CUILING (AMY) XU

Cell: 412-***-**** • E-mail: ads7t7@r.postjobfree.com

Professional Summary

Experienced scientist skilled in performing, conducting, and analyzing laboratory assays and resolving complex study and instrument problems. Extensive knowledge of molecular and cellular biology, virology, hematology, flow cytometry and chemistry. Professional Experience

2014-Present Research Instructor/Lab Coordinator

Department of Pathology, University of Pittsburgh, PA Research Responsibilities:

• Performed highly complex flow cytometric assays, functional studies and data analysis; Catalogued and monitored flow cytometric reagent and supply inventory; Cell separation from blood, tissues and fats; ELISA.

• Initiated and troubleshoot research protocols independently.

• Analyzed, interpreted, and presented data.

• Trained and guided new members on laboratory protocols. Lab Coordinator Responsibilities:

• Maintain detailed record of PI’s funding accounts.

• Handed the purchase and inventories of lab supplies, chemicals, and equipment.

• Interpreted and complied with laboratory regulations and EHS policies.

• Overhauling the onboarding process to ensure new members engagement in the lab in accordance with university policies.

• Handling waste disposal including biohazard waste, electronic waste, retired large equipment, sharp waste, and glasses.

• Coordinated with 3rd party vendors for annual preventative maintenance for freezer monitor systems, PCR machines, hoods, pipette calibration and lab inspections.

• On monthly basis, clean more than 22 freezers’ filters.

• On weekly basis, test and record that eye wash stations, safety equipment and NHP first Aids are in proper working order.

• On daily basis, checking the lab supplies and the freezers’ batteries and ordering. 2011-2014 Flow Cytometry Specialist/Lab Manager

Center for Vaccine Research, University of Pittsburgh, PA

• Flow-cytometry staining and functional studies; cell separation from blood and tissues; PCR and RT-PCR, cell cultures, ELISA.

• Created, implemented, standardized and revised laboratory techniques and test procedures.

• Handled and tested variety of non-human primate samples (blood and tissues) in the laboratory.

• Delegated operational tasks to the laboratory members.

• Trained and guided all lab assistants and undergraduate students, on laboratory procedures.

• Interpreted and complied with laboratory regulations.

• Procured all necessary laboratory supplies and maintained their adequate stock levels. 2007-2011 Postdoctoral Fellow in Biochemistry, The Ohio State University Columbus, OH

• Elucidated the conformational dynamics of DNA polymerases and protein-protein interaction by utilizing pre-steady state kinetic methodologies (rapid chemical quench, stopped-flow and single molecule FRET techniques).

• Established the productive method of purifying and labelling the proteins with fluorophores, which involved in the techniques: site-directed mutagenesis (PCR, primer design, molecular cloning, plasmid purification, cell culture), HPLC/FPLC chromatography, SDS-PAGE, western blot, gel electrophoresis, EMSA, UV-VIS and CD spectroscopes).

• Operated effectively the laboratory instruments including spectrophotometers, fluorometers and stopped-flow.

2004-2007 Postdoctoral fellow in Microbiology, SUNY at Buffalo, Buffalo, NY

• Aligned laser manipulator and established the optical laser tweezers single molecule systems (fluorescence spectroscopy, various data simulation, analysis and fitting programs).

• Purified and characterized intact EcoR124I holoenzyme in both bulk phases and single molecule level for the first time.

• Executed RecBCD helicase by ATPase, fluorescence and gel helicase assays and single molecule techniques.

2001-2003 PhD research assistant in Applied Biophysics, University of Fukui, Japan

• Synthesized and characterized uniform electroactive or functional surface group modified polystyrene microspheres for the attachment of peptides, proteins, oligonucleotides, and other biochemical by electrochemical voltammetries, Raman spectroscopy, SEM and elemental analysis. A mimic model of proteins/enzymes provides the electrochemical images of macromolecules in vitro and facilitates the drug discovery.

