statisitcian

LE CHEN

Gaithersburg, MD /Cell (text): 301-***-****/Email: *******@*****.***

Citizenship: United States of America

Eligibility: Schedule A – hearing impaired

Objective: Seeking a position as a Statistician, Biostatistician, Bioinformatics, Data Scientist, or Statistical programmer

EDUCATION:

●M.S. 2016, Mathematics with Statistics concentration, Georgia State University Atlanta GA. Thesis: Seeking Direct Coastal Erosion Associated Factors in the United States Shorelines

●B.S. 2013, Mathematics, Gallaudet University, Washington DC

TRAINING CLASSES AND WORKSHOPS (physical & virtual):

9th Workshop on Biostatistics and Bioinformatics (May 2024, Atlanta, GA, USA)

2024 ADD Health Users Conference (July 2024, Chapel Hill, NC, USA)

Meta-Analysis: Quantifying a Systematic Review

Best Practices and Patterns for Prompt Generation in ChatGPT

Crafting Your Generative AI Usage Strategy (2024, NIH)

WORK EXPERIENCES:

Dec 2023 - Present: Statistician (GS-13) Office of the Director/National Institute of Deafness and Communication Disorder (NIDCD)/National Institutes es of Health (NIH), Bethesda, MD, USA

Provided statistical analysis guidance and service in NIDCD.

Leading multiple statistical analysis projects from suitable data QC, statistical methods, efficiency computation, results summary, and presentation to manuscripts. these projects involve wide type studies, such as survey, cohort, longitudinal, observational studies.

Develop pipeline for pre-GWAS, GWAS, and past-GWAS analysis, leading a GWAS analysis in ADD-Health Study

University of Maryland School of Medicine, Research Assistant (Volunteer), Baltimore MD USA (Sept 2023 - Dec 2023)

Using published GWAS summary statistics and gene pathway data base to develop a gene enrichment analysis by traits.

Develop analysis pipeline to fine mapping causal genetic variants using GWAS summary statistics and published LD in HapMap and 1000 genome projects.

Develop pipeline to calculate genetic risk score using GWAS summary statistics

Develop analysis pipeline to perform analysis for heart disease traits in a special Amish cohort.

Genetic software, PLINK, epacts, sumSTAAR, SKAT, pathview, GSEA, IPA, and g: Profiler etc

AFTAC, Department of the Air Force, Statistician (GG-12) (Top Secret/SCI Clearance), Patrick Space Force Base FL USA (Aug 2022 - Aug 2023)

Provided guidance to colleagues on statistical theory, methods, application, and interpretation of results.

Evaluated and implemented new statistical methods, developed an automated reporting system that reduced report preparation time from months to minutes with zero errors, and improved reporting scripts.

Led analytic research projects from data QC, statistical method, development of custom statistical programs (due to top security restrictions on published packages), and presentation of findings.

Intramural Research/NIDCD/NIH, Bioinformatics (Federal Contractor by RemedyBiz Inc), Bethesda MD USA (Mar 2022 - Aug 2022)

Develop pipeline for single cell analysis from raw data to scientific report.

Develop analysis pipeline to analyze scRNA-seq and SnRNA-seq from auditory mice samplers in series time to understand auditory development.

Single cell analysis from data QC, reference genome selection, annotation to presentation.

Genetic software/tools: Seurat, Slingshot, Monocle 3, and SCENIC

Develop pipeline for scRNA-seq and snRNA-seq gene enrichment and pathway analysis.

Division of Scientific Programs (DSP)/NIDCD/NIH, Guest Researcher, Bethesda, MD, USA (2015 - summer); Statistician (GS-7) (Pathways programs) (2016 - summer); Statistician (GS-7) (Pathways programs), Guest researcher, and Volunteer, Bethesda MD USA (Jan 2017-Aug 2022)

Provided guidance to colleagues on statistical analysis methods and result interpretation.

Developed a two-stage statistical model to identify risk factors for hearing loss

Conducted statistical analysis for longitudinal cohort studies, serving as the first author on an article in Applied Statistics Journal.

Led analytic research projects, selecting databases/software, creating analysis plans, and interpreting findings.

Maryland School for the Deaf, Substitute Teacher Aide, Frederick MD USA (2019 – spring semester)

Facilitated effective communication for deaf students.

Supported specialized education environments.

Georgia State University, IT Assistant (Graduate Laboratory Assistant), Atlanta GA USA (2015-2016)

Administered and maintained for conferences and resolved technical issues.

