Executive Director Vice President

Andrei L. Laikhter, Executive Director

Arden, ***04, United States, 319-***-****, **********@*****.***

SUMMARY Dynamic Vice-President R&D with over 20 years of experience in oligonucleotide chemistry and biotechnology. Expertise in developing novel nucleic acid products and oligonucleotide synthesis methods, coupled with a Ph.D. in Synthetic Organic Chemistry. Successfully increased annual sales from 50K to 1.5M within 5 years. Proven track record of establishing and leading laboratories and teams to achieve innovative goals. Ready to leverage extensive background in oligonucleotide synthesis to drive success in the role of Executive Director/Vice President.

WORK EXPERIENCE

Aug 2023 – Feb 2025 Vice-President R&D, Raybow USA, Inc. Brevard, NC Engineered innovative nucleic acid products.

Instituted an oligonucleotide synthesis laboratory, enhancing research capabilities.

Jan 2015 – Feb 2023 Chief Scientific Officer, ChemGenes Corporation Wilmington, MA Pioneered novel oligonucleotide-bio-conjugation methodologies.

Formulated and launched a novel solid support for oligonucleotide synthesis – CPSG.

Conducted installation and training of personnel in the operation of HPLC

equipment.

Authored standard operating procedures (SOPs) and conducted training on UV-Vis spectrophotometry.

Feb 2014 – Jan 2015 Chief Scientific Officer, Biosynthesis, Inc. Lewisville, TX Engineered in vitro protein synthesis methods with unique site-specific

modifications.

Established an analytical laboratory specializing in Ion-Exchange HPLC. Introduced innovative solid supports compatible with carboxy-, carbonyl-,

alkynyl-, and azido-modified oligonucleotides.

Developed advanced oligonucleotide-peptide and protein conjugation techniques.

May 2008 – Feb 2014 Chief Scientific Officer, ChemGenes Corporation Wilmington, MA Established an oligonucleotide synthesis laboratory, focusing on the

production of highly modified oligonucleotides.

Developed and patented highly efficient chromophores as quencher dyes for qPCR and FRET-based technologies.

Implemented and patented new CombiClick technology utilizing combinatorial 'Click chemistry'.

Designed innovative oligonucleotide-peptide and protein conjugation strategies.

Accelerated annual sales of highly modified oligonucleotides from $50K to

$1.5M within 5 years.

Jan 2002 – May 2008 Vice President, Chemistry, Integrated DNA Technologies, Inc. Coralville, IA

May 2000 – May 2002 Director of Chemical Synthesis, Integrated DNA Technologies, Inc. Coralville Established a synthetic laboratory specializing in organic synthesis.

Synthesized a range of nucleosides and components essential for automated oligonucleotide synthesis.

Revamped automated RNA synthesis processes.

Optimized various DNA and RNA purification techniques.

Dec 1996 – Nov 1999 Senior Scientist, Cruachem, Inc. Dulles, VA Established an analytical laboratory primarily focused on HPLC.

Synthesized dinucleotides amino-acylated by non-natural analogs of aspartic acid and glycosylated amino acids for the in vitro protein synthesis of modified enzymes.

Streamlined automated RNA synthesis methodologies.

Enhanced automated oligonucleotide synthesis processes.

Jan 1994 – Nov 1999 Research Associate, University of Virginia Charlottesville, VA Synthesized dinucleotides amino-acylated by non-natural analogs of

aspartic acid and glycosyl-amino acids for in vitro protein synthesis of modified enzymes (HIV protease, DHFR, luciferase, RNase-B).

Executed solid-phase glycopeptide synthesis with precision.

Feb 1993 – Nov 1993 Postdoctoral Fellow, University of Delaware Newark, DE Developed electro-chemical chiral synthesis techniques for thio- and nitro-

glycosides.

EDUCATION

Jan 1982 – May 1987 N.D. Zelinsky Institute of Organic Chemistry

Ph.D., Synthetic Organic Chemistry

Moscow, USSR

PhD thesis: 'Synthesis of Nitroheterocycles'. Research adviser: Prof. A.A. Fainzilberg. Designed and synthesized new nitro polyheterocyclic systems.

Sep 1977 – May 1982 Lomonosov Moscow University of Fine Chemical Technology

B.Sc., Organic and Bioorganic Chemistry

Moscow, USSR

Diploma work: 'Synthesis of the Carotenals.' Research advisers: Dr. B.I. Mitzner and Prof. E.N. Zvonkova. Synthesis of modified retinoids and their incorporation into Bacterioopsin.

SKILLS Spectroscopy (NMR, FT-IR, UV-VIS) Mass-spectrometry (GC-MS, LC-

MS, MALDI/ESI TOF, ESI ion-trap)

Chromatography (Analytical and Preparative HPLC, GC, Flash, TLC)

Synthesizers: PS 250, Expedite, 380B, 394, 3900, 8900, Akta

Oligopilot 100, Mermaid 4

Electro synthetic equipment Computer programming (Basic,

Fortran, Unix)

Familiar with various IBM/PC and Macintosh systems

Microsoft Office

Chem Draw Molecular Modeling

Knowledge of ISO-9004:2000 and

ISO-13485

Strong problem-solving skills Excellent ability to work

independently and as part of a team

Proven written and oral communication skills

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