H.No: **-*-***/*/A/**, West Rakshapuram Colony, Beside Umamaheswara Temple, Kanchanbagh Post,

Hyderabad-500058, Telangana State, India. E-mail: adk64j@r.postjobfree.com ; Ph:+91-960*******. 1

Dr. Kishore Lingam Gangadhara Ph.D.

Date of Birth : 29/07/1980

Contact Address : H.No: 95/C, Raghavendra Colony, C-Block, Kondapur, Hyderabad-500084, Telangana State, India. Contact Details : (Mob): +91-960*******.

E-mail : adk64j@r.postjobfree.com

LinkedIn : linkedin.com/in/kishore-lingam-gangadhara-ph-d-77679925 Synthetic Organic & Medicinal Chemist with Business Management Experience Finest synthetic & analytical skills, ability to design, planning and working to target time lines. Major projects handled on the synthesis of molecules for Medicinal Chemistry & its applications in various conditions including analytical method development. Published results from research in international journals. Good communication and negotiable skills with keen interest in Business Development. CV at a glance:

Education

2008- 2015: Ph.D in Pharmaceutical Sciences Katholieke Universiteit Leuven, Major: Medicinal Chemistry Leuven, Belgium.

Thesis Title: Nucleolipids with Lipophilic Hydroxyacids: Activity and Properties 2006-2008: M.Phil in Organic Chemistry Katholieke Universiteit Leuven, Major: Organice Chemistry Leuven, Belgium.

2003-2005: Master of Science (M.Sc.) in Chemistry Bharathidasan University, Major: Chemistry Tamilnadu, India.

1998-2001: Bachelor of Science (B.Sc.) Osmania University, Major: Mathematics, Physics, Chemistry Hyderabad, Telangana, India. Employment

10/2019 – 05/2020 Business Development Manager YMC India Pvt Ltd., HYD. 12/2017 – 03/2019 Assistant General Manager Chromachemie Laboratory Pvt Ltd.,

(Business Development-Technical) Bangalore, India

05/2016 – 06/2017 Senior Scientist Anthem Bioscience Private Ltd.,

(Small scale & Process R&D) Bommasandra, Bangalore. 09/2015-05/2016 Senior Research Associate Izenbiosciences Private Ltd.,

(Small scale & Process R&D) Nacharam, Hyderabad, India. 07/2014 – 12/2014 Scientist DSK Innosciences Private Ltd.,

(Small scale & Process R&D) Hosur, Tamilnadu, India. H.No: 18-8-254/1/A/45, West Rakshapuram Colony, Beside Umamaheswara Temple, Kanchanbagh Post, Hyderabad-500058, Telangana State, India. E-mail: adk64j@r.postjobfree.com ; Ph:+91-960*******. 2

Career Aspiration

Aim to be associated with an organization that gives me the scope to apply my knowledge and skills for the growth of the organization. To pursue a challenging and fruitful career, where I can utilize my skills in the best possible manner.

Analytical and Technical Skills

Milligrams to Kilograms

Multi-step synthesis, crystallization

Analytical HPLC, MS, NMR

Oligonucleotide Synthesis (Mermade)

GE Akta Oligopilot-Basic handling

Non GMP, technical writing

Process safety and hazard handling

Process optimization and characterization

Dedicated chemist and good team player

Business Development/Project Management

Employment

09/2017 –till date Founder & Director Saanvika Pharma. Hyderabad,Telangana, India.

Roles & Responsibilities:

• Prioritize, Plan, and execute development strategies to ensure timeline adherence and project alignment with company goals for the ongoing and upcoming synthesis projects and active pharmaceutical ingredients by using both internal & external resources.

• Assign and Lead the R&D & process chemistry group to chemical route ideation, design, feasibility and development studies.

• Lead the teams to demonstrate, optimize, and document chemical processes, drive to clear decision points to ensure timeline adherence and project alignment with company goals.

