Asok Ranjan Karuri

**** ****** ****

Memphis TN *8134

901-***-****

901-***-****

opqc21@r.postjobfree.com

opqc21@r.postjobfree.com

EDUCATION: B.Sc (Chem-Hons), M. Sc and PhD in Biochemistry from University of Calcutta in the year 1991.

Certificates from WPI (Worcester, MA) in Unix, C, C++ and Client/Server Technology (2001).

North Central Mississippi Regional Cancer Center, Greenwood, Leflore (2007-) Medical Physicist

Responsible for: Treatment planning, chart checks, QA and all standard physics duties.

Ensure the quality control of components of the physical components of radiation oncology treatment including: equipment functioning, safety, treatment planning, weekly/monthly machine QA, IMRT QA, treatment planning reviews, applications and personnel radiation safety, 40 patients daily.

Received PET/CT Hands-on course from M D Anderson Cancer Center, Houston.

Able to perform radiation dose measurements for both PET & CT, design, perform, and assess appropriate quality control for PET & CT imaging systems, perform shielding calculations for PET & CT, and perform relevant image quality evaluations for

PET images.

University of Memphis (Nov 2003- July 2006) Research Faculty

Responsibilities: Design, perform, analyze and document research on Molecular Mechanisms of Chemoprevention by 3H-1, 2-Dithiole-3-thione.

Techniques: Development of In- vivo model and in-vitro toxicology models, Western Blotting to detect phosphorylation studies of targets in liver samples for determination of PK/PD relationship, Real time PCR, Non-invasive arterial blood pressure measurement, Physiological temperature measurement, Signal transduction pathway analysis, Electrophoretic mobility shift assay, Various enzyme assay, Toxicological evaluation of physiological end point study, Toxicological studies by immunostaining hepatic tissue sectioning.

Priority Call Management ( Dec 2000- April 2001) Methods and Procedure Engineer

Responsibilities: Provided technical leadership, system analysis, implementing Oryx Call management System, Unix, C, C++, Client/Server Technology, Oracle.

Rhode Island Hospital (Dec 2001-Feb 2002) Research Associate

Responsibilities: Regulation and Role of Rat TA1/LAT1/CD98 Expression in Hepatic Neoplasia.

Brigham and Women's Hospital (June 2003- Aug 2003) Research Associate

Responsibilities: Understanding role of neurochemicals for inflammatory network in neurological disorders.

University of Massachusetts Medical Center (Sep 1999-Dec 2000) Postdoctoral Research Associate

Responsibilities: Design, perform, analyze and document research on molecular immunology, molecular components regulating alcohol-induced hepatitis.

Techniques: Development of In- vivo model and in-vitro toxicology models, Western Blot analysis, Real time PCR, Physiological temperature measurement, Signal transduction pathway analysis, Liver perfusion, Hepatocyte primary culture,

Electrophoretic mobility shift assay, Toxicological studies by immunostaining hepatic tissue sectioning, Use of hepatology and blood chemistry for preliminary toxicology evaluation, method development and validation of hepatic metabolism, various enzyme assay.

Tufts Univ. School Vet Med (Nov1995-Nov 1999) Postdoctoral Research Associate

Responsibilities: Design, perform, analyze and document research on molecular neurobiology, angiogenesis, neuro-chemical components regulating nitrous oxide induced infertility problems, Teaching students.

Techniques: Development of In- vivo model and in-vitro toxicology models, Inhalation toxicologic studies with N2O, Endocrine disruptor toxicology, Peptides and physiological hormone assay by Radio-immunoassay (RIA), immunohistochemistry, in situ hybridization, Northern blot analyses, Cell culture and extraction technique and HPLC.

CSR/IBR Center for Dev Neurosc, NY (Jun 1995- Sep 1995) Postdoctoral Research Associate

Responsibilities: Organizing and performing studies on stress regulation of serotonin 1A receptors and opioid receptors. Techniques: Primary culture of hippocampal neurons, signal transduction, fluorescent microscopy, DNA sequencing, PCR and Gel Electrophoresis.

Ontario Cancer Institute, Canada (July 1990- Aug 1992) Postdoctoral Fellow

Responsibilities: Novel approaches on prospects of weak organic acids exploiting lower tumor pH in tumor suppression. Techniques: Use of fluorescent probe for quantitation of intracellular pH, Spheroid production, Acid/base physiology, Spectrofluorometry and flow cytometry, In vitro tumor cell cytotoxicity assay, Evaluation of tumor suppression in vivo.

