EWEN Y. BAO

**** *. ******* ** *** Arboles, Thousand Oaks, CA 91362; (Home) 805-***-****, (cell) 805-***-****; email: adunjd@r.postjobfree.com

OBJECTIVE

An Analytical Chemist

TECHNICAL EXPERIENCES

• Analytical Chemistry: Assay of Bio-molecules since 2021, 13 year chemical analysis of OTC samples, 11 years in tests of Fruits and biological products.

• Research and Development: 8-year-research experience in organic chemistry including organic synthesis, isotopic labeling (H2, H3 and C14). Familiar with modern and classical reactions, separation, and purification. Experienced in the multi-step synthesis and analysis

• Chromatography: UPLC, GC, HPLC, UPLC, TLC, optometry.

• Spectroscopy: High resolution NMR, IR, UV, LC-MS.

• Other Instruments: ICP, Radioscanner, Perkin-Elmer 341 polarimeter, sclerometer, melting point. PH meter, Osmolarity meter.

• Write analytical procedure, SOP and reports.

PROFESSIONAL EXPERIENCES

Sept. 2021-Jan 2023 QC Analyst (II), Curia Global in Camarillo, CA

Assay of Bio-molecules with RP or SE-HPLC, UV.

Aug. 2008-Sept 2021 Analytical chemist, Thibiant International

Assay of product stabilities, Bulks, finished goods and raw materials. Analysis of active materials in OTC samples by UPLC, HPLC, GC, UV, ICP and other analytical instruments.

Method validations: Spike-recovery, limitation and linearity tests. Develop new test methods. Update and modify test methods. Write SOP. Train new chemists.

Jan. 2004-May 2006 Staff Research Associate, M&M Pharmacology Department, UCLA

Synthesis of PET Molecular Imaging Probes: Synthesis of different precursors and fluoro-reference compounds.

Apr. 2001-Jan. 2003 Research Associate, Triad Therapeutics, Inc, San Diego

Synthesis of substrates and kinase inhibitors: Multi-step organic synthesis.

Jan. 2000-Apr. 2001 Research Associate, Combi-Blocks, Inc, San Diego

Synthesis of Building-blocks of Organic Compounds: Developed, purified, analyzed and synthesized analogs of heterocycles and arylboronic acid.

Feb. 1997-May 1998 Research Student, Department of Chemistry, Auckland University, New Zealand

Synthesis of Prodrugs of Anticancer Agents: Synthesized an aglycon (seco-CI-TMI, and a glycosyldonor, O-(2,3,4,6-tetra-O-acetyl-(alfa-D-glucopyranosyl))-trichloroacetimidate. Initiated and completed model experiments. Succeeded in synthesizing a new target compound, O-beta-D-glycopyl-seco-CBI-TMI.

Sep. 1985-Jun. 1996 Research Associate, Shanghai Institute of Plant Physiology, Academia Sinica

Production and Development of Cellulase: Responsible for post-treatment of cellulase production.

Production, Analysis and Development of Gibberlins: Charged with the research project, post treatment workshop, laboratories and developed the application of Gibberlins.

Synthesis and Assay of Coloring Agents of Some Fruits: Designed and synthesized a series of compounds, which enhanced the biosynthesis of lycopene in some plant tissues and analyzed lycopene, carotenoids.

Study of ethylene in Plants and Preservation of fruits: Studied metabolism from MACC to ACC then to ethylene analysis of ethylene in fruits and their respiration.

Sep. 1982-Sep. 1985 Research Student, Organic Synthesis Department, Shanghai Institute of Materia Medica, Academia Sinica

Study and Synthesis of Isotope-labeled Changrolin Compounds: Designed and synthesized 6 new isotope-labeled Changrolin (an anti-arrhythmia drug).

Established the mechanism of splitting of Changrolin in mass spectra. Studied the stable isotopic effects of Changrolin in bodies and the absorption and distribution of Changrolin in bodies with C14, H3-labeled Changrolin.

EDUCATION

1998 M.S. in organic chemistry, Auckland University, New Zealand

Supervisors: Professor William A. Denny, Dr. Carol Taylor.

Thesis title: Glycoside prodrugs of anticancer agents

1985 M.S. in organic chemistry, Shanghai Institute of Materia

Medica, Academia Sinica, Shanghai, P.R.China.

Supervisor: Professor Zhang Xin.

Thesis title: Synthesis and study of isotope-labeled Changrolin (an antiarrhythmia drug)

1982 B.S. in chemistry, Shandong University, Jinan, China

PUBLICATIONS

• Wu Youmei, Bao Yuewen and Liu Yu, "Effect of epibrassinolide on formation of 1-(malonylamino)-cyclopropane-1-carboxylic acid and ethylene in etiolated mungbean hypocotyl segments", Acta. Phytophysiogica Sinica 13(1), 107(1987)

• Zhang Xin, Bao Yuewen, Ding Ruiqin, "Synthesis of H3 and C14 labeled

Changrolin", International Conference on Nuclear and Radiochemistry, P.231, September, 1986, Beijing

• Bao Yuewen, Cheng Weizhou, Dong Yueli, Zhang Xin, "Bioisotopic

Effect of H2 labeled Changrolin", The Fifth Chinese Conference on Stable Isotope, 1986 Shanghai

• Bao Yuewen, Yu Qitao, Zhangxin, "Application of H2 in studying the splitting mechanism of Changrolin in mass spectra", Journal of Stable Isotope, 3, 21(1985) (China)

• Bao Yuewen, Zhang Xin, "Synthesis of H2 labeled Changrolin", The Third Chinese Conference on Stable Isotope, 1984, Xining, China

REFERENCES: Available upon request

Contact this candidate