Biostatistics and Bioinformatics Branch (BBB)/NICHD/NIH, Editor Assistant (GS-5), (NIH DREAM summer program), Bethesda MD USA (5/2013 – 10/2013)

Developed a comprehensive model for longitudinal data analysis, published as the first author in the Journal of Applied Statistics.

Led analytic project to identify copeptin as a risk factor for Preeclampsia in pregnant and more than one time measurement of copeptin can be use to predict Preeclampsia with 80% accuracy.

Howard University National Human Genome Center, Laboratory Assistant, Washington DC USA (2011 - summer)

Conducted fundamental biological laboratory tasks, encompassing cell culture, DNA extraction, DNA amplification, and PCR.

REFERENCES:

Judith A. Cooper, Deputy Director, NIDCD/NIH

301-***-****, Email: *******@*****.***.***

Paul S. Albert, Director and Senior Investigator, Biostatistics Branch, NCI/NIH,

240-***-****, Email: *******@****.***.***

Howard J. Hoffman, Director, Epidemiology, Statistics and Population Sciences, NIDCD/NIH

301-***-****, Email: ********@*****.***.***

Chuan-Ming Li, Statistician (Health/Medicine), NIDCD/NIH

301-***-****, Email: *****-****.**@***.***

Xiaojing Ye, Professor, Georgia State University

404-***-****, Email: ***@***.***

PUBLICATIONS:

1.Le Chen, Ruochen Tian, et al. "Semiparametric Partial Linear Modeling of Risk Factors for Ear Infections: The Early Childhood Longitudinal Study." Applied Statistics, vol. 11, 2022, https://doi.org/10.1080/02664763.2022.2134316.

2.Chuan-Ming Li, Le Chen, Guanjie Chen, and Howard J. Hoffman. "A Missense Variant in COMT Associated with Hearing Loss among Young Adults: The National Longitudinal Study of Adolescent to Adult Health (Add Health)." Biomedicines, vol. 10, 2022, 2756, https://www.mdpi.com/2227-9059/10/11/2756.

3.Xuan Guo, Bing Liu, Le Chen, Yi Pan, Guantao Chen, and Jing Zhang. "Bayesian Inference for Functional Dynamics Exploring in fMRI Data." Computational and Mathematical Methods in Medicine, vol. 2016, Article ID 3279050, 2016, 9 pages, doi:10.1155/2016/3279050.

4.Jessica Chen, Le Chen, Derrick Liu. "Intersections of Cycles in k-connected Graph." Journal of Graphs and Combinatorics, vol. 31(4), 2015, pp. 897-914.

5.Zhichao Lian, Xiang Li, Yi Pan, Xuan Guo, Le Chen, Guantao Chen, Zhihui Wei, Tianming Liu, and Jing Zhang. "Dynamic Bayesian Brain Network Partition and Connectivity Change Point Detection." 2015 IEEE 5th International Conference on Computational Advances in Bio and Medical Sciences (ICCABS), Miami, FL, 2015, pp. 1-6, doi:10.1109/ICCABS.2015.7344714.

6.Le Chen, Ao Yuan, Aiyi Liu, and Guanjie Chen. "Longitudinal Data Analysis Using Bayesian-Frequentist Hybrid Random Effects Model." Journal of Applied Statistics, vol. 41(9), 2014, pp. 2001-2010.

7.Le Chen, Chuan-Ming Li, Howard J. Hoffman, Gudny Eiriksdottir, Christa L. Themann, Lenore J. Launer, Tamara B. Harris, Vilmundur Gudnason, and Hannes Peterson. "Bayesian Network Approaching to Estimating 'Direct' Hearing Loss Risk Factors." Manuscript in preparation.

8.Chuan-Ming Li, Howard J. Hoffman, Le Chen, Mable L. Rice, Christa L. Themann, Greg A. Flamme. "Children's Hearing and Reading, Mathematics, and Science Achievement in Early Primary School Grades: The U.S. Early Childhood Longitudinal Study – Kindergarten Class of 2010-11 (ECLS-K:2011) Study." Manuscript in preparation.

