Sr. product development engineer - grafts
Resume:
Eric Simone
Philadelphia, PA 19121
*******@****.*****.***
EDUCATION
UNIVERSITY OF PENNSYLVANIA, SCHOOL OF ENGINEERING AND APPLIED SCIENCES Philadelphia, USA
Ph.D. in Bioengineering Dec 2008
• Thesis: “Filamentous and Spherical Polymer Nanocarriers for Enzyme Therapeutics”
• Consultant to Solixia, Inc., for Penn Biotech Group (Wharton), top 3 finalist, 2007
• Journal (Biomacromolecules, Controlled Release, & Nano) & grant reviewer (Nanotech. Institute, NTI), 2008-present
• Teaching Assistant in Cardiovascular System Dynamics (undergraduate and graduate course), 2006-present
• Teaching Assistant in Engineering Principles of Human Physiology (undergraduate course), 2007
• Research mentor to UPenn undergraduate student, 2007-present
• Trained two post doctoral fellows in polymer chemistry and nanoparticle formulation techniques, 2006-present
PATENTS AND PATENT APPLICATIONS
E. Simone, T. Dziubla, V. Muzykantov, filed Oct. 27th, 2007
US Patent application 11/925834 “Method and compositions for polymer nanocarriers containing therapeutic molecules.”
JOHNS HOPKINS UNIVERSITY, WHITING SCHOOL OF ENGINEERING Baltimore, USA
B.S. in Biomedical Engineering, Concentration in Mechanical Engineering May 2004
Minor in Mathematics
• Nominated for MIT’s Technology Review Top 100 Most Influential People Under 35, 2004
• Graduated with general and departmental honors
• Article in Popular Mechanics on BioMEMS research, “Chip moves DNA,” August 2004
• Senior Mechanical Engineering Design Team Member, 2003-2004
• National Society of Collegiate Scholars (NSCS), 2002-present
• Biomedical Engineering Society (BMES) JHU student chapter, 2001-2004
• Biomedical Engineering Design Team Member, 2001-2002
• Varsity letter, NCAA Indoor and Outdoor Track and Field
EXPERIENCE
UNIVERSITY OF PENNSYLVANIA Philadelphia, USA
Drug Delivery Laboratory – Polymer and Drug Delivery Scientist (Principal Investigator) Sep 2004-present
• Polymer synthesis and organic bioconjugate chemistry.
• Polymer nanocarrier formulation for encapsulation of high molecular weight enzymes, and low molecular weight compounds such as contrast agents for PET and CT imaging applications.
• Polymer and macromolecule characterization techniques of gel permeation chromatography (GPC), proton nuclear magnetic resonance (1H-NMR), dynamic light scattering (DLS), and differential scanning calorimetry (DSC).
• Fluorescent and transmission electron microscopy (TEM) techniques for the characterization of cell internalization of nanoparticles and nanostructure morphology, respectively.
• Research collaborations established and maintained with Drexel Univ., Univ. of Kentucky, and physicians at UPenn.
JOHNS HOPKINS UNIVERSITY Baltimore, USA
BioMEMS Single Molecule Laboratory – Principal Investigator Jan 2003-June 2004
• Developed electrode embedded microchips to manipulate DNA for single nucleotide polymorphism (SNP) detection.
• Utilized different nanofabrication techniques including photo lithography, thin film deposition, wet etching
• Worked with quantum dot (QD) and hairpin probe fluorescence techniques for high-throughput SNP detection.
• Helped design and construct custom optical microscopes and BioMEMS lab from start-up, and updated microfabrication lab as the senior lab member.
• Assisted with NIH, NSF, and Whitaker Foundation grant proposal writing.
Orthopedics and Bioinstrumentation Laboratory – Research Assistant June 2002-Jan 2003
• Worked with orthopedic surgeons to develop novel fracture fixation techniques.
• Developed procedure for spiral-fracture-free hip implant removal.
• Tested mechanical stability of different fixation procedures for spinal (vertebroplasty), wrist and ankle fractures.
• Performed DEXA scans, x-rays, MTS testing, and cadaver harvesting and surgeries.
