International Internal Medicine Physician with Infectious Diseases

Zhang, York Yonglong, M.D.& Ph.D.

Present Mailing Address

* ******* ***

Littleton, MA 01460

Mobile Phone: 732-***-****

***************@*****.***

Medical Education

Graduate - Peking University Health Science Center, Beijing, China

Internal Medicine (Infectious Disease)

D.M.S.

Graduate - Peking University Health Science Center, Beijing, China

Clinical Pharmacology

M.M.S.

Undergraduate - Peking University Health Science Center, Beijing, China

Clinical Medicine

B.M.

USMLE Steps 1–3 and CS Pass.

Certification/Licensure

Board certification: Beijing Bureau of Health; ECFMG certificate, CPR certificate, Proficiency in EMR-EPIC, US citizen.

Membership and Honorary/Professional Societies

Association of Chinese American Physicians, Member 2012; American Society of Biochemistry and Molecular Biology, Member 2005-Present; Organization Committee of the Beijing International Symposium on Antibiotics, Member 2000 to present.

Medical School Honors/Awards

Excellent Undergraduate Student Award, Beijing Medical University 1989, 1990, 1991, 1992; Excellent master’s degree Graduate Student Award, Beijing Medical University 1996; Excellent Ph.D. Graduate Student Award, Peking University Health Science Center 2001.

Work Experience

01/2026- Average Hours/Week: 36

Tufts Medical Center, Neuro Unit, Boston, Massachusetts

Clinical Care Technician

As a Clinical Care Technician, my duties include assisting with ADLs (bathing, feeding, turning, ambulating), taking vital signs, checking blood sugars, helping with admissions, supporting RNs with patient care, stocking rooms with supplies, and handling miscellaneous tasks as they arise. I also take the patient's history, perform the physical examination, and review the patient's history and treatment plan.

12/2025- Average Hours/Week: 33-39

Innovative Renal care-Leominster hemodialysis center, Massachusetts

Patient Care Technician

I offer comprehensive dialysis care by providing patients with various treatment options tailored to their needs. I educate those with end-stage renal disease about their condition, treatment choices, and lifestyle management. To ensure safety and effectiveness, I meticulously monitor vital signs during hemodialysis and conduct post-treatment lab tests.

8/2025-12/2025 Average Hours/Week: 36

Emerson Hospital, Massachusetts

Medical Assistant

All aspects of clinical care in the intensive care unit were performed.

7/2013 Average Hours/Week: 40

Associates of Cape Cod, Inc. Massachusetts

Senior Clinical Research Scientist

Performing (1 3)-β-D-glucan detection enables earlier and more sensitive diagnosis of invasive fungal infections. This method also facilitates the study of relationships between endotoxin and systemic inflammation, malnutrition, cardiac injury, and reduced survival.

10/2011-7/2013 average hours/week: 40

Boston Medical Center, Massachusetts

Postdoctoral Fellow, Robert Lafyatis, MD, Director, Attending Physician

Research was performed on a project entitled "Wnt-mediated fibrillinogenesis in systemic sclerosis".

10/2010 - 10/2011 Average Hours/Week: 40

Brigham and Women's Hospital, Massachusetts

Research Fellow, John Iacomini, Ph.D., Professor

Researchers have investigated the function of microRNAs in the development and transplantation of human kidneys. Funded by NIH 5 T32 AI070085-04

09/2001 - 10/2010 Average Hours/Week: 40

UMDNJ-Robert Wood Johnson Medical School, New Jersey

Postdoctoral fellow Masayori Inouye, Ph.D., Distinguished professor

The molecular mechanism of antibiotic resistance has been studied. The toxin MazF, the first ribosome-independent mRNA interfase that I described, is now being used to treat HIV infection.

09/1998 - 09/2001 Average Hours/Week: 40

Peking University Hospital, Department of Medicine, China

Minwu Zhao, MD, director, attending physician

As an attending physician in the Department of Internal Medicine, I provided high-quality medical care while actively participating in Phase I and II clinical trials. These trials focused on evaluating the safety, efficacy, and side effects of novel antibiotics.

