Training Pvt Ltd
Resume:
AKENA VENKATESHAM
Corresponding address:
Dr. A. Venkatesham
H. No. 1-8-81, G5
M L S Apartments, Beyond M L Apartment, Mobile: 094********
Temple Alwal, Alwal, Secunderabad-10, A. P E-mail: ***********@*****.***
EDUCATION:
Ph.D. in Pharmacology Mar 2003-Sep 2006
University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India.
Advisors: Dr.M.Sarangapani, Professor in Pharmacy and Dr. Devarakonda R. Krishna, Dean, Professor in Pharmacology.
Dissertation project: Screening of new nitrogen heterocyclic compounds for possible CNS activity.
M. Pharmacy in Pharmacology Mar 2000- Jul 2002
University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India.
Advisor: Dr. Devarakonda R. Krishna, Dean, Professor in Pharmacology.
Dissertation Project: Effect of reactive oxygen species on cholinergic receptor in isolated heart and rectus abdominis muscle of frog.
B. Pharmacy Nov 1995-Nov 1999
University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India.
AWARDS RECEIVED:
• Secured All India 21 Rank in GATE with 99.36 percentile (National level entrance for admission into M.Pharmacy).
• Secured 3rd Rank in B.Pharm-CET conducted by Kakatiya University, Warangal, A.P., India.
• Received UGC (University Grants Commission) fellowship during M. Pharm.
• Received DST Senior Research fellowship during Ph.D.
PROFESSIONAL EXPERIENCE:
1. ORGANISATION: Sun Pharma Advanced Research Centre (SPARC), Baroda, Gujarat, India.
DURATION: Sep 2002 – Mar 2003
2. ORGANISATION: Nektar Therapeutics India Private Ltd Hyderabad, India. Nektar Therapeutics is an US based company well known for its PEGylation technology. EXUBERA (Inhaled Insulin) has been developed by Nektar and marketed by Pfizer
DURATION: – Sep-2006-Till date
JOB PROFILE:
• Responsible for Bioanalytical method development, method validation and routine sample analysis by using LC-MS/MS as per Regulatory requirements (GLP).
• Watson LIMS Implementation, trouble shooting and training the personnel.
• Handling of the analytical instruments and troubleshooting like LC-MS/MS, Tomtec Quadra 4 Liquid Handling System etc.
• Documentation of bio-analytical procedures as per GLP practices.
• Routine maintenance & Calibration of LC-MS/MS and other instruments.
• Train the juniors to perform the work according to good laboratory practice.
• Participate in development of the system and up gradation of the laboratory.
• Involve in preparation & periodic review of all Standard Operating Procedures.
• Preparation of the Bioanalytical protocol, validation & Study sample analysis report and relevant SOPs
INSTRUMENTS HANDLED:
Automated 96-well plate Tomtec Quadra 4 Liquid Handling System
Workstation
LC/MS/MS MDS SCIEX API 4000 Applied Biosystems
HPLC Waters, Shimadzu
Agilent 1200
UV –Vis Spectrophotometer Perkin Elmer, Shimadzu
Supporting Lab Equipments Solid Phase extraction Unit, Evaporator (Turbo vap LV), SpeedVac Concentrator (Thermo),
Homogenizer (Biofuge, Eppendorff) etc.,
WORK EXPERIENCE:
• Development of Bio-Analytical Methods and application to drug and their Products in Bioavailability/Bioequivalence, Toxicokinetic, Pharmacokinetic and NCE studies
• Bio-analytical method validation and study sample analysis as per the regulatory
• Hands on Experience on PEGylated molecule analysis on LC-MS/MS
• Hands on experience in protein and peptide analysis
• Development extraction methods of drug/metabolite in Biological fluids (Plasma, Serum, Urine, Blood, Fecal) for various products
• Hands on experience on Homogenization and quantitation of analyte in various tissues like Lungs, Brain, Kidney etc.