• Constructed and characterized in nano-environment oil/water interface. Education

9/2001 – 9/2004 University of Fukui, Japan

PhD in Physics, Department of Applied Physics

9/1998 - 7/2001 Wuhan University, China

M.S. in Chemistry, College of Chemistry and Molecular Science 9/1994 - 7/1998 Hubei University, China

B.S. in Chemistry, Department of Chemistry and Material Science Honors & Awards

Monbushou Scholarship in University of Fukui, Japan, 2003 Achievement of science of Hubei, China: “The study of sensor of heavy metal in water” Certificate Number: EK030, 2002

Excellent Graduate Student Awards, Wuhan University, 1998-2002 Blue Moon Prize, Wuhan University, 1998-2002

Academic Achievement Scholarship, Wuhan University, 1998-2002 Second-grade Scholarship Awards, Hubei University, 1997 Patent Application

2001 National patent: “A simple and highly sensitive mini-sensor for oxygen in solution” New practical Type, Certificate Number: 400544

Media Reports

1. http://researchnews.osu.edu/archive/dnaenzyme.htm 2. http://www.bionity.com/news/e/108629/

3. http://www.bionity.com/news/e/pdf/news_bionity.com_108629.pdf 4. http://news.upmcphysicianresources.com/2014/05/19/breakthrough-in-hivaids-researh

-gives-hope-for-improved-drug-therapy/

5. http://www.sciencedaily.com/releases/2014/05/140*********.htm Publications (* Corresponding author)

1. Kleinman AJ, Sivanandham S, Sette P, Sivanandham R, Policicchio BB, Xu C, Penn E, Brocca-Cofano E, Hingrat QL, Ma D, Pandrea I, Apetrei C. Changes to the Simian Immunodeficiency Virus (SIV) Reservoir and Enhanced SIV-Specific Responses in a Rhesus Macaque Model of Functional Cure after Serial Rounds of Romidepsin Administrations. J. Virol. 2022 Jun 22;96(12):e0044522. doi: 10.1128/jvi.00445-22. Epub 2022 May 31.

2. Kleinman AJ, Xu C, Cottrell ML, Sivanandham R, Brocca-Cofano E, Dunsmore T, Kashuba A, Pandrea I, Apetrei C. Pharmacokinetics and Immunological Effects of Romidepsin in Rhesus Macaques. Front Immunol. 2020 Dec 11;11:579158. doi: 10.3389/fimmu.2020.579158. eCollection 2020.PMID: 33362765 3. Sivanandham R, Kleinman AJ, Sette P, Brocca-Cofano E, Kilapandal Venkatraman SM, Policicchio BB, He T, Xu C, Swarthout J, Wang Z, Pandrea I, Apetrei C. Nonhuman Primate Testing of the Impact of Different Treg Depletion Strategies on Reactivation and Clearance of Latent Simian Immunodeficiency Virus. J. Virol., 2020 Jul 15:JVI.00533-20. 4. Raehtz KD, Barrenäs F, Xu C, Busman-Sahay K, Valentine A, Law L, Ma D, Policicchio BB, Wijewardana V, Brocca-Cofano E, Trichel A, Gale M Jr, Keele BF, Estes JD, Apetrei C, Pandrea I. African green monkeys avoid SIV disease progression by preventing intestinal dysfunction and maintaining mucosal barrier integrity. PLoS Pathog., 2020 Mar 2;16(3):e1008333.

5. He T, Xu C, Krampe N, Dillon SM, Sette P, Falwell E, Haret-Richter GS, Butterfield T, Dunsmore TL, McFadden WM Jr, Martin KJ, Policicchio BB, Raehtz KD, Penn EP, Tracy RP, Ribeiro RM, Frank DN, Wilson CC, Landay AL, Apetrei C, Pandrea I. High-fat diet exacerbates SIV pathogenesis and accelerates disease progression. J. Clin. Invest., 2019 Dec 2;129(12):5474-5488.

