Bioorganic chemist

CV of Dr. Md. Joynal Abedin

*** * **** ***** ****** Dr, Bozeman,MT 59715 Department of Chemistry & Biochemistry Bozeman, MT 59717 Mobile:406-***-**** Montana State University, Bozeman, MT 59717, Work: 406-***-**** *******@*********.*******.*** 406-***-****

Highlights

Extensively experienced in organic chemistry

Extensively experienced in multistep organic synthesis towards complex organic molecules, purification and characterization of organic products by flash chromatography, HPLC, MALDI- and LC-MS MS/MS and 1-and 2D-NMR.

Extensively experienced in water soluble chemistry and multi-step synthesis of bio-linker molecules.

Developed new methodology for functionalization of heterocyclic molecules towards organic synthesis.

Extensively experienced in protein, peptide, bioorganic chemistry

Extensively experienced in chemical modification of protein cages, antibody and peptides, and bioconjugation with small organic molecules.

Developed dendritic like covalent polymers with small organic molecules inside nano protein cages.

Developed methodology for bioconjugation of therapeutic agents inside nano protein cages.

Developed new bioconjugation methods for attaching antibody and peptides and PEG on the surfaces of viral and archeal protein cages for targeted drug delivery

Developed new protein-small organic molecule based targeted MRI contrast agents for imaging cancer cells and tissues.

Experienced in expression, and purification of protein cages, antibody and peptides by SEC, ion exchange and other affinity column (Protein G, Protein A and Ni2+), and analyzing by protein assays, Gel electrophoresis, western blotting, HPLC and LC-MS.

I am eligible to work in the USA (a green card holder)

Education

2002 Ph.D., Synthetic Organic/Organometallic Chemistry, The University of Montana, Missoula; Thesis Title: “ Reactivity of Electron Deficient Benzoheterocycle Triosmium Clusters” Advisor: Professor Edward Rosenberg

1991 M. Sc., Organic Chemistry, Jahangirnagar University, Bangladesh

Thesis Title: “ An Alternative Synthesis of Adrenalol”; Advisor: Professor Abdul Hai

1988 B. Sc., Chemistry, Jahangirnagar University, Bangladesh

Professional Experiences and Employments

2005 (September) to until Postdoctoral Research Associate in the lab of Prof Dr Trevor Douglas and Dr Prof Mark Young of Montana State University, Bozeman. Working in several biomedical

and nanomedicine projects:

i) Synthesis and construct of protein based targeted MRI agents for cancer cells, ii) Synthesis of protein cage-therapeutic agent constructs for targeted therapeutic delivery to the tumor cells, Iii) Bio-conjugation of adjuvants (prophyrin and small drug molecules) to protein cage nanoparticles for stimulation of T-cells for greater immune response against respiratory viral infection. Iv) protein cage architectures as bio-templates for catalytic and magnetic nanomaterials, and fabrication for application in photocatalytic hydrogen fuel production and advanced sensors.

2004 – 2005 (Postdoc)Worked on a project investigating the role of spur of ribosomal subunit in protein bio-synthesis by recombinant DNA technology) under the supervision of Prof Stephen Lodmell of Division of Biology, The University of Montana, Missoula.

2003 – 2004 Post-doc (material science), worked on chemical synthesis and characterization of diluted magnetic semiconductor nanocrystals from organometallic compounds and their fabrications for industrial applications under Dr. Jiye Fang at Advanced Material Research Institute (AMRI) of University of New Orleans, New Orleans.

2002 – 2003 Post-doc(organic), Worked on development of new spirocyclization reactions by ‘Heck’ type reaction for the generations of organic molecules containing adjacent chiral centers using Pd(IV) intermediate under Dr Helena Malinakova at Department of Chemistry, The University of Kansas, Lawrence

1997–2002 Graduate Teaching Assistant and Graduate Research Assistant, The University of Montana, Missoula; Advisor: Professor Edward Rosenberg; Developed synthetic methodology for functionalizing benzoheterocycles using electron deficient bonding to triosmium cluster to make new heterocyclic compounds. Investigated mechanistic studies of the reactivity of electron deficient benzoheterocycles. Involved in teaching organic lab for 3 years.

1996-1997(summer) Assistant Professor, Department of Chemistry, Jahangirnagar University, Bangladesh. Taught organic chemistry in the graduate and undergraduate levels.

1994-1996(summer) Lecturer, Department of Chemistry, Jahangirnagar University, Bangladesh, Taught chemistry in the graduate and undergraduate levels. Worked on synthetic organic chemistry under professor M. Rabiul Islam

1992-1993 Research Scientist, Bangladesh Council for Scientific and Industrial Research, Bangladesh. Gained experience in the isolation and purification of natural products.

