OCTAVIO QUIÑONES

Cell: 939-***-**** Email: adun2g@r.postjobfree.com

PROFILE

I am a bilingual (English/Spanish) professional with experience as a biostatistician and mainframe programmer. Recognized for advanced knowledge of statistical theory and methods particularly with the pre-clinical phase of assays, as well as superior computer programming dexterity and wealth of knowledge with numerous statistical packages. Possess strong communication and interpersonal skills, and consistently ensure accuracy of analyses, programs, reports and applications from design through implementation.

EDUCATION

M.S.P.H. Biostatistics, University of South Florida, Tampa, FL, graduated May 2000

B.S. Degree in Mathematics with Minor in Computer Science, University of Puerto Rico at Mayagüez, PR, graduated Magna Cum Laude, June 1995

COMPUTER SKILLS

Operating Systems: UNIX, Windows NT, 2000, Windows XP, OS 10.x and MVS

Software / Tools: VSAM, DB2, IMS, TSO/ISPF, CICS, MS-Office, Xpediter, Endevor, SPUFI, Platinum, QMF, and SQL Server 7.0, MS-Outlook, MS- Access

Programming: MicroFocus COBOL II, JCL, C/C++, SQL, Pascal, SAS/BASE, SAS/GRAPH, SAS/MACRO, SAS/Stats, S-plus, R, and JMP

PROFESSIONAL EXPERIENCE

Data Management Services, Inc., Frederick, MD 6/2006 to 8/2014

Biostatistician – Worked in the capacity of a pre-clinical consulting biostatistician at Data Management Services, Inc., in the Statistical Consulting group under the direction of Dr. Greg Alvord. The client was the Frederick National Laboratory (FNL), formerly known as the National Cancer Institute, at Frederick, MD.

Environment: Windows XP, Mac OS X

Responsibilities included (1) consulting with investigators to interpret oncological data driven questions to experiments, studies, and assays at the FNL and Ft. Detrick community; (2) preparing statistical analysis plans; (3) writing code/scripts/macros to perform statistical analyses with statistical software, e.g. S-plus, R, SAS, JMP, and Matlab; (4) generating graphs, plots, related visual aids and tables to summarize the data and make inferences regarding the data; (5) preparing detailed statistical reports; and (6) meeting with investigators to discuss reports, results, and preparation of statistical methods section in manuscript preparations as well as review of manuscripts.

The focus of this work was on the pre-clinical phase ontological data to assist investigators with their research efforts in cancer. Their research topics included but were not limited to animal studies, proteomics, flow cytometry, and genetic studies. Examples of statistical analyses performed included microarray analysis with Affymetrix .CEL files, survival analysis, four parameter logistic model (estimation of upper and lower asymptote, ED50/LD50, and ‘slope’ parameters), mixed models, non-linear logistic regression, genomics and proteomics analysis, categorical data analysis, cluster analysis, principal components analysis, discriminant analysis, SNP analysis, analysis of variance, data manipulation, data management, power analysis, sample size determination, linear models, and randomization techniques among others.

Lockheed Martin, Woodlawn, MD 4/2005 to 6/2006

Programmer/Analyst– Consultant for Lockheed Martin IT. The client was the Social Security Administration (ORSIS group).

Environment: IBM OS/MVS 0390, Windows XP, Windows NT

Utilized all four phases of the software full life programming cycle, (1) requirements gathering, (2) design, (3) development and testing of modules (4) and implementation day-to-day. This work was performed in a Mainframe environment. Worked on numerous projects including Garnishment and SUMS (Social Security Unified Measurement System) under strict deadlines. Following software languages were used: COBOL85, JCL, and DB2, as well and as documenting processes, and programs using tools such as Excel, Visio, and Word. Received an Associate Commissioner’s Citation for work performed on the time-critical SUMS project.

Translator, Cincinnati, OH 6/2004 to 3/2005

Client was Firmware Manager at Lexmark, Inc. Utilized bilingual skills. Duties were to translate documents for client from Spanish to English so that she could comprehend them. I also translated client’s documents from English to Spanish for the client’s Latin American contact.

Keane, Inc., Cincinnati, OH 4/2001 to 6/2004

Programmer/Analyst in the personal lines insurance arena for clients GAI, IPACC, and DRC. Experience with CMMi Level 3 processes.

Utilized COBOL and SAS to analyze, maintain, enhance, develop, and provide production support to several systems including ASSIST Driver Club, ASSIST Quote Print, Collections, and NAII Reporting.

