James Aden CCV
Resume:
James Aden, Ph.D.
Berkeley CA 94703
Educational Experience:
School: University of New Mexico
Date: 9/1998 to 5/2005
Degree: Ph.D. in Statistics
Major area of study: Measure Theory, Probability Theory, Time Series, Bayes methods, Applied Statistics, and Bioinformatics. My Ph.D. dissertation was on the topic of Machine Learning. I effectively developed new methods for model selection related specifically to optimize support vector machines. These new methods were then applied to two subjects in Bioinformatics: microarray analysis, and gene function prediction. (Advisor: Koltchinskii, V. PhD)
Contact: 505-***-****, Humanities 415 Albuquerque, NM 87131
School: University of Texas at Arlington
Date: 1/1996 to 8/1998
Degree: Master’s degree in Pure Mathematics
Major area of study: Functional Analysis, Differential Equations and Probability Theory.
My master’s thesis was on Numerical Methods for Solving Stochastic Differential Equations. (Advisor: Korzenowskii, A. PhD)
Contact: 817-***-****, 701 S. Nedderman Drive, Arlington, TX 76019
School: University of Texas at Arlington
Date: 9/1992 to 12/1995
Degree: Bachelor’s Degree in Mathematics with a minor in Physics
Major area of study: Math Methods in Physics, Statistics and Differential Equations. In Physics my main areas were Quantum Mechanics and Optics.
Contact: 817-***-****, 701 S. Nedderman Drive, Arlington, TX 76019
Work Experience:
Roche Molecular Diagnostics 10/2005 to 1/2009
Bio-statistician: My primary responsibilities were support for scientists in the Biometrics division where I engaged in statistical support for Phase 1 studies (Research and Development) to Phase 3 studies (Clinical Studies and FDA submission). I was responsible for designing, analyzing and reporting on experimental, developmental and clinical studies involving Bio-assay Systems used for diagnostics designed by RMD. (supervisor: Abha Sharma)
Contact:925-***-****, 4300 Hacienda Drive, Pleasanton, CA 94588
Lovelace Respiratory Research Institute 5/2001 to 10/2005
Statistician: LRRI is a research and development firm dedicated to research associated with the lung especially in the areas of inhalation and toxicology. I worked in close collaboration with Scientists, Biologists, Chemists, Toxicologists, and Epidemiologists. I have been involved in several areas of research including topics in Mathematical Modeling, Statistical Analysis, Monte Carlo Simulation, Health Physics, Genomics, and Proteomic Research including Protein assay analysis: PCR, RT-PCR, and Mass Spec. analysis, Microarray analysis, and Phylogenetic profile classification. (supervisors: Cindy Knall, PhD, Bobby Scott, PhD, Susan Boggs, PhD).
Contact:505-***-****, 2425 Ridgecrest SE, Albuquerque, NM 87108.
New Mexico Institute of Mining and Technology 9/2000 to 5/2001
Visiting Professor: I was employed by New Mexico Tech as a Visiting Instructor, where I taught Calculus, Probability, Stochastic Modeling and Statistics courses. In addition, I gave some statistical support. (supervisor: Brian Borchers, PhD)
Contact: 800-***-****, 801 Leroy Place, Socorro, NM 87801.
Areas of Research:
Statistics: Experimental Design and Analysis, Parametric and Non-parametric Regression and Classification; Sampling; Time Series; Probability; Neural Networks; Machine learning, Risk estimation; Survival Analysis; Stochastic Processes, and Markov Chains.
Programming:
I have become proficient in SAS, JMP, Matlab, Genespring, all Microsoft Office applications, and UNIX. I am competent in R, S+, Mathematica, Minitab, html, Fortran and many other software applications.
Affiliations:
American Statistical Association (ASA) Member
Research Publications and Professional Experience:
1994 Master’s Degree Thesis: Numerical Methods for Solving Stochastic Differential
Equations. Advisor: Korzeniowski A.
2001 Analytic Solutions Derived For the NEOTRANS2 Model for Radiation-Induced
Neoplastic Transformation. Aden J. Scott B. Future Publication
2002 Modeling Variability and Uncertainty Associated with Inhaled PuO2 for the
Stochastic Intake Paradigm. Aden J., Longmire P., Scott B. Published in Proceedings For the Radiation Protection and Shielding Division (RPSD)
2002 Respiratory Tract Deposition Efficiencies: Evaluation of Effects from Smoke Released in the Cerro Grande Forest Fire. Schöllnberger H. Aden J. Scott B. J. Aerosol Med. Vol 15:4.
2003 Modeling Variability and Uncertainty Associated with Inhaled Weapons Grade PuO2. Aden J. Scott B. Health Physics Journal. Vol. 84, No. 6, pp. 726 - 736
2004 Molecular Analysis of Hprt Mutants in Splenic T-lymphocytes of Male B6C3F1 Mice Exposed to 1,3-Butadiene by Inhalation Primary Author: Quanxin M. Peterson VE. Aden J. Environmental and Molecular Mutogenesis Vol 43:75-92.
2004 Characterization of Hprt Mutants in in cDNA and Genomic DNA of T-Cell Mutants From Control and 1,3-Butadiene-Exposed Male B6C3F1 Mice and F344 Rats. Authors: Quanxin M. Walker DM, Scott BR, Seilkop SK, Aden JK, Walker VE.. Environmental and Molecular Mutogenesis Vol 43:75-92.
2005 Ph.D. Dissertation: Model Selection in Kernel Machine Classification with applications in Bioinformatics. Advisor: Koltchinskii, V.
2005 Mainstream Cigarette Smoke Increases Tight Junction Permeability Through Rho Kinase and Protein Tyrosine Kinase Activation and Myosin Light Chain Kinase Inactivation. Dorian S. Olivera, Chris Beenhouwer, Susan E. Boggs, James Aden and Cindy Knall. Submitted April 1 2005: Journal of Biological Chemistry.
2006 17-allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathway. Wang X, Ju W, Renouard J, Aden J, Belinsky SA, Lin Y. Cancer Res. 2006 Jan 15;66(2):1089-95.
2007 Resolution of LPS-induced airway inflammation and goblet cell hyperplasia is independent of IL-18 Harris JF., Aden J., Lyons R., Tesfaigzi Y. Respir Res. 2007; 8(1): 24
2007 Cellular mechanisms of mainstream cigarette smoke-induced lung epithelial tight junction permeability changes in vitro. Olivera DS, Boggs SE, Beenhouwer C, Aden J, Knall C. Inhal Toxicol. Jan;19(1):13-22.
2007 Subchronic inhalation of soluble manganese induces expression of hypoxia-associated angiogenic genes in adult mouse lungs. Bredow S, Falgout MM, March TH, Yingling CM, Malkoski SP, Aden J, Bedrick EJ, Lewis JL, Divine KK. Toxicol Appl Pharmacol. 2007 Jun 1;221(2):148-57. Epub 2007 Mar 23.
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