Organic chemistry, MS-based Proteomics, Photo proximity labeling tools

DR AFSANEH TAHERI KAL-KOSHVANDI

Andisheh, Tehran, Iran Zip • 335-***-****, *****************@*****.*** Afsaneh Taheri is a Ph.D., in Organic Chemistry at Alzahra University, Tehran, Iran with 3 years of PostDoc experience, Afsaneh Taheri is experienced in: Scientific (Organic chemistry; Heterocyclic chemistry, Click chemistry; Green chemistry; Pharma; Biological chemistry (MS-based proteomics, photo- proximity protein labeling tools,..); Material Chemistry; Analytical chemistry); and Chemical engineering. She has more than 12 years of academic experience in organic chemistry with 2 years of experiences in mass spectroscopy based proteomics; protein labeling tools, cell culture, protein-protein interaction, protein purification and characterization, mass spectroscopy, statistical data analysis, bioinformatics, and other related analysis. Also, she has excellent writing expertise. Proven track record of initiating and delivering successful projects.

RESEARCH INTEREST

Photocatalytic proximity labeling

Light-activate labeling

MS-based Proteomics

Asymmetric synthesis

Photochemistry

Biological chemistry

Organic chemistry

Total synthesis

Click chemisty

EDUCATION

Ph.D. in Organic Chemistry Sep 2012 - March 2018

Department of Chemistry, Alzahra University, Tehran, Iran, Tehran Thesis: Click chemistry, biopolymers, grafting, catalysis, multi-step reactions and natural products Advisor: Dr Majid M. Heravi

Master of Science in Organic Chemistry Sep 2008 - Sep 2011 Department of Chemistry, Razi University, Kermanshah, Iran Thesis: Synthesis of alkylnitriles based on cyanide and isocyanide multicomponent reactions, Ionic liquids, one-pot synthesisAdvisor: Dr Mohammad M. Khodaei & Dr Ebrahim Soleimani Bachelor of Science in Chemistry Sep 2003-Sep 2007 Department of Chemistry, Razi University, Kermanshah, Iran EMPLOYMENT

Postdoctoral researcher December 2018 – 2022 9 February Iran National Science Foundation and Iran Technology and Science University, Tehran, Iran Project title: Design, synthesis and application of zeolit-based magnetic nanocomposites in the organic synthesis. Working on MOFs, Zeolites, Magnetic Nanoparticles, Biopolymer composites, Biosensors, Antimicrobial tests, Green chemistry, 1,3-dipolar reaction

Editor

Materials & Interfaces Journals 2023-Present

S K I L L S A N D A C C O M P L I S H M E N T S

Organic chemistry and related techniques like Purification methods for organic compounds such as: TLC, HPLC, Column Chromatography, Anti-solvent crystallization and Filtration, Evaporation of Liquid Phase and Then Rub with a Spatula, Distillation, Extraction, Adsorption, Sublimation, Recrystalization, Automated flash chromatography

Characterization techniques in organic chemistry & Material chemistry: solid phase chromatography methods, NMR, MS, EM, EDX, FT-IR, TGA, XRD, BET, Uv-Visible, ICP–OES, TEM, XPS, VSM, DSC, DTA, GC, Ultrasonication and other methods

Proteomics: Mass spectroscopy-based proteomics, Cell Culture, 2D-Electrophoresis, Sample preparation, Depletion, Protein Chromatography and HPLC, LC/MS-based proteomics, Flow cytometry, Western blotting, SDS-PAGE, Elisa plate reader, Volcano plot, Protein-protein interaction, Protein purification, Protein Characterization, Drug-biomarker interaction, Biomarker detection

Bioinformatics: such as; biological sequence database, BLAST and FASTA, search tools (Like Unprot, Ensemble, NCBI, Gene), For peptide sequence: Mascot, SEQUEST, MaxQuant, Tandom X!..), Bioinformatic (like String, KEGG, BioGRID, Statistical data analysis methods for Biologists (like PCA )

Biological chemistry and Medicinal chemistry

Assay Development, Process analytical chemistry

Photocatalytic proximity labeling tools, Mapping tools, Protein Crosslinking (Chemical/UV), Photo- affinity labeling, Photo-uncaging, Photosensitizers,..

Bioconjugation, Biosensor, Antimicrobial tests (Colony Forming Unit)

Synthetic database (Reaxys, SciFinder,..)

