Administrative Assistant Have Experience

Samantha Matson

978-***-****

************@*******.***

Experience

Ixcela Inc., Beverly Ma (2013-Feb 07,2025)

Director of Research and Development

• Co-founder

• Safety officer

• Laboratory Manager 2013-2019

• Customer Service for questions involving test taking, odd results, and other issues.

• Designed and implemented the R&D and Clinical Laboratory

• Trained and onboarded all lab personnel

• Method development for metabolomics using HPLC and ECD techniques and pharmacokinetics.

• Implementation and Management of outside research projects

• Created all SOP’s for laboratory

• Tracked and maintained all purchases for laboratory

• Sample analysis

• Statistical analysis

• Data presentation to clients, collaborators, and investors

• White paper review and dissemination of information to dietitians and nutritionists

• New and novel metabolite identification

• Repair, maintenance, and operation of all analytical machinery

• Patents on the Detection and modification of gut microbial population and Methods and devices for quantifying blood samples

• Member of IAACU at Bedford VA, Bedford Ma 01730

Massachusetts General Hospital, Experimental Neuropathology, Boston, Ma (2008-2013) Research Technician and Laboratory Manager

• Biochemistry and Metabolomics

• Sample preparation

• Created all SOPs for laboratory

• Trained all laboratory personnel

• Wrote all IRB and safety documentation and tracked all data for Clinical studies for laboratory

• DNA isolation

• ECD-HPLC and ECD-MS

• Method development

• Statistical Analysis

• Document, inventory, and sample tracking

• Repair, maintenance, and operation of all analytical machinery

• Tissue dissections and preparations

• Human and Murine clinical studies

• Certificates for HIPPA, GPC/GLP, Hazcom, Hazwoper

• Member of Safety Committee at Bedford VA, Bedford Ma 01730 Boston University School of Medicine, Experimental Neuropathology, Bedford Ma (Aug 2001-2008)

Research Technician

• Biochemistry, Immunohistology and Metabolomics

• Care and breeding of Transgenic Murine Colony

• DNA isolation

• PCR

• ECD-HPLC

• Tissue dissections and preparations

• Perfusions

• Western and Dot Blot

• Histology

• Animal and human clinical experience

• Certificates for HIPPA, GPC/GLP, Hazcom

• Safety Chair

Biochemical Genetics-Inborn Errors Screening Mayo Clinic, Rochester, MN (Dec 1998 to Aug 2001)

Clinical Technician and Research Assistant

• Extraction and analysis of organic acids, long chain fatty acids, cholesterols/sterols and pipecolic acids.

• Maintenance and operation of GC/MS.

• Quality control and quality assurance of a certified clinical lab

• Interpretation and editing of GC/MS generated data

• Reporting test results

• Assisting in the implementation of new assays into laboratory for clinical use.

• LIMS

• SIDS research looking at FAO disorders in livers of infants who had died of SIDS Boston Biomedical Research Institute, Boston, MA (1995-Dec1998) Research Assistant

• Protein purification from whole tissues.

• Tissue and blood harvesting from rabbit and ferret models

• Isolation of muscle cells to measure electrical current

• Radioisotope use (certified by Harvard University)

• Western blots

• Peptide cleavage

• Blood drawing from lab animals

• Gel Electrophoresis

• Train incoming students and post docs

• Analytical machine repair

• Laboratory Manager

Epigen Inc., Wellesly, MA (1992-1995)

Associate Scientist

• Immunology

• Assisted in the research and development of a cancer monitoring assay

• Elisa assay development

• Antibody production, purification and screening

• HPLC, FPLC

Charles River Professional Services, Wilmington, MA (1990) Laboratory Technician

• Ascites fluid collection

• Care and handling of laboratory animals

• Sterile environment SOP's

• Clean room experience

Naval Blood Research Laboratory, Boston, MA (1988-1990) Laboratory Research Technician

• Biochemistry

• Assisted in research projects involving baboons, dogs, rats, rabbits. (Focusing on Hypothermia and Artificial Blood)

• ATP and ADP assays

• Study of oxygen transport and osmosis in red blood cells

• Assisted with anesthesia for dogs and baboons

• Rat and rabbit heart perfusions

• Preliminary testing of experimental medical equipment (non biological testing)

• Data entry

• Maintenance and Repair of analytical machinery

Education

Long Island University Sept 1986- May 1990

Chemistry and Biology Did not complete.

Skills

Teaching and Training. Microsoft Office. The ability to break down complicated ideas and writings into simple to understand documents. Document creation. Organization, communication, and contract negotiation. Strong understanding and respect for NDA/CDA. Administrative skills that include phone answering, setting up appointments, and greeting guests. I am flexible and know how to learn. Publications

1. Sex and race differences of cerebrospinal fluid metabolites in healthy individuals. Reavis ZW, Mirjankar N, Sarangi S, Boyle SH, Kuhn CM, Matson WR, Babyak MA, Matson SA, Siegler IC, Kaddurah-Daouk R, Suarez EC, Williams RB, Grichnik K, Stafford-Smith M, Georgiades A. Metabolomics. 2021 Jan 18;17(2):13. doi: 10.1007/s11306-020-01757-0. Erratum in: Metabolomics. 2021 Jun 9;17(6):56. PMID: 33462762; PMCID: PMC8041469. 2. Huntington Study Group PHAROS Investigators. HTRF analysis of soluble huntingtin in PHAROS PBMCs Moscovitch-Lopatin M, Goodman RE, Eberly S, Ritch JJ, Rosas HD, Matson S, Matson W, Oakes D, Young AB, Shoulson I, Hersch SM;. Neurology. 2013 Sep 24;81(13):1134-40. doi: 10.1212/WNL.0b013e3182a55ede. Epub 2013 Aug 21. PMID: 23966247; PMCID: PMC3795598.