• Screen & Select outsourcing partners and help technology transfer and troubleshoot chemical processes to meet project goals in timelines.

• Collaborate with all research groups to design project timelines and generate materials in support of planned R&D/Plant activities including, planning and execution to deliver raw materials, reference standards, impurities, and other intermediates as needed.

• Organize & collaborate with R&D, Plant, Formulators, Analytical and Supply Chain groups to design project timelines and generate materials in support of R&D, Process, Plant & commercialization.

• Assist with troubleshooting efforts in the commercial stage of projects, as well as process scale- up and site transfers.

10/2019 –05/2020 Business Developent Manager YMC India Pvt Ltd. Roles & Responsibilities:

• Sourcing new prospects through all available mediums to introduce the projects on purifications

& Separations business and arrange an appointment.

• To create and execute the projects for Chiral/achiral purifications from industries/Academics.

• Ensuring all company provided leads handled in the most suitable way.

• Drive growth in the region by supporting and developing existing distributors, as well as identifying new partners and opportunities in the region.

• Develop business plans for each customer which are strategically aligned with the company’s objectives.

• Nurture business relationships with distribution partners and suppliers to build trust and mutual understanding.

• Negotiate distribution contracts, including pricing, payment terms, incoterms, and targets.

• Manage existing accounts to maximise profit via pricing strategies, budgets, etc. H.No: 18-8-254/1/A/45, West Rakshapuram Colony, Beside Umamaheswara Temple, Kanchanbagh Post, Hyderabad-500058, Telangana State, India. E-mail: adk64j@r.postjobfree.com ; Ph:+91-960*******. 3

• Ensure efficient flow of product to distributors, paying attention to stock levels and accounts receivable.

• Liaise with Marketing Managers to create/manage marketing budget and implement any promotional plans or brand projects with customers

• Prepare monthly reports on regional sales activity and pipeline planning for senior management 12/2017 –03/2019 Assistnt General Manager Chromacheme Laboratory Pvt Ltd.

(Business Development-Technical) Bangalore, Karnataka, India. Roles & Responsibilities:

Understanding the company’s goals and purposes to enhance the company’s performance.

Research and building relationship with new clients, decision makers in the organization and converting into new business.

Prospect for potential new clients for Pharmacopeia’s of USP, EP, BP, IP Reference Standards, Impurities and HPLC analytical & Prep & Semi prep columns.

Headed the Project Management Team of ongoing R&D projects.

Setting up meetings between client decision makers and companies’ key leaders.

Presenting new products and enhancing new and existing relationship.

Working with Technical & internal staff to meet customer needs.

Arranging and participating in internal & external client debriefs.

Identifying opportunities for campaigns, services, and distribution channels leading to the increase in sales.

Forecasting sales targets and ensuring they are met by the marketing and sales team within a timely manner.

05/2016 –06/2017 Senior Scientist Anthem Bioscience Private Limited.

(Small scale & Process R&D) Bangalore, Karnataka, India. Roles & Responsibilities:

Project Management, Planning and execution of R&D and process R&D projects and lab activities in support of research activities in timeline.

Carried multiple multistep synthesis on bench in support of Process R&D and R&D activities.

Evaluated and modify current synthesis route and developed scalable methods.

Implemented process in kilo-lab/Production plant to produce intermediates and API for the non GMP delivery.

Involved in route planning for cost efficient long-term synthesis.

Process optimization, process validation and process characterization.

Developed commercial process and support the late stage development.

Supported technology transfer and internal commercial manufacturing sites.

Identified and prepare process impurities.

09/2015-05/2016 Senior Research Associate Izenbiosciences Pvt Ltd.

(Small scale & Process R&D) Hyderabad, Telangana, India. Roles & Responsibilities:

Synthesis of molecules, designing and performing lab activities related to experiments and projects in support of research.

Method development for Process to Kilo lab.

Project Management, Plan studies including timeline to follow and strategy in alignment with project objective.

