chemist
Resume:
Yousry Naguib, Ph.D.
Arcadia, CA 91006
Education:
Ph.D. (Organic), Simon Fraser University, British Columbia, Canada.
Thesis: Electronic configuration of imidyl free radicals.
M.Sc. (Natural Products Synthesis), University of Western Ontario, London, Ontario, Canada.
Thesis: A stereoselective total synthesis of the natural product trachyloban-19-oic acid (enantiomer of sunflower diterpene) from the natural product podocarpic acid.
B.Sc. (Chemistry), Ain Shams University, Cairo, Egypt.
Member of the American Chemical Society
Brandeis University. Post-doctoral and Research Associate.
Synthesis of fluorescent materials and study of their photochemistry and photophysics.
Patents:
Holds ten U.S. Patents.
Publications:
Published more than 20 scientific papers in peer- reviewed journals; wrote more than 50 articles about health and nutrition in various magazines.
Skills:
Hands on experience with organic synthetic methods, and analytical techniques (HPLC, GC, flash and thin layer chromatography) and spectroscopic methods (NMR, UV-Vis, FT-IR, Fluorometer) and instruments that photochemist routinely use.
Formulation of dietary supplement products for various health conditions.
Accomplishments:
1) Developed analytical methods and SOP for standardization and quality control of dietary supplements.
2) Developed and patented analytical assays for measuring ORAC (Oxygen Radical Absorbance Capacity). Employing ORAC assay, Developed a new dietary ingredient, Isomer E which is widely distributed at GNC stores.
3) Developed new dietary supplement products marketed under trade names: Isomer E, Amorin, Flex Relief, Viv, Proserene, Vasochol, XcessTrim.
4) Published over 20 papers in peer-reviewed journals.
5) Wrote articles about Health and Nutrition in various magazines.
6) Awarded10 US patents and wrote patent applications, and I own two of which on an herb from middle-east. This herb has been shown in human clinical trials to enhance sexual function.
7) Coordinated clinical trials for evaluation of efficacy of dietary supplement products.
8) Wrote and filed a new dietary ingredient application with FDA.
9) Wrote and submitted an SBIR (Small Business Innovative Research) grant proposal on antioxidants assays to NIH (National Institutes of Health) and was approved for funding($100,000).
10) Developed diode laser fluorometer for an on-line monitoring of coatings on fibers.
11) Invented single photon near-infrared photopolymerization for image industry.
12) Supervised graduate students (PhD, MSc).
Experience:
Sylmark – Senior Scientist (October 2006 – December 2008)
Developed new dietary supplement products for joint pain (marketed under trade name Flex Relief), anti-stress formula, sleep disorder formula, energy drink (marketed under trade name Viv).
Sourced and qualified ingredients by analytical methods (ORAC, HPLC, GC) Coordinated clinical trials,
Wrote two patent applications.
Soft Gel Technologies- Manager of technical services and new products development (September 2001-May 2006)
Developed nutraceutical and herbal products, coordinated clinical trials to evaluate efficacy of dietary supplements
Formulated two products—Isomer E (with widespread distribution at GNC) and Amorin
Coordinated clinical trials on anti-diabetic, weight loss, and sexual enhancement of herbs
Created technical specification sheets
Wrote research publications and patents, and many product brochures that were used as marketing tools for sales team
Co-inventor of six US Patents
Filed a new dietary ingredient application with FDA.
Tufts University (USDA), Boston, MA, Consultant (2000-2001), developed assays for measuring antioxidant activities.
Phytochem technologies (formerly with ESA), Chelmsford, MA. Senior Scientist (1996-2000)
Developed analytical methods and SOP for standardization and quality control of dietary supplements.
Developed and patented fluorometric assays (ORAC) for measuring activities of antioxidants in natural products in aqueous, lipophilic and liposomal media.
Inventor of two US patents # 6060324 and # 6114177 on fluorometric assays for measuring antioxidant activities.
Wrote and submitted an SBIR (Small Business Innovative Research) grant proposal on antioxidants assays to NIH (National Institutes of Health) and was approved for funding.
Developed supercritical extraction process of Astaxanthin from Haematococcus pluvialis algae.
Published two scientific papers on antioxidants in Journal of Analytical Biochemistry (1998 and 2000), and a scientific paper on antioxidant activity of astaxanthin and carotenoids published in Journal of Agricultural and Food Chemistry.
