Research Assistant Teaching
Resume:
Maryam Zangi
******.*****@*****.*** • 618-***-****
www.linkedin/MaryamZangi
SUMMARY
Medicinal/Organic synthetic chemist with expertise in designing and executing organic syntheses. Results-driven scientist with extensive experience in synthetic and analytical chemistry. Skilled in multi-step milligram to gram-scale synthesis, optimization, and purification techniques. Strong track record of innovation, leadership, and collaboration in interdisciplinary environments. GENERAL TECHNIQUES AND SKILLS
• Synthetic Methods: Experienced in the synthesis of target molecules from milligram to multi-gram scale; adept at isolation and characterization of products using a full scope of instrumentation. Designed and optimized an efficient synthetic route
(multi-step, parallel and convergent synthesis) for synthesis of complex molecules while utilizing microwave synthesis; lyophilization; purification and isolation of target molecules through extraction, distillation, trituration, and recrystallization.
• Computational Skills: Schrödinger MestReNova software suite, SciFinder, ChemDraw, Microsoft Office (Word, Excel, PowerPoint), LATEX, PyMol, Gaussian, Chemical and Database Searching.
• Analytical Techniques: NMR (1D, 2D), qNMR, UV-Vis absorption, LC-MS, IR spectroscopy, prep-HPLC, automated flash chromatography systems.
RESEARCH AND PROFESSIONAL EXPERIENCE
• Staff Scientist, City of Hope (National Medical Center), Duarte, CA 01/2024- Present o Synthesizing and characterizing novel compounds for AOH1996 (phase 1 clinical trial), utilizing advanced organic and medicinal chemistry techniques to support drug development and optimization
• Research Assistant II, City of Hope, Duarte, CA 06/2023- 01/2024 o Performing anti-cancer drug discovery research and lead optimization
• Intern at Biogen, Cambridge, MA 06/2022 – 08/2022 o Assessed qNMR method parameters, purity, potency, specificity, linearity, instrument method precision and accuracy analysis on therapeutic drugs for Acute Ischemic Stroke at phase 2
• Research and Teaching Assistant, St. Louis University, St. Louis, MO 08/2018 – 06/2023 o Synthesized derivatives of the anti-fungal drug Ciclopirox as an active compound against herpes simplex virus II o Developed structure-activity relationships for pyrazolopyrimidines as potential drug for cryptosporidiosis o Synthesized and assessed analogs for HNOs as anti-HBV compounds for their antiviral potency and potential as lead compounds
o Managed laboratory chemical waste and hazardous materials removal in collaboration with St. Louis university Environmental Health and Safety Center
• Research and Teaching Assistant, SIUE, Edwardsville, IL 01/2017 – 01/2018 o Worked on tandem Oxa-Michael Ugi-Smiles couplings with α,β-unsaturated aldehydes o Teaching Assistant, General Chemistry Lab
• Research Assistant, Tehran University of Medical Sciences Tehran, Iran 03/2016 – 12/2016 o Synthesized organic compounds, designed small organic molecules, developed methodology towards optimize reaction conditions and characterization of synthesized compounds
• Research Assistant, Sharif University of Technology, Tehran, Iran 01/2008 – 08/2008 o Worked on calculation of hydrogen bonding strength on the overall inter-molecular interactions between series of anions helping Gaussian software
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PUBLICATIONS, PATENTS, AND CONFERENCE PRESENTATIONS
• Haratipour, P.; Zangi, M.; Yaghoubi, M.; Gu, L.; Li, C.; Jossart, J.; Lingman, R.; Perry, J.; Malkas, L.; Hickey, R. Enhancing AOH1996 through structure-activity-relationship exploration for caPCNA inhibition. Abstract, AACR Meeting, San Diego, CA April 2023.
• Xun, G.; Miller, W., Zangi, M.; McElderry, J. Application of Quantitative NMR in Pharmaceutical Analysis: Method Qualification and Potency Determination for Two New Chemical Entities in Early-Stage Clinical Studies. J. pharmaceutical and biomedical analysis 2023, (234), 115561.
• Zangi, M.; Donald, K. A.; Casals, A. G.; Franson, A. D.; Yu, A. J.; Marker, E. M.; Woodson, M. E.; Campbell, S. D.; Mottaleb, M. A.; Narayana Hajay Kumar, T. V.; Reddy, M. S.; Raghava Reddy, L. V.; Sadhukhan, S. K.; Griggs, D. W.; Morrison, L. A.; Meyers, M. J. Synthetic Derivatives of the Antifungal Drug Ciclopirox Are Active Against Herpes Simplex Virus 2. Eur. J. Med. Chem. 2022, 238, 114443.
• Thessing, A.; Ayres, R.; Jones, J.; Bauer, H.; Zangi, M.; Luesse, S. B. Oxa-Michael/Ugi-Smiles Cascade Reaction With α,β- Unsaturated Aldehydes. Results in Chemistry 2022, 4, 100416.
. Lin, J.; Zangi, M.; Kumar, T. V. N. H.; Shakar Reddy, M.; Reddy, L. V. R.; Sadhukhan, S. K.; Bradley, D. P.; Moreira-Walsh, B.; Edwards, T. C.; O’Dea, A. T.; Tavis, J. E.; Meyers, M. J.; Donlin, M. J. Synthetic Derivatives of Ciclopirox Are Effective Inhibitors of Cryptococcus neoformans. ACS Omega 2021, 6 (12), 8477-8487.
. 1H-Pyrazolo[3,4-D]Pyrimidin-4-Amines as Anti-Infectious Agents, US Provisional Patent Application: 073777.00104
. PCNA Inhibitors and Uses Thereof, Provisional Patent Application: 048440-888P01US
• Synthesis of Derivatives of the Antifungal Drug Ciclopirox for Evaluation Against Herpes Simplex Virus 2, Zangi, M., Morrison, L. A., Meyers, M. J., Midwest Regional Meeting (MWRM), Iowa City, IA October 2022.
• Synthetic Derivatives of Ciclopirox as an Effective Inhibitors of Cryptococcus neoformans, Zangi, M., Lin, J., Meyers, M. J., Donlin, M. J., 34th Annual Organic Chemistry Day, University of Missouri-Columbia, MO April 2022.
• Synthesis and evaluation of ciclopirox analogs as antiviral agents against herpes simplex virus 2, Zangi, M., Meyers, M. J., ACS National Meeting, San Diego, CA March 2022.
• Exploration of Ugi-Smiles Reactions Involving Oxy-Michael Additions, Zangi, M., Luesse, S. B., 255th ACS National Meeting, New Orleans, LA March 2018.
AWARDS, AND AFFILIATIONS
• National Institutes of Health (NIH) funded project 2019 – 2023
• Graduate Scholarship from Chemistry Department at SIUe 2017 – 2018
• Research Grants for Graduate Students (RGGS) award 2017
• Member of American Chemical Society (ACS) 2017 – Present EDUCATION
Ph.D. Organic Chemistry, Saint Louis University, St. Louis, MO 07/2018- 12/2023 M.S. Organic Chemistry, Southern Illinois University Edwardsville, Edwardsville, IL 01/2017- 07/2018 B.S. Chemistry, Sharif University of Technology Tehran, Iran 09/2004- 09/2008
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