Manager Plant

Ranjit S. Verma, Ph.D.

**** * ******* ******, ***. # 6. ************@*****.***

Milwaukee, WI 53211. Phone No. 414-***-****

Highlights of Expertise: Synthetic organic chemist, Process development chemist,

medicinal chemist, Tech-transfer and Intellectual property.

15+ years of experience in laboratory research, scale-ups and technology transfer of API’s, Active

Pharmaceutical intermediates and fine chemicals. Expertise in designing & implementing

medicinal chemistry and drug discovery projects. 4+ years of experience leading a team of 30+

researchers. Expert in Intellectual property right issues.

Core Competencies

Synthetic organic chemistry Chemical process development

Drug discovery Medicinal chemistry

Technology transfer Scale-ups for commercialization

Trouble shooting Equipment design modification

Tailoring synthetic process Team motivator and builder

Pilot plant and Plant audits

Employment profile

Cytometix Inc. Milwaukee WI. A start-up pharmaceutical company engaged in developing a drug

October 2011 to May 2012

for pain relief.

Director of Operations.

Successfully lead the process development of lead drug candidate CMX-020 by an

external CRO. The yield increased from less than 10% to more than 23% in 9 steps.

The costly Pd catalyst was replaced by a cheaper and easy to scale catalyst for the final

step stereo-specific partial reduction of 3-triple bonds (a real challenge).

Critically reviewed the CMC-section of IND application submitted to the FDA.

University of Wisconsin-Milwaukee, WI. 2009-2011

Post Doctoral Research Fellow. Supervisor: Professor James M. Cook.

Worked on Medicinal chemistry, synthetic methodology development and Natural product

synthesis projects.

Arch Pharmalabs limited, Taloja,(New Bombay) India. Manufactures and sells API’s &

Intermediates globally. 11 facilities, employing over 2000+ employees. 2005-2009

Group Leader - R & D at Arch Pharmalabs Ltd.

Awarded promotion as a Group leader within year of joining for successfully rescuing

2-important failing projects, DMPAC and Triflusal, for a customer in Italy, this resulted

in new projects and greater business from the same customer.

Guided team to scale-up 10+ projects from bench level to plant scale. Managed, trained

& carried out the performance appraisal of the scientists and chemists (18+12).

Chaired the safety committee, successively for 3 years, implemented safe work

environment through training, counseling and audits.

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Multi organics Pvt. Ltd, Mumbai. Manufacturer of specialty chemical and pharma

2004-2005

Intermediates, outsourcee to global chemical companies, 200+employees.

Asst. Manager- New product development.

Headed and supervised the set-up of New R&D center, recruited and trained a team of chemists.

Effectively managed external CRO & chemists to develop process technology for new products.

Coromandel Fertilizers India Limited (CFL), Mumbai. Leaders in fertilizers, specialty

nutrients, and crop protection. Markets around 2.9 million ton of product globally. The

Company turnover of $ 1.93 billion in 2012 & employs over 5000 people. 2002 -2004

Asst. Manager- R & D Centre. (Formerly EID Parry India Limited).

Awarded a promotion from Scientist to Asst. Manager for successfully re-developing process for

Phenthoate with 21% overall cost reduction and shorter time cycle. This product till date is

being produced in the plant and CFL is the second largest producer.

Successfully resolved the process difficulties in endosulfan and made the process very robust,

this product was the core business, I was rewarded for this exceptional contribution.

Volunteered to accept added responsibility to setup a new advanced formulation center. Attend

fully sponsored course conducted by IPFT, Govt of India. Developed formulations like Gels,

micro-emulsions and WDG’s, one of the products was commercialized.

Calyx Chemical and Pharmaceuticals limited, Dombivali, India. A custom synthesis

2002 (March-Aug)

and manufacturing organization, employing about 200 people.

Scientist – R & D.

Successfully completed the n-1 intermediate of duloxtine for a Japanese company in record

time, collaborated with analytical team to develop a better and faster HPLC method of analysis.

Nicholas Piramal India limited, Thane, India. It is a Part of Piramal health care & ranks 5th in

list of top 10 pharmaceutical contract manufacturers globally as per UNCTD’s, World Investment

2000-2002

Report, 2011, employs more than 400 scientists.

Junior Manager - R & D.

Demonstrated, synthesized and scaled up Crotamiton to kilogram scale in the lab in record time.

Skillfully completed impurity profiling for Verapamil hydrochloride and Bulaquin.

Collaborated with various teams and Completed laboratory work on Levobunolol, Valdecoxib and

successfully introduced the process to manufacturing. Completed the plant trials of Gabapentin.

Education

Ph.D. (Organic Chemistry) 1997-2002

Institute of Science, Mumbai, India. Advisor: Professor Madhukar S. Chande.

Thesis: "On the Chemistry of Spiro Compounds Containing N & S."

The project included synthesis of series of various novel heterocyclic, spiro compounds and

spiro-crown ethers built on an oxindole nucleus. The compounds synthesized were

characterized and scanned for their biological activity against mycobacterium tuberculosis.

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