Suez Canal University, EGYPT. Associate Professor
Teaching organic chemistry and natural products, supervising graduate students. Research on photochemistry of heterocyclic.
Albany International Research Co., Mansfield, MA. Senior Scientist Chemist
Developed diode laser fluorometer for on-line monitoring of coatings on fibers. Modified nylon fibers by chemical cross-linking methods.
Brandeis University. Post-doctoral and Research Associate.
Synthesis of fluorescent materials and study of their photochemistry and photophysics. The research work involved mechanistic and preparative organic photochemistry, photochemistry and photophysics of dyes, fluorescent sensors, near infra-red photopolymerization for image and holography industry (work sponsored by Polaroid). Invented single photon near-infrared photopolymerization for image industry.
Some Issued United States Patents (US PAT. NO.)
7,449,491 Natural vitamin E compositions with superior antioxidant potency
7,008,932 Hyaluronic acid in soft gel form
6,855,733 Formulation and manufacturing process for coenzyme Q10 soft gel capsules
6,780,440 Herbal compositions and methods for diabetes and weight loss management
6,623,768 Pharmaceutically active composition extracted from Ferula hermonis and process of its extraction
6,114,177 Fluorometric assay for measurement of antioxidant activity
6,060,324 Fluorometric assay composition for measurement of antioxidant activity
List of Publications in Peer Reviewed Journals:
“Synthesis of cryptand [2.2.2] containing reactive functional groups,” an ionophore of potassium ions, Yousry Naguib, Molecules 14, 3600-3609 (2009).
“Studies on LC/MS analysis of Sesquiterpenes from Ferula Hermonis,” Yousry Naguib, submitted for publication.
“Antioxidant activities of natural vitamin E formulations.” Naguib Y, Hari SP, Passwater R Jr, Huang D. J Nutr Sci Vitaminol (Tokyo). 49:217-20 (2003).
“Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study.” Judy WV, Hari SP, Naguib YM, Passwater R. J Ethnopharmacol 87:115-7 (2003).
“Antioxidant activities of astaxanthin and related carotenoids.” Naguib, Y.M.A. J. Agric. Food Chem. 48, 1150 (2000).
“Efficient photoreduction and ring contraction of 3,5,6-triphenyl-1,2,4-triazine in neat triethylamine.”
Dopp, D., Youssef, W.A.F., Dittmann, A., Kaddah, A.M., Shalaby, A.A., Naguib, Y.M., J. Inf. Rec. (Journal of Information Recording Materials) 25 (1-2): 57-63 (2000).
“Efficient electron transfer mediated phototransformations of electron-poor aza-arenes in neat aliphatic amines.” Dopp, D., Youssef, W.A.F., Dittmann A., Gorner H., Kaddah, A.M., Naguib, Y.M., Shalaby, A.A., 17th International Congress on Heterocyclic Chemistry, Vienna, August 02-06 (1999).
“Light induced reduction and ring contraction of some phenylated azines,” Dopp, D., Youssef, W.A.F., Henkel, G., Kaddah, A.M., Shalaby, A.A., Naguib, Y.M., 4th International Conference on Solar Energy Storage and Applied Photochemistry (Solar ’97), Cairo, January 1-6 (1997).
“Photoconversion of some pi-deficient aza-heterocycles in triethylamine. ,” Dopp, D., Youssef, W.A.F., Henkel, G., Kaddah, A.M., Naguib, Y.M.A. Symposium Proceedings XVI th IUPAC on Photochemistry, Helsinki, Finland, 1996.
“A fluorometric method for measurement of oxygen radical scavenging activity of water soluble antioxidants.” Naguib, Y.M.A., Analytical Biochemistry, 284, 93-98 (2000).
“A fluorometric method for measurement of peroxyl radical scavenging activities of lipophilic antioxidants.” Naguib, Y.M.A. Analytical Biochemistry, 265, 290 (1998).
"Novel fluorometric assays for measurement of oxygen radical absorbance capacity (ORAC) of antioxidants." A poster presented at the natural products drug discovery conference, November 12-14, 1997, Baltimore, MD.
“Decay kinetics of photosensitized triplet crystal violet in acetonitrile.” Yousry Naguib, Colin Steel, Michael Young. J Photochem Photobiology A: Chemistry 101 (2001)
“Triplet sensitized photobleaching of crystal violet.” Naguib, Y.M.A.; Steel, C.; Cohen, S.G.; Young, M.A. J. Photochem. Photobiol. A. Chem., 96, 149 (1996).