09/1993 - 07/1998 Average Hours/Week: 40

Peking University Hospital, Internal Medicine, China

Internal Medicine residency, Jiatai Li, MD, Director, Attending Physician

I worked as a resident physician in the Department of Internal Medicine at Peking University First Hospital for five years. During my training, I rotated through various subspecialties, including infectious diseases, cardiovascular diseases, endocrinology, gastroenterology, hematology and oncology, nephrology, pulmonary medicine, critical care, and emergency medicine.

Volunteer Experience

08/2012 - 09/2012 Average Hours/Week: 78

New York Hospital Queens-Medical ICU, New York

Observer, Cristina Guitierrez, MD, Attending Physician

All aspects of clinical care in the intensive care unit were observed.

07/2012 - 08/2012 Average Hours/Week: 40

Boston Medical Center-Department of Pathology, Massachusetts

Observer, Huihong Xu, MD, Attending Physician

During this period, I learned about many aspects of surgical pathology. I received instructions in microscopy, frozen section preparation and diagnostic skills during this informative rotation.

05/2012 - 09/2012 Average Hours/Week: 4

Boston Medical Center, Department of Rheumatology, Massachusetts

Observer, Robert Lafyatis, MD, director, attending physician

The patient’s medical history, physical examination, and diagnosis and treatment of a wide range of rheumatologic diseases were recorded. I formulated and presented assessment and treatment plans to this board-certified attending physician.

05/2012 - 06/2012 Average Hours/Week: 78

New York Hospital Queens-Medical ICU, New York

Observer, Melvin Hochman, MD, director, attending Physician

All aspects of clinical care in the intensive care unit were observed. I attended and participated in morning reports, clinical lectures and discussions.

11/2012-12/2012 Average Hours/Week: 78

Cooper University Hospital-Pediatric Inpatient, New Jersey

Observer, Indira L. Amato, MD, Attending Physician and Douglass-Bright April, MD, Attending Physician

Patient history, physical exams, and the diagnosis and treatment of a wide range of pediatric diseases were recorded. I formulated and presented the future treatment plans to this board-certified attending physician.

07/2012-07/2013 Average Hours/Week: 20

Maimonide Medical Center-Pediatric outpatient, New York

Observer, Svetlana Ten, MD, Attending Physician, Pediatric Endocrinology Fellowship Program Director

Patient history, physical exams, and the diagnosis and treatment of a wide range of pediatric diseases were recorded. I formulated and presented the future treatment plans to this board-certified attending physician.

Prior training

09/1998 - 09/2001

M.D. Fellowship

Peking University Third Hospital, Beijing, China

Pulmonary Medicine (Internal Medicine)

(Supervisor: Minwu Zhao)

09/1993 - 09/1998

M.D. Residency

Peking University First Hospital, Beijing, China

Internal Medicine

(Supervisor: Jiatai Li)

Publications

Peer Reviewed Journal Articles/Abstracts

1.Britton N, Yang H, Fitch A, Li K, Seyed K, Guo R, Qin S, Zhang Y, Bain W, Shah F, Biswas P, Choi W, Finkelman M, Zhang Y, Haggerty CL, Benos PV, Brooks MM, McVerry BJ, Methe B, Kitsios GD, Morris A. Respiratory Fungal Communities are Associated with Systemic Inflammation and Predict Survival in Patients with Acute Respiratory Failure. medRxiv [Preprint]. 2023 May 16:2023.05.11.23289861. doi: 10.1101/2023.05.11.23289861.PMID: 37292915

2.D'Ordine RL, Garcia KA, Roy J, Zhang Y, Markley B, Finkelman MA. Performance characteristics of Fungitell STAT™, a rapid (1 3)-β-D- glucan single patient sample in vitro diagnostic assay. Med Mycol. 2021 Jan 4;59(1):41-49. PMID: 32400855

3.Fahal AH, Finkelman MA, Zhang Y, van de Sande WW. Detection of (1 3)-β-d-Glucan in

