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BIOCHEMIST

PhD in Molecular Biology

ORCID: https://orcid.org/0000-0002-7539-2382

Responsible for Research and Development Scientifiques PERSONAL INFORMATION

Name Luis CRUZ RODRIGUEZ

Address 27521 SW 134th CT 33032, Homestead, FL 33032, USA Telephone +1-813-***-**-**

E-mail adlc4y@r.postjobfree.com

Date (place) of Birth 7th November, 1978 (Cuba)

Prof. Dr. Luis CRUZ RODRIGUEZ does research in virology and Molecular Biology and Cell Biology. From 2002 he is focused in virology and Hereditary Cancer Diseases. Their most recent publication “A miRNA-Peptide fusion as a vaccine candidate against the novel Coronavirus (COVID-19)" is a key in RNA-peptide as antiviral mechanisms. completed with their article: "ELIDAN Certificate: BEHAVIOR is the key to save places from Covid-19"

FORMATION

2014: PhD in Physiology and Molecular Genetics: UNIVERSITY CLERMONT FERRAND 2, BLAISE PASCAL - CLERMONT FERRAND, France. http://www.theses.fr/2013CLF22423 2009 : MASTER in PROTEOME AND GENOMIC: UNIVERSITY PARIS VII, PARIS, France. Institut National de la Transfusion Sanguine, INSERM UMR-S 665, Paris, France, Université Paris 7/Denis Diderot, Paris, France

Reference : Dr. Marie Christine Lecomte adlc4y@r.postjobfree.com 2002: Graduated in Biochemistry (Bac+5): UNIVERSITY OF HABANA, Cuba. CURRICULUM VITAE 2020

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WORK EXPERIENCE

11/2013 05/2017: Manager Director of Research and Development in Biotechnology and Biopharmacie, CESA ALLIANCE SA, 80, Rue des Romains, L-8041 Strassen, Luxembourg 01/2010 02/2011: Post Doc : Responsable of Research, PROTENIA SA Université de AL AKHAWAYN, Marocco

2007 2010: Molecular Screening using SSCP, PCR ARMS of breast cancer in Cuban population. Collaboration with l'IARC, Lyon France 09/2002 07/2007: Research Biochemist, National institute of Genetics Diseases, INGM, 31 Esq. 146 N 3102, Havana, CUBA.

COMPETENCE

Culture Gel, Electrophoresis, DNA Gene Expression, Western Blot, Southern Blot, Analysis Cloning, Electrophoresis, DNA Isolation, DNA Extraction, DNA Sequencing, RNA Isolation, Reverse Transcription, SDS-PAGE, DNA Amplification, PCR/ Hot PCR/ RT PCR/ ARMS PCR/ qPCR, Immunofluorescence RNA, Transfection RNA, DNA Gel Electrophoresis, Agarose Gel Electrophoresis, Culture Bacterial, Protein Expression, Protein Purification, Cell Culture, Molecular Genetics, Extraction Cell Line, Genetic Engineering, Bacterial Transformation, Restriction Digestion, Plasmid Cloning, Plasmid Extraction, Plasmid Expression, Confocal Microscopy, Protein Sequencing, Bioinformatics Analysis of DNA Sequences, Bioinformatics Analysis of Protein Sequences, DNA vaccine design, RNA-Protein vaccine design, Protein vaccine design. SCIENTIFIC PUBLICATIONS

PUBLICATION

1. Ziarati P., Amina Sultan, Bahareh Kamyab-Moghadas, Faezeh Shirkhan, Cruz– Rodriguez L., Akanksha Juneja. “An insight into the prevailing trends of self-immunity and lifestyle in protection from Covid-19 amongst the health care workers": J MED DISCOV (2020); 5(4): JMD20065; DOI:10.24262/JMD.5.4.20065. http://www.e- discoverypublication.com/wp-content/uploads/2020/11/JMD20065.pdf 2. AHMADREZA FATAHI, ZIARATI P, AFSHIN JAFARPOUR, CRUZ-RODRIGUEZ L.

“Heavy Metal Removal from Edible Leafy Vegetable by Low Cost Novel Adsorbents: Hazelnut Shell ": J SCI DISCOV (2020); 4(2): JSD20039; DOI:10.24262/JSD.4.2.20039. http://www.e-discoverypublication.com/wp-

content/uploads/2020/11/JSD20039.pdf

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3. CRUZ-RODRIGUEZ L., ZIARATI P., HOCHWIMMER B., KAABAR M., BIN ZHAO. DILSIZ N., SANCHEZ BATISTA L., BAREA R., PELAEZ Y. “A DNA-PEPTIDE FUSION AS A VACCINE CANDIDATE AGAINST BREAST AND OVARIAN CANCER METASTASIS: CONSEQUENT BENEFIT IN CERTAIN LUNG CANCER": J B & BIO ENGINE 2020. DOI : DOI.ORG/10.47485/2693-2504.1021 4. SEPIDEH TAJIK, PARISA ZIARATI, CRUZ-RODRIGUEZ L. Coffee Waste as Novel Bio- adsorbent : “ Detoxification of Nickel from Contaminated Soil and Coriandrum Sativum“ 2020. Journal of Bioscience & Biomedical Engineering. DOI : doi.org/10.47485/2693- 2504.1019