Managing multiple projects of varying priority and technical difficulty. To supervise, work in multifunctional teams, interact with customers and suppliers. Literature searching, patent example development and reviewing. H.No: 18-8-254/1/A/45, West Rakshapuram Colony, Beside Umamaheswara Temple, Kanchanbagh Post, Hyderabad-500058, Telangana State, India. E-mail: adk64j@r.postjobfree.com ; Ph:+91-960*******. 4

July 2014 – Dec 2014 Scientist DSK Innosciences,

(Small scale & Process R&D) Gowthalam Village, Hosur, Tamilnadu Roles&Responsibilities:

Worked with Managing Director to improve R&D and quality of laboratory processes.

Recruited to perform research, conduct experiments and provide scientific project assistance encompassing diverse areas of Organic chemistry and Medicinal Chemistry for projects.

Designed effective research projects and recommended improvements.

Assisted in development of budgets and controlled expenses within assigned budget.

Implemented employee discipline standards including for timekeeping and performances.

Supervised laboratory staffs to finish testing within deadlines.

Recorded all results in laboratory information system.

Implemented employee discipline standards including for timekeeping and performances. Education

2008-2015 Ph.D. in Pharmaceutical Science (Medicinal Chemistry) Katholieke Universiteit Leuven, Leuven, Belgium

RESEARCH THESIS

Title: Nucleolipids with Lipophilic Hydroxyacids: Activity and Properties 1. The main research project on nucleolipids focuses on their ability to form different kinds of lipid aggregates such as micelles, vesicles and lipid nanotubes which may result in nucleotide polymer in micellar/vesicle conditions. Developed a series of modified Nucleosides (A, T, U, C- analogues of ribose, de-oxy ribose, xylo sugars) and Nucleotides along with various saturated fatty acids and amino acids which were investigated for their capabilities of polymerization in micellar or in vesicular conditions.

Several lipid phosphoramidites (α- and β-hydroxy stearic acid) were prepared and conjugated to modified nucleosides to form nucleolipids and evaluated for their oligonucleotide formation under various physiological conditions. 2. Lipophilic phosphodiester prodrugs were synthesized with a small library of dideoxy and didehydro derivatives of bases-A,T, and U. Hydroxy fatty acids capability was evaluated for delivering antiviral nucleos(t)ides into cells. Lability of the phosphoester bond is investigated to monitor, either a nucleoside or a nucleotide or a cyclic nucleotide could be delivered in the cell. Out of the series of compounds synthesized, nucleolipid with d4A nuleobase has shown excellent antiviral activity against HIV virus in different cell lines. Various phosphoramidites of modified nucleosides (dideoxydidehydro nucleosides) and lipid phosphoramidites were synthesized and coupled to synthesize modified nucleolipids which were evaluated against anti-HIV RT virus. 2006-2008: Pre-Doc (M.Phil) in Organic Chemistry

Katholieke Universiteit Leuven, Leuven, Belgium

Research Project-1:

Diversely functionalized oxacalix[2]arene[2]pyrimidines have been synthesized starting from a bis(methylsulfanyl)-substituted oxacalix[4]arene by two efficient post- macrocyclization pathways. Functionalized aryl groups were introduced on the pyrimidine building block via Liebeskind- Srogl cross-coupling reactions, while a variety of O-, S-, N- H.No: 18-8-254/1/A/45, West Rakshapuram Colony, Beside Umamaheswara Temple, Kanchanbagh Post, Hyderabad-500058, Telangana State, India. E-mail: adk64j@r.postjobfree.com ; Ph:+91-960*******. 5

, and C-nucleophiles were inserted on the calixarene skeleton by nucleophilic aromatic substitution reactions on the bis(methylsulfonyl)oxacalix[4]arene analogue. Research Project-2:

