Life Sciences Team Leader
Resume:
Dr. Sukant Kishore Das
Senior Scientific Manager
Aragen Life Sciences, Hyderabad
Mobile: +91-986*******, email: ************@*****.*** OBJECTIVE:
Principal Scientist position in the Organic Chemistry/Medicinal Chemistry offering personal growth, challenge, and responsibility that merges my teaching,leadership and synthetic skills in a progressive environment.
Highlights of qualifications and skills:
• 14 Years of research experience in medicinal chemistry, drug discovery, Total Synthesis and methodology.
• Strong background in the theory and practice of classical and modern synthetic organic chemistry with a thorough understanding of modern synthetic methods and reaction mechanisms.
• Superior written, communication skills and presentations.
• Ability to manage multiple projects in parallel.
• Strategic, analytical thinker with strong business acumen.
• Development of new synthetic methodologies as tools in multiple step organic synthesis.
• Expert in the purification and characterization of organic compounds using chromatography (HPLC) and spectroscopic techniques including NMR, MS, and IR spectroscopy. PROFESSIONAL EXPERIENCES & EDUCATION:
Aragen Life Sciences,
Hyderabad, India
Senior Scientific Manager (Oct 2022 - Continue)
Job Responsibilities:
• Management and leadership of a group of 10 chemists.
• Weekly TC with client. Effectively communicate and coordinate with relevant departments
• Synthesis of New Chemical Entities (NCE) and intermediates to stringent specifications
• Responsible for indenting the raw materials to deliver the specified product within the provided time lines
• Writing scope of work for new projects and weekly updates. 2
Syngene International Ltd,
Bengaluru, Karnataka,
India
Senior Research Investigator-II (June 2020-Oct 2022) Job Responsibilities:
• Management and leadership of a group of 4 to 5 chemists.
• Weekly TC with client.
• Synthesis of New Chemical Entities (NCE) and intermediates to stringent specifications
• Responsible for indenting the raw materials to deliver the specified product within the provided time lines
• Writing scope of work for new projects, weekly/biweekly updates and campaign reports.
• Effectively communicate and co ordinate with relevant departments Indrashil University,
Rajpur, Gujarat, India
Assistant Professor (October 2019-June 2020)
Job Responsibilities:
• Teaching Responsible for B.Sc and M.Sc students
.• Co-supervise for 4 to 5 Ph.D students
.• Responsible for drug discovery for Cadila Pharmaceuticals. Texas A&M University,
Texas, USA.
Postdoctoral Research Associate (April 2018-Sept 2019) Research responsibilities:
• Synthesis of non-canonical Amino acids, Drug Discovery. SAI Life Sciences Ltd:
(Hyderabad, India)
Research Scientist, ProceA Associate Research Scientist (Jan 2015-April 2018) Job Responsibilities:
• Management and leadership of a group of 4 to 5 chemists.
• Synthesis of New Chemical Entities (NCE) and intermediates to stringent specifications
• Route scouting, initial optimization and scale-up with the goal of cost efficient and safe chemical process
• Synthesis of compounds from milligram scale to gram scale
• Responsible for indenting the raw materials to deliver the specified 3
product within the provided time lines
• Writing scope of work for new projects, weekly/biweekly updates and campaign reports.
• Effectively communicate and co ordinate with relevant departments. Kwa-Zulu Natal
University, Durban, South
Africa.
Postdoctoral Research Associate (June 2013-Jan 2015)
• Successfully completed Towards a stereoselective synthesis of α,α- disubstituted proline analogues.
• Completed Stereoselective synthesis towards unnatural proline-based amino acids.
Indian Institute of
Chemical Technology
Hyderabad:
Doctoral Research Scholar under the guidance of Dr. J. S. Yadav,
(Bhatnagar Fellow, CSIR), Former Director IICT (2007-2012) Research responsibilities: Achievements
• Successfully completed Stereoselective Total Synthesis of FD-891.
• Completed First Total Synthesis of Pectinolide C and Total Synthesis of Pectinolide A.
• Successfully completed Stereoselective Total Synthesis of Pectinolide H.
• Completed Synthesis of (3R,5R)-harzialactone A and its (3R,5S)-isomer.
• Completed the first total synthesis of pectinolides D, E and total synthesis of pectinolides A, C.
AWARDS AND FELLOWSHIPS:
• Junior Research Fellowship (CSIR- based on National Aptitude Screening) for the period of 2 years in Indian Institute of Chemical Technology, March 2007 to March 2009.
• Senior Research Fellowship (CSIR- based on National Aptitude Screening) for the period of 3 years in Indian Institute of Chemical Technology, March 2009 to March 2012.
