Student-Centered Chemistry Laboratory Educator

MD.TANIM-Al-HASSAN, PhD

*************@*****.*** 208-***-**** Harrison, NJ-07029 LinkedIn Portfolio PROFESSIONAL SUMMARY Student-centered chemistry educator with extensive experience teaching undergraduate general, analytical, organic, and physical chemistry laboratories. Demonstrated ability to support diverse and non-traditional student populations through clear communication, hands-on instruction, and emphasis on core laboratory techniques, data analysis, and scientific writing. Committed to inclusive teaching and academic accessibility, mentoring students with varied levels of preparation to promote confidence, retention, and success in STEM. Strong background in laboratory safety, course organization, and assessment, with a practical approach that connects chemistry concepts to real-world and workforce-relevant applications. EDUCATION

• PhD Chemistry GPA: 3.87/4.0 New Jersey Institute of Technology Dec 2025

• M.S. Chemistry GPA: 3.35/4.0 University of Idaho Idaho, U.S.A May 2021

• M.S. Chemistry GPA: 3.55/4.0 University of Dhaka Dhaka, Bangladesh July 2014

• B.S. Chemistry GPA: 3.24/4.0 University of Dhaka Dhaka, Bangladesh Sep 2012 PROFESSIONAL EXPERIENCE Teaching assistant, University of Idaho Aug-2018 to May-2021 CHEM-111 and 112 (General chemistry lab)

• Supervised undergraduate CHEM-111 and CHEM-112 laboratory sections and enforced laboratory safety and chemical hygiene protocols.

• Instructed students in fundamental laboratory techniques, including solution preparation, titration, calorimetry, kinetics, equilibrium, electrochemistry, and spectroscopy.

• Assisted students with experimental setup, quantitative data analysis, error analysis, and interpretation of results.

• Graded laboratory reports, quizzes, and assignments, providing constructive feedback to enhance scientific understanding and technical writing.

• Prepared reagents, standardized solutions, and laboratory materials; maintained equipment and inventory.

• Held office hours and provided academic support to reinforce lecture and laboratory concepts. Teaching assistant, New Jersey Institute of Technology Sep-2021 to Dec-2025 CHEM-221, 244, and 339 (Analytical chemistry, Organic chemistry, and Physical Chemistry Lab)

• Supervised undergraduate laboratory sections for CHEM-221 (Analytical Chemistry), CHEM-244 (Organic Chemistry), and CHEM-339 (Physical Chemistry), ensuring strict compliance with laboratory safety and chemical hygiene protocols.

• Instructed students in analytical techniques, including quantitative analysis, titration, gravimetric methods, UV–Vis spectroscopy, chromatography, and error analysis.

• Guided students through organic synthesis, purification (recrystallization, distillation), reaction monitoring, and spectroscopic characterization (IR, NMR).

• Assisted with physical chemistry experiments involving thermodynamics, kinetics, electrochemistry, and molecular spectroscopy, emphasizing data modeling and interpretation.

• Supported students in experimental design, data analysis, and scientific report writing.

• Prepared reagents, calibrated instruments, managed laboratory inventory, and assisted with grading laboratory reports and assessments.

Doctoral Research Assistant Sep-2021 to Dec-2025

Prof. Hao Chen Lab, NEW JERSEY INSTITUTE OF TECHNOLOGY Mass spectrometry-based method development for analysis of emerging wastewater contaminants (PFAS)

• Designed a novel paper spray-based mass spectrometry ionization technique to simultaneously desalt and enrich samples to identify and quantify PFAS in trace levels (parts per trillion) in different matrices. Optimized spray ionization parameters, such as solvent, Spray voltage, and distance for efficient ionization, for high sensitivity. This technique is licensed to a startup company, PureTrace Labs.

Develop a quantitative mass spectrometry imaging technique using desorption electrospray ionization combined with coulometric mass spectrometry (CMS) techniques (in collaboration with Dr. Katy Margulis in the Hebrew University of Jerusalem, Israel)

• Developed a standard-free LC-HRMS technique to image and quantify the drug olanzapine and its metabolites from tissue. Separated complex mixtures of drug and its metabolites by RP-LC and optimized MS parameters to improve sensitivity, enabling quantification at fmol concentrations. This resulted in a new absolute quantification method that can quantify drug metabolites (e.g., hydroxy olanzapine) without the need for calibration standards, which are typically expensive and require time-consuming synthesis.

