Research Chemist QC and R&D experience

Summary:

Research Chemist with strong background in Analytical Chemistry and excellent accomplishments in the fields of pharmaceutical quality control, GMP and GLP, defense mechanism in plants, natural products isolation, purification, and biological assessment, soil/water analysis, basic microbiological analysis.

Core Competence: Research in the fields of natural products, defense mechanism in plants, fermentation of microorganism, biomolecules and natural polymers isolation and characterization. Instrumental chromatographic analytical techniques ( HPLC, GC, FPLC ), and Spectroscopy (FT-IR, uv-vis, FT-NIR, MS and NMR interpretation) among others (disintegration test, KF, potentiometric titration, Dissolution test, SDS-PAGE eletrophoresis). Method development experience .Bilingual English/Spanish. Scientific and bibliographic background focused on defense mechanism of plants and pharmaceutical developments.

Last 5 years Professional Experience:

Perrigo,FL- (Temp,Manpower)

Quality Inspector Hollywood, July 2010- May25, 2011

• Quality inspection of plastic bottles and containers, designed for pharmaceutical industry.

• Control of production from molding machines. Documented results of tests and analyses

• Reliability and reproducibility of production on a daily basis.

Nature’s Products, Inc. Sunrise, FL

QC Lab Analyst (temp) 12/01/2009 to 05/11/2010

• Successful setting-up of ID system of raw materials using FT-NIR NIRFLex N-500 and NIRCal 5.2 software, including new approved SOP’s. Setting-up the equipment without training by Buchi, Switzerland, saving $30 000.

• Developing a new methodology to built calibration groups using wide range of raw materials, using cluster classification in 3D and chemometrics.

• Results by FT-NIR Reports and Power Point , including future development on quantitative analysis ( protein and beta carotene content) and using FT-NIR as an analytical tool for improving blending of pharmaceuticals.

Staffing Now/Swiss Caps USA, Miami, FL

QC Lab Analyst (temp, subst. of sick person) 07/27/2009 to 10/05/2009

• Sampling raw materials by GMP procedures, Sampler Room. Running ID by FT-IR and FT-NIR following SOP's. Manage lab and test data and results compilation procedures.

• Execute wet chemistry techniques to characterize raw materials and soft-gel capsules as finished products (p-anisidine, peroxide, acid value, refractive index, etc).

• Running assays of API’s by Spectrophotometer and titration techniques.

• Set-up new analytical techniques and assays procedures following USP guidelines.

Synthon Hispania, Barcelona, Spain

QC Analyst 03/ 2008 to 12/2008

• Tested and analyzed raw materials, finished products (solid oral dosage forms) and API's by FT-IR, Dissolution Test, water content (KF), Titration Assays, TLC and wet chemistry techniques.

• Determined uniformity content, stability, purity and chemical content of raw materials and API's by uv-vis spectrophotometric methods and HLPC (Agilent and Empower 2 software).

• Documented results of tests and analyses by SQL-LIMS.

FAGESA, S.A., Barcelona, Spain

QC and R&D Technician 07/2007 to 03/2008

• Conducted chemical (stability, purity, active substance content) and physical laboratory tests of finished products (disinfectants and sanitizing products).

• Analyzed and documented test data and results for research, product development and quality control to release products for sale.

• Developing new analytical method for insecticide pyrethroids by RP18-UPLC-Empower 2 .

• Applied knowledge of biological processes to develop new powerful disinfectants by green approach design.

Almirall Prodesfarma, S.A., Barcelona, Spain

QC Lab Analyst 01/2007 to 07/2007

• Tested and analyzed raw materials, finished products and API's by FT-IR, Dissolution test, water content (KF), TLC, GC (volatile residues, head space) and wet chemistry techniques.

• Determined uniformity content, stability, purity and chemical content of raw materials and API's by Spectrophotometric, titration methods and HLPC (Agilent).

• Documented results of tests and analyses by SQL-LIMS.

FARMHISPANIA, Barcelona, Spain

Quality Operator 08/2006 to 11/2006

• Handling all operations during chemical synthesis in reactors (6000L) and other manufacturing operations (centrifugation, filtration, sieving) following SOP's and GMP procedures. Working on clean room filling finished products.

• Supervised quality and chemical characteristics of new synthesis by uv-vis and AA Absorption spectrophotometer (catalizer type and yield of reaction).