• Senior Research Trainee in Indian Institute of Chemical Technology, March 2012 to May 2013.
PARTICIPATED IN SYMPOSIA AND PRESENTATION:
• Participated in “21st International Conference on Organic Synthesis” Dec 11-13, 2016 at Indian Institute of Technology, Bombay, India.
•Participated in “Chemistry and Chemical Biology of Natural Products”,August 2-4, 2012 at Indian Institute of Chemical Technology, Hyderabad, India. 4
•Participated in “Organic Synthesis and Human Well Being: Emerging Opportunities and Challenges (OSHWB)”, August 1-4, 2010, at Indian Institute of Chemical Technology, Hyderabad, India.
PERSONAL DETAILS:
• Nationality/Sex/Marital Status: Indian/Male/Married. LIST OF PUBLICATIONS:
1. Phage-assisted, active site-directed ligand evolution of a potent and selective histone deacetylase 8 inhibitor. Jared S. Morse, Yan J. Sheng, Joshua Trae Hampton, Lauralee D. Sylvain, Sukant Das, Yugendar R. Alugubelli, Peng-Hsun Chase Chen, Kai S. Yang, Shiqing Xu, Carol A. Fierke. Protein Science. 2022, 31, 12, 4512.
2. Desymmetrisation of meso 2,4 Dimethyl 8 oxabicyclo[3.2.1] oct 6 ene 3 ol and its Application in Natural Product Syntheses. Krishnaji Tadiparthi, Pragya Anand, Raghavendra Sakirolla, T Prakash Gupta, Krishna A Jadhav, Sukant Kishore Das, Jhillu Singh Yadav. The Chemical Record. 2022, 22, 3
3. Discovery of selective small-molecule inhibitors for the ENL YEATS domain. Xinyu R Ma, Longxia Xu, Shiqing Xu, Brianna J Klein, Hongkuan Wang, Sukant Das, Kuai Li, Kai S Yang, Sana Sohail, Andrew Chapman, Tatiana G Kutateladze, Xiaobing Shi, Wenshe Ray Liu, Hong Wen. J. Med. Chem., 2021, 64, 15, 109**-*****.
4. A Genetically Encoded, Phage Displayed Cyclic Peptide Library. Xiaoshan Shayna Wang, Peng Hsun Chase Chen, J Trae Hampton, Jeffery M Tharp, Catrina A Reed, Sukant K Das, Duen Shian Wang, Hamed S Hayatshahi, Yang Shen, Jin Liu, Wenshe Ray Liu. Angewandte Chemie International Edition. 2019, 98, 2-8.
5. Stereoselective Total Synthesis of FD-891. J. S. Yadav*, Sukant Kishore Das and G. Sabitha. J. Org. Chem. 2012, 77, 24, 111**-*****.
6. First Total Synthesis of Pectinolide C and Total Synthesis of Pectinolide A. G. Sabitha,* Sukant Kishore Das, PraveenAnki reddy and J. S. Yadav. Tetrahrdron Lett 2013, 54, 9, 1097-1099.
7. Stereoselective Total Synthesis of Pectinolide H. G. Sabitha*, PraveenAnki Reddy, Sukant Kishore Das and J. S. Yadav. Synthesis 2013, 45, 651-654. 8. Synthesis of (3R,5R)-harzialactone A and its (3R,5S)-isomer. Gowravaram Sabitha*, Rangavajjula Srinivas, Sukant Kishore Das and Jhillu Singh Yadav. Beil. J. Org. Chem. 2010, 6, No- 8. 9. Trimethylsilyl Iodide-Promoted Aza-Prins Cyclization for the Synthesis of 4-Iodopiperidines. Gowravaram Sabitha,* Sukant Kishore Das, Rangavajjula Srinivas and Jhillu Singh Yadav. Helv. Chim. Acta. 2010, 93, 2023-2025.
10. The first total synthesis of pectinolides D, E and total synthesis of pectinolides A, C. G. Sabitha*, PraveenAnki Reddy, Sukant Kishore Das. Synthesis. 2015, 47(03), 330-342. 11. Towards a stereoselective synthesis of α,α-disubstituted proline analogues. Sukant K. Das, Nilay Bhatt, Mohammad Mujahid, Per I. Arvidsson, Hendrik G. Kruger, Tricia Naicker*, Thavendran Govender*. Tetrahrdron Lett 2015, 56, 37, 5172-5174. 12. Stereoselective synthesis towards unnatural proline-based amino acids Makhathini, S. S.; Das, S. K.; Singh, T.; Arvidsson, P. I.; Gunosewoyo, H.; Kruger, H. G.; Govender, T.; Naicker, T. Arkivoc 2016, 134.
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