Project manager,chemist,chemical engineer

Isil YASA MS (Analytical Chemistry), BS (Chemical Engineering)

**** ******* ****** *** *** Phone #: 314-***-****

St. Louis, MO 63108 Email: jypjle@r.postjobfree.com

SUMMARY OF QUALIFICATIONS:

• cGMP and cGLP Practices and Laboratory Information Management Services (LIMS)

• HPLC (High Performance Liquid Chromatography) (RP, SEC, Ion Exchange) Agilent ChemStation, Waters Empower systems, MS, LC-MS Xcalibur Software

• UV/Vis & IR (Ultraviolet/visible& infrared) Spectrophotometry

• Electrophoresis, ICE (Imaged Capillary Electrophoresis), SDS/PAGE

• SPE (Solid Phase Extraction), TLC (Thin Layer Chromatography), CV ( Cyclic Voltammetry), EIS (Electrochemical Impedance Spectroscopy)

• Trace Analysis, DNA isolation, extraction, digestion, enzymatic reactions, protein assays

• Research and development, stability and release testing of Drug Substance (DP) and Drug Product (DP)

• Radioactive Material Safety Training (NYS Department of Health)

• Methods Development, Method Qualifications

EXPERIENCE:

Retail Shop, St.Clair Square Mall, Fairview Heights, IL Oct 09 – Apr 10

Owner of a Small Business

• Owned and handled a seasonal business, which offered range of home and garden decorations, wrote a business plan, managed all features of business, including sales, buying and employing, timely arrival of the products and marketing

NY State Dep. of Health, Division of Environmental Health Sciences, Albany, NY Sept 07 – May 09

Asst. Research Scientist

• Worked on a research programs to develop analytical methods to assess human health risk posed by heterocyclic aromatic amines (HAAs), dietary and environmental gentoxicants, which are believed to contribute to some common forms of human cancers

• Measured HAAs in foods, hair, fur and urine, and related biomarkers in human-derived specimens. Responsible for the trace analysis, sample extraction and clean-up, instrumental support, data production and HPLC method development and analytical troubleshooting

• Responsible to isolate DNA from biological fluids, human and animal tissues; conducted enzymatic digestion of DNA to mononucleosides, to assay purity and RNA contamination by HPLC; performed protein assays, isolated HAA isomers from cooked meats by tandem solid phase extraction techniques

• Conducted bioorganic synthesis of HAAs and their metabolites, purification by HPLC

• Quantified and reviewed data of biomarkers by LC-MS, using Thermo Electron Xcalibur software

Pfizer Global Research and Development, Chesterfield, MO Jan 06-Jan 07 Contract Scientist

• Worked on the drug product development of biological human therapeutics in the Analytical Research and Development Department. Activities included work in both PEGylated Growth Hormone (PEG-hGH) and Drug Product Development Analysis (DPDA) Groups. The research adhered to a Good Manufacturing Practice (GMP) environment

• Conducted research on a PEGylated growth hormone drug product, performed stability and release testing on drug substance (DS) and drug product (DP), using HPLC with Waters Empower chromatography and ChemStation software

• Trained on Laboratory Information Management Systems (LIMS); Responsible for appearance testing; various HPLC techniques (reversed-phase, size exclusion chromatography, ion exchange), method development; UV spectroscopic methods; imaged capillary electrophoresis (ICE); and troubleshooting all apparatus

• Developed a UV method for Phase III DP release of PEG-hGH

Chemistry Department, SIUE, Edwardsville, IL Aug 03-Jan 06 Teaching/Laboratory Assistant

• Provided support in performing experiments; established safe laboratory environment; and tutored undergraduate and graduate students

• Courses Taught: Quantitative Analytical Chemistry Lab (CHEM 335), General Chemistry Lab for Engineering Students, General Chemistry Lab (CHEM 125 a,b), General Organic and Biological Chemistry Lab (CHEM 124 a,b)

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Can Health Devices& Supplies Co., Ankara, Turkey Apr 01-May 03

Product Manager

• Responsible for the importation of disinfectants/antiseptics from Lysoform Disinfection Ltd, Germany, and hygienic detergents from Ecolab, USA for usage in hospitals

• Conducted extensive written and verbal communications with chemists and regulatory affair personnel from Germany and USA, to ensure proper and timely delivery of products; translated English documents into Turkish dossiers and prepared the registration files for the Ministry of Health

