Analytical chemist, Research chemist, Chemist

Inayat Rahman, Ph. D

PCSIR Labs Complex

University PO, Peshawar – 25120

Pakistan

Tel: 092 332-***-****

E-mail: *******@*******.***

Qualifications

Ø Ph. D. Chemistry (Natural Products), 1999, University of Peshawar, Pakistan

Ø M. Phil Chemistry (Organic), 1994, University of Peshawar, Pakistan

Ø M. Sc. Chemistry (Organic), University of Karachi, Pakistan

Training Obtained

§ HPLC Waters: Calibration, validation and troubleshooting techniques by Waters, Bangkok,April 1987

§ Fuel Technology: Two months training in Japan (Jan – Feb 1987) under JICA

§ HPLC – HP: On-site hands-on training included calibration, troubleshooting and maintenance by Gentex @ FSTC, Mississauga, 2003

§ GC: On-site hands-on training included calibration, method development and maintenance by Varian Canada @ FSTC, Mississauga, 2003

§ GC: Hands-on training included troubleshooting and maintenance by Varian Canada Inc., Mississauga, Canada, 2005 (diploma awarded)

§ Atomic Absorption: On-site hands-on training included calibration, method development, validation, troubleshooting and maintenance by Varian Canada @ FSTC, Mississauga, 2003

§ UV-Visible (Cary 100): On-site hands-on training included calibration, method development, maintenance and troubleshooting by Varian Canada @ FSTC, Mississauga, 2003

Summary of Job and Research Experience

Senior Chemist/Lab Supervisor (July, 2001 – Feb 2006): Food Science & Technology Centre, Maple Lodge Farms C/O Bodycote Technology Centre, Mississauga, Ontario, Canada

Ø Operation, calibration & maintenance and Troubleshooting of laboratory equipments and GLP compliant documentation

Ø Development and validation of Analytical (HPLC, GC, Atomic Absorption) and extraction methods for the analysis of vitamin A (retinol & b-carotene), vitamin E, Fatty acid profile, Antioxidants profile, Cholesterol and minerals in food products

Ø Management, supervision and necessary training of 10-12 analysts and technicians in the Chemistry Laboratory Section to ensure that:

o All laboratory work is performed in accordance with applicable SOP’s, analytical methods of AOAC, AOCS and GLP’s.

o All required quality control standards and procedures are implemented.

Ø Summarizing of the experimental data according to guidelines, entering the data into spreadsheets and reviewing analysts’ data by defined procedure to ensure validity.

Ø Providing day-to-day technical support, direction and guidance to the members of the group.

Principal Scientific Officer: (June 2007 - Present); Medicinal Botanic Center; Pakistan Council of Scientific & Industrial Research (PCSIR), Pakistan

v In charge Analytical section regarding analysis of medicinal and herbal products, which include both qualitative and quantitative analysis using GC, HPLC, Atomic Absorption and other wet chemistry techniques. This include:

§ Quality evaluation of Sea buckthorn oils – work completed

§ Quality evaluation of Olive oil- work is in progress

§ Pesticides residue determination in soil, water and fruits – work in progress.

Senior Scientific Officer: (June 1988 -June 2007); Medicinal Botanic Center; PCSIR Labs Complex, Peshawar

v Remain engaged in R & D work related with the chemical investigations of various medicinal plants of biological importance. This includes extraction/isolation, purification and structural elucidation of compounds derived from plant sources applying modern analytical and spectroscopic techniques. This include:

· Pilot – plant preparation of odourless garlic powder – process developed and sold to bio care international.

· Commercial utilization of spent resinous matter of Dioscorea deltoida – process developed for extraction/recovery of diosgenin and fabricated for the party against payment.

· Phytochemical investigations of Zyziphus oxyphylla, Swertia ciliata and s. thomsonii – project completed and isolated eleven compounds including five new discoveries.

· Synthesis of Dimethyl aniline – process developed for the preparation of N, N – dimethyl aniline.

