Medicine School
Resume:
Santiago Rebolledo Antúnez
*******@*****.***
Ph: +525*********
Salubridad 65
Mexico City
MEXICO
.
EDUCATION
• Ph.D., Biophysics (2009), School of Medicine, Universidad Nacional Autónoma de México (UNAM), México City, México
• BA, Biomedical Sciences (1998), School of Medicine, UNAM, México City, México
• 1st
School in Mathematical Biology (1999), CENTER OF MATHEMATICS INVESTIGATION, Guanajuato, México
• Advanced training for users of AutoProbe Scanning Probe Microscopes (1996), PARK SCIENTIFIC INSTRUMENTS, Sunnyvale, CA, USA
• Complex Fluids, Science, and Technology Workshop (1994 & 1996), UNIVERSIDAD AUTONOMA DE SAN LUIS POTOSI, San Luis Potosí, México
• Fortran and Pascal programming languages
• Fluent in Spanish, English and Portuguese
• Basic in French
RESEARCH SKILLS
• Electrophysiological techniques: current-clamp, voltage-clamp and patch-clamp
(single channel and macroscopic recordings using cell-attached, inside-out, outside-out, macropatch, whole cell and perforated whole cell configurations and tip dip method), cut open oocyte voltage clamp, voltage clamp fluorometry.
• Biochemical, cellular and molecular biology techniques: protein purification, enzymatic kinetics, gel electrophoresis of DNA, RNA and protein, primary cell isolation/culture (neurons and cardiomyocytes), cell line culture, heterologous gene expression, bacterial transformation, cell transfection, polymerase chain reaction (PCR), site-directed mutagenesis, cRNA transcription in vitro, and fluorescence microscopy.
• ICT skills: Office, Origin, Sigmaplot, pClamp, MatLab, pClamp, Unix. PROFESSIONAL EXPERIENCE
WRIGHT STATE UNIVERSITY 2020-Present
Dayton, USA
Postdoctoral Associate
TELEPERFORMANCE 2019-2020
Mexico City, Mexico
Bilingual Agent
UNIVERSITY OF NEVADA, RENO
Reno, USA
Scientific Researcher
UNIVERSIDAD TECMILENIO
Mexico City, Mexico
Lecturer
UNIVERSITY OF PECS
Pécs, Hungary
Lecturer: Comparative Physiology
UNIVERSITY OF PECS
Pécs, Hungary
Postdoctoral associate
INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY
Prague, Czech Republic
Postdoctoral associate
UNIVERSIDADE DO PORTO
Porto, Portugal
Postdoctoral associate
2017-2018
2017
2017
2016-2017
2015
2014
UNIVERSITE DE MONTREAL
Montreal, Canada
Postdoctoral associate
2012-2013
UNIVERSITY OF MIAMI
Miami, USA
Postdoctoral associate
2009-2012
UNIVERSIDAD AUTONOMA DE LA CIUDAD DE MEXICO
Mexico City, México
2008-2009
Lecturer: General Chemistry
UNAM, School of Medicine
Mexico City, México
Lecturer: Physics
2007-2008
UNAM, School of Engineering
Mexico City, México
Lecturer: Anatomy and Physiology
2004-2007
Centro de Investigación y Estudios Avanzados IPN
Mexico City, México
Academic technician
2000-2004
WESTHILL INSTITUTE, School of Medicine
Mexico City, México
Lecturer: General Chemistry
1999-2000
UNIVERSIDAD AUTONOMA DEL ESTADO DE MORELOS
Cuernavaca, México
Professor: General Physics
1997-1998
PUBLICATIONS
1. Cotero BV, Rebolledo-Antúnez S, Ortega-Blake I (1998) On the role of sterol in the formation of the amphotericin B channel. Biochim Biophys Acta 1375:43-51 2. García R, Carrillo E, Rebolledo S, García MC, Sánchez JA (2002) The beta1a subunit regulates the functional properties of adult frog and mouse L-type Ca2+ channels of skeletal muscle. J Physiol 545 (Pt 2): 407-19 3. Corona M, Coronas F, Merino E, Becerril B, Rebolledo-Antúnez S, Gutiérrez R, García DE, Posanni LD (2003) A novel class of peptide found in scorpion venom with neurodepressant effects in peripheral and central nervous system of the rat. Biochim Biophys Acta 1649: 58-67
4. Hernández-Ochoa EO, Rebolledo-Antúnez S, Cuellar-Quintero JL, García- Ferrero RE, Farías JM, García DE (2003) Canales de Calcio Neuronales: Blanco de Autoanticuerpos Onconeuronales en el Síndrome de Lambert-Eaton. Archivos de Neurociencias 8: 106-112
