KAREN E. VIGNEAU-CALLAHAN

Cell: 978-***-**** Home: 978-***-**** adt0cp@r.postjobfree.com

PROFESSIONAL SUMMARY

Highly skilled medical/research technologist with 25+ years of experience. Co-author of several published methodology papers. Worked as a Laboratory technician in a full service Independent Clinical Laboratory in chemistry, hematology, and toxicology. Participated in establishing and validating laboratory developed LC-MS-MS assays for pain and substance abuse clinics. Experienced in developing and validation of biomarker assays on a variety of analytical platforms for Research and Clinical testing.

CORE QUALIFICATIONS

Olympus AU640, AU640E and AU680

Cell-Dyn 3500R

ACL-1000 and ACL-Advance Coagulation Analyzer

Coulochem Electrode Array System (CEAS)

TDX Blood Chemistry Analyzer

1200 Infinity Series HPLC System

Densitometer

Spectrophotometer

Florometer

Hitachi 717

SMAC II

Agilent Technologies 6430 Triple Quad LC/MS

Cirascan Imagiing and Analysis System

SKILLS & EXPERIENCE

Performed biomarker testing following established Standard Operating Procedures (SOPs)

Generated standard and custom data reports to meet customers’ requirements

Collaborated with clients to establish timelines and resolve any issues regarding data reporting

Managed the receipt, storage, tracking and testing schedule of pre-clinical and clinical trial samples

Created data transfers according to agreed Data Transfer Specifications (DTS)

Monitored the maintenance and calibration of laboratory equipment

Fulfilled all ELISA multiplex tests for biomarkers in pre-clinical trials for R+D lab

Examined all plasma and serum samples for biomarkers for Oncology, Inflammatory and Neurodegenerative diseases

Completed sample testing for Quality Control and Service Departments, CLIA, as needed

Implemented all tests in the Chemistry, Hematology and Toxicology labs

Tested blood (whole, serum, plasma) and urine samples, and read blood smear slides

Prepared blood cultures and plating swabs, throat, and wound cultures

Conducted drug screening, rheumatoid arthritis, C-reactive protein, complete blood count, pro-thrombin times and Sed rates tests

Assisted in the writing, proofing, and publication of several methodology papers

EMPLOYMENT HISTORY

Lead Medical Technologist March 2018 – August 2022

Quanterix – Billerica, MA

Research Scientist March 2015 – January 2018

Aushon Biosystems – Billerica, MA

Medical Lab Technologist May 2002 – March 2015

Diagnostic Laboratory Medicine – Bedford, MA

EDUCATION

Bachelor of Science Degree

University of Massachusetts – Amherst, MA

PROFESSIONAL MEMBERSHIPS

American Society of Clinical Pathologists ASCP Reg. No: MLT029528

PUBLICATIONS

Kristal BS, Vigneau-Callahan KE and Matson WR, Simultaneous Analysis of the Majority of Low-Molecular-Weight, Redox-Active Compounds from Mitochrondria, Analytical Biochemistry 263, 18-25, 1998.

Kristal BS, Vigneau-Callahan KE, Moskowitz AJ and Matson WR Purine Catabolism: Links to Mitochondrial Respiration and Antioxidant Defenses, Arch. of Biochemistry and Biophysics 37, 22-33 1999.

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