Standard-free absolute quantitation of post-translationally modified peptides and mAb by CMS technique

• Developed derivatization techniques to incorporate electrochemical tags to phosphopeptides and glycopeptides for absolute quantification by CMS.

• Quantified glycopeptides from tryptic mAb digest. HILIC separation was used to separate glycopeptides.

• Achieved cost-effective & standard-less absolute quantification. Probe protein 3D conformational structure

• Developed an electrochemistry-assisted mass spectrometric method to predict protein 3D structure as an alternative technique to X-ray crystallography. Labelled Lysine and Tyrosine residues of proteins with electroactive functional groups, such as Fe-C6-NHS and 4-nitrobenzene diazonium, at native pH, and quantified digested peptides to measure protein 3D structures. Compared CMS results with SASA values from X-ray crystallographic structure for method validation.

Research Associate (USA)

Prof. Hao Chen Lab, NEW JERSEY INSTITUTE OF TECHNOLOGY Jan-2026 to present ADC and antibody charge variant analysis using online ultrafast microdroplet digestion

• Characterized ADC drug-mimic using IdeS, PNGaseF, and Endo S2 enzymatic workflows integrated with microdroplet- accelerated digestion, followed by pseudo-DAR calculation.

• Devised a strong cation exchange-based chromatographic method for the separation of NIST mAb charge variants and performed ultrafast digestion in microseconds based on our online microdroplet digestion technique using enzymes such as IdeS and FabRICATOR Xtra.

Pharmaceutical Quality Control Officer, ACI Limited (Bangladesh) Sep 2014- July 2018

• Performed GMP-compliant QC assays, impurity profiling, and stability testing of APIs and finished dosage forms.

• Executed analytical testing using HPLC-UV, GC, FT-IR, UV-Vis, AAS, and Karl Fischer titration.

• Ensured compliance with USP, BP, and ICH guidelines through adherence to SOPs, GMP, ALCOA+, and accurate documentation practices, while developing proficiency in ELN and LIMS systems for real-time data recording, traceability, and data integrity in a regulated laboratory environment. SKILLS

• Biologics LC-HRMS analysis: Peptide mapping, protein identification, post-translational modification analysis, and antibody/ADC analysis

• Sample pretreatment techniques for protein analysis by LC-HRMS: Protein precipitation, disulfide bond reduction (DTT, TCEP and IAA), desalting by molecular weight cutoff filter (MWCO), gel filtration, C4 and C18 spin column desalting and Ziptip desalting, protein digestion (Trypsin, Glu-C, Pepsin, Chymotrypsin, IdeS, FabRICATOR Xtra, GingisKHAN and S-trap), antibody deglycosylation (PNGase, EndoS2, GlycINATOR), ADC mimic characterization (DAR analysis), Phospho/Glyco peptide enrichment using (TiO2 spin tips, boronic acid magnetic beads).

• Small molecule LC-HRMS analysis: MS and MS/MS analysis of PFAS, drug, and drug metabolites

• Pharmaceutical analysis: Assay, purity, stability studies, forced degradation studies of Active Pharmaceutical Ingredient (API) and finished products.

• Mass Spectrometry instruments: Q-Exactive Orbitrap, Agilent Q-TOF

• Chromatography instruments: Waters UPLC, Agilent UPLC, Shimadzu GC-FID

• Chromatography techniques: Reversed-phase LC, HILIC, Ion Exchange, Size Exclusion

• Others: HPLC-UV, FT-IR, AT-IR, NIR, UV-Vis, Atomic Absorption Spectroscopy (AAS), Dissolution, Disintegration, Karl Fischer titration, Particle size analyzer, SEM-EDX, XRD

• Software: MS Office, Python (basic), Xcalibur, Proteome Discoverer, Skyline, UniDec, UCSFChimera, Agilent Mass Hunter & Bioconfirm, Chemdraw, Origin, ImageJ US PATENT METHOD FOR RAPID DETECTION OF PFAS. Inventor: Hao Chen and Md. Tanim-Al-Hassan. Application no. 19/189,055. [Filed] [Licensed by PureTrace Labs; invested by New Jersey Institute of Innovation (NJII) for $1M] PUBLICATIONS

