Chemical Engineering Assistant
Resume:
Javad Hashemi
Status: U.S. Permanent Resident
Address: ***** ** ****, ******* ******* NY 11364, United States
*******.****@*****.***
Education
****-**** **.*., ******** Engineering, University of Louisville, KY, USA 2010-2013 M.Sc., Biomedical Engineering, Tarbiat Modares University, Tehran, Iran 2006-2010 B.S., Chemical Engineering, University of Sistan and Baluchestan, Zahedan, Iran Relevant Courses: <Tissue Engineering>, <Polymer Engineering>, <Biochemistry>, <Physiology>,
<Design of Drug Controlled Release Systems> <Immunology>, <Tissue Culture Laboratory>, <Transport Phenomena>, <Design of Experiments>, <Advanced Thermodynamics>, <Bioreactor Design>,
<Computational Fluid Dynamics>
Work Experience
Postdoctoral Fellow, California Medical Innovation Institute, San Diego CA Dec. 2019 - Present
• 3D design and manufacturing microfluidic device.
• Designed microfluidic device for cell isolation and microencapsulation and cell culture.
• Developed computational fluid dynamics (CFD) and finite element modeling (FEM) models to design device.
• Analyzed and communicated data in a timely manner to mentor and collaborators.
• Presented research at internal and external scientific meeting and publishing in peer-reviewed journals. Research Assistant, University of Louisville, KY Aug. 2014 - Dec. 2019
• Design 3D models and mesh generation and 3D reconstruction from angiography, CT-Scan and MRI.
• Developed a noninvasive method using CFD for diagnosing coronary artery stenosis.
• Worked on simulation and improvement in design of mixing tank and bioreactor.
• Optimized and scaled up mixing tank using mean residence time calculation and validated with experimental data.
• Cultured primary cell (bone marrow cell, lymphocyte, and islet of Langerhans), cell line (CHO, Vero and PC12) and bacteria (E. coli)
• Experienced in review and optimization PFDs and PID, utility flow diagrams and utility consumption sheets, and equipment data sheets.
Intern, Saman Daroo 8 Co. (Biopharmacutical Company), Tehran, Iran Jun. 2013 - Dec. 2013
• Performed cell culture operations per SOPs under cGMP environment to maintain sterility and health of cell culture as they scale up from roller bottles to 80L bioreactors.
• Systematically monitored temperature, cell viability, cell density, pH, and other parameters from cell culture samples to ensure quality.
• Prepared cell culture media, batch media into bioreactors, inoculate and transfer cell culture, and harvest Factor VIII.
• Maintained excellent documentations and data recording on all operations. Research Assistant, Tarbiat Modares University, Tehran, Iran Dec. 2010 - Mar. 2013
• Islet of Langerhans and lymphocyte isolation.
• Optimized Islet of Langerhans Immunoisolation using activated methoxy polyethylene glycol.
• Cocultured islet of Langerhans and lymphocyte and perform immunoassay like ELISA and, FAC analysis.
• Studied effect of pentoxifylline as suppressive drug on Islet of Langerhans transplantation.
• Managed clean room and responsible for developing and implementing sterilization procedures and policies and performing validations of the sterilization processes. 2
Awards and Honor
2018 CO-PI, EXCITE Fund (NIH REACH), Non-Invasive Real-Time Assessment of Coronary Stenosis Using RBC AGE, $200,000
2018 Entrepreneurial Lead, NSF Innovation Corps (I-Corps) 2014 University of Louisville, University Fellowship Patents
1. J. Hashemi, R. E. Berson, S. Ghafghazi. System and Method for Determining Fractional Flow Reserve Through a Coronary Stenosis. U.S. Patent Application 62803636, filed February 2019. Provisional Patent. 2. R. E. Berson, J. Hashemi, S. Ghafghazi. Method and System for Assessing a Coronary Stenosis. U.S. Patent Application 62701136, filed July 2018. Provisional Patent. Experimental and Modeling Techniques
Modeling
Methods
Computational Fluid Dynamics
Finite Element Analysis (FEA)
Fluid Structure Interaction (FSI)
3D Design and Reconstruction
Multiphase Method (Eulerian and Lagrangian)
Experimental
Methods
Functionalization of mPEG
PEGylation
Polymer Processing
Encapsulation
Fermentation
Bioreactor Scale up
Analysis
ELISA
Cell Counting
Fluorescent Microscopy
FTIR
SPEC – Spectrophotometer
SEM
Design of Experiment (DOE)
Animal
Working
Medical ethics course
Animal Handling (Rat & Mouse)
Animal Anesthesia
Animal Surgery
Cell and
Tissue
culture
Cell isolation (Islet of Langerhans, Lymphocyte
and Bone Marrow)
Cell and tissue Culture (Islet of Langerhans,
Lymphocyte, MSCs, PC12, CHO, Vero)
Cell culture medium preparation
Subculture
Cryopreservation
Programming
and Software
Matlab
C++
SolidWorks
ABAQUS
ICEM
ANSYS
Fluent
SPSS
Publications
1. J. Hashemi, B. Patel, Y. S. Chatzizisis, G. S Kassab. Study of coronary atherosclerosis using blood residence time. Frontier Physiology. Under Review.
2. J. Hashemi, S. Ghafghazi, R. Eric Berson. Blood Residence Time to Assess Significance of Coronary Artery Stenosis. Scientific Reports, 2020, 10:11658.
3. M. Hashemi, A. Zali, J. Hashemi, S. Oraee-Yazdani, A. Akbari. Down-regulation of 14-3-3 zeta sensitizes human glioblastoma cells to apoptosis induction. Apoptosis. 2018, 23(11–12):616–625. 4. M. Hashemi, M. Hadjighassem, A. Zali, J. Hashemi. Tumoricidal effect of human olfactory ensheathing cell mediated suicide gene therapy in human glioblastoma cells. Mol Biol Rep, 2018, 45(6):2263–2273. doi: 10.1007/s11033-018-4388-0. 5. J. Hashemi, S. Hashemi-Najafabadi, E. Vasheghani-Farahani. Synergistic effect of PEGylation and pentoxifylline addition on immunoprotection of pancreatic islets, Journal of Biomaterials Science, Polymer Edition, 2017; 28:33-49. 6. F. Bahrami, M. Hashemi, F. Khalili, J. Hashemi, A. Asgari. Stimulation of cannabinoid CB1 and n-methyl-d-aspartate receptors increases neuroprotective effect against diazinon-induced neurotoxicity, Neurophysiology, 2013; 45(5-6): 433-440. 7. J. Hashemi, A. Samimi. Steady state electric power generation in up-flow microbial fuel cell using the estimated time span method for bacteria growth in domestic wastewater, Biomass and Bioenergy, 2012; 45: 65–76.
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