Shilpa Kiran

Scientist/Senior Research Associate

adri05@r.postjobfree.com 513-***-****

ABOUT ME

A highly accomplished Research & Development of Synthetic Chemistry and Analytical Chemistry, with 6+ years of professional experience. Excellent understanding of Synthesis and Analysis of various chemical pro-drugs area. I possess strong technological forte and proven ability to adapt to new environments.

PROFESSIONAL SUMMARY

Have 1+ years of experience in Analytical Chemistry

Have 5 years of experience in Research & Development

Analytical Department/Quality Control

Good experience on HPLC, GC and IR instruments

Expertise in determination of purity of Final compounds and other Raw materials by HPLC.

Experience in Method Validation Protocol Writing, Method Transfer Protocol Writing, and Analytical Method Writing.

Analysis of Raw Materials and Finished Products as per specifications and making the Final Reports of the same for house application and customers respectively.

Have knowledge of Chromatographic analysis such as tailing factor, resolution, theoretical plate count, peak purity, threshold capacity factor troubleshoots the instrumentation.

Maintaining laboratory notebook as per the FDA regulations cGMP requirement.

Preparation of Organic Molecules in Multi Steps Synthesis using various organic and inorganic reagents.

Innovative skill in synthesis of organic molecules by C-C bond and C-hetero atom bond formation via carbocation, carbanion, radical intermediates and by metal catalyzed reactions from lab scale to process development using anhydrous/under air reaction conditions

Preparation includes Small-scale ( 30 mg) and Large-scale ( 500 g)

Variety of Oxidation reactions.

Bond formation reactions like Suzuki, Buchwald type of couplings, and Reformtosky, Grignard reactions.

High pressure and high-temperature reactions using autoclaves and pressure tubes.

Purification techniques of Organic compounds using flash column chromatography, preparative thin layer chromatography and preparative HPLC techniques.

Handling of Biotage column for parallel purification (of 10 – 12 compounds), Genevac for parallel liquid evaporation and drying of the organic compounds and Microwave oven for high temperature reactions using microwave radiations.

Chiral synthesis (asymmetric synthesis)

Purification of the racemic mixture by HPLC methods and analyzing through Chiral – NMR techniques.

EDUCATION

Master of Science in Chemistry from Kuvempu University

Batchelor of Science in Physics, Chemistry & Mathematics from Kuvempu University

SKILLS

Designing and synthesis of organic molecules in Mg to Kg scale, transition metal catalyzed reactions, macro and micro-scale reactions, purification/separation methods and other basic laboratory techniques.

Hands-on experience in NMR spectrometer, preparative/semi-prep/analytical/ion-exchange HPLC, GC, IR, UV/Vis. Spectrometers.

Well-versed in interpreting NMR (1H, 13C) spectra, LC-MS data, IR, UV/Vis. spectra.

Experienced in both conventional and on-line literature search programmers (Scifinder, and Beilstein Cross Fire.).

Experienced with MS office, ChemDraw, ISIS, Nova (NMR), Mass hunter software and Origin.

PROFESSIONAL EXPERIENCE

Company: Galore Pharmaceuticals Pvt Ltd, Bangalore Duration: May 2020 - Nov 2021

Role: Scientist-Analytical chemistry

HPLC and Mass spectroscopy analysis for customized synthesis molecules for quality check.

Preformed finished product and stability sample testing using HPLC/ UV Visible Spectrometric analysis.

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Company: SYNGENE INTERNATIONAL LTD., Bangalore Duration: Feb 2007-Mar 2011

Role: Senior Research Associate

Synthesized and characterized complex organic small molecules for pharmaceutical drug development using reported or novel reaction schemes for Merck Serono projects, PTC, Astra Sweden.

Syngene International is in the business of exploration and production of complex organic molecules using reported or novel reaction schemes and has acquired technical capabilities in scaling up complex chemical and biochemical processes.

Company: Bio Organics, Bangalore Duration: Jun 2006 – Dec 2006

Role: Research Associate

The custom synthesis unit supplies various customized molecules in large scales to several highly reputed research units in Australia and USA.

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