Utilized SAS including proc SQL statements to analyze, maintain, enhance, develop, and support shell scripts, permanent dataset updates, as well as analyzing situations where ad-hoc programming was performed per client request. Permanent SAS data sets were updated on a weekly and monthly basis via submission of scripts and then data were verified via proc SQL queries. Performed analysis of SAS data whenever there were discrepancies with the data and eventually resolved data issues via proc SQL querying, deletion of suspect data and reinsertion of data that client deemed correct after exhaustive analysis.

Performed project management, administered system production support, and prepared reports for clients and Keane.

Main projects included the following:

Provided Production Support (24X7), Maintenance, Enhancement and New Development as primary and/or secondary to over 300 programs and scripts (COBOL, SAS and Easytrieve) and jobs (JCL) in a Mainframe environment, UNIX Sun Solaris and ASSIST Batch.

Performed requirements gathering, analysis, and modification code in Easytrieve and COBOL programs as well as JCL jobs in a Mainframe environment in order to make changes to reports that were to be altered due to new requirements specified by the client.

For System that I provided support, maintenance, enhancement and new development, Driver Club, I made numerous changes to COBOL code in client/server environment in order to keep up with constant and new changes ordered by the client. Used Mainframe as well since data was FTP’d on a nightly basis from the Server to Mainframe, and processed by Mainframe COBOL programs with JCL jobs and then FTP’d to vendors.

For client DRC rewrote Road Assist application by performing requirements gathering with DRC, analyzing new code to replace old code, and writing a DTS package in SQL Server 7.0 that extracted data on a weekly basis and then reformatted data via client/server COBOL program to vendors’ specifications. Data was then FTP’d to vendors via ASSIST Batch.

For Collections, performed requirements gathering, analysis and wrote DTS package in SQL Server 7.0 that extracted Collections data on a monthly basis. I then analyzed and wrote up procedure to modify manually in Excel the HTML output produced.

Programmer/Analyst - Consultant - Clients were Great American Insurance Group-Specialty Division, Infinity Property & Casualty Corporation, and Direct Response Corporation

Environment: IBM OS/MVS 0390, Client/Server, Windows NT, Sun Solaris Server, SAS Version 6.0, UNIX, SQL Server 7.0

Purdue University, West Lafayette, IN 6/2000 to 3/2001

Research Associate – Computational Genomics Group

Environment: Sun Solaris Server, SAS V. 8.2, UNIX

Worked for the Computational Genomics Group as a Statistical Programmer setting up and analyzing simulations that dealt with the genotype/phenotype relationship.

Wrote and analyzed output independently from SAS macros and C/C++ programs on UNIX platform to simulate conditions found in genomics experiments.

Main project included writing SAS macro on SAS Version 8.2 in UNIX platform Sun Solaris server that produced a simulation of the different possibilities of what a third generation family of alleles would be given a random set of alleles for the first generation. Results were then statistically analyzed to confirm or deny their validity.

KForce.com, Tampa, FL 1/2000 to 4/2000

Biostatistician – client was pharmaceutical company named Romark Laboratories, L.C.

Environment: Mac-OS 8.0, SAS V 8.2, JMP

Functioned as a Biostatistician for Romark Laboratories, L.C. by setting up databases and analyzing datasets. Exposure and experience in phase II and III of clinical trials. Applied a wide array of tests, including Chi-Square, Fisher's Exact Test, T-tests, and Survival Analysis for developmental drug NTZ.

Wrote SAS data steps, (version 8.2), and used SAS procedures as well as JMP software in order to perform these analyses on Mac environment.

Decision Consultants Inc., Tampa, FL 4/1998 to 5/1999

Consultant & Instructor Assistant: Mainframe Programmer

Environment: IBM OS/MVS 0390

Trained employees in COBOL, VSAM, JCL, C and UNIX as a Consultant in Austin, TX and Tampa, FL locations; assisted instructor with lectures as well as assisted students with coding concepts, prepared materials, graded students’ papers and exams, and wrote and tested sample programs.

Main project was with client GTE. Wrote COBOL code as well as tested Y2K Security Systems applications for GTE: STOMPS (Security Toll Online Message Processing Systems) and GSAS (GTE Security Administration System) to ensure Y2K compliance. This work was performed on a Mainframe.