Eumycetoma Patients J Clin Microbiol. 2016 Oct;54(10):2614-7. PMID: 27440815

4.Gianella S, Letendre SL, Iudicello J, Franklin D, Gaufin T, Zhang Y, Porrachia M, Vargas-Meneses M, Ellis RJ, Finkelman M, Hoenigl M. (1 3)-β-D-Glucan Levels Correlate with Neurocognitive Functioning in HIV-Infected Persons on Suppressive Antiretroviral Therapy: A Cohort Study. J Neurovirol. 2019 Dec;25(6):837-843. PMID: 31297727

5.Gorgone M, Singhvi D, Mehdi Nouraie S, Finkelman M, Zhang Y, Pu J, Chandra D, Zhang Y, Kitsios GD, Morris A, Sciurba FC, Bon J. Circulating 1,3-Beta-D-Glucan is Associated with Lung Function, Respiratory Symptoms, and Mediators of Matrix Degradation in Chronic Obstructive Pulmonary Disease. Chronic Obstr Pulm Dis. 2022 Jul 29;9(3):325-335. PMID: 35550241

6.Hoenigl M, de Oliveira MF, Pérez-Santiago J, Zhang Y, Woods SP, Finkelman M, Gianella S. Correlation of (1 3)-β-D-glucan with other inflammation markers in chronically HIV infected persons on suppressive antiretroviral therapy. GMS Infect Dis. 2015;3: PMID: 27917362

7. Hoenigl M, de Oliveira MF, Pérez-Santiago J, Zhang Y, Morris S, McCutchan AJ, Finkelman M, Marcotte TD, Ellis RJ, Gianella S. (1 3)-β-D-Glucan Levels Correlate with Neurocognitive Functioning in HIV-Infected Persons on Suppressive Antiretroviral Therapy: A Cohort Study Medicine (Baltimore). 2016 Mar;95(11). PMID: 26986173

8. Hoenigl M, Pérez-Santiago J, Nakazawa M, de Oliveira MF, Zhang Y, Finkelman MA, Letendre S, Smith D, Gianella S. (1 3)-β-d-Glucan: A Biomarker for Microbial Translocation in Individuals with Acute or Early HIV Infection? Front Immunol. 2016 Oct 3; 7:404. PMID: 27752257

9.Hoenigl M, Lin J, Finkelman M, Zhang Y, Karris MY, Letendre SL, Ellis RJ, Burke L, Richard B, Gaufin T, Isnard S, Routy JP, Gianella S. Glucan rich nutrition does not increase gut translocation of beta-glucan. Mycoses. 2021 Jan;64(1):24-29. PMID: 32780885

10.Hoenigl M, Moser CB, Funderburg N, Bosch R, Kantor A, Zhang Y, Eugen-Olsen J, Finkelman M, Reiser J, Landay A, Moisi D, Lederman MM, Gianella S; Adult Clinical Trials Group NWCS 411 study team. Soluble Urokinase Plasminogen Activator Receptor Is Predictive of Non-AIDS Events During Antiretroviral Therapy-mediated Viral Suppression. Clin Infect Dis. 2019 Aug 1;69(4):676-686.PMID: 30418519

11.Hou F, Zhang Y, Hao F, Li J. A randomized controlled clinical study on ceftibuten and cefuroxime in the treatment of bacterial infections. Chinese Journal of Internal Medicine. 1998 Sep; 37(9): 612-615.

12.Isnard S, Lin J, Fombuena B, Ouyang J, Varin TV, Richard C, Marette A, Ramendra R, Planas D, Raymond Marchand L, Messaoudene M, Van der Ley CP, Kema IP, Sohail Ahmed D, Zhang Y, Finkelman M, Routy B, Angel J, Ancuta P, Routy JP. Repurposing Metformin in Nondiabetic People With HIV: Influence on Weight and Gut Microbiota.

