Laboratory Operations & Compliance Leader

Chad F. Chamberlin

*******@*****.*** 617-***-**** Winchester, MA

Areas of Expertise

• Lab Operations • Health and Safety • Smartsheet/Excel/AI

• Compliance • Relocations & 3PL • Procurement

• Troubleshooting • Inspections/Audits • Vendor Management Employment History

Resilience US, Inc., Allston, MA

Manager, Laboratory Operations 2021 - 2025

• Hands-on support of a start-up CDMO process development site (15,000 sq. ft lab space), headcount growth from 20 to 80 lab members over 3 years.

• Lab build-out coordination with general contractor to convert organic chemistry labs into cell biology lab space, including electrical system upgrades, lab gas line extensions, and new equipment installations.

• Facilities management, including compressed gas inventory, LN2 bulk tank installation, pest control, lab coat rental, cold room/HVAC PMs, BMS monitoring, placing service requests with building engineers for office repairs.

• Capital equipment budgeting, maintenance tracking, relocation and storage.

• Service contracts for more than one hundred instruments

• Lab consumables procurement, including creating purchase orders, daily item receiving, invoices, and budget tracking for $10M annual spend.

• Receiving/Restocking for all lab consumables.

• Shipping of all outgoing packages, including general carriers and couriers.

• Monitor remote sensor alarms of cold storage systems and incubators.

• Biological and hazardous waste disposal and handling, RCRA/DoT certified. Merck Research Laboratories, Boston, MA

Scientist, Quantitative Biosciences 2005-2021

• High-throughput Screening of small molecules against protein targets.

• Trained new scientists in LCMS operations and data analysis.

• HPLC Troubleshooting and MS source cleaning/calibration.

• Oversaw procurement and installation of instruments for lab build out.

• Review and approval of annual service contracts for lab instruments.

• Conducted annual clean-outs and monthly 5S inspections.

• Safety Committee member and Building Evacuation Lead.

• Lab safety compliance: monthly lab inspections, hazardous materials

• inventory, enforcing PPE, and safety hygiene rules. Education

Tufts University M.S. Engineering Management

University of New Hampshire B.S. Microbiology

University of New Hampshire B.A. Chemistry

Publications

Ellsworth, K. et al. The Discovery of a Novel Anticoagulant Mechanism: FactorXI Activation Inhibitors. ACS PHARMACOL. TRANSL. SCI. 2025. Li, D. et al. Carbamate and N-Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors. ACS Medicinal Chemistry Letters 2021, 12 (3), 389-396. Rizvi, N., et al. Targeting RNA with Small Molecules: Identification of Selective, RNA-Binding Small Molecules Occupying Drug-Like Chemical Space. SLAS DISCOVERY. 2019, 25, (4), pp 384-396.

Flusberg, D., et al. Identification of G-Quadruplex-Binding Inhibitors of Myc Expression through Affinity Selection–Mass Spectrometry. SLAS DISCOVERY. 2019, 24, (2), pp 142-157.

Rizvi, N., et al. Discovery of selective RNA-binding small molecules by affinity-selection mass spectrometry. ACS Chem. Biol. 2018, 13 (3), pp 820-831.

Santa Maria, J., et al. Linking high-throughput screens to identify MoAs and novel inhibitors of Mycobacterium tuberculosis dihydrofolate reductase. ACS Chem. Biol. 2017, 12 (9), pp 2448-2456.

Su, H., et al. Structural characterization of nonactive site, TrkA-selective kinase inhibitors. Proceedings of the National Academy of Sciences. E297- E306. Dec. 30, 2016.

Kutilek, V., et al. Integration of affinity selection-MS and functional cell- based assay to rapidly triage drug-gable target space within the NF-kB pathway.Journal of Biomolecular Screening. Vol. 21, Issue 6, p608-619. Mar. 11, 2016.

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