Computational Biologist

KYAW MYINT

U.S. Citizen

Department of Computational Biology

Carnegie Mellon University and University of Pittsburgh

**** ****, **** ***** ***., Pittsburgh, PA 15213.

917-***-****. **************@*****.***

RESEARCH INTERESTS

Computational biology, ADME and Toxicity predictions, QSAR and statistical modeling, cheminformatics, structure-based and ligand-based drug design.

HIGHLIGHTS

Computational biologist with dual degrees and interdisciplinary background

Developed several QSAR and ADMET prediction models

Discovered novel ligands for cannabinoid receptor and p62 proteins

Co-inventor of a patent for novel p62 inhibitors

Published several manuscripts in peer-reviewed journals

EDUCATION

Ph.D. in Computational Biology

Expected in June-August, 2012

Joint Computational Biology Ph.D. Program

Carnegie Mellon University and University of Pittsburgh, Pittsburgh, PA

Thesis Title: Virtual Screening, QSAR Methods Development and Experimental Validations for GPCR Cannabinoid Ligand Discovery

Advisor: Professor Xiang-Qun Xie

B.S. in Computer Science (GPA: 3.75/4.0)

2003-2007

Hampden-Sydney College, Hampden-Sydney, Virginia, VA.

B.S. in Biology (GPA: 3.8/4.0)

2003-2007

Hampden-Sydney College, Hampden-Sydney, Virginia, VA.

PROFESSIONAL EXPERIENCE

University of Pittsburgh and Carnegie Mellon University

2007-Present

Graduate Research Assistant

Implemented a novel fragment-based QSAR method and other machine learning hit ranking algorithms to predict bioactivities and ADMET properties of chemical ligands using Matlab and C++ programming tools.

Optimized CB2 lead ligands for better affinity and potency using 3D-QSAR studies.

Performed virtual screening using ligand-based and structure-based approaches for novel GPCR Cannabinoid (CB2) ligand and p62 inhibitor discoveries.

Discovered and patented novel p62 inhibitors important for multiple myeloma.

Performed 3H-radioligand binding assays to validate my predicted hit ligands for affinity/selectivity.

Johnson and Johnson Pharmaceuticals Inc.

June-September, 2011

Polypharmacology Summer Intern

Advisor: Dr. Radu Dobrin

Implemented cheminformatics-based polypharmacology approach to identify off-targets/side-effects.

Constructed drug-target networks, drug-drug networks and analyzed using CytoScape.

Discovered and validated side-effects of some of known drugs and presented final results to the members of the In Silico Immunology (ISI) group.

National Institute of Health

May-August, 2007

Computational Imaging Summer Intern

Advisor: Dr. Bernard Heymann

Analyzed noisy 2D electron microscopy images to improve 3D image reconstruction of particles.

Provided initial insights and data analyses to improve image reconstructions.

Wrote a scientific report and presented a poster at the Summer Internship Program (SIP) Retreat.

Texas A&M University

May-August, 2006

Bioinformatics Summer Researcher

Advisor: Dr. Sing-Hoi Sze

Conducted an independent research on studying local gene rearrangements for certain yeast species.

Wrote a scientific report and presented a poster at the REU Summer Program.

Hampden-Sydney College

May-August, 2005

Computational Chemistry Summer Researcher

Advisor: Professor Paul Mueller

Performed computations to predict activities of Baylis-Hillman catalysts by using GAUSSIAN03

Produced a written scientific report and presented it to the members and faculty of Honors Council.

RESEARCH AND TECHNICAL SKILLS

Computational: QSAR method development, CoMFA, machine learning, structure-based and ligand-based drug design, statistical and mathematical modeling.

Software: Cytoscape, Sybyl Tripos, OpenBabel, VMD, Chemoffice, ChemAxon, Marvin.

Programming Languages: Matlab, C/C++, Python.

Experimental: Mammalian cell culture, radioligand (using radioactive ligands) binding assay.

PUBLICATIONS AND PATENT

A complete list is attached as a separate file. It includes:

1. 3 publications in peer-reviewed journals (2 more manuscripts submitted)

2. 1 patent

3. 6 conference presentations

HONORS AND AWARDS

NIH Predoctoral fellowship (2010-Present)

Patrick Henry Scholarship and Dean’s List-All Semesters (Hampden-Sydney College, 2003-2007)

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