GRANTS/FELLOWSHIPS/AWARDS
• National Institutes of Health (NIH) Pre-doctoral Training Grant/IME (Inst. For Medicine and Engineering) Interdisciplinary Training Grant, $91284 total award, 9/06-present
• Best Speaker Award, 4th Annual Biomedical Graduate Research Symposium, 2007
• Resomer® Scholarship Award, Boehringer Ingelheim Chemicals, Inc., 2007
• Best Poster Award, ITMAT Targeted Nanocarriers and Therapeutics Retreat, 2006
• American Heart Association (AHA) Pre-doctoral Fellowship, $42000 total award, 7/06-9/06
• Provost Undergraduate Research Award (PURA), $3000 total award, 6/03-8/03
SELECTED PUBLICATIONS AND PRESENTATIONS
(Complete list available upon request)
Book Chapters
E. Simone, T. Dziubla, V. Shuvaev, and V.R. Muzykantov, “Synthesis and characterization of polymer nanocarriers for the targeted delivery of therapeutic enzymes,” Methods in Molecular Biology, (In Press).
Peer Reviewed Journal Publications
E. Simone, E. Arguiri, V.V. Shuvaev, T. Dziubla, M. Christofidou-Solomidou, and V. Muzykantov (2009). Loading PEGylated enzymes into filamentous and spherical polymer nanocarriers. Pharmaceutical Research, 26(1)250-260.
E. Simone, B. Ding, V. Muzykantov (2009). Endothelial targeting of drugs for therapeutic interventions. Cell and Tissue Research, 335(1)283-300.
E. Simone, T. Dziubla and V. Muzykantov (2008). Polymeric carriers: role of geometry in drug delivery. Expert Opinion on Drug Delivery, 5-12-128*-****.
C. Garnacho, R. Dhami, E. Simone, T. Dziubla, J. Leferovich, E.H. Schuchman, V. Muzykantov, and S. Muro, “Delivery of acid sphingomyelinase in normal and Niemann-Pick disease mice using ICAM-1-targeted polymer nanoparticles,” J. Pharm. Exp Therap., 325(2)400-408, 2008.
E. Simone, T.D. Dziubla, F. Colon-Gonzalez, D.E. Discher, and V.R. Muzykantov, “Effect of polymer amphiphilicity on loading of a therapeutic enzyme into protective filamentous and spherical polymer nanocarriers,” Biomacromolecules, 8-12-391*-****, 2007.
Conference Papers
H.C. Yeh, E. Simone, C.Y. Zhang, T.H. Wang, “Single bio-molecule detection with quantum dots in a microchannel,” IEEE Micro Electro Mechanical Systems Conf. Technical Digest, 17:371-374, 2004.
Conference Abstracts
E. Simone, T.D. Dziubla, F. Colon-Gonzalez, D.E. Discher, and V.R. Muzykantov, “Polymer MW determines nanocarrier characteristics to reveal an ideal vehicle for targeted enzyme delivery,” Controlled Release Society Annual Conference, 34:559, 2007.
E. Simone, Y. Geng, F. Colon, D. Discher, V.R. Muzykantov, T.D. Dziubla, “Shape and pH determine degradation kinetics of PEG-PLA polymer nanocarriers,” Intl Nanomedicine and Drug Delivery Symposium, 3:100, 2005.
Presentations
“Catalase polymer nanofilaments of tunable stiffness and morphology”, Nanotechnology for Biotech and Pharmaceuticals II Session, American Institute of Chemical Engineers (AIChE) Annual Meeting, Philadelphia, PA, 11-08
“Polymer nanocarriers for delivery of antioxidants to endothelium”, PPG Steering Committee, Institute for Environmental Medicine, University of Pennsylvania, 05-15-08.
“Teaching an old dog new tricks: loading PEGylated enzymes into filamentous and spherical polymer nanocarriers”, Institute for Medicine and Engineering (IME), University of Pennsylvania, 2-1-08.
“Polymer Molecular Weight influences Enzyme-loaded nanocarrier characteristics”, 4th Annual Biomedical Graduate Research Symposium, University of Pennsylvania, 4-19-07.
ADDITIONAL INFORMATION
• Proficient with Matlab and C++ programming, L-Edit and Pro/Engineer WildFire CAD, and MS office.
• Controlled Release Society Member, Inst. for Translational Medicine and Therapeutics (ITMAT) Associate Member.
• Judge, Pennsylvania Junior Academy of Science (PJAS), 2007-present.
• Competitive bodybuilding (NPC Maryland Open lightweight bodybuilding competition, 2nd place, MD, 2003), Surfing, Skurfing, Snowboarding, Wakeboarding, Rock Climbing, Spanish guitar (was Church choir lead guitarist at JHU).
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