• Recorded all batch productions data and revised results keeping GMP procedures.

• Conducting internal audits in order to receive FDA inspections.

Acadomia and Pitagora’s Academy---Barcelona and Canary Islands, Spain

Professor, Part Time, High School/ university students 11/1999 to 04/2009

• Teaching Mathematics, Physics and Chemistry to High School Spanish students.

•. Teaching several disciplines to university Pharmacy career students: Pharmaceutical Chemistry, Biochemistry, Organic Chemistry, Physics-Chemistry, Instrumental Techniques, Analytical Chemistry, BioStatistics.

Education:

Bachelor of Science, Chemistry (Honors, 5 years+Thesis),Havana University-1986

Quality Control/Management master, Barcelona-Catalunya’s Generalitat- 2006

Seminar: GMP Guidelines for API pharmaceuticals manuf., FarmHispania-Barcelona-2006

Grants and scholarships:

Scientific researcher, National Institute of Agricultural Science-Havana-1986-1992

Oligosaccharin’s Laboratory creation grant-National Institute of Agricultural Science-Havana-1992

Research Scholarship-Natural Products and Agrobiology Institute-CSIC-Spain-1998-1999

Areas of specialization:

• Set up laboratory equipment: FT-NIR, HPLC, AA Spectrophotometer, uv-vis Spectrophotometer, FPLC. Practical skills with SDS-PAGE electrophoresis, viscosity measurements, liquid/solid extraction, ultrafiltration, concentration techniques. Understanding of immunology/ELISA, and related diagnostic techniques. Actualized on biomagnetic/MABs separations research. Familiar with basic microbiology techniques.

• Trained in all areas of submerged culture fermentation of bacterial and fungal strains, isolating resulting culture medium and biomass. Trained into a biotechnology pilot plant ( vaccines from genetically modified yeast): 1997-1998. Basic knowledge on thermal analysis (ATD, DSC) both interpretation and equipment, and RX diffraction.

• Computer skills: Office 2007, SQL-LIMS, Chemstation for uv-vis Spectrometer, HPLC and Dissolution Test, Empower 2 trained for HPLC Waters(2008). Statistical programs.

Awards:

• Founder of Oligossaccharin’s Laboratory, by means of 200K (to Lab equipment and reactive purchase) investment from Cuban Science Academy, to isolate new bioactive products from plant and microbial sources and study defense molecular mechanism in vegetables.1992.

• Chief of scientific projects 1995-1998

“Development of new culture medium for Bradyrhizobium japonicum to induce nod-factors biosynthesis and increased biofertilizer effectiveness. Still active until 2008”

“Evaluate the potential of fungal elicitors to induce systemic resistance against fungal diseases on tobacco and potato plants. Financed by PRECODEPA.”

International Congress and Publications:

VII Cell Wall Meeting, Santiago de Compostela, Spain, Sept 1995

• Preparation and preliminary assessment of heat stable fragments isolated by enzymatic hydrolysis of hemicelluloses from sugar cane with biological activities

• Highly pure peptic acid and bioactive oligogalacturonides from citrus peel.

• Isolation, partial characterization and eliciting activity of water-soluble extracts from cell walls of Phytophtora cinnamomi Rands.

VIII International Congress of Molecular Plant-Microbe

Interaction, Tennessee, July 1996

• Tomato immunization against Fusarium oxysporum lycopersici by means of different elicitor combination

More than 20 scientific articles already published as author and coauthor, on Cuban and international scientific reviews.

Scientific Dreams/Goals: To develop a solid capsule to oral delivery of peptide drugs (like insulin), based on natural polysaccharides, to localized release into small intestine, avoiding losses of effectiveness due to gastric pH and partially substitute intravenous supply of drugs.

Developing new herbicides and disinfectants using commercial chemical products which mimics natural defense mechanism of vegetable and plants, leading to powerful and wide spectrum killing microbicides and post-emergence herbicides without toxic residues to environment.

References: Contact with Mrs. Irene Labrada, QC Supervisor, Swiss Caps USA.

Phone: 305-***-****, ext 132; E-mail: ***********@*********.***. Cell: 786-***-****

Patricia Waikel, QC Supervisor, Nature’s Products. Cell: 812-***-****. E-mail:*******@***.***.

Beverly, Quality Inspector (coworker)-Georgia, US. Phone: 305-***-****.

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