“The photodecomposition of cyclic N-bromoimides: Evidence for stereoelectronic control in intramolecular hydrogen transfer in imidyl radicals.” Chow, Y.l.; Zhao, D.C.; Kitadani,M.; Pillay, K.S.; Naguib, Y.M.A.; Ho, T. J. Chem. Soc., Perkin Trans 2, 361 (1990).
“Proton-electron transfer: Kinetics and mechanism in the ketone-ketyl redox system.” Naguib, Y.M.A.; Steel, C.; Cohen, S.G. J.Phys. Chem. 92, 6574 (1988).
“Photoreduction of benzophenone by acetonitrile. Correlation of hydrogen abstraction from RH with ionization potentials of the radicals R. ” Naguib, Y.M.A.; Steel, C.; Cohen, S.G.; Young, M.A. J. Phys. Chem. 91, 3033 (1986).
“Reduction of crystal violet by diphenyl ketyl radicals.” Naguib, Y.M.A., Steel, C.; Cohen, S.G. J.Am.Chem.Soc. 108, 128 (1986).
“Recent controversy on imidyl radical chemistry.” Chow, Y.L.; Naguib, Y.M.A. Reviews of Chemical Intermediates 5, 325 (1984).
“(2+2) photocycloadditions of dichloromaleimide and dichloromaleic anhydride to cyclic olefins.” Chow, Y.L.; Naguib, Y.M.A. J.Chem.Soc., Perkin Trans. I, 1165 (1984).
“Stereoelectronic probes on the electronic configuration of imidyl radicals. Decomposition of N-bromo-7,8-dichloro-cis- bicyclo[4.2.0]octane-endo,cis-7,8-dicarboximide.” Chow, Y.L.; Naguib, Y.M.A. J.Am. Chem. Soc., 106, 7557(1984).
“An investigation of the photodecomposition of N-Bromosuccinimde; the generation and reactivity of succinimidyl radiacl.” Fu-Lung Lu, Yousry M.A. Naguib, Masayuki Kitadani, Yuan L. Chow. Canadian Journal of Chemistry 57:1967-1976 (1979).
“Vinylphosphonium bicycloannulation of cyclohexenones and its use in a stereoselective synthesis of trachyloban-19-oic acid.” Cory, R.M.; Chan. D.M.T.; Naguib, Y.M.A.; Rastal, M.H.; Renebog, R.M. J. Org. Chem. 45, 1852 (1980).
“Bicycloannulation with isoprpenyltriphenylphosphonium bromide. The synthesis of trachyloban-19-oic acid.” Cory, R.M.; Naguib, Y.M.A, Rasmussen, M.H. Journal of the Chemical Society Chemical Communications 504 (1979).
Articles on Health and Nutrition:
1. Understanding Soft Gel Encapsulation, Natural Products Insider Magazine (March 2006)
2. The Skin Your Customers are in, Vitamin Retailer Magazine (Nov 2005)
3. Blood Sugar Regulation & Supplements, Vitamin Retailer Magazine (Sept 2005)
4. Complementary Approaches to Depression, Vitamin Retailer Magazine (Aug 2005)
5. Liver Health and Botanicals, Vitamin Retailer Magazine (June 2005)
6. Eye Health Update. Nutraceuticals World (May 2005)
7. Healthy Aging, Vitamin Retailer Magazine (May 2005)
8. Supplements to Address Circulatory Health, Vitamin Retailer Magazine (March 2005)
9. The Effects of Supplements on Weight Control, Vitamin Retailer Magazine (Dec 2004)
10. Natural Alternatives for Maintaining Healthy Cholesterol, Vitamin Retailer Magazine (Oct 2004)
11. Brain Health Influenced By Diet and Supplements, Vitamin Retailer Magazine (June 2004)
12. Hyaluronic Acid in Joint, Skin and Eye Health, Nutrition Industry Executive (March 2004)
13. Nutritional Relief for Allergy and Asthma, Vitamin Retailer Magazine (March 2004)
14. Bone Building Ingredients. Nutraceuticals World, Part 1 (March 2004)
15. Joint Health and Supplementation, Vitamin Retailer Magazine (January 2004)
16. Digestive Tract Disorders, Vitamin Retailer Magazine (Dec 2003)
17. Blood Pressure Management and Supplements, Vitamin Retailer Magazine (Nov 2003)
18. Ephedra Alternatives in Weight Management, Nutrition Industry Executive (Aug/Sept 2003)