6. Barrenas F, Raehtz K, Xu C, Law L, Green RR, Silvestri G, Bosinger SE, Nishida A, Li Q, Lu W, Zhang J, Thomas MJ, Chang J, Smith E, Weiss JM, Dawoud RA, Richter GH, Trichel A, Ma D, Peng X, Komorowski J, Apetrei C, Pandrea I, Gale M Jr. Author Correction: Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control. Nat. Commun., 2019 Dec 13;10(1):5768. 7. Barrenas F, Raehtz K, Xu C, Law L, Green RR, Silvestri G, Bosinger SE, Nishida A, Li Q, Lu W, Zhang J, Thomas MJ, Chang J, Smith E, Weiss JM, Dawoud RA, Richter GH, Trichel A, Ma D, Peng X, Komorowski J, Apetrei C, Pandrea I, Gale M Jr. Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control. Nat. Commun., 2019 Nov 8;10(1):5101. 8. Brocca-Cofano E, Xu C, Wetzel KS, Cottrell ML, Policicchio BB, Raehtz KD, Ma D, Dunsmore T, Haret-Richter GS, Musaitif K, Keele BF, Kashuba AD, Collman RG, Pandrea I, Apetrei C. Marginal Effects of Systemic CCR5 Blockade with Maraviroc on Oral Simian Immunodeficiency Virus Transmission to Infant Macaques. J. Virol., 2018 Aug 16;92(17):e00576-18.

9. Policicchio BB, Cardozo EF, Sette P, Xu C, Haret-Richter G, Dunsmore T, Apetrei C, Pandrea I, Ribeiro RM. Dynamics of Simian Immunodeficiency Virus Two-Long-Terminal-Repeat Circles in the Presence and Absence of CD8+ Cells. J. Virol., 2018 Jun 13;92(13):e02100-17.

10. Policicchio BB, Sette P, Xu C, Haret-Richter G, Dunsmore T, Pandrea I, Ribeiro RM, Apetrei C. Emergence of Resistance Mutations in Simian Immunodeficiency Virus

(SIV)-Infected Rhesus Macaques Receiving Non-suppressive Antiretroviral Therapy

(ART). PLoS One, 2018 Feb 21;13(2):e0190908.

11. Brocca-Cofano E, Kuhrt D, Siewe B, Xu C, Haret-Richter GS, Craigo J, Labranche C, Montefiori DC, Landay A, Apetrei C, Pandrea I. Pathogenic Correlates of the Simian Immunodeficiency Virus (SIV)-Associated B Cell Dysfunction. J. Virol., 2017 Nov 14;91(23). pii: e01051-17.

12. He T, Brocca-Cofano E, Policicchio BB, Sivanandham R, Gautam R, Raehtz KD, Xu C, Pandrea I, Apetrei C. Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes. J. Immunol., 2016, 197(12):4535-4539. 13. Policicchio BB, Xu C, Brocca-Cofano E, Raehtz KD, He T, Ma D, Li H, Sivanandham R, Haret-Richter GS, Dunsmore T, Trichel A, Mellors JW, Hahn BH, Shaw GM, Ribeiro RM, Pandrea I, Apetrei C. Multi-dose Romidepsin Reactivates Replication Competent SIV in Post-antiretroviral Rehesus macaque Controllers. PLoS Pathog. 2016, 12(9):e1005879. 14. Pandrea I, Xu C, Stock JL, Frank DN, Ma D, Policicchio BB, He T, Kristoff J, Cornell E, Haret-Richter GS, Trichel A, Ribeiro RM, Tracy R, Wilson C, Landay AL, Apetrei C. Antibiotic and Antiinflammatory Therapy Transiently Reduces Inflammation and Hypercoagulation in Acutely SIV-Infected Pigtailed Macaques. PLoS Pathog., 2016, 12(1):e1005384.