Review of Scientific Articles

1) Reviewed scientific articles of Bangladesh and American Chemical Society;

Professional Activities

American Chemical Society

References

Dr Trevor Douglas, Professor of Chemistry, Department of Chemistry and biochemistry and Center for Bio-inspired nanomaterials, Montana State University, Bozeman, MT 59717, 406-***-****; ********@*********.*******.***

Dr Mark Young, Professor of virology, Department of Plant Bio-Science and Center for Bio-inspired nanomaterials Montana State University, Bozeman, MT 59717, 406-***-****; ******@*******.***

Dr Peter Suci, Associate Research Professor, Department of Plant Sciences and Plant pathology & Center for biofilm engineering, Montana State University, Bozeman, MT 59717; 406-***-*****

Dr Stephen Lodmell, Associate professor, Division of Biological Sciences, The University of

Montana, Missoula, MT 59812, 406-***-****; *******.*******@********.***

Dr. Jiye Fang, Associate Professor of chemistry and nanotechnology, New York State University, Binghamton, NY 13902-6000; 607-***-****; *****@**********.***

Dr Edward Rosenberg, Professor of chemistry, Department of Chemistry, The University of Montana, Missoula, MT 59812, 406-***-****; ******.*********@***.***.***

Funding

Collaborator, Targeted combinatorial therapy to treat periodontal disease (NIH grant 1R21DE019237-01A1) Mark Young, PI

Publications

* Synthesis of Catechol metal Based Coordination Polymer Inside viral protein nanoparticles as a potential T2 MRI Contrast Agent (manuscript in preparation)

**Synthesis of Dendritic Polymer of DTPA-Gd inside P22 as a Potential MRI Contrast Agent (manuscript in preparation).

***Protein Cage-small organic molecule architecture as an Extremely Efficient T1 MRI Contrast Agent (manuscript in preparation).

1. Janice Lucon, Md Joynal Abedin, Masaki Uchida, Lars Liepold, Craig C. Jolley, Mark Young, Trevor Douglas,” A Click Chemistry Based Coordination Polymer Inside Small Heat Shock Protein,”Chem. Commun.”, 2010, 46, 264–266.

2. Lars O. Liepold, Md Joynal Abedin, Emily D. Buckhouse, Joseph A. Frank, Mark J.Young, Trevor Douglas; “Supramolecular protein cage composite MR contrast agents with Extremely Efficient Relaxivity Properties”, Nano letters, 2009, 9, 4520-4526.

3. “Synthesis of a Cross-Linked Branched Polymer network In the Interior of a Protein Cage.” ; Md Joynal Abedin, Lars Liepold, Peter Suci, Mark Young, Trevor Douglas; Journal of the American Chemical Society , 2009, 131 (12), 4346-4354. (Highlighted in ACS website)

4. Joynal Abedin, Edward Rosenberg, Djamaladdin G. Musaev, Taraneh Nowroozi-Isfahani, and Keiji Morokuma, Kenneth I. Hardcastle; “Experimental and Computational Studies of Nucleophilic Attack, Tautomerization, and Hydride Migration in Benzoheterocycle Triosmium Clusters.” Organometallics, 2006, 25 (1), 203 -213.

5. “Reactions of Electron-Deficient Benzoheterocycle Triosmium Complexes with Lithium Isobutyronitrile; Edward Rosenberg, Shariff E. Kabir, Md. Joynal Abedin. Hardcastle, Kenneth I; Organometallics, 2004, 23(16), 3982-3989

6. Kabir, Sharif E.; Malik, K.M. Abdul; Mondal, S. Himadri; Mottalib, M. Abdul; Abedin, M. Joynal; Rosenberg, Edward; “The Reaction of Os3(CO)9(3- H2C7H3(2-CH3)NS)( -H) with Diazomethane. The First Example of a Trimetallic Cluster Containing a m-Methylidyne and a s-Methyl”, Organometallics (2002), 21(13), 2593-2595.

7. Edward Rosenberg, Md. Joynal Abedin, Dalia Rokhsana, Alessandra Viale, walter Dastru, Roberto Gobetto, Luciano Milone, kenneth hardcastle, “ Ligand Dependent Structural Changes in the Acid – Base Chemistry of Electron deficient Benzoheterocycle Triosmium Clusters,” Inorganica Chimica Acta (2002), 334, 343-354.

8. Islam, Rafiqul; Abedin, M. Joynal; Khayer, Khurshida; Islam, M. Rabiul. “Synthesis of 5-Spiro(5’- Methylisatin)-4-Acetyl-2-(Acetylamino) -D2-1,3,4-Thiadiazoline and 5-Spiro(5’-Methylisatin)-4-Acetyl-2-(5’- Methylisatin-3’-Hydrazino)-D2-1,3,4-Thiadiazoline”. Indian J. Chem., Sect. B: Org Chem. Incl. Med. Chem. (2001), 40B(3), 240-242

9. Abedin, S. M. Tareque; Hardcastle, Kenneth I.; Kabir, Sharif E.; Malik, K.M. Abdul; Mottalib, M. Abdul; Rosenberg, Edward; Abedin, M. Joynal “Carboxylation of a 3-Diazo Methylidyne Triosmium Cluster”. Organometallics (2000), 19(26), 5623-5627.

