design of inhibitors of zink containing enzymes and investigation of anti-cancer activity. No. 1DP/1.1.1.2.0/09/APIA/VIAA/023

Latvian Institute of Organic Synthesis, Aizkraukles str. 21, LV-1006, Riga, Latvia

• Main activities and responsibilities Development of new patent-free anti-cancer agents based on innovative approach for use as pharmacological target zinc containing enzymes. Design, synthesis, purification and identification of novel heterocyclic hydroxamic acid derivatives as inhibitors of histone deacetylase. Development of alternative methods for biological screening and analyzing of carbonic anhydrase inhibitors as well as histone deacetylase inhibitors using human CA I, CA II and HeLa extract.

• Date 2002-2008

• Name and address of project The design and synthesis of novel, patentable compounds with therapeutic potential against TopoTarget drug discovery targets.

Latvian Institute of Organic Synthesis, Aizkraukles str. 21, LV-1006, Riga, Latvia

• Main activities and responsibilities Design, synthesis, purification and identification of novel heterocyclic hydroxamic acid derivatives as inhibitors of histone deacetylase. Quantum molecular calculations by HyperChem software package.

• Date 2002-2005

• Name and address of project Investigations of melanocortin receptors inhibitors.

Latvian Institute of Organic Synthesis, Aizkraukles str. 21, LV-1006, Riga, Latvia

• Main activities and responsibilities Design, synthesis, purification and identification of N-phenylpyrrole guanidine derivatives.

• Date 2001-2004

• Name and address of project Design, synthesis and investigation of new organic chromophore systems.

Faculty of Chemistry, Riga Technical University, Riga, Latvia

• Main activities and responsibilities Design, synthesis, purification and identification of 4’-hydroxy and 4’-mercapto-N-(indan-1,3-dion-2)-yl pyridinium betaines derivatives. Molecular modelling of the new organic compounds with chromophore system’s potential using HyperChem software package.

PUBLICATIONS AND PATENTS

1. Roberts E., Mittapalli G. K., Wang Y., Yang J., Toussaint M., Habarova O. Modulators of receptors for Oxytocin and Vasopressin with therapeutic potential: Piperazines and analogs thereof. US patent application Serial No. 61/596,888.

2. Roberts E., Mittapalli G. K., Wang Y., Yang J., Toussaint M., Habarova O. Modulators of receptors for Oxytocin and Vasopressin with therapeutic potential: Pyrimidines and analogs thereof. US patent application Serial No. 61/596,890.

3. Roberts E., Mittapalli G. K., Wang Y., Yang J., Toussaint M., Habarova O. Modulators of receptors for Oxytocin and Vasopressin with therapeutic potential: Quinazolines and analogs thereof. US patent application Serial No. 61/596,864.

4. Roberts E., Mittapalli G. K., Wang Y., Yang J., Toussaint M., Habarova O. Modulators of receptors for Oxytocin and Vasopressin with therapeutic potential: Thiazoles and analogs thereof. US patent application Serial No. 61/596,895.

5. Roberts E., Mittapalli G. K., Wang Y., Yang J., Toussaint M., Habarova O. Modulators of receptors for Oxytocin and Vasopressin with therapeutic potential: Spiro-dihydroisobenzofuranyl-piperidines and analogs thereof. US patent application Serial No. 61/596,901.

6. Habarova O., Bobileva O., Loza E., Romanchikova N. Sunthesis of 2-quinolinecarboxamide derivatives as potential HDAC inhibitors. Chem. Het. Comp., 2011, 6, 871.

7. Finn P.W., Kalvinsh I., Loza E., Andrianov V., Habarova O., Lolya D., Piskunova I. Carbamic acid compounds comprising a bicyclic heteroaryl group as HDAC inhibitors. Pat. US 201******* (A1), 2010.

8. Bobileva O., Habarova O. Preparation and isomerization of E- and Z-3-quinolin-2-ylacrylonitriles. Latvijas Kimijas Zurnals., 2009, 4, 332.

9. Pelcman B., Olofsson K., Habarova O., Kalvins I., Suna E., Trapencieris P., Andrianov V. Naphthalene-disulfonamides useful for the treatment of inflammation. Pat. US 200-***-**** (A1), 2009.

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