15. X Hao, CM Lucero, B Turkbey, ML Bernardo, DR Morcock, C Deleage, CM Trubey, J Smedley, NR Klatt, LD Giavedoni, J Kristoff, C Xu, G Q Del Prete, BF Keele, SS Rao, WG Alvord, PL Choyke, JD Lifson, JM Brenchley, C Apetrei, I Pandrea, JD Estes, Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection. Nat. Commun., 2015, 18(6), 8020. 16. He T, Brocca-Cofano E, Gillespie DG, Xu C, Stock JL, Ma D, Policicchio BB, Raehtz KD, Rinaldo CR, Apetrei C, Jackson EK, Macatangay BJ, Pandrea I. Critical Role for the Adenosine Pathway in Controlling SIV-Related Immune Activation and Inflammation in Gut Mucosal Tissues. J. Virol., 2015, 89(18):9616-30. 17. Ma D, Xu C, Cillo AR, Policicchio BB, Kristoff J, Haret-Richter G, Mellors JW, Pandrea I, Apetrei C, Simian Immunodeficiency Virus SIVsab Infection of Rhesus Macaques as a Model of Complete Immunological Suppression with Persistent Reservoirs of Replication-Competent Virus: Implications for Cure Research., J. Virol., 2015, 89(11), 6155-6160.

18. Xu C, Maxwell BA, Suo Z, Conformational Dynamics of Thermus aquaticus DNA Polymerase I during Catalysis, J. Mol. Biol., 2014, 426(16). 2901-17. 19. Kristoff J, Haret-Richter G, Ma D, Ribeiro RM, Xu C, Cornell E, Stock JL, He T, Mobley AD, Ross S, Trichel A, Wilson C, Tracy R, Landay A, Apetrei C, Pandrea I, Early Microbial Translocation Blockade Reduces SIV-mediated Inflammation and Viral Replication, J. Clin. Invest., 2014, 124(6), 2802-6. Comment in JCI: Shan L, Siliciano RF: Unraveling the relationship between microbial translocation and systemic immune activation in HIV infection. J. Clin. Invest., 2014;124: 2368-2371. 20. Mandell DT, Kristoff J, Gaufin T, Gautam R, Ma D, Sandler N, Haret-Richter G, Xu C, Aamer H, Dufour J, Trichel A, Douek DC, Keele BF, Apetrei C, Pandrea I, Pathogenic Features Associated with Increased Virulence upon Simian Immunodeficiency Virus Cross-Species Transmission from Natural Hosts, J. Virol., 2014, 88(12), 6778-92. 21. BA Maxwell, C Xu, and Suo, Z* Conformational dynamics of a Y-Family DNA polymerase during substrate binding and catalysis as revealed by inter-domain Förster resonance energy transfer, Biochemistry, 2014, 53(11), 1768-78. 22. V Wijewardana, J Kristoff, C Xu, D Ma, G Haret-Richter, R Nusbaum, H Aamer, A Trichel, C Apetrei and I Pandrea,* Kinetics of Myeloid Dendritic Cell Trafficking and Activation: Impact on Progressive, Nonprogressive and Controlled SIV Infections, PLOS Pathogens, 2013, 9(10), e1003600.

23. I Pandrea, E Cornell, C Wilson, RM Ribeiro, D Ma, J Kristoff, C Xu, G.S. Haret-Richter, A Trichel, C Apetrei, A Landay, R Tracy, Coagulation biomarkers predict disease progression in SIV-infected nonhuman primates, Blood, 2012,120(7), 1357-66. 24. BA Maxwell, C Xu, Z Suo,* DNA lesion alters global conformational dynamics of Y-family DNA polymerase during catalysis, J. Biol. Chem. 2012, 287(16), 130**-*****. 25. C Xu, BA Maxwell, JA Brown, L Zhang and Z Suo,* Global conformational dynamics of a Y-family DNA polymerase during catalysis PLos Biol., 2009, 7, e1000225. 26. P R Bianco*, C Xu, M Chi, Type I restriction endonucleases are true catalytic enzymes, Nucleic Acids Res., 2009, 37, 3377-3390.

27. C Xu, MY Losytskyy, VB Kovalska, DV Kryvorotenko, SM Yarmoluk, S McClelland and PR Bianco,* Novel, monomeric cyanine dyes as reporters for DNA helicase activity, J. Fluoresc., 2007, 17, 671-685.

28. C Xu, K Aoki,* Enhancement of electrochemical activity by small-sizing the vinylferrocene-immobilized polystyrene latex particles, Langmuir, 2004, 20, 101**-*****.

29. C Xu, J. Chen*, K Aoki,* Partial charge transfer of poly(vinylferrocene)-coated latex particles adsorbed on pyrolytic graphite electrode, Electrochem. Commun., 2003, 5, 506-510.