5. Rebolledo-Antúnez S, Farías JM Arenas I, García DE (2009) Gating charges per channel of CaV2.2 channels are modified by G protein activation in rat sympathetic neurons.. Arch Biochem Biophys 486:51-57 6. Osteen JD, Gonzalez C, Sampson KJ, Iyer V, Rebolledo S, Larsson HP, Kass RS (2010) “KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate” Proc Natl Acad USA 107:227**-***** 7. Rebolledo S, Qiu F, Larsson HP. Molecular structure and function of Hv1 channels. WIREs Membr Transp Signal 2012. doi: 10.1002/wmts.49 8. Bravo-Martínez J, Arenas I, Vivas O, Rebolledo-Antúnez S, Vázquez-García M, Larrazolo A, García DE (2012). A novel CaV2.2 channel inhibition by piracetam in peripheral and central neurons. Exp Biol Med (Maywood). 237:1209-18. 9. Qiu F, Rebolledo S, Gonzalez C, Larsson HP. (2013) Subunit Interactions during Cooperative Opening of Voltage-Gated Proton Channels. Neuron. 77:288-98. 10. Gonzalez C, Rebolledo S, Perez ME, Larsson HP. (2013) Molecular mechanism of voltage sensing in voltage-gated proton channels. J Gen Physiol. 141:275-85. 11. Chamberlin A, Qiu F, Rebolledo S, Wang Y, Noskov SY, Larsson HP. (2014) Hydrophobic plug functions as a gate in voltage-gated proton channels. Proc Natl Acad Sci U S A. 111:E273-82.
12. Barro-Soria R, Rebolledo S, Liin SI, Perez ME, Sampson KJ, Kass RS, Larsson HP. (2014) KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps. Nat Commun. 5:3750.
PRESENTATIONS
57th
Annual Meeting of the Biophysical Society
Boston, MA, USA
Cooperative Opening of Voltage Gated Proton Channels Involves Inter-Subunit Interactions
56th
Annual Meeting of the Biophysical Society
San Diego, CA, USA
A novel Beta Subunit Mechanism in a Critical Heart K Channel: KCNE1 Alters the Voltage Sensor Movements Necessary to Open the KCNQ1 Channel Gate 56th
Annual Meeting of the Biophysical Society
San Diego, CA, USA
Allosteric properties of KCNQ1 (Kv7.1) channel gating detected by voltage clamp fluorometry
55th
Annual Meeting of the Biophysical Society
Baltimore, MD, USA
Contribution of S4 charges to gating mechanism in Hv channels 55th
Annual Meeting of the Biophysical Society
2013
2012
2012
2010
Baltimore, MD, USA
A novel beta subunit mechanism in a critical heart K channel: KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel Gordon Research Conference, Ion Channels
Tilton, NH, USA
Contribution of S4 Charges to Gating Mechanism in Hv Channels 48th
Annual Meeting, of the American Society for Cell Biology San Francisco, CA, USA
Charge transfer of CaV2.2 channels during G-protein modulation in rat sympathetic neurons
2010
2010
2008
36th
Winter Meeting on Statistical Physics
Taxco, Mexico.
A markovian model for the G-protein voltage-sensitive modulation of N-type calcium channels.
2007
48th Meeting of the Mexican Society of Physiology
Guadalajara, México
Elementary charges of the N-type calcium channel.
2005
46th Annual Meeting of the Biophysical Society
San Francisco, CA, USA
Actions of β1 subunit on L-type currents of adult frog and mouse skeletal muscle.
2002
8th
Meeting of Bioenergetics and Biomembranes
Cocoyoc, México
The amphotericin B single channel.
1997
INVITED TALKS
2009 School of Medicine, University of Miami, Miami, FL, USA 2008 Vollum Institute, Oregon Health and Science University, Portland, OR, USA
2008 School of Medicine, Oregon Health and Science University, Portland, OR, USA
2008 School of Medicine, Stanford University, Palo Alto, CA, USA AWARDS
Gabino Barreda Medal (1998), UNAM (Awarded annually to the best student in the school of medicine). Mexico
IBMC Postdoctoral Fellowship (2014) Portugal
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