Open Forum Infect Dis. 2020 Sep 11;7(9): PMID: 32964062

13.Isnard S, Fombuena B, Sadouni M, Lin J, Richard C, Routy B, Ouyang J, Ramendra R, Peng X, Zhang Y, Finkelman M, Tremblay-Sher D, Tremblay C, Chartrand-Lefebvre C, Durand M, Routy JP. Circulating β-d-Glucan as a Marker of Subclinical Coronary Plaque in Antiretroviral Therapy-Treated People with Human Immunodeficiency Virus. Open Forum Infect Dis. 2021 Mar 7;8(6): PMID: 34189152

14.Kitsios GD, Kotok D, Yang H, Finkelman MA, Zhang Y, Britton N, Li X, Levochkina MS, Wagner AK, Schaefer C, Villandre JJ, Guo R, Evankovich JW, Bain W, Shah F, Zhang Y, Methé BA, Benos PV, McVerry BJ, Morris A Plasma 1,3-β-d-glucan levels predict adverse clinical outcomes in critical illness. BMC Nephrol. 2020 Apr 6;21(1):118. PMID: 32252666

15.Li GY, Zhang Y, Chan MC, Mal TK, Hoeflich KP, Inouye M, Ikura M. Characterization of dual substrate binding sites in the homodimeric structure of Escherichia coli mRNA interferase MazF. J Mol Biol. 2006 Mar; 357(1): 139-50. Cited in PubMed; PMID: 16413577.

16.Li GY, Zhang Y, Inouye M, Ikura M. Inhibitory mechanism of Escherichia coli RelE-RelB toxin-antitoxin module involves a helix displacement near an mRNA interferase active site. J Biol Chem. 2009 May; 284(21): 14628-36. Cited in PubMed; PMID: 19297318.

17.Li GY, Zhang Y, Inouye M, Ikura M. Structural mechanism of transcriptional autorepression of the Escherichia coli RelB/RelE antitoxin/toxin module. J Mol Biol. 2008 Jun; 380(1): 107-19. Cited in PubMed; PMID: 18501926.

18.Liu M, Zhang Y, Inouye M, Woychik NA. Bacterial addiction module toxin Doc inhibits translation elongation through its association with the 30S ribosomal subunit. Proc Natl Acad Sci U S A. 2008 Apr; 105(15): 5885-90. Cited in PubMed; PMID: 18398006.

19.Lu Y, Li J, Zhang Y. A randomized controlled open study of ampicillin/sulbactum in the treatment of 172 cases with bacterial infections. Chinese Pharmaceutical Journal. 2000 Jan; 35(1): 56-57.

20.Mehraj V, Ramendra R, Isnard S, Dupuy FP, Lebouché B, Costiniuk C, Thomas R, Szabo J, Baril JG, Trottier B, Coté P, LeBlanc R, Durand M, Chartrand-Lefebvre C, Kema I, Zhang Y, Finkelman M, Tremblay C, Routy JP. CXCL13 as a Biomarker of Immune Activation

During Early and Chronic HIV Infection. Front Immunol. 2019 Feb 1; 10:289. PMID: 30846990

21. Swift O, Dasari BVM, Finkelman MA, Zhang Y, Sridharan S, Vilar E, Farrington K.

Post-Hemodialysis Flow-Dependent Hepatic Function Impairment in Individuals HYPERLINK "https://pubmed.ncbi.nlm.nih.gov/40814038/" HYPERLINK "https://pubmed.ncbi.nlm.nih.gov/40814038/" HYPERLINK "https://pubmed.ncbi.nlm.nih.gov/40814038/"w HYPERLINK "https://pubmed.ncbi.nlm.nih.gov/40814038/" HYPERLINK "https://pubmed.ncbi.nlm.nih.gov/40814038/" HYPERLINK "https://pubmed.ncbi.nlm.nih.gov/40814038/"ith End Stage Kidney Disease and Chronic Inflammation. Hemodial Int. 2025 Aug 14. PMID: 40814038

