JIN organic synthesis chemistry scientist

JIAN JIN

** ******** ***

Oakdale, Connecticut **370

Home: 860-***-****

Cell: 860-***-****

**********@*****.***

SUMMARY OF QUALIFICATIONS

* Solid organic-synthesis chemistry and process-chemistry knowledge.

* 10 years of experience in the pharmaceutical industry.

* Proven ability to solve complex organic-synthesis and chemical-process problems.

* Extensive experience with multiple-step reactions.

* Adept at analyzing and interpreting experimental data; skillful with HPLC, LC_MS, GC_MS, and NMR.

* Excellent verbal and written communication skills.

PROFESSIONAL EXPERIENCES

PFIZER INC., Groton, Connecticut 1999 – 2009

Senior Associate Scientist, Development API, Chemical R&D (2003 – 2009)

Improved synthetic routes for drug candidates. Produced APIs by evaluating and redesigning organic syntheses suitable for scale up. Synthesized reference standards. Determined structures of synthesized products with HPLC, LC_MS, GC_MS and NMR. Prepared gram or kilogram quantities of intermediates, impurities, and final APIs.

* Significantly reduced the environmental impact of the synthetic route for a Macrolide project by altering Corey-Kim oxidation to eliminate the use of dimethylsulfide.

* Created a greener synthetic method for protection of C-11 and C-12 alcohols of macrolide type molecules to avoid usage of triphosgene.

* Reduced costs $1000/Kg by developing a new route for synthesis of a key intermediate for a JAK-3 project.

* Optimized a key step reaction for JAK-3 project that dramatically increased yield and product quality; thereby reducing costs by $1500/Kg for API.

* Developed an innovative new process of lithium aluminum hydride reduction for scale-up that produced 100 Kg of a key intermediate for JAK-3 project.

* Successfully synthesized two key impurities for Lasofoxifene project that helped validate the synthetic route for production of API.

* Effectively validated a synthetic route for a Torcetrapib (CP-529414) project by developing a new methodology to synthesize a key impurity.

Assistant Scientist II, Process Research, Chemical R&D (1999 – 2003)

Prepared intermediates, synthesis reference standards, and APIs for development of projects. Redesigned and improved synthetic routes for production of API. Conducted multiple-step reactions. Interpreted experimental data to determine structures of organic compounds.

* Engaged in route development for synthesis of Torcetrapib (CP-529414).

* Successfully met purity requirements for the final API of Torcetrapib by devising a method that reduced a difficult-to-isolate impurity from 1.6 % to below 0.5%.

* Greatly improved overall yield by developing a new synthetic route for a GABA project.

VILLANOVA UNIVERSITY, Villanova, Pennsylvania 1997– 1999

Graduate Student/Teaching Assistant

* Completed master’s thesis research in organic chemistry under instruction of Dr. J. Herman Schauble: conducted extensive study on oxidation of sulfur-containing heterocycles. Synthesized five- to seven-membered ring bisthioacylals by using dithioisobutyric acid.

* Assisted lab instructors in undergraduate-level general and organic laboratory classes.

EDUCATION

VILLANOVA UNIVERSITY, Villanova, Pennsylvania

M.S. in Organic Chemistry

Thesis: Oxidation and cyclization reactions of dimethyltrithiomalonic acid and dithioisobutyric acid.

GPA 3.8

LANZHOU UNIVERSITY, Lanzhou, China

B.S. in Chemistry

GPA 3.9

COMPUTER SKILLS

SciFinder, Beilstein, Microsoft Office, ChemOffice, and ACD labs.

PROFESSIONAL TRAINING

Synthetic Organic Chemistry: Modern Methods and Strategies

Asymmetric Synthesis

Good Manufacturing Practices in Chemical Development

Chemical Development and Scale-Up in the Fine Chemical Industry

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