10. Rosenberg, E.; Abedin, M. J.; Rokhsana, D.; Osella, D.; Milone, L.; Nervi, C.; Fiedler, J. “The Electrochemical Behavior of Electron Deficient Benzoheterocycle Triosmium Clusters”. Inorg. Chim. Acta (2000), 300-302, 769-777.

11. Md. J. Abedin, B. Bergman, R. Holmquist, R. Smith, E. Rosenberg, J. Ciurash, K. Hardcastle, J. Roe, V. Vazquez, C. Roe, S. Kabir, B. Roy, S. Alam, K.A. Azam, “Electron Deficient Bonding of Benzoheterocycles to Triosmium Clusters: Synthesis and Applications to Organic Chemistry,” Coord. Chem. Rev. (1999) 190-192, 975.

12. Islam, Md. Rabiul; Abedin, Md. Joynal; Md. Mamun; Duddeck Helmut,“Synthesis of

1-Methyl-bisDioxopyrrolino[2’,3’:2,3:2”,3”: 6.5]Benzene and its Heterocycles via Thiocarbohydrazone, Thiosemicarbazone,” J. Bangladesh Chem. Soc.(1998) 11(1 & 2), 71-78.

13. Rahim, M. Abdur; Abedin, M. Joynal; Islam M. Rabiul; “Methylation of 9- Bromo- and 7- Chloro- Indolo[2,3-b] Quinoxalines (indophenazines). Jahangirnagar University Journal of Science, Bangladesh (1995), vol 19, 23-29.

Conference Presentations

August 2009 238th National Meeting of ACS, Washington DC, (Oral Presentation) “Synthesis of a crosslinked branched polymeric network in the interior of a nano protein cage as a potential MRI contrast agent” Abedin, Md Joynal; Liepold, Lars; Suci, Peter; Young, Mark; Douglas, Trevor.

March 2007 Montdiego Science Meeting co-sponsored by center for bio-inspired nanomaterials (Oral presentation )- Analysis of Intact Protein Cages by Mass Spectrometry, Lars Liepold and Joynal Abedin

November 2003 Louisiana Materials Research and Development Conference, Lafayette, LA. ( Oral Presentation) “Chemical Synthesis and Characterization of Diluted Mn-Doped Semiconductors Nanocrystals”, J. Abedin, J. Fang.

June 2002 57th Northwest Regional Meeting of the A.C.S., Spokane, WA.

(Oral presentation) “Reactivity of Electron Deficient Benzoheterocycles

with Carbon based nucleophiles”, J. Abedin, E. Rosenberg

June 2001 56th Northwest Regional Meeting of the A.C.S., Seattle, WA.

(Oral presentation)“Reaction of Electron Deficient

Benzoheterocycles with H-/H+ “, J. Abedin, E. Rosenberg.

March 2001 A.C.S. Montana Section Meeting, Butte, MT. (Oral presentation)

“Reaction of Electron Deficient Benzoheterocycles with H-/H+ ”,

J. Abedin, E. Rosenberg

June 1999 54th Northwest Regional Meeting of the A.C.S., Oregon, Portland.

(Oral presentation) “Synthesis and Reactivity of Electron Deficient Benzoheterocycles, J. Abedin, E. Rosenberg

March 1999 A.C.S. Montana Section Meeting, Butte, MT. (Oral presentation)

“Synthesis and Reactivity of Electron Deficient

Benzoheterocycles , J. Abedin, E. Rosenberg

Professional Skills

Synthesis of organic (including peptides and other water soluble molecules), inorganic and organometallic compounds. Air-sensitive chemistry: Schlenk techniques, Glove boxes etc. High-Pressure hydrogenation, carbonylation and carbonyl enrichment (13CO) reactions. Excellent NMR spectroscopy techniques: 1D & 2D, T1 and T2 measurement, variable temp. Spectroscopy: UV-Vis, FT-IR, LCMS, GC-MS, EPR. Excellent separation experience for both small and macromolecules (proteins, peptide and anti-body): flash chromatography, HPLC, FPLC (SEC, ion exchange) and affinity column. Synthesis and fabrication of nanoparticles and their characterization through Transmission, Surface Electron Microscopy (TEM & SEM), and ICP Cell culture, cloning, transformation, other recombinant DNA technology, gel electrophoresis, western blotting, mutation, PCR, transcription, protein expression, purification and characterization.

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