22.Ouyang J, Isnard S, Lin J, Fombuena B, Chatterjee D, Wiche Salinas TR, Planas D, Cattin A, Fert A, Moreira Gabriel E, Raymond Marchand L, Zhang Y, Finkelman M, Chen Y, Kaufmann DE, Cermakian N, Ancuta P, Routy JP. Daily variations of gut microbial translocation markers in ART-treated HIV-infected people. AIDS Res Ther. 2020 May 12;17(1):15. PMID: 32398104

23.Prysak MH, Mozdzierz CJ, Cook AM, Zhu L, Zhang Y, Inouye M, Woychik NA. Bacterial toxin YafQ is an endoribonuclease that associates with the ribosome and blocks translation elongation through sequence-specific and frame-dependent mRNA cleavage. Mol Microbiol. 2009 Mar; 71(5): 1071-87. Cited in PubMed; PMID: 19210620.

24.Ramendra R, Isnard S, Mehraj V, Chen J, Zhang Y, Finkelman M, Routy JP. Circulating LPS and (1 3)-β-D-Glucan: A Folie à Deux Contributing to HIV-Associated Immune

Activation. Front Immunol. 2019 Mar 18; 10:465. eCollection 2019.PMID: 30967860

25.Ramendra R, Isnard S, Lin J, Fombuena B, Ouyang J, Mehraj V, Zhang Y, Finkelman M, Costiniuk C, Lebouché B, Chartrand-Lefebvre C, Durand M, Tremblay C, Ancuta P, Boivin G, Routy JP. Cytomegalovirus Seropositivity Is Associated with Increased Microbial Translocation in People Living with Human Immunodeficiency Virus and Uninfected Controls. Clin Infect Dis. 2020 Sep 12;71(6):1438-1446. PMID: 31608409

26.Rhein J, Bahr NC, Morawski BM, Schutz C, Zhang Y, Finkelman M, Meya DB, Meintjes G, Boulware DR. Detection of High Cerebrospinal Fluid Levels of (1,3)-beta-d-Glucan in Cryptococcal Meningitis. Open Forum Infect Dis. 2014, Nov; 1(3): 1-7.

27.Rhein J, Bahr NC, Morawski BM, Schutz C, Zhang Y, Finkelman M, Meya DB, Meintjes G, Boulware DR. Detection of High Cerebrospinal Fluid Levels of (1 3)-β-d-Glucan in Cryptococcal Meningitis. Open Forum Infect Dis. 2014 Nov 26;1(3): PMID: 25734173

28.Stevens DA, Zhang Y, Finkelman MA, Pappagianis D, Clemons KV, Martinez M. Cerebrospinal Fluid (1,3)-Beta-d-Glucan Testing Is Useful in Diagnosis of Coccidioidal Meningitis. J Clin Microbiol. 2016 Nov;54(11):2707-2710.PMID: 27558179

29.Styczynski A, Bonilla H, Treynor E, Shashank J, Zhang Y, Finkelman M. Beta-Glucanemia after Coronary Artery Bypass Graft Surgery: A Case Report. J Fungi (Basel). 2018 Oct 2;4 (4):114. PMID: 30279391

30.Shimazu T, Degenhardt K, Nur-E-Kamal A, Zhang J, Yoshida T, Zhang Y, Mathew R, White E, Inouye M. NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition. Genes Dev. 2007 Apr; 21(8): 929-41.

Cited in PubMed; PMID: 17403773.

31.Sun G, Luo P, Sun B, Zhang W, Zhang Y. A randomized controlled open study of ampicillin/sulbactum in the treatment of 35 cases with bacterial infections. Herald of Medicine. 2005 Aug; 24:(8): 133-136.

