Process Chemistry Development

GERARDO FRANCISCO

845-***-**** • ************@*****.*** • NY, 10962

CHEMIST with extensive background in traditional medicinal, scale-up and process chemistry and a broad knowledge of parallel synthesis and purification techniques. Established knowledge to prepare small molecule libraries of compounds under strict timelines. Skilled in optimization of conditions to improve purity of compounds and yield of reactions. Proven ability in preparing milligrams to kilograms scale quantities of key intermediates towards final target.

TECHNICAL/SCIENTIFIC SKILLS

Multi-step organic synthesis, parallel synthesis, scale-up, process chemistry • Automated/purification equipment (Normal and Reverse Phase) • Pressurized Reactions and Microwave Assisted Organic Chemistry • Scifinder, Beilstein, Excel, ISIS, ChemDraw, MS Word, Microsoft Outlook, Excel PowerPoint on both PC and Macintosh

PROFESSIONAL EXPERIENCE

ICL Industrial Products - Ardsley, NY

Senior Research Chemist 2011-2024

• Supported ICL-Process Technology by delivering high quality useful quantities of pre-candidates and intermediates fire retardants compound. Prepared grams to kilograms of flame retardants compounds.

• Conducted efficient experimental campaigns in pilot and manufacturing scale to gather relevant information on process parameters and provide recommendations for their implementation.

• Perform detailed investigation to identify causative relationships between process variables (e.g., temperature, pressure, flow rates) and product performance.

• Characterized process outputs using chemical, physical, and engineering methods as baseline for equipment design, process improvements, or to predict manufacturing performance based on process testing.

Sanofi-Aventis Pharmaceuticals - Bridgewater, NJ

Scientist I, Chemical Development (January 2010-December 2010)

• Supported Chemical Development Programs. Delivered high quality useful quantities of Active Pharmaceutical Ingredient (API) pre-candidate and intermediate compounds consistent with process development.

• Assisted in the process development of intermediates, precandidates, API transferred to the pilot plant

Scientist I, Scale-Up Chemistry (December 2005-December 2009)

• Support Therapeutic Discovery (TD) programs by preparing multigram quantities of key intermediates. Prepared multigram quantities of API for in-vivo testing.

• Prepared and delivered high quality and useful quantities of pre-candidate and intermediates consistent scale-up process.

• Performed synthesis, purification and analysis of advanced leads and intermediates in support of TD optimization programs.

• Synthesized and scale up low molecular weight novel compounds that involved modification of methods, running reactions, isolating products, collecting and interpreting analytical data used in the identification of compounds (hands on NMR, HPLC, LC/MS, elemental analysis, IR) as well as development of new synthetic methods schemes for the purification of these compounds.

Recognition and Awards

• Two Recognition Awards for Contributions in Scale-Up Synthesis (2008, 2009)

• Two Special Achievement Awards for Drug Development Compound (2008, 2009)

• Recognition Award for Service as 2009 Chemistry Safety Officer

Aerotek Scientific - Parsippany, NJ (Temp)

Scientist - Sanofi-Aventis

Prepared library of 28 nNOS compound for in-vitro testing

Joule Scientific - Edison, NJ

Scientist- Schering Plough, (Union, NJ)

• Assisted and supported a late stage project in preparation for NDA filing. Carried out experiments to ensure quality regulatory submissions. Followed SOPs and worked in a Current Good Manufacturing Practice (cGMP) compliant environment.

Scientist- Eulsys Therapeutics, (Pine Brook, NJ

• Worked on PEG (Polyethylene Glycol) synthesis. Analyzed small molecules using capillary electrophoresis (CE).

Wyeth Research - Pearl River, NY

Scientist

• Prepared molecule libraries in support of beta-lactamase, cell wall inhibitors, Tace inhibitors, Beta 3-Adrenergic Receptor Agonist, Angiotensin II Receptor Antagonist, Calcitonin-Inducing Agents.

• Prepared small molecule library for Potassium Channel Openers Targeted for Urge Urinary Incontinence which led to a Phase I trial. Mentored summer intern in the synthesis of benzimidazole.

• Collaborated with a team of chemists, biologists and biochemists during synthetic work, biological testing of active compounds and patent preparation.

EDUCATION

BS Chemistry, Ramapo College, Mahwah, NJ

ADDITIONAL COURSEWORK

Practical Process Research and Scale-Up, Presented by Neal G. Anderson, Ph.D. May 13-14, 2010, Princeton NJ

Electronic Laboratory Notebook (Kalabie version 3.6), June 2010

Attended In-House Group Chemistry Short Courses (2006, 2007, 2008, 2009)

PROFESSIONAL DEVELOPMENT

In-House Training Course “Communicating Everyday Essentials” (2008)

In-House Training Course “Present With Success” (2009)

PROFESSIONAL MEMBERSHIP

American Chemical Society (1993-Present)

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