Mohammad Borna Bahramsari, Md. Tanim-Al Hassan, Hao Chen, Alexei Khalizov*, “Reactive Paper Spray Mass Spectrometry Enables Speciation of Trace Levels of Mercuric Halides” Analytical Chemistry, 2026 (Revision submitted) Yongqing Yang, Juana Perez Sanchez, Timothy Yaroshuk, Md. Tanim-Al Hassan, Praneeth FNU, Thomas Walker, Jim Lau, Michael Knierman, Hui Zhao, Xi Qiu, Karen Luo, * Harsha Gunawardena, Munkhtsetseg Baatar, Hao Chen*, “Rapid Determination of Drug-to-Antibody Ratios in Antibody–Drug Conjugates Using Ultrafast Microdroplet Digestion Technology”, Analytical Chemistry, 2026 (Submitted) Md. Tanim-Al Hassan, Amani Zoabi, Anna Morshin, Hao Chen*, and Katherine Margulis*, “Mass Spectrometry Imaging Coupled with Pixel-Level Absolute Quantification of Olanzapine and Its Metabolites by Coulometric Mass Spectrometry”, Journal of American Society for Mass Spectrometry, 2026 [Accepted] Md Tanim-Al Hassan, Yongling Ai, Bhavya Deshaboina, Timothy Yaroshuk, Arjun Sharma, Quentin Young, Howard D. Dewald, Hao Chen*, “Absolute Quantitation of Phosphopeptides and Glycopeptides Using Coulometric Mass Spectrometry

(CMS)”, ACS Measurement Science Au, 2025, 5, 559–571. [Link] Yongqing Yang, Md Tanim-Al Hassan, Timothy Yaroshuk, Juana Perez Sanchez, Quentin A. Young, Richard N. Zare, and Hao Chen*, “Ultrafast PFAS degradation using oxidant-containing microdroplets”, Chemical Communications, 2025, 61, 176**-*****. [Link]

Kai-Yuan Chiu, Yongling Ai, Md Tanim-Ai Hassan, Xuanwen Li, Harsha P Gunawardena, Hao Chen*, “Standards-Free Absolute Quantitation of Oxidizable Glycopeptides by Coulometric Mass Spectrometry”, Journal of American Society for Mass Spectrometry, 2024, 35, 1441-1450 [Link]

Praneeth Ivan Joel Fnu, Md Tanim-Al-Hassan, Timothy Yaroshuk, Yongling Ai, Hao Chen*, “Absolute quantitation of peptides and proteins by coulometric mass spectrometry after derivatization”, International Journal of Mass Spectrometry, 2024, 495, 117153 [Link]

Md Tanim-Al Hassan, Xingzhi Chen, Praneeth Ivan Joel Fnu, Francis J Osonga, Omowunmi A Sadik, Mengyan Li, Hao Chen*, “Rapid Detection of Per- and Polyfluoroalkyl Substances (PFAS) Using Paper Spray-Based Mass Spectrometry”, Journal of Hazardous Materials, 2024, 465, 133366 [Link] Francis J Osonga, Gaddi B Eshun, Huize Xue, Stephen Kurilla, Md Tanim-Al Hassan, Areej Qamar, Hao Chen, Michel Boufadel, Omowunmi A Sadik*, “ IMPACT: Innovative (nano) Materials and processes for advanced catalytic technologies to degrade PFOA in water”, 2024, Chemosphere, 364, 143057 [Link] Matrika Bhattarai, Qi Wang, Zawar Hussain, Md Tanim-Al Hassan, Hao Chen, Ahmed Faik *, “New insight on β-glycan synthases using in vitro GT-array (i-GT-ray) platform”, Plant Physiology and Biochemistry, 2024, 215, 109052 [Link] Matrika Bhattarai, Qi Wang, Tasleem, Javaid, Akshayaa, Venkataraghavan, Md Tanim-Al Hassan, Malcolm O'Neill, Li Tan, Hao Chen, Ahmed Faik *, “Streamlining enzyme assays of glycosyltransferase activity using in vitro GT-array (i-GT- ray) platform. Application to family GT37 fucosyltransferases”, Journal of Biological Chemistry, 2024, 300(3), 105734