32. Wong J, Zhang Y, Patidar A, Vilar E, Finkelman M, Farrington K. Is Endotoxemia in Stable Hemodialysis Patients an Artifact? Limitations of the Limulus Amebocyte Lysate Assay and Role of (1 3)-β-D Glucan. PLoS One. 2016 Oct 20;11(10). PMID: 27764208

33.Wong J, Davis P, Patidar A, Zhang Y, Vilar E, Finkelman M, Farrington K. The Effect of Intra-Dialytic Exercise on Inflammation and Blood Endotoxin Levels. Blood Purif. 2017;44(1):51-59 PMID: 28241125

34.Wong J, Zhang Y, Swift O, Finkelman M, Patidar A, Ramanarayanan S, Vilar E, Farrington K. Beta-glucans in advanced CKD: role in endotoxemia and inflammation. BMC Nephrol. 2020 Apr 6;21(1):118. PMID: 32252666

35.Xia T, Finkelman M, Kolomeyer A, Ying GS, Bracha P, Miller CG, Elnahry AG, Carroll R, Zhang Y, Saluadades A, Brucker AJ, Kim BJ. Utility of Ocular β-D-Glucan Testing in Patients with Fungal Endophthalmitis. Retin Cases Brief Rep. 2022 Feb 21. PMID: 35199648

36.Yoshizumi S, Zhang Y, Yamaguchi Y, Chen L, Kreiswirth BN, Inouye M. Staphylococcus aureus YoeB homologs inhibit translation initiation. J Bacteriol. 2009 Sep; 191(18): 5868-72. Cited in PubMed; PMID: 19581360.

37. Zhang J, Zhang Y, Inouye M. Characterization of the interactions within the mazEF addiction module of Escherichia coli. J Biol Chem. 2003 Aug; 278(34): 32300-6. Cited in PubMed; PMID: 12810711.

38. Zhang J, Zhang Y, Inouye M. Thermotoga maritima MazG protein has both nucleoside triphosphate pyrophosphohydrolase and pyrophosphatase activities. J Biol Chem. 2003 Jun; 278(24): 21408-14. Cited in PubMed; PMID: 12657645.

39. Zhang J, Zhang Y, Zhu L, Suzuki M, Inouye M. Interference of mRNA function by sequence-specific endoribonuclease PemK. J Biol Chem. 2004 May; 279(20): 20678-84. Cited in PubMed; PMID: 15024022.

40.Zhang L, Li J, Lu Y, Li M, Zhang Y, Liu Y, Li T, Zhang J. Pharmacokinetic study of levofloxacin in Chinese healthy volunteers. Chinese Pharmaceutical Journal. 2001 Dec; 36(12): 834-837.

41.Zhang L, Li J, Lu Y, Li MN, Zhang Y, Liu Y, Li T, Zhang J. Pharmacokinetics of multiple intravenous instillations of levofloxacin in Chinese healthy subjects. Acta Pharmacol Sin. 2002 Apr; 23(4): 381-4. Cited in PubMed; PMID: 11931699.

42. Zhang Y, Li J. Comparative kinetic study of beta-lactamase inhibitors tazobactam with sulbactum. Chinese Pharmacological Journal. 2000 Apr; 35(4): 240-243.

43. Zhang Y, Li J, Zhao M. Development in Amp C enzyme. The Chinese Journal of Clinical Pharmacology. 1999 Sep; 15(4): 381-388.

44.Zhang Y, Inouye M. RatA (YfjG), an Escherichia coli toxin, inhibits 70S ribosome association to block translation initiation. Mol Microbiol. 2011 Mar; 79(6): 1418-29. Cited in PubMed; PMID: 21323758.

45.Zhang Y, Inouye M. The inhibitory mechanism of protein synthesis by YoeB, an Escherichia coli toxin. J Biol Chem. 2009 Mar; 284(11): 6627-38. Cited in PubMed; PMID: 19124462.

46. Zhang Y, Li J. Molecular characteristics study of extended spectrum beta-lactamase from Klebsiella pneumonia. National Medicine Journal of China. 2002 Feb; 82(4): 279-283.

47. Zhang Y, Li J. Meropenem-a novel carbapenem antibiotics. The Chinese Journal of Clinical Pharmacology. 1998 Sep; 14(3): 174-180.

48. Zhang Y, Li J. A comparative study of beta-lactamase inhibitors tazobactam and sulbactum. Chinese Journal of Antibiotics. 1997 Aug; 22(4): 287-293.

49.Zhang Y, Li J. Ceftibuten-a new oral third generation cephalosporin. The Chinese Journal of Clinical Pharmacology. 1997 Sep; 13(3):177-182.