30. J Chen*, C Xu, K Aoki,* Suspensions of poly(vinylferrocene)-coated latex particles, J. Electroanal. Chem., 2003, 546, 79-86.

31. C Xu, K Wu, S Hu*, D Cui, Electrochemical detection of parathion at a glassy carbon electrode modified with hexadecane, Anal. Bioanal. Chem., 2002, 373, 284-288. 32. S Hu*, C Xu, G Wang, D Cui, Voltammetric determination of 4-nitrophenol at a sodium montmorillonite-anthraquinone chemically modified glassy carbon electrode, Talanta, 2001, 54, 115-123.

33. S Hu*, C Xu, D Cui, Biosensor for detection of hypoxanthine based on xanthine oxidase immobilized on chemically modified carbon paste electrode, Anal. Chim. Acta, 2000, 412, 55-61.

34. S Hu*, C Xu, D Cui, Electrocatalytic reduction of dioxygen at the surface of glassy carbon electrodes modified by calix[6]arene-methyl viologen, Microchem. J., 2000, 65, 311-317.

35. S Hu*, C Xu, D Cui, Electrochemical oxygen sensor based on host-guest inclusion complex of calixarene and methyl viologen, Proceedings of SPIE, The International Society for Optical Engineering, 2000, 4077, 309-312. 36. C Xu, G Wang, S Hu,* The development of electrochemical biosensor of organophorus pesticides, Journal of Analytical Science, 2002, 18, 502-507. 37. G Wang; C Xu; S Hu,* Voltammetric Property and Analytical Application of Parathion at C(16) Chemically Modified Electrode, Journal of Analytical Science, 2001, 4, 303-306. Presentations & Seminars

Oral Presentations

1. BB Policicchio, EF Cardozo, C Xu, D Ma, T He, K Raehtz, R Sivanandham, A Kleinman, G Haret-Richter, T Dunsmore, C Apetrei, I Pandrea, R Ribeiro, CD8+ T cell depletion leads to a different profile of SIV viral decay under integrase inhibitor monotherapy. IAS 2017 (9th IAS conference on HIV Science) 23-26 July 2017, Paris, France, Abstract: TUAA0103.

2. C Xu, T He, G Haret-Richter, D Franck, BB Policicchio, E Brocca-Cofano, D Ma, J Stock, R Tracy, A Landay, C Wilson, C Apetrei, I Pandrea, Impact of a fat-rich diet on the pathogenesis of SIV infection in the African green monkey host. AIDS 2016 • 21st International AIDS Conference • 18 - 22 July 2016 • Durban, South Africa, Abstract: TUAA0102.

3. BB Policicchio, C Xu, D Ma, T He, K Raehtz, R Sivanandham, A Kleinman, N Krampe, G Haret-Richter, T Dunsmore, C Apetrei, I Pandrea, R Ribeiro, CD8+ cytotoxic T lymphocytes exert a strong cytolytic effect on virally-infected cells prior to viral integration in SIVmac251-infected rhesus macaques. AIDS 2016 • 21st International AIDS Conference • 18 - 22 July 2016 • Durban, South Africa, Abstract: THPDA0103. 4. T He, B Policicchio, E Brocca-Cofano, J Stock, C Xu, K Raehtz, T Gaufin, R Gautam, I Pandrea, C Apetrei, T regulatory cell depletion in controller macaques reactivates SIV and boosts CTLs. AIDS 2016 • 21st International AIDS Conference • 18 - 22 July 2016 • Durban, South Africa, Abstract: THAA0205.

5. E Brocca-Cofano, C Xu, D Ma, BB Policicchio, K Raehtz, T Dunsmore, G Haret-Richter, C Sykes, BF.Keele, ADM Kashuba, I Pandrea, C Apetrei, Oral administration of maraviroc, in infant rhesus macaques, fails to prevent SIVmac oral transmission. AIDS 2016 • 21st International AIDS Conference • 18 - 22 July 2016 • Durban, South Africa, Abstract: TUAC0101.

