Postdoctoral Fellow

Pierpaolo Cordone

mailto:*********@*******.**

**********@*****.*** +1-347-***-**** Tampa, FL

EDUCATION

Hunter College, City University of New York (CUNY), 2015 – 2021

PhD in Biochemistry

Università di Pavia / University of Pavia, Italy 2014

Pharmacist Licensure Examination

Università di Bologna / University of Bologna, Italy 2006 – 2013

Combined B.A./M.S. degree, Chemistry and Pharmaceutical Technologies, Passing grade: 107/110

John Jay College, Columbia University - Master's Thesis, September 2012 - February 2013

"Chiral organophosphates: separation and spectroscopic characterization"

Universitat de Valencia – Erasmus, September 2010 - September 2011

Exams of Pharmacology, Applied Pharmacology, Toxicology and Molcular Biology; Internship at pharmacy store Dr. Vicente Fullana

PROFESSIONAL EXPERIENCE

Postdoctoral Fellow, University of South Florida, February 2021 – present

Purification, biological evaluation, and characterization of metabolites extracted from pine rosin:

By using flash chromatography, MPLC and HPLC fractions of metabolites are isolated

The isolated fractions are then tested for TNF-α and COX2 activity

The fractions having the most promising activity are further purified to identify which specific molecules are the most active

Such purified metabolites are characterized via mass spectrometry and NMR

By using chromatographic editing anti-inflammatory formulas are generated by keeping the active molecule and eliminating the toxic molecules

The most active fractions are then tested for permeability assays (PAMPA)

Graduate Student, Hunter College/Brooklyn College, August 2015 – January 2021

Identification and synthesis of molecules against drug abuse:

By using structure activity relationship, a molecular scaffold has been rationalized

Docking simulation to identify potential effective and selective molecular candidates

Synthesis of Dopamine D3 receptor selective antagonist. This receptor has been discovered to be present only in a specific region of the brain (i.e. nucleus accumbens) and to be involved in drug-seeking and drug-craving behavior

Researcher Aboca S.p.a., Sansepolcro (Italy), February 2015 – July 2015

Research and development of methods for quantification of total polyphenol in artichoke leaf

Research and development of methods for quantification of total polyphenol and tannins in agrimony flower top

Quantification of total flavonoids in orange

Quantification of the concentration of total flavonoids in hawthorn

Administrative Assistant Biella Hospital (Italy), August 2014 – January 2015:

Management of the purchase and installation of medical instrument within the hospital:

Claim documentation to companies

Supervision of the documentation provided by the companies

Control of payments and deposits

Publication of tender notices and results on the website

Research Assistant Brooklyn College, July 2013 – June 2014:

Synthesis of potential anticancer molecules:

By using common methods, I synthesized gold-thiolate complexes to be attached to titanium complexes to synthesize heterobimetallic complexes. Those complexes may have special interest in anti-cancer research

Characterization of gold-thiolate complexes by NMR and IR

General organization of the lab

Weekly reports and monthly presentations of my experiments

Research Assistant Columbia University & John Jay College, September 2012 – June 2013:

Isolation, characterization and determination of absolute configuration of chiral organophosphates:

Enantiomeric separation of chiral organophosphates by using HPLC. Enantiomers of organophosphates have been separated from racemic mixtures commercially available. The separation has been performed through chiral column, modifying the following factors: flow, mobile phase, temperature, pressure

Spectroscopic characterization of chiral organophosphates by using optical rotatory dispersion (ORD), electronic circular dichroism (ECD) and vibrational circular dichroism (VCD)

Determination of the absolute configuration of chiral organophosphates by comparing experimental spectra with theoretical spectra, previously calculated with quantum chemical predictions

Research Assistant University of Bologna, Italy, March 2012 – July 2012:

Analysis of fluorescence of Lawsome's derivates properties and application to fingerprint detection

Synthesis of macromolecules using desoxyguanosine and porphyrins

Pharmacy Intern Bologna, Italy, October 2011 – February 2012:

Provided medications and associated services

Preparation of creams and solutions

General organization of the pharmacy and inventory stock

Pharmacy Intern Valencia, Spain, June 2011 - September 2011:

Provided medications and associated services

General organization of the pharmacy and inventory stock

SELECTED PUBLICATIONS:

New tetrahydroisoquinoline-based D3R ligands with an o-xylenyl linker motif.

Pierpaolo Cordone, Hari K.Namballa, Bryant Muniz, Rajat K. Pal, Emilio Gallicchio, Wayne W. Harding; Bioorg. Med. Chem. Lett. 2021.

First synthesis of thiazepino[3,4 a]isoquinolines, a facile new synthetic route to diazepino[3,4 a]isoquinolines and assessment of their dopamine and σ receptor affinities.

Pierpaolo Cordone, Hari Krishna Namballa, Wayne Wesley Harding; J. Heterocyclic Chem. 2020.