50. Zhang Y, Li J. A comparative study on enzyme stability of beta-lactamase inhibitors tazobactam and sulbactum. Chinese Pharmacological Bulletin. 1998 Apr; 14(2): 133-137.

51.Zhang Y, Li J. Studies on the resistance of clinical isolates and the resistant mechanism in Beijing region. Chinese Journal of Antibiotics. 1998 Oct; 23(5): 371-376.

52.Zhang Y, Li J. Beta-lactamase inhibitor: tazobactam. Sheng Li Ke Xue Jin Zhan. 1997 Oct; 28(4): 370-3. Cited in PubMed; PMID:11038697.

53. Zhang Y, Li J. The in vitro activity of sulbactum in combination with third-generation cephalosporins against third-generation cephalosporins resistant bacteria. The Chinese Journal of Clinical Pharmacology. 2000 Sep; 16(5): 323-326.

54.Zhang Y, Li J, Zhao M. The inducibility of Amp C enzyme of Enterobacter cloacae and its susceptibility to enzyme inhibitor. Zhonghua Yi Xue Za Zhi. 2001 Feb; 81(4): 227-30. Cited in PubMed; PMID: 11798880.

55. Zhang Y, Li J, Zhao M. Study on Amp C enzyme in Enterobacter cloacae. The Chinese Journal of Antibiotics. 2000 Dec; 25(6):428-435.

56.Zhang Y, Li J, Zhao M. Detection of amp C in Enterobacter cloacae in China. Int J Antimicrob Agents. 2001 Oct; 18(4): 365-7. Cited in PubMed; PMID: 11691570.

57.Zhang Y, Yamaguchi Y, Inouye M. Characterization of YafO, an Escherichia coli toxin. J Biol Chem. 2009 Sep; 284(38): 25522-31. Cited in PubMed; PMID: 19617347.

58. Zhang Y, Zhang J, Hara H, Kato I, Inouye M. Insights into the mRNA cleavage mechanism by MazF, an mRNA interferase. J Biol Chem. 2005 Feb; 280(5): 3143-50. Cited in PubMed; PMID: 15537630.

59.Zhang Y, Zhang J, Hoeflich KP, Ikura M, Qing G, Inouye M. MazF cleaves cellular mRNAs specifically at ACA to block protein synthesis in Escherichia coli. Mol Cell. 2003 Oct; 12(4): 913-23. Cited in PubMed; PMID: 14580342.

60. Zhang Y, Zhu L, Zhang J, Inouye M. Characterization of ChpBK, an mRNA interferase from Escherichia coli. J Biol Chem. 2005 Jul; 280(28): 26080-8. Cited in PubMed; PMID: 15901733.

61. Zhang Y, Li J. The in vitro activity of sulbactam combined with third generation cephalosporins against third generation cephalosporin-resistant bacteria. Int J Antimicrob Agents. 2001 Feb; 17(2): 143-6. Cited in PubMed; PMID: 11165119.

62.Zhu L, Inoue K, Yoshizumi S, Kobayashi H, Zhang Y, Ouyang M, Kato F, Sugai M, Inouye M. Staphylococcus aureus MazF specifically cleaves a pentad sequence, UACAU, which is unusually abundant in the mRNA for pathogenic adhesive factor SraP. J Bacteriol. 2009 May; 191(10): 3248-55. Cited in PubMed; PMID: 19251861.

63. Zhu L, Zhang Y, Teh JS, Zhang J, Connell N, Rubin H, Inouye M. Characterization of mRNA interferases from Mycobacterium tuberculosis. J Biol Chem. 2006 Jul; 281(27): 18638-43. Cited in PubMed; PMID: 16611633.

Peer Reviewed Book Chapter

Zhang Y, Li J. (2004). Enterobacteriaceae bacterial infection. In Si C, Jia F, Li J (Ed.), Infectious Disease (pp. 513-523). Beijing, China. The Chinese People’s Public Health Press.