• Hands on experience on Watson LIMS (Laboratory Information Management System) Implementation for GLP studies
• Troubleshooting, Instrument installation, calibration and maintenance of instruments/glassware, various pipettes as per GLP
• Biogenic amines estimation: Dissection and isolation of different regions of brain and estimation of biogenic amines
• Western blot analysis: Dissection and isolation of different regions of brain and expression of glucocorticoid receptors density in different brain regions
• Pharmacological screening: Pharmacological screening of new molecules for possible activities like antidepressants, anti-inflammatory etc.
• In vitro (MTT assay) and in vivo (EAC induced tumor model) toxicity evaluation
• Teaching assistantship (lectured, graded undergraduate course pharmacology and biopharmaceutics and pharmacokinetics)
• Dissection, Cannulation and Handling of laboratory animals like Mice, Rats, Guinea pigs and Rabbits
• Knowledge on ADME
• Proficient at computer based software applications like GraphPad Prism, and Microsoft Office (Power Point, MS Excel and MS Word)
DOCUMENTATION:
• Preparation of protocols, validation and Project reports.
• Maintaining of instruments usage/chemicals/indent log file, with daily work profile and respective project wise registers in Bioanalytical Department.
• Preparation of SOP’s for the activities and methods of bioanalytical department.
WORK SHOPS / SEMINARS/TRAINING:
• Attended for Training on Tomtec QUADRA 4 Liquid Handling system (Automated 96-well plate technology) by Tomtec Inc. New Haven, CT, US
• Attended for Training on Watson LIMS (Laboratory Information Management System) by Thermo Scientifics.
• Attended for Training on LC-MS/MS API 4000 by Lab India, Gurgoan, India
• Attended for Training on HPLC Method Development by Waters, Hyderabad
• Soft Skills Training from CELT Osmaina University, Hyderabad.
• Basic Building Blocks Workshop: Communication Skills Training from Polaris Management, Hyderabad.
• Attended various training programmes during the period at Nektar Therapeutics Pvt Ltd like GLP training, Management training programme, Business communication by Insignia, Hyderabad, etc.,
RFERENCES:
1. Dr. M. Sarangapani
M. Pharm., Ph.D
Professor in Pharmacy
University College of Pharmaceutical Sciences
Kakatiya University
Warangal-506 009, A.P., INDIA
E-mail: ****************@*****.**.**
Phone: 087*-*******, Mobile: 098********
2. Dr. J. Sreekanth
M. Pharm., Ph.D
General Manager
NATCO PHARMA
Hyderabad, A.P., INDIA
E-mail: *********@***********.**.**
Mobile: 099********
3. Dr. Swaroop Kumar Vakkalanka
M. Pharm., Ph.D
MD & CEO
INCOZEN Therapeutics Pvt Ltd
Genome Valley, Shameerpet,
Hyderabad, A.P., INDIA
E-mail: *************@*****.***
PUBLICATIONS:
Research Papers:
1. Venkatesham A, Babu P Sharath, Sagar J Vidya, Krishna DR.
Effect of reactive oxygen species on cholinergic receptor function; Ind J Pharmacol, November-December 2005, Volume 37,Issue 6: 366-370.
2. A. Ravi Kumar, N. Sudhakar, B. Venkateswara Rao, N. Raghunandan, A. Venkatesh and M. Sarangapani. A short, stereoselective, and common approach for the synthesis of 4,5-disubstituted δ-lactones simplactone B and its C-5 analogue; Bioorg & Med Chem Lett, 15 April 2005, 5(8): 2085-2086
3. Gopalakrishna. B, Raghunandan. N, Rao V.J, Bari.S,Srinivas.B, A. Venkatesham and Sarangapani. M. Synthesis and Anti-inflammatory activity of some new benzoxazole schiff bases; Indian drugs, June 2005, 42(6): 369-374
4. Gopal krishna. B, A. Venkatesham, B. Srinivas, J.Venkatesswar rao, and M.Sarangapani. Synthesis of 5-(2-Substituted benzoxazol-5yl)-2-methylthio/benzylthio/arylaminocarbonyl methylthio-1,3,4,-thiadiazoles as Anti-inflammatory activity; Indian Journal of heterocyclic Chemistry, Oct-Dec 2005, 15:109-112.