6. K Raehtz, G Haret-Richter, C Xu, BB Policicchio, C Barrenas, D Ma, V Wijewardana, E Brocca-Cofano, J Stock, A Trichel, B Keele, J Estes, M Katze, I Pandrea, C Apetrei, Characterization of early events of SIVagm dissemination following intrarectal inoculation in adult AGMs. AIDS 2016 • 21st International AIDS Conference • 18 - 22 July 2016 • Durban, South Africa, Abstract: WEAA0103. 7. E Brocca-Cofano, C Xu, D Ma, BB Policicchio, K Raehtz, T Dunsmore, G Haret-Richter, B Keele, I Pandrea, C Apetrei, Administration of maraviroc, a CCR5 receptor antagonist, in infant rhesus macaques blocks CCR5 receptor but fail to prevent SIVmac oral transmission. 33rd Annual Symposium on Nonhuman Primate Models for AIDS. 13rd-16th October 2015, Monterey Bay, Monterey, CA.

8. BB Policicchio, E Brocca-Cofano, C Xu, D Ma, T He, H Li, G Haret-Richter, T Dunsmore, G Shaw, R Ribeiro, I Pandrea, C Apetrei, Latency reversal Agent (LRA) romidepsin reactivates latent virus in two rhesus macaque (RM) models of controlled SIV infection in the absence of antiretroviral therapy (ART). 33rd Annual Symposium on Nonhuman Primate Models for AIDS. 13rd-16th October 2015, Monterey Bay, Monterey, CA. 9. BB Policicchio, E Brocca-Cofano, C Xu, D Ma, T He, H Li, G Haret-Richter, T Dunsmore, G Shaw, R Ribeiro, I Pandrea, C Apetrei, Latency reversal Agent (LRA) romidepsin reactivates latent virus in two rhesus macaque (RM) models of controlled SIV infection in the absence of antiretroviral therapy (ART). The 8th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015). 19th-22nd July 2015, Vancouver, Canada.

10. D Ma, S Ross, H Li, G Haret-Richter, R Anand, J Kristoff, C Xu, J Mellors, G Shaw, B Hahn, C Apetrei, Use of a new, transmitted founder SIV Strain (SIVsmmFTq) to achieve control of virus replication with conventional antiretroviral therapy (ART) in rhesus macaques (RMs), 20th International AIDS Conference, July 2014, Melbourne, Australia. 11. T He, E Brocca-Cofano, DG Gillespie, C Xu, J Kristoff, S Ross, D Ma, G Haret-Richter, CR Rinaldo, C Apetrei, EK Jackson, BJC Macatangay, and I Pandrea, Comparison between Pathogenic and Nonpathogenic SIV Infections and Focus on Mucosal Tissue Compartment Reveal a Critical Role for the Adenosine Pathway in the Control of SIV-Related Immune Activation and Inflammation, 20th International AIDS Conference, July 2014, Melbourne, Australia.

12. I Pandrea, G Haret-Richter, D Ma, R Ribeiro, C Xu, J Kristoff, K Raehtz, A Trichel, C Wilson, R Tracy, A Landay, & C Apetrei, Administration of Rifaximin and Sulfasalazine during Acute SIV Infection Decreases Microbial Translocation and Coagulation Marker Levels and Significantly Impacts Viral Replication 30th Annual Symposium on NHP Models for AIDS, October 2012, San Antonio, TX.

13. C Apetrei, D Ma, A Cillo, C Xu, J Kristoff, G.Haret-Richter, JW Mellors, I Pandrea, SIVagm infection of rhesus macaques: a model of functional cure with persistent reservoirs of replication-competent virus 30th Annual Symposium on NHP Models for AIDS, October 2012, San Antonio, TX.

14. D Ma, A Cillo, C Xu, J Kristoff, J Fang, G Haret-Richter, JW Mellors, I Pandre, C Apetrei, SIVagm infection of rhesus macaques: A model of functional cure with persistent reservoirs of replication-competent virus. “Towards an HIV Cure” International AIDS Society Symposium July 2012, Washington DC, Abstract: S7.1. 15. D Ma, A.Cillo, C Xu, J Kristoff, J Fang, G Haret-Richter, JW Mellors, I Pandre, C Apetrei, SIVagm infection of rhesus macaques: A model of functional cure with persistent reservoirs of replication-competent virus. XIX International AIDS Conference, July 2012, Washington DC, Abstract: THAA0104.