Highly competent in organic synthesis skills with up-to-date knowledge of synthetic reagents, synthetic methods, reaction mechanisms, and conformational analysis

Physicochemical properties of molecules

Material chemistry: Nanomaterials, Metal-polymer nanoparticles, Porous compounds, MOFs, Zeolites, Film formation, Polymer Grafting, Hydrogel polymers, Carbonization, Magnetic nanocomposites,..

Ability to coordinate and manage research projects, work productively with others, recognize and highlight key information

Independent scientific records and review writing

Knowledge in NMDA and AMPA receptors in brain and their functions

Ionic Liquids and Deep eutectic solvents

Heterocycles, Natural products, Catalysis, Metal-complex catalysis

Multi-step & multicomponent reactions, Click chemistry, Green Chemistry, Isocyanide reactions RESEARCH EXPERIENCES

Postdoctoral Researcher / Iran National Science & Foundation (INSF) & Iran University of Science & Technology, Tehran, Iran 2/2018- 02/2022

Designed, and synthesized porous magnetic polymer-based nanocomposites (Zeolite & MOFs) in organic synthesis and maintained their porosity

Won Iran National Science Foundation (INSF) award

Finished the project with obtained remarkable results and established their antimicrobial activity

Introduced a new synthetic path for Silicalite-1 as a Zeolite

Launched synthesis of ultrapure HKUST MOFs for tetrazole derivative synthesis in one, two, three, and four-component reactions

Fabricated metal-polymeric nanoparticles, magnetic core-shell nanoparticles & metal-complexes with increased efficiency

Pioneered the successful use of the Eu-complex as a catalyst

Collaborated closely with other scientific communities and laboratories

Guided and inspired junior students in their research activities

Interpreted results, tables, and curves, also wrote, revised, and submitted manuscripts, and determined proposed referees during the submission process.

Prepared one review on the topic of optical biosensors

Actively attended courses and conferences to help the scientific community’s knowledge Doctoral / Alzahra University, Tehran, Iran 2012-2018

Innovated new polymer film hydrogels (copper nanoparticles embedded in polyvinyl alcohol grafted acrylic acid) via ultrasonication

Assessed their antimicrobial activity to use in click reaction (1,3-dipolar cycloaddition), film capacitor ( because of high-temperature resistance), and biomedicine

Implied multistep reactions in the synthesis of quinolines and bis(indolyl)methanes using starch-coated Fe3O4 nanoparticles

Performed formylation, oxidation, and N-arylation reactions, as well as Sonogashira couplings, 5 and 7- membered heterocycles, and bioconjugation

Conducted experimental evaluations, and data analysis to ensure the reliability and effectiveness of the proposed methods

Actively participated in and organized laboratory meetings and clean-up efforts

Purified and characterized synthetic compounds, then calculated and optimized data to publish.

Published three reviews as a main author in asymmetric synthesis, and one other review in multicomponent reactions

Supervised bachelor and master students

Graduate student/ Razi University, Kermanshah, Iran 2008-2011

Carried out research tasks following established procedures effectively

Investigated multicomponent reactions, Knoevenagel condensation and reduction, one-pot reactions, new synthetic methodologies, Isocyanide and Cyanide reactions

Applied Ionic Liquids, non-expensive catalysts and green conditions

Synthesized Benzo-oxazines, β-cyanocarbonyls, Xanthenes, Tetrahydrobenzo[b]pyrans

Identified many new organic compounds with improved procedure

Formulated new path to synthesize of alkyl nitriles with sodium cyanide and the use of un-expensive catalysts like Bicl3 for xanthenes

Presented at conferences to assist the scientific community’s knowledge

Read articles and books, biult an experimental process and examined new routs

Assisted with: research implementation, data collection, data observation/entry, and lab maintenance Other research activities, Iran 2022-Present

Enhanced experiences in photo-catalytic proximity labeling tools, Light activate labeling methods, MS- based proteomics, bioinformatics and required skills such as cell culture, mass spectroscopy,..

Provided one review and running some projects in photocatalytic proximity labeling

Devised self-assembly and supramolecular chemistry techniques (self-assembly of novel Tröger's base

(TB)-oligophenyleneethynylene derivatives (OPE))

Extended usage of Deep Eutectic Solvents (DESs) in medicinal chemistry, Nanotechnology, chemical engineering, and organic reaction

Created new types of DESs, Supramolecular DESs & Supported DESs

Instructed one book & 2 review papers about Deep Eutectic Solvents HONORS & AWARDS

Selected to receive a Funding Grant from Iran National Science Foundation (INSF) for my postdoctoral project.