5. Radhika C*, Venkatesham. A, Akhila. A, Reshma. A, Dileep Kumar, and Pallavi A.N. Anti-inflammatory activity of novel isatin analogues; Pharmacologyonline, 2009, 2:389-393.
6. N.Prasad*, A. Rama Narsimha Reddy, A.Venkatesham, D.R Krishna and M.C. Prabhakara. Antioxidant activity of animal bile using frog heart as a model; Pharmacologyonline, 2008, 2:390-396.
Presentations:
1. A. Venkatesham, J.Venkatesswar rao, S.Chendrashekar, M.Sarangapani and DR.Krishna. CNS activity of 2-(Dialkylaminoethyloxymethyl) [1,3,4] oxadiazino- [6,5-b] indoles. E34, 57th Indian Pharmaceutical Congress, Hyderabad, Dec- 2005.
2. P.Sharath babu, A. Venkatesham, J.Vidya sagar, K.Rajanarayana, Sripal M.Reddy and P.Kishore. Effect of reactive oxygen species (ROS) on Cholinergic receptor activity in frogs rectus abdominis muscle and heart. CVS-3, In Southern Regional Conference-Indian Pharmacological Society (SRC-IPS), Mangalore, 2002.
3. J.Vidya sagar, P.Sharath babu, A. Venkatesham, K.Rajanarayana, Sripal M.Reddy, P.Kishore and D.R.Krishna. Effect of reactive oxygen species on adrenergic receptor activity in frogs heart. CVS-4, In Southern Regional Conference-Indian Pharmacological Society (SRC-IPS), Mangalore, 2002.
4. Gopalakrishna. B, A. Venkatesham, Sanjay kumar Bari, G.Sammaiah and Sarangapani. M. Synthesis and Anti-inflammatory activity of 5-(2-Substituted benzoxazol-5yl)-2-methylthio/benzylthio/arylaminocarbonyl methylthio-1,3,4,-thiadiazoles. p67, Emerging research trends & Development in chemistry, Warangal, Dec-2003.
5. Gopalakrishna. B, N.Raghunandan, J.Venkatesswar rao, A. Venkatesham and Sarangapani. M. Synthesis and CNS activity of 5-(2-Substituted benzoxazol-5yl)-3-(N,N-disubstituted aminmethyl) - 1,3,4,-oxadiazolin –2-thiones. B35, 55th Indian Pharmaceutical Congress, Chennai, Dec- 2003.
6. N.Raghunandan, J.Venkatesswar rao, A. Venkatesham, B.Srinivas, G.Sammaiah and M.Sarangapani. Synthesis and evaluation of novel 1-N-substituted -3- (3-phenylquinazolin-4-(3H)- on-2-yl)methylene]indolin-2-ones for anticancer activity. BP19, 56th Indian Pharmaceutical Congress, Kolkata, Dec- 2004.
7. Sanjay kumar Bari, B.Srinivas, G.Sammaiah, A. Venkatesham, N.Raghunandan, J.Venkatesswar rao, and M.Sarangapani. Development of new Isatin hydrazones as cytotoxic agents. B33, 56th Indian Pharmaceutical Congress, Kolkata, Dec- 2004.
8. J.Venkatesswar rao, A. Venkatesham, M.Sanjay kumar Bari, B.Srinivas, N.Raghunandan, B.Gopalakrishna, and M.Sarangapani. Synthesis of new indole derivatives as cytotoxic agents. B34, 56th Indian Pharmaceutical Congress, Kolkata, Dec- 2004.
9. M.Sarangapani, J.Venkatesswar rao, A. Venkatesham, S.Shoba Rani, K.Suresh Kumar, and G.Sammaiah. Development of new Isatin-[N2-2-mercaptobenzoxazole-5-carbonyl] hydrazones as cytotoxic agents. B35, 56th Indian Pharmaceutical Congress, Kolkata, Dec- 2004.
10. J. Venkateshwar Rao, A. Venkatesham, M. Raghunandan, M.R. Baig and M. Sarangapani, Development of new isatin-3-[N2-(3-benzalamino-4-hydroxybenzoyl)]-hydrazones as antioxidant and cytotoxic agents. APTI, Nagpur, Oct-2005.
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