Quality Control Assurance
Resume:
SWEETY VADLAMUDI
*********.******@*****.***
Objective
Interested for full time opportunities in the areas of Bio-chemistry and Bio-analytical Method Development
Educational Background
Graduate level Masters of Science Degree in Biochemistry
Texas A&M University – Kingsville, Texas.
Department of Chemistry GPA: 3.6/4.0
Aug ‘11
Undergraduate level Bachelor of Pharmacy Degree
Dr. MGR Medical University – JSS College of Pharmacy.
Department of Pharmaceutical Sciences GPA: 4.0/4.0 Aug ‘06
Technical Skills
• Operation of HPLC: LC-MS, Ion Exchange Chromatography, Reverse Phase Chromatography, Affinity Chromatography, Size Exclusion Chromatography, Gas Chromatography, GC-MS, knowledge of protein-purification and protein-separation techniques, DNA-Purification.
• Operational knowledge of Infrared, Mass Spectrometer, Ultraviolet and Nuclear Magnetic Resonance Spectrophotometer and interpretation NMR data and mass spec data.
• Electrophoresis Techniques: SDS Page, 2-Dimensional SDS Page, Capillary Electrophoresis, Native Gel Electrophoresis, Western Blotting, Southern Blotting, Iso-electric Focusing and ELISA.
• Other techniques including Gelatinise Assay, Fibrinolytic Assay, Direct and Indirect Hemolytic tests, Hemorrhagic test, Tissue collection, Cell culture, Cell Isolation and Plate Development, Centrifugation techniques, Molecular Biology techniques like DNA Isolation & Preparation, PCR, RT-PCR.
• Experienced in laboratory operations, animal handling techniques, maintaining technical documentation, protocol design, submission of quality assurance protocols and journal article composition.
Academic Projects
• Worked on Isolation and Partial Characterization of Antibacterial Peptides from the venom of Naja pallida at National Natural Toxins Research center (NNTRC) in collaboration with the Department of Pharmaceutical Sciences at Irma Lerma Rangel School of Pharmacy.
• Worked on the Isolation of DNA& RNA from snake venom gland, venom gland of queen bees, PCR, RT-PCR and sequence analysis and analysis of samples by Northern and Southern Blotting Techniques at the NNTRC.
• Worked on a project in Department of Medicinal chemistry at Irma Lerma Rangel School of pharmacy on synthesis of antimicrobial drugs and its derivatives and analyzed them on NMR Spectroscopy and IR Spectroscopy and collected them on LC-MS.
• Worked on a project with Effect of Cannabinoid Receptor Antagonist on Insulin induced feeding behaviors on mice in Department of Clinical Pharmacology.
• Worked on a research project to test the effectiveness of a polyherbal formulation in treatment of Insomnia and to determine the possible adverse effects on the Central Nervous system in mice in area of Clinical Pharmacology.
Internship Experience
2012 Working at Diabetic Health Care Clinic where I carried out testing of Drug samples, analyzing them by HPLC, LC-MS and carrying out quality control stability studies, carrying out statistical analysis.
2011 Working at Diabetic Health Care Clinic where I carried out testing of Drug samples, analyzing them by HPLC, LC-MS and carrying out quality control stability studies, carrying out statistical analysis.
2011 Internship at Irma Lerma Rangel College of Pharmacy, Department of Pharmaceutical Sciences, where my responsibilities were to help study the effects of Cannabinoid Receptor Antagonist in insulin administered mice. Monitoring mice subjects’ feeding behavior, administering dosages, analyzing subjects’ brain tissue samples and plotting observational data, were some of my tasks.
2010 Internship at National Natural Toxins Research Center at Texas A&M University – Kingsville, where I was exposed to the process of testing venoms for anti-cancer activity on various mammalian cell lines, techniques like ELISA test, Affinity Chromatography and Native SDS-Page.
2007 In-plant training at NATCO Pharmaceuticals in R&D Department on Quality control. Carried out Quality Control procedures like stability testing.
2006 In-plant training at Aurobindo Clinical Laboratories on preformulation development of tablet and capsule manufacturing.