5. KAMYAB-MOGHADAS B., ZIARATI P., CRUZ-RODRIGUEZ L. “BREAST CANCER DISEASE AND ARSENIC : GEOLOGY BEHAVIOR AS KEY “ 2020 Gynecology and Women’s Health Care. https://unisciencepub.com/storage/2020/09/Breast-Cancer- Disease-And-Arsenic-Geological-Behavior-Gbr-As-Key.pdf 6. TAIBI BEN HADDA, FAISAL A. ALMALKI, MALIKA BERREDJEM, VESNA RASTIJA, AMMAR BADER, JOAZAIZULFAZLI JAMALIS, TALHA BIN EMRAN, TAREQ ABU- IZNEID, EMAN ESHARKAWY, LUIS CRUZ-RODRIGUEZ "How to face COVID-19: Proposed Treatments based on Remdesivir and Hydroxychloroquin in presence of Zinc- sulfate and POM Theory" Elsevier Editorial (Revision) 7. ZHAOXUAN WANG, ZHIYU YU, CHANGLIN TIAN, CRUZ-RODRIGUEZ L, SANCHEZ BATISTA L and BIN ZHAO. "Differential equation analysis on COVID-19“ 2020. Journal : Clinical Research and Clinical Trials Volume 2, Issue 1. https://www.auctoresonline.org/images/currentissue/1595488878Differential_equation_ analysis_on_COVID.pdf

8. CRUZ-RODRIGUEZ L., RODOLFO BAREA, ZAYAS TAMAYO A.M., HOCHWIMMER B., BEN HADDA T., ALMALKI F. A., LAMBERT BROWN D, PELAEZ FIGUEROA Y., SANCHEZ BATISTA L. and WARAD I. "ELIDAN Certificate: BEHAVIOR is the key to save places from Covid-19", July 2020, Journal of Bioscience & Biomedical Engineering, Volume 1, Issue 2 DOI : doi.org/10.47485/2693-2504.1014 9. CRUZ-RODRIGUEZ L, SANCHEZ BATISTA L, HOCHWIMMER B, BIN ZHAO and ZIARATI P. " The mathematical formula to estimate the Exosome Affinity between miRNA-peptide and Exosome : ALGORITHM “CRUZRODRIGUEZ (EA) “2020 ; Journal of Bioscience & Biomedical Engineering, Volume 1, Issue 2 DOI : doi.org/10.47485/2693-2504.1012

10. CRUZ-RODRIGUEZ L., SANCHEZ BATISTA L., HOCHWIMMER B., TAIBI BEN HADDA, ALMALKI F.A., DILSIZ N., CAPARROS J.L., LAMBERT BROWN D., ZIARATI CURRICULUM VITAE 2020

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P., ZAYAS TAMAYO A.M., PELAEZ FIGUEROA Y., HERRERA SANCHEZ M.B., GARCIA HERNANDEZ A., BIN ZHAO. “How to Evaluate Viral Transmission in Enclosed Areas. Medical Geology saving places from Covid-19” Journal of Bioscience & Biomedical Engineering; 2020, vol 1, issue 1. DOI : doi.org/10.47485/2693-2504.1009 11. ZIARATI P., HOCHWIMMER B., LAMBERT BROWN D., MORADI M. and CRUZ- RODRIGUEZ L;" Breast Cancer disease and Heavy Metal: Cadmium as Key in “Medical Geology”: G Women’s Health Car; 2020. vol 2 issue 2 https://unisciencepub.com/wp- content/uploads/2020/06/Breast-Cancer-disease-and-Heavy-Metal-Cadmium-as-Key-in- Medical-Geology.pdf

12. CRUZ-RODRIGUEZ L., DILSIZ N., ZIARATI P., LAMBERT BROWN D., HOCHWIMMER B., ZAYAS TAMAYO AM., SANCHEZ BATISTA L., MORADI M. "A miRNA-PEPTIDE FUSION AS A VACCINE CANDIDATE AGAINST THE NOVEL CORONAVIRUS

(COVID-19). EXOSOMES AS POTENTIAL BIOMARKERS OF SARS-COV-2 IN LUNG: AFTER AND BEFORE VACCINATION LCR_2020_B008-13" J B & Bio Engine; 2020. DOI : doi.org/10.47485/2693-2504.1005