Ranked 44th in the nationwide doctoral exam in Iran, 2012

Ranked 1st in the doctoral exam in Alzahra University, 2012

Achieved the best test score among all students in the doctoral comprehensive exam, 2014

Selected as a Outstanding student in MSc and PhD and as a Postdoc TEACHING EXPERIENCE

Razi University, Azad Islamic University and Payam Nour University, The courses taught are as follows:(General Chemistry, Organic Chemistry) 2018-Peresent

VOLUNTEER EXPERIENCE

Scientific committee/ Graphene 2D Materials 2023

Reviewer 01/2020- present

Peer-Reviewed Articles for:

1. journal, Journal of Inorganic and Organometallic Polymers and Materials ISSN: 1574-1451 2. journal, Journal of Inorganic and Organometallic Polymers and Materials ISSN: 1574-1443 3. journal, Polycyclic Aromatic Compounds ISSN: 1563-5333 4. journal, Research on Chemical Intermediates ISSN: 1568-5675 5. journal, Research on Chemical Intermediates, Springer Nature ISSN: 0922-6168 6. Journal of Advanced Research

7. New Journal of Organic Chemistry

Seminar Reviewer:

10th National Seminar of Chemistry and Environment, Quchan University of Technology, Iran 2021 CONFERENCES

World Academy of Science, Engineering, and Technology 2010 PUBLICATIONS

1. A.T. Kal-Koshvandi. Recent advances in optical biosensors for the detection of cancer biomarker α-fetoprotein

(AFP), TrACTrens in analytical chemistry. 2020,128: 115920. DOI: 10.1016/j.trac.2020.115920. As a sole author and corresponding author.

2. E. Soleimani, M.M. Khodaei, A.T. Kal-Koshvandi. The efficient synthesis of 14-alkyl or aryl 14H-dibenzo [a, j] xanthenes catalyzed by bismuth (III) chloride under solvent-free conditions. Chinese Chemical Letters. 2011, 22(8): 927-930.

3. A. T. Kal-Koshvandi, A. Maleki, A. Tarlani, M. Soroush. Synthesis and Characterization of Ultrapure HKUST 1 MOFs as Reusable Heterogeneous Catalysts for the Green Synthesis of Tetrazole Derivatives, ChemistrySelect, 2020,5(11):3164-3172, As a first author and corresponding author. 4. A.T. Kal-Koshvandi, M.R. Ahghari, A. Maleki, Design and Antibacterial Activity Assessment of “Green” Synthesized 1,4-disubstituted 1,2,3-triazoles via a Fe3O4/Silicalite-1/PVA/Cu(I) nanocomposite catalyzed three component reaction, New Journal of Chemistry, 2020, 44(29):126**-*****. DOI: 10.1039/d0nj01984d. As a first author and corresponding author.

5. T. Tamoradi, A.T. Kal-Koshvandi, A. Maleki,… Synthesis of Eu(III) fabricated spinel ferrite based surface modified hybrid nanocomposite : Study of catalytic activity towards the facile synthesis of tetrahydrobenzo [b] pyrans, Journal of Molecular Structure, 2020,1219:128598. DOI: 10.1016/j.molstruc.2020.128598. As a corresponding author.

6. A.T. Kal-Kashvandi, M.M. Heravi, S. Ahmadi, T. Hosseinnejad. Copper Nanoparticles in Polyvinyl Alcohol– Acrylic Acid Matrix: An Efficient Heterogeneous Catalyst for the Regioselective Synthesis of 1, 4-Disubstituted 1, 2, 3-Triazoles via Click Reaction. Journal of Inorganic and Organometallic Polymers and Materials 2018, 28(4):1457-67, As a first and main author.

7. E. Soleimani, M.M. Khodaei, A.T. Koshvandi. One-pot three-component reaction: Synthesis of substituted β- cyanocarbonyls in aqueous media. Comptes Rendus Chimie. 2012,15(4):273-7. 8. A.T. Kal-Koshvandi, M.M. Heravi. Applications of Danishefsky’s dienes in asymmetric Oxo-Diels-Alder reactions. Tetrahedron: Asymmetry. 2017;28(11):1506-56, As a first and main author. 9. A.T. Kal-Koshvandi, A. Maleki,… Immobilization of La on THH-CO2H@Fe3O4 nanocomposite for the synthesis of one pot multicomponent reactions, Materials Research Express, 2021,8 (5):056101. As a corresponding author.

