Project Manager

CHANDRANI MUKHERJEE, Ph.D.* 410-***-**** (Cell)

** ********* *****, ***. **, Baltimore, MD 21208 ***********@*****.***

Objective:

Seeking a challenging chemist position utilizing my analytical, technical and interpersonal skills in organic chemistry and acquire additional expertise.

Profile Summary

• Extensive experience in synthesis of small organic molecules, peptides, and nucleosides

• Evaluating Structure-activity relationship studies in medicinal chemistry

• Experienced in Hit to Lead optimization and highly skilled in drug discovery and development process

• Strong knowledge and experience in developing active product intermediates (API)

• Skilled in project management, organized work, troubleshooting problems.

• Skilled in GLP, GMP, process development and knowledge of peptide and small molecule formulation

• Experienced in working collaboratively in a team and independently handling projects.

• Technical marketing by making presentations and writing research papers and reports.

• Skilled in Analytical Techniques: NMR, UV-Vis, FT-IR, Polarimeter, ESI-MS and HRMS, MALDI, and Amino Acid analysis.

• Skilled in Organic Seperation techniques: HPLC (Analytical, preparative and Semipreparative), Flash chromatography, LCMS, ion-exchange chromatography, column chromatography, size-exclusion gel, and crystallization

• Skilled in Instruments for Synthesis: Microwave synthesizer, Automated Peptide Synthesizer, pH Meter, Lyophilizer, Centrifuge, Incubator, Autoclave and Parr apparatus, and parallel synthesizer.

• Computer skills/Database: MS Office, ChemDraw, ISIS Draw, SciFinder Scholar, Belistein abstract, Pub Med, web of science, Cache and MOPAC, Endnote, Adobe Photoshop, ACD NMR processing, and e-SAP for lab resources.

• Understanding of DMPK, computational and molecular modeling techniques and biological sciences

• Skilled in natural product isolation, characterization and synthesis

• Communication Skills: Can build rapport with people at all levels of organization. Ability to publish papers, prepare grant/funding applications, and presentations to industry and scientific community at various conferences and meetings.

Experience:

Johns Hopkins University, Baltimore, MD

Post Doctoral Fellow February 2008-Present

• Developed novel heterocyclic compounds as anti-cancer agents targeting p300 protein HAT

• Developed peptides and bio-conjugates for biological testing and drug-development using solid phase technology; perform cleavage and post-synthesis modification on peptides

• Developed purification methods for better yield, scale-up and cost efficiency

• Demonstrated strong analytical and technical skills while synthesizing new molecular entities

• Exercised good judgments in dealing confidential information and worked with honesty

• Adapted well to new routines and procedures quickly and efficiently

• Knowledge and experience of safety guidelines and eco-friendly work standards in synthetic labs

Acadia University, Wolfville, NS, Canada

Post Doctoral Fellow July 2006-June 2007

• Synthesized and developed unsaturated ketones as potential anticancer agents

• Performed enzyme catalyzed organic synthesis.

• Demonstrated leadership and organizational skills while supervising undergraduate and graduate students with their lab projects, poster presentations, and manuscripts preparation.

Jubilant Chemsys Ltd., CRO, Noida, India

Research Scientist February 2006-July 2006

• Synthesized medicinally important organic compounds and active product intermediates (API), handled Raney Ni, dry Pd-C, Grignard reaction, mCPBA, azides, cyanation, synthesis of urea and pyrimidine derivatives, Curtius reaction, reactions at low temperature using dry-ice.

• Supervised trainee research assistants, developed and trained in lab management and lab safety skills.

• Delivered productivity in given timeframe with quality.

Acadia University, Wolfville, NS, Canada

Visiting Research Fellow December 2002-March 2003

• Synthesized, designed, and developed anticancer compounds for biological evaluation.

• Displayed efficiency and innovativeness while working on different projects.