• Organized and supervised the logistics of purchases of ingredients and scheduling the timely production of disinfectants and antiseptics under the name of Can Health Devices in Istanbul and Ankara factories

• Supported the conversion of small scale process into commercially viable large scale operations

• Wrote training documents, product proposals and usage manuals; established training programs on product usage for nurses/new employees; reviewed scientific/technical literature on antiseptics; provided the company’s sales department with advice on new product developments and bench-marked the products against the products of competitors

Belgin Lubricants and Motor Oils Co., Gebze, İzmit, Turkey Feb 00-Jan 01

Sales Engineer

• Responsible for the sales of lubricants and motor oils, provided technical support after sales; worked with customer to ensure satisfaction of products and services ’post-sale’; identified target markets

• Conducted interviews to determine the engineer’s needs of specific lubricants; trained the employees on proper usage

Canakkale Ceramic Inc., Canakkale, Turkey Jun 99-Aug 99 Engineering Intern

• Worked as an intern in the research and development laboratory of a 10,000 tons/year capacity insulator plant and performed instrumental UV analysis on insulator for quality control

PETKIM Petrochemicals Holding, Izmir, Turkey May 98 - Aug 98 Engineering Intern

• Worked as an intern at ACN plant production department of a 90,000 tons/year capacity acrylonitrile plant in Petkim Complex; observed and participated in troubleshooting and chemical production

EDUCATION:

• M.S., Analytical Chemistry, Southern Illinois University Edwardsville (SIUE), IL (2007) GPA 3.8/4.0

Thesis: Bioelectrochemical applications of chemically modified electrodes (CMEs) for the detection of thiamin dependent enzymes

• B.S., Chemical Engineering, Ankara University, Ankara, Turkey (1999) GPA 3.0/4.0

Research Project: One year project to develop a preliminary design of a sulfuric acid manufacturing plant (design of columns, chemistry, finance and production of the plant)

HONORS:

• Full scholarships for B.S. and M.S. Degrees

• Award of outstanding teaching assistant (Southern Illinois University Edwardsville), 2005

COMPUTER SKILLS:

• Knowledge of FORTRAN, well versed in Windows Applications (Microsoft Word, Excel, PowerPoint, Adobe Illustrator), Chem-Draw, ChemStation, Waters Empower, Xcalibur

PUBLICATIONS:

• Bessette, E.E., Goodenough, A.K., Langouët, S., Yasa, I., Kozekov, I. D., Spivack, S.D., and Turesky, R. J. (2009), Screening for DNA adducts by data-dependent constant neutral loss-triple stage (MS3) mass spectrometry with a linear quadrupole ion trap mass spectrometer. Anal. Chem. 81, 809-819

• Turesky, R.J., Bendaly, J., Yasa, I., and Hein, D.W. (2008).The Impact of NAT2 acetylator genotype on mutagenesis and DNA adducts from 2-amino-9H-pyrido[2,3-b]indole. Chemical Research in Toxicology, 2009, 22(4), 726-733

• Bessette,E.E., Yasa,I., Wilkens, L., Marchand, L.L., and Turesky, R.J. (2008). Biomonitoring of carcinogenic heterocyclic aromatic amines in hair and correlation of hair: A Validation Study. Chemical Research in Toxicology, 2009, 22 (8), 1454-1463

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ABSTRACTS:

• David W. Hein, Jean Bendaly, Isil Yasa, Christy M. Denham, Mark A. Doll, Robert J. Turesky. Human NAT2 acetylator genotype-dependent DNA adducts and mutagenesis by 2-amino-9H-pyrido [2,3-b] indole (AαC). University of Louisville School of Medicine, Louisville, KY, Wadsworth Center, New York State Department of Health, Albany, New York., presented at Translational Cancer Medicine 2008: Bridging the Lab and the Clinic in Cancer Medicine Conference, Jerusalem, Israel, Nov 3-6, 2008

• Erin E. Bessette, Isil Yasa, Lynne Wilkens, Loic Le Marchand, Robert J. Turesky, Rapid biomonitoring of carcinogenic heterocyclic aromatic amines in rodent fur and human hair. American Association of Cancer Research Conference, Denver, CO, April 18-22, 2009

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