19. Natural Alternatives for a Good Night’s Sleep, Vitamin Retailer Magazine (Aug 2003)
20. Inflammation Control Options from Nature, Vitamin Retailer Magazine (July 2003)
21. The Cholesterol Lowering Properties of Nutrients, Vitamin Retailer Magazine (May 2003)
22. The Options for Cancer Prevention, Vitamin Retailer Magazine (April 2003)
23. The Joint Health Market, Nutraceuticals World (April 2003)
24. Carotenoids Come of Age, Functional Foods & Nutraceuticals (March 2003)
25. Breathing Easier: Asthma and Allergy Solutions, Vitamin Retailer Magazine (March 2003)
26. Dietary Indoles- Chemo preventive Agents, Nutrition Industry Executive (March 2003)
27. Supplementation to Manage Diabetes, Vitamin Retailer Magazine (Feb 2003)
28. From Boswellia to Vitamins: Arthritis Solutions are Many, Vitamin Retailer Magazine (January 2003)
29. The compelling Case for Chromium Supplementation, Supplement Industry Executive (Nov/Dec 2002)
30. Facing Up to Skin Disorders Naturally, Vitamin Retailer Magazine (November 2002)
31. Essential Fatty Acids- Essential for Good Health. Supplement Industry Executive (Oct 2002)
32. Astaxanthin: Nature’s Potent Pink carotenoid, Supplement Industry Executive (Sept 2002)
33. Soft Gel Capsules: An Elegant & Versatile Dosage Form, Vitamin Retailer Magazine (July 2002)
34. Multi-Systemic Benefits of Soy, Supplement Industry Executive (June 2002)
35. Conjugated Linoleic Acid, Vitamin Retailer Magazine (April 2002)
36. Carnitine: Essential Fuel for the Cellular Engine, Supplement Industry Executive (March 2002)
37. Healing with MSM, Vitamin Retailer Magazine (February 2002)
38. Color Your Customers Healthy with Carotenoids, Vitamin Retailer Magazine (January 2002)
39. Hydroxycitric Acid- A Weight Loss Aid, Vitamin Retailer Magazine (December 2001)
40. Quercetin, Vitamin Retailer Magazine (November 2001)
41. Chromium: A Nutritional Trace Mineral, Vitamin Retailer Magazine (October 2001)
42. Alpha-Lipoic Acid: A versatile Antioxidant, Vitamin Retailer Magazine (October 2001)
43. Probiotics: A new Look at the Many Strains, Supplement Industry Executive (July/Aug 2001)
44. Biotherapeutic Potential of L-Acidophilus, Vitamin Retailer Magazine (July 2001)
45. Echinacea- Immune System Stimulant, Vitamin Retailer Magazine (June 2001)
46. Lutein Keeps An Eye On Healthy Vision, Vitamin Retailer Magazine (May 2001)
47. Folic Acid Protects Against Birth Defects and More, Supplement Industry Executive (May 2001)
48. EPA/DHA: Omega-3 fatty acids, Vitamin Retailer Magazine (April 2001)
49. Beta-Glucans: Immune Boosters & Cholesterol Lowering Supplements, Supplement Industry Executive (March 2001).
50. Chondroitin Sulfate: Foremost for Arthritis Formulas, Supplement Industry Executive (Jan/Feb 2001).
51. OPC- Antioxidant Superstar, Vitamin Retailer Magazine (February 2001).
52. Lycopene, Vitamin Retailer Magazine (January 2001).
53. Pioneering Astaxanthin, Nutrition Science News (February 2001)
54. Lycopene. Miracle Nutrient for 21 Century, Supplement Industry Executive (October 2000).
55. Nature's Super Antioxidant, total Health magazine, v.22, no.4 (2000).
56. Review of Antioxidants, American Botanical Council; HerbClip HC 011204, March 15 (2000).
57. Carotenoids in the Prevention of Cardiovascular, Cancer and Eye Diseases, Vitamin Retailer Magazine (December 1999).
58. An Overview of Antioxidants, Nutraceuticals World (March 1999).
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