University of Delhi, Delhi, India

Nucleic acid research (NAC) Project Fellow April 2002-January 2006

• Developed a multi-step synthesis of novel L-Arabino nucleosides of importance in chemical etiology

• Acquired excellent ability to design, synthesize, analyze and develop lead antibacterial compounds

• Knowledge of antibacterial and anticancer drug development and discovery

• Trained undergraduate and graduate students to operate various instruments, performing chemical synthesis, purification, analyzing and interpreting data.

India HQ Inc., Noida, India

Research Executive May 2001-April 2002

• Acquired excellent ability to interpret the journal content quickly.

• Developed excellent writing skills while abstracting journals and performed content writing for biochemical database; and developed and maintained e-SOPs for data management.

Education:

Ph.D., Synthetic, Bioorganic and Medicinal Chemistry 2002-2006

Institution: University of Delhi, Delhi, India

M.S., Organic Chemistry 1999-2001

Institution: University of Delhi, Delhi, India

B.S., Organic Chemistry 1996-1999

Institution: University of Delhi, Delhi, India

Publications:

Peer-Reviewed Journal articles 15 published and 2 in preparation

Peer-Reviewed Conference Proceedings 1 published

Conference Presentations 10

Patents (See below for details**) 1

Selected Peer-Reviewed Publications:

• B.P. Barnett, Y. Hwang, M. Taylor, H. Kirchner, P.T. Pfluger, V. Bernard, Y.-Y. Lin, E.M. Bowers, C. Mukherjee, W.-J. Song, P.A. Longo, D.J. Leahy, M.A. Hussain, M.H. Tschöp, J.D. Boeke, P.A. Cole. “Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor”. Science 2010, 330, 1689.

• E.M. Bowers, G. Yan, C. Mukherjee, A. Orry, L. Wang, M.A. Holbert, N.T. Crump, C.A. Hazzalin, G. Liszczak, H. Yuan, C. Larocca, S.A. Saldanha, R. Abagyan, Y. Sun, D.J. Meyers, R. Marmorstein, L.C. Mahadevan, R.M. Alani, P.A. Cole. “Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor.” Chemistry and Biology 2010, 17, 471.

• P. Mali, B.-K. Chou, J. Yen, Z. Ye, J. Zou, S. Dowey, R.A. Brodsky, J.E. Ohm, W. Yu, S.B. Baylin, K. Yusa, A. Bradley, D. J. Meyers, C. Mukherjee, P.A. Cole, L. Cheng. “Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes.” Stem Cells 2010, 28, 713.

• C. Mukherjee, E. D. Maclean, T. S. Cameron, A. Jha. “Enzyme-Assisted Kinetic Resolution of Novel 2-Naphthol Mannich Bases.” Journal of Molecular Catalysis B: Enzymatic 2010, 62, 46.

• Jha, C. Mukherjee, A. K. Prasad, V. S. Parmar, E. De Clercq, J. Balzarini, J. P. Stables, E. K. Manavathu, A. Shrivastav, R. K. Sharma, K. H. Nienber, G. A. Zello, J. R. Dimmock. “E,E,E-1-(4-Arylamino-4-oxo-2-butenoyl)-3,5-bis(arylidene)-4-piperidones: a topographical study of some novel potent cytotoxins.” Bioorg. Med. Chem. 2007, 15, 5854.

• S. Kumar, P. Arya, C. Mukherjee, B. K. Singh, N. Singh, V. S. Parmar, A. K. Prasad, B. Ghosh. “Novel aromatic ester from Piper longum and its analogs inhibit TNF-α induced expression of cell adhesion molecules on endothelial cells.” Biochemistry 2005, 44, 15944.

Professional Activities:

• Member of American Chemical Society (2008-present)

• Attended Research Ethics Workshop at Department of Pharmacology, Johns Hopkins University Medicine

• Member of Canadian Society for Pharmaceutical Sciences (2007)

• Presented seminar on “Biocatalysts-A Green Tool for Organic Synthesis” in Department of Chemistry, University of Acadia, NS, Canada, 5 Oct, 2006

• Attended and helped in organizing book of abstracts for Indo-Italian Workshop on Chemistry and Biology of Antioxidants, New Convention Hall, Delhi University, Delhi, India, 8-9 Jan, 2006

• St. John Ambulance certified First-aid training

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