10. E. Soleimani, M.M. Khodaei, A.T. Koshvandi. Three-Component, One-Pot Synthesis of Benzo [b][1, 4] oxazines in Ionic Liquid 1-Butyl-3-methylimidazolium Bromide. Synthetic Communications. 2012,42(9):1367- 71.

11. M.M. Heravi, V Zadsirjan, M. Mollaiye, M. Heydari, A.T. Kal-Koshvandi, Salicylaldehydes, as the Privileged Synthons in Multicomponent Reactions, 2018, Russian Chemical Reviews 2018,87:553, DOI: 10.1070/RCR4780, As a authorship.

12. A.T. Kal Koshvandi, M.M. Heravi. Applications of Dainshefsky's Dienes in the Asymmetric synthesis of Aza Diels Alder Reaction. The Chemical Record. 2019,19(2-3):550-600, As a first and main author. 13. A.T. Kal-Koshvandi, M.M. Heravi, T. Momeni. Current Applications of Suzuki–Miyaura Coupling Reaction in The Total Synthesis of Natural Products: An update. Applied Organometallic Chemistry. 2018,32(3), e4210, As a first and main author.

14. A.T. Kal-Koshvandi, Phot-Protolabelling: An emerging tool for molecular network interactions. 15. A.T. Kal-Koshvandi, Supported-Deep Eutectic Solvents (SDESs). CONFERENCE PAPER

Ionic Liquid Promoted One-pot Synthesis of Benzo[b][1,4]oxazines, World Academy of Science, Engineering and Technology, International Journal of Chemical and Molecular Engineering, 2010, 4,755-756. BOOK

Afsaneh Taheri Kal-Koshvandi, Deep Eutectic Solvents, Springer. as an Editor PROFESSIONAL DEVELOPMENT TRAINING

Workshop

2D-Electrophoresis and proteomics, Tehran, Iran, Tarbiat Modares University Aug 29-31, 2022 Seminars/Webinars

10th National Seminar of Chemistry and Environment, Quchan University of Technology, Iran Nov 1&2, 2021 COMMUNITY SERVICE

National Blood Transfusion Service, Iran, Blood donor 2008-Present Provide mentoring for prospective graduate school applicants 2020-Present COMPUTER SKILLS

Office, Word, PowerPoint, Chem Draw, Excel, EndNote, Google Apps (Gmail, Google Calendar, Google Docs), Outlook, Access, and statistical software ……

LANGUAGE SKILLS

English: Fluent

Persian: Native

INTERESTS AND ACTIVITIES

Theater

Tehran, Iran, Alzahra University 2015

Tehran, Iran, Karnameh institue 2016

Sport

Running, volleyball

IDs

Google Scholar : https://scholar.google.com/citations?user=j7ldfL0AAAAJ&hl=fa, Linkedin: https://www.linkedin.com/in/afsaneh-taheri-kal-koshvandi-95ba93187/, Orcid ID: 0000-0001-5904-6159, Researcher ID: AAM-3621-2020, Scopus ID: 372******** REFERENCES

1. Ebrahim Soleimani, Razi University and Dalhousei University, Canada / Associate Professor (email: *.*********@***.**, ***************@*****.***)

2. Nasim Batooie, Razi University, Kermanshah, Iran/ Research Advisor ( E-mail: *****.*********@*****.***)

3. Mohammad Hakimi, Department of chemistry, Payame Noor University, Tehran, Iran, Cell Phone: 98-915*******, (E-mail: ********@*****.***)

4. Kiumars Bahrami, Razi University, Kermanshah, Iran/ Professor(E-mail: *.*******@****.**.**) 5. Mohammad M. Khodaei, Razi University, Kermanshah, Iran/ Professor (E-mail: *******@****.**.**) 6. Firas Kobeissy, PhD, Associate Professor/ Department of Biochemistry & Molecular Genetics,Faculty of Medicine, American University of Beirut, Cell Phone: 961-**-****** (E-mail: *******@*****.***(

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