PUBLICATIONS

1: Huggins CJ, Mayekar MK, Martin N, Saylor KL, Gonit M, Jailwala P, Kasoji M, Haines DC, Quiñones OA, Johnson PF. C/EBPγ Is a Critical Regulator of Cellular Stress Response Networks through Heterodimerization with ATF4. Mol Cell Biol. 2015 Dec 14;36(5):693-713. doi: 10.1128/MCB.00911-15. PMID: 26667036; PMCID: PMC4760225.

2: Del Prete GQ, Shoemaker R, Oswald K, Lara A, Trubey CM, Fast R, Schneider DK, Kiser R, Coalter V, Wiles A, Wiles R, Freemire B, Keele BF, Estes JD, Quiñones OA, Smedley J, Macallister R, Sanchez RI, Wai JS, Tan CM, Alvord WG, Hazuda DJ, Piatak M Jr, Lifson JD. Effect of suberoylanilide hydroxamic acid (SAHA) administration on the residual virus pool in a model of combination antiretroviral therapy-mediated suppression in SIVmac239-infected indian rhesus macaques. Antimicrob Agents Chemother. 2014 Nov;58(11):6790-806. doi: 10.1128/AAC.03746-14. Epub 2014 Sep 2. PMID: 25182644; PMCID: PMC4249371.

3: Del Prete GQ, Park H, Fennessey CM, Reid C, Lipkey L, Newman L, Oswald K, Kahl C, Piatak M Jr, Quiñones OA, Alvord WG, Smedley J, Estes JD, Lifson JD, Picker LJ, Keele BF. Molecularly tagged simian immunodeficiency virus SIVmac239 synthetic swarm for tracking independent infection events. J Virol. 2014 Jul;88(14):8077-90. doi: 10.1128/JVI.01026-14. Epub 2014 May 7. PMID: 24807714; PMCID: PMC4097795.

4: Weiss JM, Gregory Alvord W, Quiñones OA, Stauffer JK, Wiltrout RH. CD40 expression in renal cell carcinoma is associated with tumor apoptosis, CD8 T cell frequency and patient survival. Hum Immunol. 2014 Jul;75(7):614-20. doi: 10.1016/j.humimm.2014.04.018. Epub 2014 May 4. PMID: 24801648; PMCID: PMC6266867.

5: Abram ME, Ferris AL, Das K, Quinoñes O, Shao W, Tuske S, Alvord WG, Arnold E, Hughes SH. Mutations in HIV-1 reverse transcriptase affect the errors made in a single cycle of viral replication. J Virol. 2014 Jul;88(13):7589-601. doi: 10.1128/JVI.00302-14. Epub 2014 Apr 23. PMID: 24760888; PMCID: PMC4054409.

6: Han SJ, Marshall V, Barsov E, Quiñones O, Ray A, Labo N, Trivett M, Ott D, Renne R, Whitby D. Kaposi's sarcoma-associated herpesvirus microRNA single- nucleotide polymorphisms identified in clinical samples can affect microRNA processing, level of expression, and silencing activity. J Virol. 2013 Nov;87(22):12237-48. doi: 10.1128/JVI.01202-13. Epub 2013 Sep 4. PMID: 24006441; PMCID: PMC3807933.

7: Huggins CJ, Malik R, Lee S, Salotti J, Thomas S, Martin N, Quiñones OA, Alvord WG, Olanich ME, Keller JR, Johnson PF. C/EBPγ suppresses senescence and inflammatory gene expression by heterodimerizing with C/EBPβ. Mol Cell Biol. 2013 Aug;33(16):3242-58. doi: 10.1128/MCB.01674-12. Epub 2013 Jun 17. PMID: 23775115; PMCID: PMC3753923.

8: Tabb B, Morcock DR, Trubey CM, Quiñones OA, Hao XP, Smedley J, Macallister R, Piatak M Jr, Harris LD, Paiardini M, Silvestri G, Brenchley JM, Alvord WG, Lifson JD, Estes JD. Reduced inflammation and lymphoid tissue immunopathology in rhesus macaques receiving anti-tumor necrosis factor treatment during primary simian immunodeficiency virus infection. J Infect Dis. 2013 Mar 15;207(6):880-92. doi: 10.1093/infdis/jis643. Epub 2012 Oct 19. PMID: 23087435; PMCID: PMC3571439.