· Extraction, isolation and purification of natural products of biological significance, using HPLC, TLC, DCCC and Flash chromatographic techniques

· Analysis of raw material, finished products and in process compounds using various analytical techniques (HPLC, GC, AA, UV, FTIR and other wet chemistry techniques).

· Structure Elucidation of compounds by NMR (1D & 2D) and Mass Supervision of the R & D method development for natural products to ensure compliance with the current GMP/ GLP’s

· Investigation and documentation of out of specification results

· Performing laboratory inventories, SOP writing, chemical disposal, work planning, auditing and calibration schedule

· Extraction, isolation and purification of natural products of biological significance, using HPLC, TLC, DCCC and Flash chromatographic techniques

· Analysis of raw material, finished products and in process compounds using various analytical techniques

· Structure Elucidation of compounds by NMR (1D & 2D) and Mass Spectrometry.

Processes developed:

1. Dr. Inayat-ur-Rahman and Dr. Iqbal Mir "A process for the recovery of diosgenin from the spent resinous matter of Dioscorea deltoida".

2. Dr. Inayat ur Rahman “Pilot plant scale preparation of odourless garlic powder”

3. Dr. Inayat ur Rahman & Dr. Murad Ali Khan; Synthesis of N, N-Dimethylaniline (DMA)

Patents obtained:

b. "Production of humic acid-plant hormone/soil conditioner from indigenous coals of Pakistan".

c. "A process for the recovery of diosgenin from the spent resinous matter of Dioscorea deltoida".

Methods developed and validated (@ FSTC, Ontario, Canada)

A. Fatty Acids profile determination applying GC techniques.

B. Cholesterol profile using GC techniques.

C. Quantitative determination of Vitamin A using HPLC techniques.

D. Quantitative determination of sugars by HPLC techniques.

E. TBA Value.

F. Salt determination

G. Minerals determination (Ca, Co, Cr, Cu, Fe, K, Mg, Mn, Na, and Zn) applying Atomic Absorption techniques

H. Specrtophotometric determination of Phosphorous, Starch, Nitrite, Pepsin digestibility and Dietary fibre

I. Oxidative Stability Index

J. Crude Fibre determination using FiberTech system

K. SOPs Writing

Training given:

1. At Food Science and Technology Centre (FSTC) Canada: Training of post-graduate level students under Canadian Government sponsored programme:

Total number of students trained: 72

Number of students trained per batch: 5-7

Number of batches: 12

Duration of training per batch: 3 months

2. Training and supervision of technical staff at FSTC, Canada: Training of newly appointed technical staff (post-graduate level) and supervision of analysts (10-15 chemists) in day-to-day analytical work under the guidelines of ISO 17025 was part of duty in addition to research work.

3. Training given at MBC, PCSIR, Pakistan:

Ø Name of party: Pakistan Oil Seed Development Board

Ø Sponsoring agency: IAO Italian Cooperation Office, Pakistan

Ø Duration of training: May 19 – June 07, 2008 (three batches; 15 trainees per batch)

Ø Performed:

§ Multimedia presentations on Extraction, Purification & Chemical studies of Olive oil

§ Practical demonstrations/training on determination of FAMES on GC and supervision of other wet chemistry tests demonstrations.

Skills and Technical Experience

Separation Methods

· HPLC

· GC

· Star Chromatography Data System, Peaksimple Chromatography Data System and Chemstation software

Spectroscopy

· IR; NMR (1D/2D); Mass Spectrometry (structure elucidation)

· UV/Vis. Spectrophotometry

· FTIR

· Atomic Absorption

Analytical

· Fatty acid profile

· Glyceroid profile

· Cholesterol

· Vitamins analysis

· Sugar profile

· Minerals analysis

· Salt analysis

· Oxidative Stability Testing

· Protein Analysis

Routine Computer Usage

· Microsoft Word

· Excel Spreadsheet

Organizational Skills

· Research & Development of chemicals, natural products and food products and quality control.