Tetrahydroisoquinoline-based D3R ligands with a phenyl linker motif

Cordone, Pierpaolo, Namballa, Hari Krishna, Muniz, Bryant, Pal, Rajat K.; Gallicchio, Emilio, Harding, Wayne; RSC Medicinal Chemistry, MD-RES-10-202*-******

New Dopamine D3- Selective Receptor Ligands Containing a 6- Methoxy- 1, 2, 3, 4- tetrahydroisoquinolin- 7- ol Motif. Gadhiya, Satishkumar; Cordone, Pierpaolo; Pal, Rajat K.; Gallicchio, Emilio; Wickstrom, Lauren; Kurtzman, Tom; Ramsey, Steven; Harding, Wayne W. ACS Medicinal Chemistry Letters (2018), 9(10), 990-995.

Inclusion of enclosed hydration effects in the binding free energy estimation of dopamine D3 receptor complexes. Pal, Rajat Kumar; Gadhiya, Satishkumar; Ramsey, Steven; Cordone, Pierpaolo; Wickstrom, Lauren; Harding, Wayne W.; Kurtzman, Tom; Gallicchio, Emilio. PLoS One (2019), 14(9), e0222902.

Diverse Approaches and Recent Advances in the Synthesis of Tetrahydroprotoberberines. Gadhiya, Satishkumar V.; Giri, Rajan; Cordone, Pierpaolo; Karki, Anupam; Harding, Wayne W. Current Organic Chemistry (2018), 22(19), 1893-1905.

Novel selective D3R antagonists with a 6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-ol "head" group.

Cordone, Pierpaolo, Gadhiya, Satish, Muniz, Bryant, Gallicchio, Emilio, Pal, Rajat K., Kurtzman, Tom, Harding, Wayne W. Poster presentation at the conference “Behavior, Biology, and Chemistry (BBC): Translational Research in Addiction”, San Antonio, Texas, TX, United States, March 2-3, 2019.

Design, synthesis and biological evaluation of D3 antagonists with an aryl linker motif.

Cordone, Pierpaolo; Muniz, Bryant; Gallicchio, Emilio; Pal, Rajat K.; Kurtzman, Thomas; Harding, Wayne W. Abstracts of Papers, 256th ACS National Meeting & Exposition, Boston, MA, United States, August 19-23, 2018 (2018).

Computational methodologies for studying the binding affinities of protein- ligand complexes by combining hydration and dynamical effects. Pal, Rajat Kumar; Ramsey, Steven; Cordone, Pierpaolo; Wickstrom, Lauren; Kurtzman, Thomas; Harding, Wayne W.; Gallicchio, Emilio. Abstracts of Papers, 256th ACS National Meeting & Exposition, Boston, MA, United States, August 19-23, 2018 (2018).

Facultad Latinoamericana de Ciencias Sociales (FLACSO) Quito, Ecuador, October 17-20, 2017

V Congreso Latinoamericano y II Congreso Ecuatoriano de Etnobiología. Domzalski, Alison; Cordone, Pierpaolo; Tavares De Almeida, Roberval. Oral and Poster presentation in Spanish, presenting author, entitled “Proyección etnobotánica en comunidades rurales y autóctonas del pacifico sur de Costa Rica” in symposium entitled “Etnobotánica, más allá de las plantas” on October 18/19. This presentation details work done in April 2017 in communities of Costa Rica whereby a multidiscliplinary team of biochemists, a biologist and an educator taught fishermen, indigenous people and farmers simple hydrodistillation techniques to extract essences from endemic plants.

Chiral organophosphates: Separation, spectroscopic characterization, and biological evaluation. Proni, Gloria; Estrada, Paola; Cordone, Pierpaolo; Hauzner, Shela; Kunjachan, Susan; Ben-Shabat, Shimon; Petrovic, Ana G. Abstracts of Papers, 245th ACS National Meeting & Exposition, New Orleans, LA, United States, April 7-11, 2013 (2013).

SKILLS & EXPERTISE

Laboratory: Organic Synthesis, NMR, Mass Spectrometry, UV/Vis, IR, HPLC, Chiral Chromatography, Inorganic Synthesis, Circular Dichroism.

Computer: ChemDraw, Schrödinger Maestro, MestRe Nova, Microsoft Office, Mac and PC Operating systems

HONORS & AWARDS

Travel award – February 2019 Winner of a travel award to attend “Behavior, Biology, and Chemistry (BBC): Translational Research in Addiction” Conference, San Antonio, Texas, TX, United States

Doctoral Student Research Grant (DSRG) – June 2018 Winner of a grant to attend conferences and buy equipment and software useful to my research.

“Cliff Soll” award – May 2018 Winner of a travel award to attend 256th ACS National Meeting & Exposition, Boston, MA, United States.

Thesis abroad - August 2012 Winner of a scholarship to study in the United States

Erasmus Exchange Program - September 2010 Winner of a scholarship to study in Spain

TEACHING EXPERIENCE

Organic Chemistry I & II recitation, John Jay College, Summer 2017, Summer 2021

Organic Chemistry I & II laboratory, Hunter College, Spring 2017 – Fall 2020

Organic Chemistry I laboratory, Brooklyn College, Fall 2017 – Spring 2017

LANGUAGE SKILLS

Native Language: Italian

English Certification: Advanced - TOEFL, 13/07/2013

Spanish Certification: Advanced - DELE C1, Instituto Cervantes, Madrid (España), 15/02/2012

MEMBERSHIP & LEADERSHIP

DSC representative for the Biochemistry PhD Program, April 2017 – September 2019.

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