Poster Presentation

Zhang J, Zhang Y, Inouye M. (2003, October). Characterization of the interactions within the mazEF addiction module of Escherichia coli. Poster presented at: Annual Retreat of the Graduate Program in Biochemistry and Molecular Biology; New Brunswick, NJ.

Zhang Y, Inouye M. (2006, May). The inhibitory mechanism of protein synthesis by YoeB, an Escherichia coli toxin. Poster presented at: American Society of Microbiology, General meeting; Orlando, FL.

Zhang Y, Inouye M. (2003, October). MazF, an mRNA Interferase, cleaves cellular mRNAs specifically at ACA to block protein synthesis in Escherichia coli. Poster presented at: Annual Retreat of the Graduate Program in Biochemistry and Molecular Biology; New

Brunswick, NJ.

Zhang Y, Li J. (2000, December). The amp C structural gene detection in Enterobacter cloacae resistance to ceftazidime in China. Poster presented at: 7th Western Pacific Congress of Chemotherapy and Infection Disease; Hong Kong, China.

Zhang Y, Yamaguchi Y, Inouye M. (2009, September). Characterization of YafO, an Escherichia toxin. Poster presented at: EMBO Conference Series on Protein Synthesis and Translational Control; Heidelberg, Germany.

Zhang Y, Zhang J, Inouye M. (2005, October). Characterization of ChpBK, an mRNA Interferase from Escherichia coli. Poster presented at: Annual Retreat of the Gradate Program in Biochemistry and Molecular Biology; New Brunswick, NJ.

Zhang Y, Zhang J, Inouye M. (2004, October). Insights into the mechanism of mRNA cleavage by MazF, an mRNA interferase. Poster presented at: Annual Retreat of the Gradate Program in Biochemistry and Molecular Biology; New Brunswick, NJ.

Zhang Y, D’Ordine R, Kowald G, Roy J. (2024, July 28th to August 1st) Characterize and reduce positive interference of hemolysis on Fungitell test for (1,3)-β-D-glucan (BDG) in serum. ADLM conference, Chicago, IL.

Oral Presentation

Zhang Y, Inouye M. (2009, April). Study of the mechanism of action of the bacterial toxin YfjG. Oral Presentation presented at TAKARA BIO Initiative Biotechnology Fourth Annual Retreat; Somerset, NJ.

Zhang Y, Inouye M. (2006, April). The study of mechanism of action of bacterial toxin (YoeB I). Oral Presentation presented at: TAKARA BIO Initiative Biotechnology First Annual Retreat; Somerset, NJ.

Zhang Y, Inouye M. (2008, April). Study of the mechanism of action of bacterial toxins (YafO). Oral Presentation presented at TAKARA BIO Initiative Biotechnology Third Annual Retreat; Somerset, NJ.

Zhang Y, Inouye M. (2007, April). The study of mechanism of action of bacterial toxin (YoeB II). Oral Presentation presented at TAKARA BIO Initiative Biotechnology Second Annual Retreat; Somerset, NJ.

Zhang Y, Li J. (1997, July). Studies on the resistance of clinical isolates and the resistance mechanism in the Beijing region. Oral Presentation: The Second National Conference on Clinical Pharmacology on Antimicrobial Agents; Beijing, China.

Zhang Y, Li J. (1999, November). In vitro activity of sulbactam in combination with third-generation cephalosporins against third-generation cephalosporin-resistant bacteria. Oral Presentation: The Third National Conference on Clinical Pharmacology on Antimicrobial Agents; Beijing, China.

Zhang Y, Li J. (2000, December). Analysis of beta-lactamase from gram-negative bacteria resistant to cefoperazone and susceptible to sulperazone. Oral Presentation presented at: Beijing International Symposium on Antibiotics; Beijing, China.

Hobbies & Interests

I like reading, football, table tennis, and children’s care.

Language fluency

Chinese (Native/functionally native)

English (Advanced)

Other Awards/Accomplishments

Excellent Youth Prize Second/Third National Conference on Clinical Pharmacology and Antimicrobial Agents Beijing China 1997, 1999.

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