· Good working knowledge of GMP, GLP regulations and practices

· Efficient organizational and time management skills

· Effective interpersonal and communication skills

·

Publications

1. Determination of germanium in original, up-graded Kotli coal and its tailings; N. Ahmad, S.A Hussain and Inayat ur Rahman; Pak. Jr. Sc. Ind. Res.1989, 32 (6), 425-427.

2. Some xanthones from Swertia ciliata and S. thomsonii; Inayat ur Rahman and M.Arfan; Pak. J. Pl. Sc.1995, 1 (1), 11-23.

3. Organic Synthetic Technology and the Environment. M. Arfan & Inayat ur Rahman; Paper presented and published in the Proceedings of the First National Conference on Fuel and Environment, held at Peshawar University Campus, Baragali, Pakistan, July 20-24, 1996. p. 160-178.

4. Phytochemistry of the Genus Swertia; Inayat ur Rahman and M.Arfan; J. Chem. Soc. Pak.1997, 19 (3), 240-255.

5. Glycosides of Astragalus species; G.A. Khan, N. Shafi and Inayat ur Rahman; J. Chem. Soc. Pak. 1997, 19(4), 333-337.

6. A triterpene ester from Swertia ciliata; Inayat ur Rahman and M. Arfan; Paper presented in 8th National Conference of Chem. Soc. Pak. at Lahore on 02.04.1997.

7. Naturally occurring isocoumarins; Inayat ur Rahman, M. Arfan and G.A. Khan; J. Chem. Soc. Pak. 1998, 20(1), 76-87.

8. A new xanthone from Swertia thomsonii; Inayat ur Rahman, M.Arfan and M.Iqbal Chaudhary; J. Chem. Soc.Pak. 1998,20(2),155-159.

9. A new xanthone glucopyranoside from Swertia ciliata; Inayat ur Rahman, M. Arfan, M. G. Reinecke & Viqaruddin Ahmad; J. Chem. Soc. Pak. 2000,22(2), 142-151.

10. Naturally occurring flavonoids; G.A. Khan, N. Shafi and Inayat ur Rahman; J. Chem. Soc. Pak. 2001, 23(1), 50 –60.

11. Cyclopeptide alkaloids of Zizyphus species; Inayat ur Rahman, M. Ali Khan, G. A Khan and V.U. Ahmad ; J. Chem. Soc. Pak. 2001, 23(4), 268 - 277.

12. A xanthone dixylopyranoside from Swertia thomsonii; Ahmad, Viqar Uddin; Rahman, Inayat-Ur; Khan, Murad Ali; Arfan, Muhammad; Siddiqui, Mohammad Tariq; Zeitschrift fuer Naturforschung, 2002,57(b), 122-126.

13. Flavonoids from Astragallus species; Gul Akhtar Khan, Inayat ur Rahman, Hamidullah Khan and Kamaluddin Khan; J. Chem. Soc. Pak. 2003, 25(3), 259-264.

14. Flavonoidal constituents from Scutellaria species; M. Arfan, G.A.Khan, N. Shafi, A.R.Khan and Inayat ur Rahman; J. Chem. Soc. Pak. 2003, 25(4), 348-356.

15. A new 14-Membered cyclopeptide alkaloid from Zizyphus oxyphylla; Inayat ur Rahman, Murad Ali Khan, Lajber Khan, M. Arfan, Gul Akhtar and Viqar Uddin Ahmad; Natural Products Research, 2007, 21(3), 243-253.

16. Effect of environmental pollutions on heavy metals content of Withania somnifera; Murad Ali Khan, Ejaz Ahmad and Inayat ur Rahman; J. Chinese Chem. Soc. 2007, 54, 339 - 343.

17. Effect of soil contamination on heavy metals content of Cannabis sativa; Murad Ali Khan, Abdul Wajid, Fareedullah Khan, Saeed Akhtar and Inayat ur Rahman; Paper accepted for publication in J. Chem. Soc. Pak. Ref # JCSP 070***-****

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