PRESENTATIONS:

1.Le Chen, Aiyi Liu PhD, Paul Albert PhD and Edwina Yeung PhD; “Prediction of Preeclampsia during Pregnancy Using Longitudinal Serum Copeptin Measures”. 2013 NIH Summer Research Program Poster, Natcher Conference Center, NIH, Bethesda, MD, Aug. 2013

2.Le Chen, Chuan-Ming Li and Howard J Hoffman “A longitudinal study of hearing in older adults with loud noise exposure and high frequency audiometric “notches”: The Age, Gene/Environment Susceptibility-Reykjavik Study “. 2015 NIH Summer Research Program Poster, Natcher Conference Center, NIH, Bethesda, MD, Aug. 2015

3.Zhichao Lian, Xiang Li, Yi Pan, Xuan Guo, Le Chen, Guantao Chen, Zhihui Wei, Tianming Liu, and Jing Zhang; “Dynamic Bayesian Brain Network Partition and Connectivity Change Point Detection” Computational Advances in Bio and Medical Sciences (ICCABS), 2015 IEEE 5th International Conference on. IEEE, Miami, FL

4.Chuan-Ming Li, Le Chen, Howard J Hoffman, Christa L. Themann, Gudny Eiriksdottir, Johanna E. Sverrisdottir, Tamara B. Harris, Lenore J. Launer, Vilmundur Gudnason, Hannes Petersen. Bayesian Network Approach to Estimating “Direct” Hearing Loss Risk Factors. American Auditory Society (AAS) 2017 annual meeting, Mar 2-4, 2015, Scottsdale, AR

5.Chuan-Ming Li, Howard J. Hoffman1, Le Chen, Mabel L. Rice, Christa L. Themann, Gregory A. Flamme. Impact of otitis media history on hearing and children’s academic achievements in early primary school grades: The United States Early Childhood Longitudinal Study, Kindergarten class of 2010-11 (ECLS-K:2011). American Public Health Association (APHA) 2017 Annual Meeting, Nov 4-8, 2017, Atlanta, GA

6.Chuan-Ming Li, Le Chen, Howard J. Hoffman, Christa L. Themann. Prevalence and Associated Risk Factors of Deafness or Serious Difficulty Hearing in the United States: The 2016 Behavioral Risk Factor Surveillance System (BRFSS) Survey. American Public Health Association (APHA) 2018 annual meeting, San Diego, CA

7.Chuan-Ming Li, Guixiang Zhao, Howard J. Hoffman, Le Chen, Christa L. Themann. “Deafness or Serious Difficulty Hearing” – 2016 National Health Survey Results. American Auditory Society (AAS) 2018 annual meeting, March 1 - 3, 2018, Scottsdale, AR

8.Chuan-Ming Li, Howard J. Hoffman, Le Chen, and Christa L. Themann. Hearing Disability Disparities: Results from the American Community Survey 2012-2016. 34th World Congress of Audiology (WCA) meeting, Oct 28-31, 2018, Cape Town, South Africa

9.Chuan-Ming Li, Le Chen, Howard J. Hoffman, Christa L. Themann. Prevalence and Associated Risk Factors of Deafness or Serious Difficulty Hearing in the United States: The 2016 Behavioral Risk Factor Surveillance System (BRFSS) Survey. American Public Health Association (APHA) 2018 annual meeting, San Diego, CA

10.Chuan-Ming Li, Howard J. Hoffman, Le Chen, Christa L. Themann, Greg A. Flamme, Mabel L. Rice. Impact of History of Otitis Media and Hearing Loss on Children’s Academic Achievement: The U.S. Early Childhood Longitudinal Study–Kindergarten Class of 2010–11 (ECLS–K:2011). ISOM 2019: 20th International Symposium on Recent Advances in Otitis Media meeting, June 9-13, 2019, Los Angeles, CA

11.Chuan-Ming Li, Howard J. Hoffman, Le Chen, and Christa L. Themann. Hearing Disability in the United States Adults Results from the American Community Survey 2012-2016. 2019 ARO annual meeting, Feb 9-13, 2019, Baltimore, MD

12.Chuan-Ming Li, Howard J. Hoffman, Le Chen, Christa L. Themann, Greg A. Flamme, Mabel L. Rice. Parent Educational Level and Potentially Biased Reporting of Childhood Ear Infections: The U.S. Early Childhood Longitudinal Study–Kindergarten Class of 2010–11 (ECLS–K:2011). Society for Pediatric and Perinatal Epidemiologic Research (SPER) 32nd Annual Meeting, June 17-18, 2019, Minneapolis, MN

13.Chuan-Ming Li, Le Chen, Guanjie Chen, and Howard J. Hoffman. A Missense Variant in COMT Associated with Hearing Loss among Young Adults: The National Longitudinal Study of Adolescent to Adult Health (Add Health). Submitted to ARO 2022 annual meeting

14.Chaun-Ming Li, Howard J. Hoffman, Le Chen, Christa L. Themann, Greg A. Flamme, Mabel L. Rice. Impact of Otitis Media History and Hearing Impairment on Children’s Academic Achievement in Primary School: The U.S. Early Childhood Longitudinal Study-Kindergarten Class of 2010-11 (ELCS-K:2011). Submitted to SPER 2022 annual meeting.

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