Oxacalix[2]arene[2]quinazoline macrocycles were prepared in good yields, as mixtures of syn and anti isomers, through nucleophilic aromatic substitution cyclocondensation reactions of 2,4-dichloroquinazolines and m-dihydroxybenzenes. The macrocyclization conditions were optimized and the isomeric ratio was investigated by means of one-step and fragment-coupling approaches. The oxacalixarene substitution pattern could easily be varied by altering the dichloroquinazolinyl biselectrophilic and dihydroxyaryl bisnucleophilic building blocks. The solid-state (1,3-alternate) conformational behavior and the oxacalix[4]arene cavity size were explored by X-ray diffraction studies. 2004-2005: Master of Science (M.Sc.) in Chemistry

Bharathidasan University, Tamilnadu, India

MASTER’S THESIS-2 (6 months)

“C2 Symmetric ligand catalytic activity and synthesis of Pyrazolo(1,5- a)Pyrimidine derivatives and evaluation of their antimicrobial activity” from Indian Institute of Chemical Technology (IICT), Hyderabad, India.

2003-2004: Master of Science (M.Sc.) in Chemistry

Bharathidasan University, Tamilnadu, India.

MASTER’S THESIS -1 (3months)

“Studies on synthesis and chemistry aspects of Triflouromethyl substituted 2-O-allyl pyridines” from Indian Institute of Chemical Technology (IICT), Hyderabad, India. 1998-2001: Bachelor of Science (B.Sc.)

Osmania University, Andhra Pradesh, India.

Major: Mathematics, Physics, Chemistry.

Languages

English, Hindi, Telugu, Dutch (Niveau-1).

Posters

1. “Hydroxystearic acid Phosphate As A d4A Selective Prodrug Approach” at 31st Camerino-Cyprus- Noordwijkerhout Symposium “Receptor Chemistry Skyline” Camerino, Italy, May 19-23, 2013. 2. Selective synthesis of functionalized thia- and oxacali(m)arene(n)pyrimidines at Louvain-la- Neuve, Belgium, April10-13, 2007.

3. Synthetic Exploration of oxacalix[2]arene[2]quinazoline at Sigma-Aldrich SPA conference, Belgium, December 6-8, 2007.

Publications

1) Kishore Lingam Gangadhara, Puneet Srivastava, Jef Rozenski, Henri-Philippe Mattelaer, Volker Leen, Wim Dehaen, Johan Hofkens, Eveline Lescrinier, Piet Herdewijn; Design and synthesis of nucleolipids as possible activated precursors for oligomer formation via intramolecular catalysis: stability study and supramolecular organization; Journal of Systems Chemistry, 2014, 5:5. H.No: 18-8-254/1/A/45, West Rakshapuram Colony, Beside Umamaheswara Temple, Kanchanbagh Post, Hyderabad-500058, Telangana State, India. E-mail: adk64j@r.postjobfree.com ; Ph:+91-960*******. 6

2) Kishore Lingam. G., Christophe Pannecouque, Eveline Lescrinier, Piet Herdewijn; Hydroxy fatty acids for the delivery of dideoxynucleosides as anti-HIV agents. Bioorganic and Medicinal Chemistry Letters, 2014, 24(3), 817-820. 3) Wim Van Rossom, Lingam Kishore, Koen Robeyns, Luc Van Meervelt, Wim Dehaen, Wouter Maes; Synthetic Exploration of Oxacalix[2]arene[2]quinazolines; Eur. J. Org. Chem. 2010, Issue 21, pages: 4122–4129. 4) Van Rossom,W.; Maes,W.; Kishore,L.; Ovaere,M.; Van Meervelt,L.; Dehaen,W.; Efficient Post- Macrocyclization Functionalizations of Oxacalix[2]arene[2]pyrimidines; Organic Letters 2008, Vol.10, No.4, pages: 585-588. References

References will be provided if necessary.

Decleration:

I hereby declare that the above-mentioned information is true to the best of my knowledge. Yours Sincerely

(Kishore Lingam Gangadhara)

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