[Link]

Yongling Ai, Praneeth Ivan Joel FNU, Pengyi Zhao, Md Tanim-Al Hassan, Arjun Sharma, Gracelynne Hao, Zhenghao Zhou, Hao Chen*, “Development of Coulometric Mass Spectrometry for Absolute Chemical Quantitation”, 2023, Encyclopedia of Analytical Chemistry. [Link]

Haoyu Zhu, Tanim Hassan, Humayun Kabir, Jeremy May, Kailash Hamal, Ricardo Lopez, Hailey J. Smith, Nolan W. Nicholas, Prasanna Sankaran, David N. McIlroy, and I. Francis Cheng*, “Voltametric pH sensor based on electrochemically modified pseudo-graphite”, Analyst, 2020, 145, 7252-7259 [Link] Md Tanim-Al Hasan, Md Lokman Hossain, Mohammad Abul Hossain*, “Mechanism of Basic Violet 3 Adsorption on Used Black Tea Leaves from Neutral Solution”, International Journal of Scientific & Engineering Research, 2017, 8 (10), 1047-1055. [Link]

Mohammad Abul Hossain*, Mohammad Lokman Hossain and Tanim-Al Hassan, “Equilibrium, Thermodynamic and Mechanism Studies of Malachite Green adsorption on Used Black Tea Leaves from Acidic Solution”, International Letters of Chemistry, Physics and Astronomy, 2016, 64, 77-88. [Link] Mohammad Abul Hossain*, Tanim-Al Hassan, Lokman Hossain, “Adsorption of Crystal Violet on Used Black Tea Leaves from Acidic Solution: Equilibrium, Thermodynamic, and Mechanism Studies”, International Journal of Sciences, 2015, 4

(10), 31-39. [Link]

Mohammad Abul Hossain*, and Tanim-Al Hassan, “Kinetic and thermodynamic study of the adsorption of Crystal Violet on used black tea leaves”, Orbital: The Electronic Journal of Chemistry, 2013, 5(3), 148-156. [Link] CONFERENCE ABSTRACTS

Md Tanim-Al Hasan et al. (2024), Rapid Degradation of Per- and Polyfluoroalkyl Substances (PFAS) in Microdroplets. Conference abstract: American Society for Mass Spectrometry (ASMS) Md Tanim-Al Hasan et al. (2024), Online ultrafast trypsin digestion of LC-separated proteins using microdroplet digestion. Conference abstract: American Society for Mass Spectrometry (ASMS) Md Tanim-Al Hasan et al. (2022), Absolute Quantitation of N-Nitrosamines by Coulometric Mass Spectrometry without Using Standards. Conference abstract: American Society for Mass Spectrometry (ASMS) CONFERENCE ORAL PRESENTATION Md. Tanim-Al Hassan, Xingzhi Chen, Praneeth Ivan Joel Fnu, Francis J. Osonga, Omowunmi A. Sadik, Mengyan Li, Hao Chen (2024), Rapid Detection of Per- and Polyfluoroalkyl Substances (PFAS) Using Paper Spray-Based Mass Spectrometry. Conference oral presentation: American Society for Mass Spectrometry (ASMS) AWARDS

Outstanding Graduate Student Award: New Jersey Institute of Technology

(College of Science and Liberal Arts)

June 2024

71st ASMS Conference: Student Stipend June 2023

Thomas F. Harland Chemistry Scholarship: University of Idaho August 2020 REFERENCES

1) Prof. Hao Chen (PhD Supervisor) 2) Prof. Guillermo Jiménez Alemán New Jersey Institute of Technology New Jersey Institute of Technology Email: ***.****.*@****.***

Phone: 740-***-****

Email: *********.*.*************@****.***

Phone: 973-***-****

3) Dr. Chaudhery Mustansar Hussain (TA Supervisor) New Jersey Institute of Technology

Email: *********.*******@****.***

Phone: 862-***-****

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