Design Data
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Motivated and performance-driven scientist equipped with years of leading complex R&D projects related to pharmaceutical R and D and project management. Analytical, innovative, and forward-thinking professional with a proven track record of turning scientists into high-performing technical teams. Solid background in organic, medicinal, heterocyclic, peptides and biological chemistry as well as conducting advanced laboratory techniques within best practice guidelines. Skilled in effectively managing competing project flows while adapting to constant changes within quick-moving, multi-faceted environments. Adept at developing comprehensive research reports, determining linking to overall business strategy, and sharing findings in written and oral formats. Skilled in modeling, analyzing, and interpreting data using a variety of approaches. Highly poised and dedicated to continuing professional growth in a scientist position.
PROFILE SUMMARY
Shankaran Kothandaraman Ph.D.
EDUCATION
Post-Doctoral Training
Universities of Wisconsin (Prof. Steven D. Burke) and Waterloo (Late Prof. Snieckus Canada).
Doctor of Philosophy
Organic Chemistry
University of Poona
Pune, India
Master of Science
Organic Chemistry
University of Poona
Pune, India
CORE COMPETENCIES
Provide senior thought leadership around small molecule, biopharmaceutical drug discovery initiatives, compound progression, as well as patent strategies.
Act as primary liaison to comment on strategies for directing synthetic organic, Medicinal, Heterocyclic, Peptide chemistry.
Collaborate with others within practice to coordinate knowledge transfer and continuous improvement initiatives.
Perform senior supporting and supervisory roles in administrating biopharmaceutical projects.
Demonstrate problem-solving ability to advance novel drug discovery approaches and guide cost-effective solutions.
Up to date with laboratory best practice standards, techniques, and advanced experimental methods.
Cognizant in dealing with CRO companies and designing molecules.
L
SKILLS
Interpersonal skills
Reasoning and analysis
Problem solving
Stakeholder engagement
Attentive to detail
Project management
Concise communication
Data evaluation
Laboratory management
Methods documentation
Results interpretation
PROJECT PORTFOLIO
Principal role in the solid phase synthesis of peptide agonists, antagonists, cell penetrating peptides, and conjugation of these as diagnostic agents for organics and drugs. Collaborated within cross-functional technical team to generate patent on novel Cell Penetrating Peptides for theranostics purposes.
Facilitated European launch of semi-synthetic macrolide antibiotic for veterinary use (Zactran). Developed backup clinical candidate.
Assisted in the discovery, development, and phase 2 clinical trial launch of an experimental rheumatoid arthritis drug (MK-0812). Provided synthetic approach to critical heterocyclic scaffold as a clinical backup contender.
Contributed to efforts in the Cannabinoid receptor (CB1/CB2) inverse agonist and anemia (HIF-1 ) program for the purposes of pre-clinical backup. Addressed issues related to pharmacokinetics and metabolism.
Established synthetic organic chemistry work for HIV inhibitors (CCR5) and inflammation (NOS inhibitors) resulting in the preparation of broadly substituted heterocyclic scaffolds.
Preparation of targeted library and parallel synthesis protocols for potent acyl hydroxylamine enzyme inhibitors (TACE).
Co-led studies in multiple therapeutic areas including cancer, anti-infective (Macrolide, β-lactam), inflammation (NOS, CCR2, TACE), obesity (CB1 inverse agonist), anemia (HIF-1 ) and other GPCR targets (CCR3, CCR5).
AFFILIATIONS/HONORS
American Chemical Society, Division of Organic and Medicinal Chemistry
Senior and Junior Research Fellowship of Government of India.
Awards for contribution to various programs while at Merck.
VISTEERNA LLC 9/2020- Present
Providing expert consulting and hands-on experimental services (in client's laboratory) supporting early-phase drug discovery, based on small molecules and peptides, medicinal, organic, and bioconjugation chemistry. Specific services include, design of novel drug candidates based on structure activity relationships and synthesis schemes, classical and HPLC purification techniques, PK and ADME, and managing CROs on behalf of the clients. Presently consulting with Wright Center Innovation and Biomolecular Imaging (WCIBMI) at Columbus, Ohio.
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Research Scientist 9/2009 – 5/2020
The Ohio State University – Columbus, Ohio
Leading design of diagnostic and therapeutic peptides and small molecules for cancers of the breast, head and neck, and prostate.
Preparing heterocyclic analogs for collaborative research in Alzheimer’s disease (Abeta plaque) and diagnostic design concepts for selective tau-protein imaging.
Proposed and carried out chemical synthesis of peptide and non-peptide molecules prior to their eventual preparation of radioactive ligands for the purposes of cell-based assays and animal models.
Discovery of cell penetrating peptide (CPP) molecule that targets head and neck cancer cells, developed SAR, conjugated to NIR probes for advancing optical surgical navigation for tumor detection and as cisplatin potentiator.
Senior Research Fellow 7/1990 – 10/2008
Merck & Co. Inc. – Rahway, New Jersey
Performed chemistry project management duties including defining scope and design, tracking project milestones, analysis, and maintaining communication through oral and written reports to run projects on lead discovery, target validation, lead optimization, SAR, DMPK, ADME, and toxicity issue resolution.
Received several awards for lead discovery, lead optimization, and target validation in several programs.
Engaged 10-15 team members to innovate within research, avoid downsides in research, and reference key literature.
Collaborated within large 20+ team to undertake research on inflammation, encompassing both enzyme inhibitors and receptor antagonists.
Drove chemistry progress in anemia, obesity, pain and arthrosclerosis.
Coordinated with cross functional team to prepare broadly substituted heterocyclic analogs to stop the cellular penetration of HIV.
Research Fellow 6/1989 – 6/1990
Hoffman-LaRoche Inc. – Nutley, New Jersey
PROFESSIONAL EXPERIENCE
PUBLICATIONS/PATENTS
60+ papers
25+ presentations in national and international conferences
12 Patents.
https://doi-org.proxy.lib.ohio-state.edu/10.3390/molecules24173070.
https://doi-org.proxy.lib.ohio-state.edu/10.3390/molecules 24162878.
https://doi.org/10.1016/j.tube.2018.01.001
TECHNIQUES
Deep knowledge of modern synthetic organic chemistry and extensive experience in fragment-based lead identification, screening data analysis, small molecule lead discovery, solid phase peptide synthesis, cell penetrating peptides, synthetic chemistry, heterocyclic chemistry, bio-conjugation, near infrared dyes, and structure-based analog design for an early lead discovery and optimization.
Application of computational, HPLC, NMR, MALDI and modeling data to structure/fragment-based lead design, and structure-activity relationship on a small molecule/peptide-based drug discovery.
Utilization of radiochemistry and application thereof (radiochemical synthesis). for PET ligand).
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