• Ph. D trained expert in NMR theory and its applications with a speci

JIPING YANG

** ******* **** • BRIDGEWATER, NJ ***07 • ******.********@*****.*** • 908-***-****

OBJECTIVE

Principal position at a leading bio-pharmaceutical that provides challenging opportunities for the application of NMR knowledge and strong analytical skills to achieve multidisciplinary, multi-functional goals

QUALIFICATIONS

• Ph. D trained expert in NMR theory and its applications with a specialty in solid/liquid-state NMR spectroscopy; extreme proficiency at designing and implementing NMR pulse sequences for multi-dimensional, multi-nuclear NMR experiments as well as seamless adoption of new cutting-edge NMR technology

• Over 13 years of experience in the pharmaceutical application of NMR technique to solve challenging problems such as elucidating structures, identifying impurities, and characterizing small molecules at both the research and commercial stages of drug development. Specifically skilled at distinguishing chiral compounds by NMR in liquid crystal medium, separating/determining structures of metabolites by LC-NMR, and characterizing drug candidates’ polymorphs by solid-state NMR

• Established a solid-state NMR lab and led the implementation of sophisticated NMR techniques to support several late stage drug development projects by characterizing drug substances (APIs) and drug products, identifying specific forms of polymorphs, determining protonation sites of API salts, and studying molecular interactions of co-crystals

• Demonstrated ability at overseeing and operating Varian and Bruker models of NMR spectrometers (300 MHz –750 MHz) equipped with auto-sampler, PFG module, and cyro-probe in regards to instrument calibration, optimization, and troubleshooting

• Skilled in operating additional analytical instruments such as GC, HPLC, MS, IR, and DSC/DTG as well as utilizing UNIX system, LIMS, FELIX, GAMMA and POAM to design NMR pulse sequences and analyze NMR data

PROFESSIONAL EXPERIENCE

Sanofi-Aventis Pharmaceuticals, Bridgewater, New Jersey 2006 Present

Principle Research Investigator Dept. of Discovery Analytics

Senior Research Scientist II Dept. of Discovery Analytics 2003 2006

Aventis Pharmaceuticals Inc., Bridgewater, New Jersey 2000 2003

Senior Research Scientist I Division of Drug Innovation & Approval

Hoechst Marion Roussel Inc. (HMR), Bridgewater, New Jersey 1998 2000

Research Scientist Division of Structural & Physical Chemistry

Pacific Northwest National Laboratories, Richland, Washington 1995–1998

Postdoctoral Fellow Battelle Memorial Institute

EDUCATION

Pacific Northwest National Laboratories, Richland, WA Postdoctoral Fellow | Mentor: Michael A. Kennedy

Research Focus: “Conformational and Dynamics of Selectively 1H Labeled DNA by NMR”

University of Toronto, Toronto, Canada

Ph.D. in Physical Chemistry | Mentor: William F. Reynolds

Thesis: “Distinguishing two-bond and three-bond 13C-1H connectivity by 2D NMR BIRD-decoupled difference spectra: The DODO pulse”

University of New Brunswick, New Brunswick, Canada

M.Sc. in Analytic Chemistry | Mentor: Douglas Brewer

Thesis: “Investigation of Antimony Oxide in Fire Retardant of Polyethylene”

PUBLICATIONS

1. “Solid-State NMR: Applications in Early Drug Development”, Jiping Yang, Vasant Kumar, Gregory Nemeth, Donglai Yang, Teng-Man Chen and Pierre deMontigny, Sanofi-Aventis LGCR Newsletter, April, 2011

2. “Getting Our Feet ‘WET’”, J. Yang and V. Kumar, NMR Newsletter, 513, 23, 2001

3. “A Comprehensive Approach for Accurate Measurement of Proton-Proton Coupling Constants in the Sugar Ring of DNA”, J. Yang, L. Silks, R. Wu, Nancy Isern, Cliff Unkefer and Michael A. Kennedy, Journal of Magnetic Resonance, 146, 260, 2000

4. “Improvement in Measuring Homonuclear Coupling Constants in DNA via a New Stripe-COSY Pulse Sequence Combined with a Novel Strategy of Selective Deuteration”, J.P.Yang, L.Silks, R. Wu, Nancy Isern, Cliff Unkefer and Michael A. Kennedy, Journal of Magnetic Resonance, 129, 212, 1997

5. “Further Briareolate Esters and Briareolides From the Caribbean Gorgonian Octocoral Bariareum Asbestinum”, B.S.Mootoo, R.Ramsewak, R.Sharma, W.F.Tinto, A.J.Lough, S.McLean, W.F.Reynolds, J.P.Yang and M.Yu, Tetrahedron, 52(30), 9953, 1996

6. “Complete Spin Dynamics of the AX, AX2 and AX3 Spin Systems. Application to BIRD Pulses”, A.D.Bain, I.W.Burton, K.A.Carpenter, J.P.Yang, W.F.Reynolds, Magnetic Resonance in Chemistry, 33, 201, 1995

7. “Investigation of the Effect of Ring Size on the Product Distribution for the Shift Base Reaction of 2-Acetylcycloalkanone with Diamino Alkanes”, R.G.Enriquez, J.F.FernandezG, I.Leon, W.F.Reynolds, J.P.Yang and M.Yu, Canadian Journal of Chemistry, 73, No.1, 16, 1995

8. “Distinguishing Two-Bond and Three-Bond 13C-1H Connectivities by 2D BIRD-Decoupled Difference Spectra: the DODO pulse”, W.F.Reynolds, J.P.Yang and R.G.Enriquez, Magnetic Resonance in Chemistry, 33, 705, 1995

9. “Total Assignment of the 1H and 13C Chemical Shifts for a Mixture of cis- and trans-p-Hydroxycinnamoyl Esters of Taraxerol with the Aid of High-Resolution, 13C-Detected, 13C-1H Shift Correlation Spectra”, S.McLean, W.F.Reynolds, J.P.Yang, H.Jacobs, L.L.Jean-Pierre, Magnetic Resonance in Chemistry, 32, 422, 1994

10. “Structural Investigations of Plant and Insect Natural Products by 2D-NMR’”, W.F.Reynolds, J.P.Yang and M.Yu, 77th Canadian Society of Chemistry Conference, May 29th-June2nd, 1994

11. “ 9,11-Seco-24-Hydroxydinosterol From Pseudopterogorgia Americana”, S.L.Miller, W.F.Tinto, J.P.Yang, S.McLean and W.F.Reynolds, Tetrahedron, 1994

12. “The Crystal and Molecular Structures of N,N’-di(2-acetylcyclohexenyl) ethylenediamine and Its Copper(II) Complex”, J.M.Fernandez-G, R.G.Rnriquez, A.T.Cervantes, W.F.Reynolds and J.P.Yang, Canadian Journal of Chemistry, 71, No.3 358, 1993

13. “Further Improvements in the FLOCK Sequence”, K.A.Carpenter, W.F.Reynolds, J.P.Yang and R.G.Enriquez, Magnetic Resonance in Chemistry, S30, 35, 1992

14. “The Influence of Antimony Trichlorides on Flammability and Ignitability of Polyethylene”, J.P.Yang, D.G.Brewer and J.E.S.Venart, Fire and Materials, 15, 127, 1991

15. “A Study of Synergistic Action of Antimony Oxide in Fire Retarding Polyethylene”, J.P.Yang, D.G.Brewer and J.E.S.Venart, Fire and Materials, 15, 37, 1991

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