13. CRUZ-RODRIGUEZ L., ZAYAS TAMAYO AM., SANCHEZ BATISTA L., LAMBERT BROWN D., HOCHWIMMER B. and ZIARATI P.;"A Novel vaccine candidate with double antiviral activity against the HIV-1 and Covid-19": International Journal of Infectious Diseases and Research,I J Infectious Disea; 2020. DOI : doi.org/10.47485/2693- 2326.1002

14. CRUZ-RODRIGUEZ L, CRUZ-RODRIGUEZ LD, SANCHEZ BATISTA L, HOCHWIMMER B.:" Calculation of Fusion Stability of [DNA or RNA] - Peptide (FS) Algorithm “Cruz-Rodriguez“J B & Bio Engine; 2020, vol 2, issue 1.DOI : doi.org/10.47485/2693-2504.1003

15. CRUZ-RODRIGUEZ L., LAMBERT BROWN D., HOCHWIMMER B., SELINUS O., CRUZ-RODRIGUEZ LD., CRUZ-RODRIGUEZ ME., ZAYAS TAMAYO AM. and SANCHEZ BATISTA L.; “A RNA-Peptide fusion as a vaccine candidate against the novel Coronavirus (COVID-19)”; Journal of Diabetes and Endocrinology Research 2020 April 2nd, 2020: J Diabetes Endocrinol Res; 2020: vol 2 issue 1. DOI : doi.org/10.47485/2693- 2458/1010

16. Hochwimmer B., Ziarati P., Selinus O., Elwej A., Lambert Brown D., Zayas Tamayo AM., Moradi M., Cruz-Rodriguez L., “A predictive geological tool of Type3 Diabetes

(Alzheimer's disease): The Polygonal Vortex Mineralisation Model a Medical Geology perspective”; Journal of Diabetes and Endocrinology Research 2020 April, 2020 Volume 2, Issue 2. DOI : doi.org/10.47485/2693-2458/1011

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17. Cruz-Rodriguez L.; “High performance liquid chromatography as acceptance criteria in antiviral capsules”; June 08-09, 2018 Philadelphia, USA. https://www.longdom.org/proceedings/high-performance-liquid-chromatography-as- acceptance-criteria-in-antiviral-capsules-12020.html 18. Cruz-Rodriguez L.; “Glycosylation and PARP polymerase activities as b: Biomarkers and drug targets in cancer diseases” ; May 23-24, 2018 New York, USA https://www.longdom.org/proceedings/glycosylation-and-parp-polymerase-activities-as- b-biomarkers-and-drug-targets-in-cancer-diseases-42224.html 19. Garreau-Balandier I, Lefebvre M, Jacquard S, Caillat S, Cruz-Rodriguez L, Ishak L, Agier V, Morel F, Lachaume P, Dubessay P, Sauvaigo S, Alziari S, Vernet P. ; “A comprehensive approach to determining BER capacities and their change with aging in Drosophila melanogaster mitochondria by oligonucleotide microarray ” FEBS Lett. 2014 May 2 ;588(9):1673-9. doi: 10.1016/j.febslet.2014.03.008. Epub 2014 Mar 15. 20. Cruz Rodriguez L. “ Réparation par excision de base au niveau mitochondrial chez la drosophile. Analyse d'un acteur potentiel de ce processus : la protéine PARP” . 2013. https://www.theses.fr/2013CLF22423, https://tel.archives-ouvertes.fr/tel-009*****-**. Hochwimmer B. and Cruz-Rodriguez L.; “The Polygonal Vortex Mineralisation Model: a predictive tool of health indices and the proposed use of such « geologically based public health indices » as a sub discipline of Medical Geology”. 2005, ISBN 969-***-**** 22. Cruz-Rodriguez L., Hochwimmer B. and Selinus O.; “Medical Geology in Cuba. 2005, ISBN 969 7117 03 7

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DIVERS

• Spanish (mother language) ·

• English (well-read, written and spoken)

• French (well-read, written and spoken)

• CEO of ELIDAN genome SAS https://fr.kompass.com/c/elidan-genome/fra04x9cl/

• CEO of ELIDAN dynamic LLC, Florida, USA

REFERENCES

1. Pr. Patrick VERNET (http://rgm.univ-bpclermont.fr/spip.php?rubrique5) patrick.vernet@univ- bpclermont.fr

2. Pr. Jean-Marc LOBACCARO (https://www.gred-clermont.fr/directory/member/jean-marc- lobaccaro/)<adlc4y@r.postjobfree.com> ) 3. Dr. Eriel Martinez. adlc4y@r.postjobfree.com

(https://www.researchgate.net/profile/Eriel_Martinez?page=1&sorting=citationCount) 4. Dr. Tito Eduardo Junco-Russeau, adlc4y@r.postjobfree.com https://www.nhs.uk/Services/hospitals/Services/Service/Team/DefaultView.aspx?id=8582 5. Pr. Olle Selinus ; http://www.conem.org/people/selinusbio/ 6. Dr. José Yelamos ; https://www.imim.cat/programesrecerca/cancer/en_polimerases.html

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