Molecular Biology Regulatory Compliance

Calla Goeke, PhD

***********@*****.*** 585-***-**** linkedin.com/in/calla-goeke-phd

BIOCHEMIST MOLECULAR BIOLOGY CELLULAR NEUROTOXICOLOGY Methodical and resilient PhD scientist with 10+ years of hands-on experience in RNA and cellular biology, neurotoxicology, and translational research. Record of designing and optimizing molecular assays, analyzing data, mentoring junior scientists, and independently leading complex projects to completion. Seeking to bring my expertise in RNA mechanisms, molecular screening, and assay development to an innovative biotech team advancing next-generation therapeutics. CORE COMPETENCIES

• RNA/DNA extraction & quantification (qPCR, RT-PCR)

• Gene expression editing (siRNA, rRNA, AAV)

• Mammalian cell cultures and co-cultures

• Protein analysis (Western Blot, ELISA, BAC, Enzymatic Activity)

• Novel protocol development & optimization

• Animal models (mouse, rat)

• Data collection and statistical analysis (R, GraphPad, JMP)

• Regulatory Compliance (GLP, GCP)

PROFESSIONAL EXPERIENCE

UNIVERSITY OF ROCHESTER — Postdoctoral Researcher, Environmental Medicine Rochester, NY 2019 – 2024

Led independent toxicology research in two neurotoxicology labs, applying molecular and biochemical techniques to explore mechanisms of developmental neurotoxicity.

• Conducted mechanistic studies of neuroinflammation using rodent inhalational models.

• Mentored 8 junior scientists in biochemical and molecular techniques, and data analysis.

• Installed and calibrated new cryostat system, improving sample preparation workflows and reducing processing time.

• Created databases to ensure long-term storage of sample data for future experiments and external stakeholder oversight.

OREGON HEALTH & SCIENCE UNIVERSITY — Principal Investigator (PhD Candidate), Behavioral Neuroscience

Portland, OR 2013 – 2019

Directed multi-year NIH-funded investigation into ethanol- and choline-mediated effects on neuronal development.

• Performed mRNA expression analysis and cellular assays using cultured neurons and astrocytes.

• Designed and implemented experimental protocols involving gene manipulation and microscopy.

• Completed federally funded F31 grant with successful reporting of milestones and research progress, along with budgetary management.

• Collaborated with multi-site teams and adapted protocols following lab relocation. STATE UNIVERSITY OF NEW YORK, GENESEO — Research Assistant Geneseo, NY 2009 – 2013

Assisted in rodent behavioral neuroscience studies; maintained 100+ animal colony.

• Provided experimental support in neurodevelopment and toxicant exposure studies.

• Mentored undergraduates in rodent handling and basic laboratory techniques. EDUCATION

PhD, Behavioral Neuroscience

Oregon Health & Science University – Portland, OR

BA, Psychology & Spanish

SUNY Geneseo – Geneseo, NY

SELECTED PUBLICATION Full list available upon request

• Goeke CM, Roberts ML, Hashimoto JG, et al. Neonatal ethanol and choline treatments alter the morphology of developing rat hippocampal pyramidal neurons in opposite directions. Neuroscience, 2018.

Contact this candidate