Atefeh Alizadehbirjandi

***** **** ********* ***, ****** Spring, MD 20906 adifmf@r.postjobfree.com 310-***-**** Education

Master of Science, Chemical Engineering, The Ohio State University, Jan 2019 Master of Science, Chemical Engineering, Sharif University of Technology, Iran, Aug 2014 Bachelor of Science, Chemical Engineering, Isfahan University of Technology, Iran, Aug 2012 TECHNICAL SKILLS

• Downstream tech transfer

• Antibody purification

• Next generation pharmaceutical manufacturing techniques

• Downstream process development

• GMP manufacturing

• Product commercialization

• Drug substance manufacturing scale up

• Project management

• Risk Analysis and management

• Mammalian cell culture

• Drug delivery

• Protein production

• Chromatography techniques

• Microscopy techniques: Fluorescence, TEM, AFM, SEM

• Scattering techniques: DLS, NanoSight

• Spectroscopy techniques: UV-Vis, fluorescence

• Data analysis and statistics software: JMP, SigmaPlot, ImageJ, Matlab,

• Nanoparticle and polymeric nanocomposite synthesis

• General equipment maintenance and handling: sonicators, electrospray, glovebox RESEARCH AND WORK EXPERIENCE

Purification Process Sciences, AstraZeneca Dec 2019 – current Associate Scientist

• Lead downstream Technology Transfer activities for clinical and commercial projects covering a wide range of modalities and therapeutic areas including COVID-19 monoclonal Antibody project.

• Lead cross functional activities to deliver tech transfer deliverables; Performed manufacturing fit analysis and risk analysis; Managed all projects with 100% on-time delivery.

• Lead cross departmental forums: Chaired data review meeting. Gained rapport and transformed the review meeting to a campaign close out presentation. The meeting served several purposes: it provided feedback to process scientists; it became a forum for continuous improvement and cross-departmental engineering problem solving. After value was recognized, scope was expanded to also cover upstream performance.

• Develop Process Descriptions, Sample and Testing Plans, and Bills of Materials in collaboration with Process Development, Manufacturing, and Analytical Sciences groups.

• Create facility fit analyses to ensure proper transfer of process from development to GMP manufacturing.

• Review GMP manufacturing production records to ensure accurate process transfer and provide operational strategies to reduce likelihood of non-conformance events.

• Provide technical overview during execution of manufacturing campaigns as well as in support of non-conformance investigations.

• Create and execute purification process and sub-step knowledge training for purification staff to highlight process specifics and improve process understanding.

• Attend cross-functional project CMC meetings to provide updates and escalations related to downstream tech transfer activities. Chemical and Biomolecular Engineering Department, The Ohio State University Aug 2014 – Jan 2019 Graduate Research Assistant

• Developed technology from concept to product for bench-top device to purify target recombinant proteins and Antibodies

• Optimized the pH-sensitive intein for the purification of therapeutic proteins and investigated cleaving kinetics

• Established a next generation electrospray technique for high throughput nanocomposite synthesis

• Designed a continuous reactor for electrohydrodynamic atomization and rapid mixing

• Achieved 30X scale-up of polymeric nanocomposite production compared to competing methods

• Process optimization: Encapsulation of functional nanoparticles in polymeric micelles

• Achieved 99.9% encapsulation efficiency of nanoparticles in polymeric micelles

• Optimized the polymeric nanoparticle synthesis to reduce processing time by 240X Chemical Engineering Department, Sharif University of Technology Sept 2012 – Jun 2014 Graduate Research Assistant

• Proposed, analyzed, and successfully pitched project to enhance the sensitivity of biosensor to detect glucose level in blood

• Developed a novel process to immobilize the glucose oxidase and catalyze in Nano-porous structures and polymeric gels Chemical Engineering Department, Isfahan University of Technology Sept 2009 – Sept 2012 Undergraduate Research Assistant

• Identified and controlled the microbial contamination in ethanol fermentation process

• Analyzed the influence of bacterial contamination on efficiency of bioethanol production

• Designed experiments and lab techniques to batch produce bioethanol Biotechnology Lab, Iranian Research Organization for Science and Technology Jun 2011 – Sept 2011 Summer Intern

• Managed and composed documentation of system design development, operating manuals, and mechanical layout LEADERSHIP EXPERIENCE

Equipment In-charge: Glovebox, Fluorescence spectrophotometer, Vacuum pumps, Manifolds, Rotovap, Base Baths Chemical Engineering Graduate Committee (Vice President), Represented chemical engineering department in the graduate school Organized events for graduate student/faculty facilitating research collaborations in the department Graduate Research Symposium (GRS) Committee (Co-chair/Member), Departmental GRS organization (~40 graduate students’ research presentations) attended by over 15 industrial organizations from all over the US promoting creative idea exchange and industry/academic networking Women in Engineering Graduate Council (Member),

Research Mentor: Mentored more than 20 Masters and Undergraduate research associate in nanoparticle synthesis/characterization TEACHING EXPERIENCE

Graduate Teaching Associate:

CBE 2200 Process Fundamentals, Ohio State University, Fall and spring 2017 Guest Lecture–CBE 2200 (more than 10 sessions for 150 students) CBE 3508 Thermodynamic, Ohio State University, spring 2018 CBE 3632 Unit operation Lab, Ohio State University, Fall 2018 AWARDS AND HONORS

Received funding for NSF drug delivery project 2016-2018 Received funding for DARPA project 2014-2016

Full Scholarship for graduate studies in the Ohio State University 2014 Funded by Endocrinology and Metabolism Research Institute-Diabetes Research Center (MSc Thesis) 2014 Ranked 1st in nationwide University Entrance Exam in Engineering, Iran 2012 Chemical Engineering Departmental Fellowship award for B.S. (Top 5%) 2010 – 2012 National Scholarship for Exceptional Talents – Isfahan University of Technology 2009

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