9: Shiao YH, Leighty RM, Wang C, Ge X, Crawford EB, Spurrier JM, McCann SD, Fields JR, Fornwald L, Riffle L, Driver C, Kasprzak KS, Quiñones OA, Wilson RE, Travlos GS, Alvord WG, Anderson LM. Molecular and organismal changes in offspring of male mice treated with chemical stressors. Environ Mol Mutagen. 2012 Jun;53(5):392-407. doi: 10.1002/em.21701. PMID: 22674528.

10: Basu SK, Malik R, Huggins CJ, Lee S, Sebastian T, Sakchaisri K, Quiñones OA, Alvord WG, Johnson PF. 3'UTR elements inhibit Ras-induced C/EBPβ post- translational activation and senescence in tumour cells. EMBO J. 2011 Jul 29;30(18):3714-28. doi: 10.1038/emboj.2011.250. PMID: 21804532; PMCID: PMC3173785.

11: Shiao YH, Leighty RM, Wang C, Ge X, Crawford EB, Spurrier JM, McCann SD, Fields JR, Fornwald L, Riffle L, Driver C, Quiñones OA, Wilson RE, Kasprzak KS, Travlos GS, Alvord WG, Anderson LM. Ontogeny-driven rDNA rearrangement, methylation, and transcription, and paternal influence. PLoS One. 2011;6(7):e22266. doi: 10.1371/journal.pone.0022266. Epub 2011 Jul 12. PMID: 21765958; PMCID: PMC3134480.

12: Groth C, Alvord WG, Quiñones OA, Fortini ME. Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP. Mol Pharmacol. 2010 Apr;77(4):567-74. doi: 10.1124/mol.109.062471. Epub 2010 Jan 11. PMID: 20064975; PMCID: PMC2845938.

13: Wei BR, Hoover SB, Ross MM, Zhou W, Meani F, Edwards JB, Spehalski EI, Risinger JI, Alvord WG, Quiñones OA, Belluco C, Martella L, Campagnutta E, Ravaggi A, Dai RM, Goldsmith PK, Woolard KD, Pecorelli S, Liotta LA, Petricoin EF, Simpson RM. Serum S100A6 concentration predicts peritoneal tumor burden in mice with epithelial ovarian cancer and is associated with advanced stage in patients. PLoS One. 2009 Oct 30;4(10):e7670. doi: 10.1371/journal.pone.0007670. PMID: 19888321; PMCID: PMC2765613.

14: Shiao YH, Lupascu ST, Gu YD, Kasprzak W, Hwang CJ, Fields JR, Leighty RM, Quiñones O, Shapiro BA, Alvord WG, Anderson LM. An intergenic non-coding rRNA correlated with expression of the rRNA and frequency of an rRNA single nucleotide polymorphism in lung cancer cells. PLoS One. 2009 Oct 19;4(10):e7505. doi: 10.1371/journal.pone.0007505. PMID: 19838300; PMCID: PMC2759515.

15: Soman G, Yang X, Jiang H, Giardina S, Vyas V, Mitra G, Yovandich J, Creekmore SP, Waldmann TA, Quiñones O, Alvord WG. MTS dye based colorimetric CTLL-2 cell proliferation assay for product release and stability monitoring of interleukin-15: assay qualification, standardization and statistical analysis. J Immunol Methods. 2009 Aug 31;348(1-2):83-94. doi: 10.1016/j.jim.2009.07.010. Epub 2009 Jul 30. PMID: 19646987; PMCID: PMC2786060.

16: Walrath JC, Fox K, Truffer E, Gregory Alvord W, Quiñones OA, Reilly KM. Chr 19(A/J) modifies tumor resistance in a sex- and parent-of-origin-specific manner. Mamm Genome. 2009 Apr;20(4):214-23. doi: 10.1007/s00335-009-9179-4. Epub 2009 Apr 4. PMID: 19347398; PMCID: PMC2713021.

17: Gregory Alvord W, Roayaei JA, Quiñones OA, Schneider KT. A microarray analysis for differential gene expression in the soybean genome using Bioconductor and R. Brief Bioinform. 2007 Nov;8(6):415-31. doi: 10.1093/bib/bbm043. Epub 2007 Sep 29. PMID: 17906332

ACADEMIC WORK EXPERIENCE

Graduate Assistantship USF [8/1997-4/1998, 5/1999-12/1999]; Tampa, FL

Student Assistantship UPR–Mayagüez [1/1995-5/1995] Conducted study on Tensor Sums; coded algorithm in Pascal in order to run simulations on tensor sums; presented findings at a scientific conference; Mayagüez, Puerto Rico

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