PUBLICATIONS IN PEER REVIEWED JOURNALS:

1. Effects of Gamma radiation alone or in combination with mitomycin C on endogenous nuclease activity of sarcoma 180 nuclei. A. R. Karuri, S. Mukherji and K. L. Bhattacharya. Ind. J. Exp. Biol. 25: 706-709, 1987.

2. Uptake of uridine and its incorporation in RNA of Sarcoma 180 ascites tumor cells following in vivo gamma radiation and mitomycin C treatment. A. R. Karuri and S. Mukherji. Ind. J. Biochem. Biophys. 24: 296-300, 1987.

3. Changes in template activity of chromatin isolated from Sarcoma 180 ascites cells treated with mitommycin C and gamma radiation in vivo. A. R. Karuri and S. Mukherji. Neoplasma 36: 321-326, 1989.

4. Prospects for drugs exploiting lower tumor pH. I Tannock, M. Boyer, A. Karuri, R. Maidorn, and K Newell. Radiation Research: Twentieth Century Perspective, Vol II, Congress Proceedings, Academic Press, 813-818, 1991.

5.Enhancement of Mitomycin-C Induced in vivo Cytotoxicity of Sarcoma 180 Cells by Gamma Radiation- An ultrastructural evaluation. S K Majumdar, A. R. Karuri, S Bhattacharya, A Mitra and S Mukherjee. Electron Microscopy in Medicine and Biology 63 163 – 169. 1994.

6. Selective cellular acidification and toxicity of weak organic acids in an acidic microenvironment. A. R. Karuri, E. Dobrosky and I. F. Tannock. Br. J. Cancer 68: 1080-1087, 1993.

7. Substance P and PGE2a levels in normal and abnormal equine joint fluids. V.K. Chandna, R.K. Agarwal, E.A. Morris, C.A. Kirker-Head, M.W. O’Callaghan, A. Karuri and M.S.A. Kumar. Equine Veterinary Journal (Accepted).

8. Effect of low and high doses of nitrous oxide on preproenkephalin mRNA and its peptide methionine enkephalin levels in the hypothalamus. R. K. Agarwal, G. Kugel, A. Karuri, A. R. Gwosdow, M.S.A. Kumar. Brain Res. 730: 47-51, 1996.

9. Alterations in the catecholamine turnover rate in specific regions of rat brain following acute exposure to nitrous oxide. A.R Karuri, G. Kugel and M. S. A. Kumar. Brain Res. Bull. 46: 557-561; 1998.

10. Differential Expression and Selective Localization of Vascular Permeability Factor/Vascular Endothelial Growth Factor (VPF/VEGF) in the Rat Uterus During The Estrous Cycle. A. R. Karuri, Amarendhra M. Kumar and Debabrata Mukhopadhyay. J. Endocrinol.159:489-499; 1998.

11. Effects of Halothane and Methoxyflurane on Regional Brain and Spinal Cord Concentrations of Substance P and Beta-Endorphin in the rat. A.R. Karuri, R. K. Agarwal and M. S. A. Kumar. Brain Res. Bull. 45:501-506; 1998.

12. Effects of Halothane and Methoxyflurane on the Hypothalamic-Pituitary-Adrenal Axis. A. R. Karuri, L. R. Engelking, and M. S. A. Kumar. Brain Res. Bull. 47: 205-209; 1998.

13. Regional distribution of GnRH-like-, Met-Enkephalin-like and beta-endorphin-like immunoreactivity in the Central Nervous System of the Goat. A.R. Karuri, L.R. Engelking, and M. S. A. Kumar. Brain Res Bull. 2000;51(1):63-8.

14. Inherited infantile dilated cardiomyopathy in dogs: clinical, biochemical and morphological findings. Josph Alroy, John E. Rush, Lisa Freeman, A. R. Karuri, M.S.A. Kumar, Megan Sleeper, Keven Chase, Gordon Lark, Satyaprita Sarkar . Am J Med Genet. 2000 695(1):57-66.

15. 3H-1,2-Dithiole-3-thione targets nuclear factor κB to block expression of inducible nitric oxide synthase, prevents hypotension, and improves survival in a rodent model of endotoxic shock. A.R. Karuri, Y. Huang, S. Bodreddigari, C. H. Sutter, B. D. Roebuck, T. W. Kensler and T. R. Sutter. J Phar Exp Ther . E-Pub- JPET fast forward JPET 317:61-67, 2006.

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