Poster Abstracts

1. C Xu, T.He, G Haret-Richte, DD Franck, BB Policicchio, E Brocca-Cofano, D Ma, J Stock, A Trichel, B Keele, M Katze, J Estes, C Apetrei, I Pandrea, Impact of a fat-rich diet on SIV pathogenesis. 33rd Annual Symposium on Nonhuman Primate Models for AIDS. 13rd-16th October 2015, Monterey Bay, Monterey, CA. 2. K Raehtz, G Haret-Richter, C Xu, BB Policicchio, C Barrenas, D Ma, V Wijewardana, E Brocca-Cofano, J Stock, R Tracy, A Landay, C Wilson, C Apetrei, I Pandrea, Characterization of early events of SIVagm dissemination following intrarectal inoculation in adult AGMs. 33rd Annual Symposium on Nonhuman Primate Models for AIDS. 13rd-16th October 2015, Monterey Bay, Monterey, CA. 3. E Brocca-Cofano, C Xu, D Ma, BB Policicchio, K Raehtz, T Dunsmore, G Haret-Richter, B Keele, I Pandrea, C Apetrei, CCR5 Blockade with Maraviroc Does Not Prevent SIVmac Oral Transmission to Macaques. 22nd Conference on Retroviruses and Opportunistic Infections, February 23rd- 26th, 2015, Seattle, Washington. 4. T He, E Brocca-Cofano, DG Gillespie, C Xu, J Kristoff, S Ross, D Ma, G Haret-Richter, CR Rinaldo, C Apetrei, EK Jackson, BJC Macatangay, and I Pandrea, Comparison between Pathogenic and Nonpathogenic SIV Infections and Focus on Mucosal Tissue Compartment Reveal a Critical Role for the Adenosine Pathway in the Control of SIV-Related Immune Activation and Inflammation, 20th International AIDS Conference, July 2014, Melbourne, Australia.

5. T He, E Brocca-Cofano, DG Gillespie, C Xu, J Kristoff, S Ross, D Ma, G Haret-Richter, CR Rinaldo, EK Jackson, BJC Macatangay, C Apetrei, and I Pandrea, Adenosine pathway is associated with the control of immune activation and inflammation in nonprogressive SIV infection, IMMUNOLOGY 2014 AAI Annual Meeting, May 2014, Pittsburgh, PA.

6. E Brocca-Cofano, B Siewe, D Kurt, C Xu, J Kristoff, D Ma, G Haret-Richter, DC Montefiori, A Landay, I Pandrea, C Apetrei, B cell subpopulations alteration in pathogenic and nonpathogenic SIV infections, IMMUNOLOGY 2014 AAI Annual Meeting, May 2014, Pittsburgh, PA.

7. T He, E Brocca-Cofano, DG Gillespie, C Xu, J Kristoff, S Ross, D Ma, G Haret-Richter, CR Rinaldo, EK Jackson, BJC Macatangay, C Apetrei, and I Pandrea, CD39/CD73/Adenosine Pathway in Progressive vs Non-progressive infections, March 2014, Boston, MA.

8. E Brocca-Cofano, B Siewe, D Kurt, C Xu, J Kristoff, D Ma, G Haret-Richter, DC Montefiori, A Landay, I Pandrea, C Apetrei, Dynamics of B Cell Subpopulations in Pathogenic and Nonpathogenic SIV infections, March 2014, Boston, MA. 9. D Ma, H Li, C Xu, B Keele, J Estes, J Lifson, I Pandrea, GM Shaw, BH Hahn, C Apetrei, Transmitted/Founder Infectious Molecular Clones of Divergent SIVsmm Strains Are Infectious and Replication Competent in Vivo, CROI 2013 20th Conference on Retroviruses and Opportunistic Infections, March 2013, Atlanta USA.

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