3. Pharmacometabolomics of response to sertraline and to placebo in major depressive disorder - possible role for methoxyindole pathway. Zhu H, Bogdanov MB, Boyle SH, Matson W, Sharma S, Matson S, Churchill E, Fiehn O, Rush JA, Krishnan RR, Pickering E, Delnomdedieu M, Kaddurah- Daouk R; Pharmacometabolomics Research NetworkPLoS One. 2013 Jul 17;8(7):e68283. doi: 10.1371/journal.pone.0068283. PMID: 23874572; PMCID: PMC3714282. 4. A high-throughput screen to identify inhibitors of SOD1 transcription.Wright PD, Wightman N, Huang M, Weiss A, Sapp PC, Cuny GD, Ivinson AJ, Glicksman MA, Ferrante RJ, Matson W, Matson S, Brown RH Jr. Front Biosci (Elite Ed). 2012 Jun 1;4:2701-8. doi: 10.2741/e584. PMID: 22652679; PMCID: PMC4083181

5. A novel method for detecting 7-methyl guanine reveals aberrant methylation levels in Huntington disease. Thomas B, Matson S, Chopra V, Sun L, Sharma S, Hersch S, Rosas HD, Scherzer C, Ferrante R, Matson WAnal Biochem. 2013 May 15;436(2):112-20. doi: 10.1016/j.ab.2013.01.035. Epub 2013 Feb 12. PMID: 23416183; PMCID: PMC4090024. 6. Reduced Creatine kinase as a central and peripheral biomarker in Huntington’s disease. Kim J, Amante DJ, Moody JP, Edgerly CK, Bordiuk OL,Samith K, Matson SA, Matson WR, Scherzer CR, Scherzer CR, Rosa HD, Hersh SM, Ferrante RJ. Biochim Biophys Acta.2010 july-Aug:1802(7- 8);673-81. Epub 2010 May 9.

7. Phase 2 Study of Soduim Phenylbuterate in ALS. Cudkowicz ME, Andres PL, Macdonald SA, Bedlack RS, Choudry R, Brown RH Jr, Zhang H, Shoenfield DA, Shefner J, Matson S, Matson WR, Ferrante RJ; Northeast ALS and Nationa VA ALS Research Consortiums. Amyotroph Lateral Scler. 2009 Apr; 10(2):99-106

8. Therapeutic attenuation of mitochondrial dysfunction and oxidative stress in neurotoxin models of Parkinson’s disease. Stack EC, Ferro JL, Del Signore SJ, Goodrich S, Matson S, Hunt BB, Cormier K Smith K, Matson WR, Ryu H, Ferrante RJ. Biochim Biophys Acta.2008 Mar;1782(3):151-62 Epub 2008 Jan 16.

9. Modulation of nucleosome dynamics in Huntington's disease.Stack EC, Del Signore SJ, Luthi- Carter R, Soh BY, Goldstein DR, Matson S, Goodrich S, Markey AL, Cormier K, Hagerty SW, Smith K, Ryu H, Ferrante RJ. Hum Mol Genet. 2007 May 15;16(10):1164-75. doi: 10.1093/hmg/ddm064. Epub 2007 Apr 2. PMID: 17403718

10. Dose ranging and efficacy study of high-dose coenzyme Q10 formulations in Huntington Disease mice. Smith K, Matson S, Matson WR, Cormier K, Del Signore SJ, Hagerty SW, Stack EC, Ryu H, Ferrante RJ. Biochim Biophys Acta. 2006 Jun;1762(6)616-26.Epub 2006 Apr 2. 11. Therapeutic Effects of cystamine in a murine model of Huntington’s Disease. Dedeoglu A, Kubilus JK, Jeitner TM, Matson SA, Bogdanov M, Kowall NW, Matosn WR, Cooper AJ, Ratan RR, Beal MF, Hersh SM, Ferrante RJ. J Neurosci. 2002 Oct 15;22(20):8942-50. 12. Immunologic quantitation of the carcinoma specific human carcinoma antigen in clinical samples Codington JF, Haavik S, Nikrui N, Kuter I, Vassileva C, Zhang H, Matson S, Chen X, Wu Z.. Cancer. 2002 Feb 1;94(3):803-13. doi: 10.1002/cncr.10124. PMID: 11857316. 13. Immunoassays for Deteriming the Concentration of a Carcinoma-Specific Antigen in the Blood of Cancer Patients J.F.Codington, S. Haavik, Z.Hui, S.Matson, Z.Wu and X. Chen ""(1993) Glycoconjugate J. Vol. 10, S15.25.

(Abstract)

14. The Presence of a Common Epitope in Human Carcinomas for Anti epiglycanin Antibodies Raises Diagnostic Expectations J.F.Codington,D.J. Green, R.C. Coombes, S. Haavik,P.T. Lavvaan, H.Zhang,S.Matson, Z.Wu,X. Chen, Z. Wen, P.J. Zielie, D. Howes, A.H.K. Lee, R.Fawwaz "" (manuscript submitted for publication).

References: Available upon request

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