2005 Worked as undergraduate researcher in Department of Pharmacology& Drug Analysis Department on a project testing the effectiveness and side effects of a formulation in treatment of Insomnia.
Quality Control Chemist Feb’11-Present
Diabetic Health Care Clinic
• Testing of Drug samples, analyzing them by HPLC
• Carrying out quality control stability studies
• Carrying out statistical analysis.
Researcher Jan’11-Feb’11 Irma Lerma Rangel School of Pharmacy
• To study the effects of Cannabinoid Receptor Antagonist in insulin administered mice.
• Monitoring mice subjects’ feeding behavior, administering dosages, analyzing subjects’ brain tissue samples and plotting observational data, were some of my tasks.
Graduate Research Assistant at NNTRC Jan ’08 - Dec ’10
Texas A&M University, Kingsville, TX
• Worked on a project on Isolation and partial characterization of antibacterial peptides from the Venom of Snake Naja pallida.
• Maintained technical documentation, record keeping, protocol design and submission of quality assurance protocols and followed research according to GMP safety guidelines.
• Knowledge in writing technical documentation, writing articles for journals, worked on research projects and associated publications.
• Worked on HPLC (Reverse Phase, Ion-exchange, Size exclusion, Affinity) and Mass spectrometry techniques, Cell culture and cell isolation, wet chemistry, general chemistry, SDS-Page, Capillary Electrophoresis, ELISA techniques following GLP Standards.
Analytical Chemist in R&D Department Aug ’06 - Dec ’07
NATCO Pharmaceuticals, Hyderabad, India
• Analyzed various drug samples using HPLC techniques like Reverse phase and Ion exchange, Thin Layer Chromatography, Gas Chromatography Techniques.
• Conducted Quality Control and Stability tests using Dissolution and Disintegration apparatus.
Undergraduate Researcher Aug ’02 - Mar ’06
Department of Pharmacology, JSS College of Pharmacy
Project: Testing the effectiveness and side effects of a polyherbal formulation in treatment of Insomnia.
• Isolation and separation of compounds through Ion Exchange Chromatography and analysis of mass by Mass spectrometry.
• Conducted various pharmacological experiments on mice and rats and analysis of data by Student T-test and SAS software.
• Have had exposure to various simulation techniques used in pharmacological experiments.
Formulation Chemist Jan ’05 - May ’06
Aurobindo Pharmaceuticals, India
• Prepared laboratory scale batches of prototype product formulations, SOP preparation and maintained the organized records for future reference.
• Conducted daily laboratory stability checks and maintained Laboratory Notebook records.
• Assisted Research and Development team in the development of process improvements and formulation of plant capabilities.
Honors and Awards
• Recipient of the “Who’s who among students in American Universities”, for excellence in research, academic and extracurricular activities for 2010-2011.
• Recipient of the “Welch Scholarship” from Texas A&M University-Kingsville for the years 2008-2011.
• Ranked 2nd in the state of Tamil Nadu based on aggregate scores in the Bachelor of Pharmaceutical Sciences program by Dr. MGR Medical University, India - 2006.
• Recipient of Student Development Scholarship award from JSS college of Pharmacy for the years 2002-2006.
Publications & Presentations
• Characterization and Partial Isolation of Antibacterial Peptides from the Venom of Snake
Naja pallida; Vadlamudi S, Lopez Johnston JC, Bashir S,Daniels L, Perez J.C (Under review).
• Characterization and isolation of Antibacterial Peptides from the venom of Snake Naja Pallida (Presented at TAMUK and won Honorable mention Award).
• Study the effects of Cannabinoid Receptor Antagonist in insulin administered mice (Presented at Texas Tech University Health Sciences Center, Amarillo)
• Studying the effectiveness and possible side effects of a polyherbal formulation in treatment of Insomnia on the Central Nervous System in mice (Presented at Indian Pharmaceutical Congress and at All India Institute of Medical Sciences, India )
• An improved high performance liquid chromatographic method for analysis of low molecular weight proteins and comparison with the standards (Presented at University of Texas San Antonio).
References available on request
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