Chemical Engineering Manager

Yuan Tian CURRICULUM VITAE Page *

Name Yuan Tian, PhD

Date of Birth Sep 13th, 1983 (Female)

Email *****@***.***

Research Interests Metabolomics, immunology, gut microbiota, cancer, obesity, diabetes, NMR, mass spectrometry Education

2006 - 2011 (PhD) Analytical Chemistry, Wuhan Institute of Physics and Mathematics, CAS, China Mentor: Dr. Huiru Tang

2002 - 2006 (BE) School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, China

Employment

2018 - Assistant Research Professor, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, USA (Line manager: Dr. Andrew D. Patterson) 2016 - 2018 Postdoctoral fellow, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, USA (Supervisors: Dr. Andrew D. Patterson and Dr. Margherita T. Cantorna) 2015 - 2019 Associate Professor, Centre for Biospectroscopy and Metabonomics, Wuhan Institute of Physics and Mathematics, CAS, China (Line manager: Dr. Huiru Tang) 2012 - 2015 Research Assistant, Centre for Biospectroscopy and Metabonomics, Wuhan Institute of Physics and Mathematics, CAS, China (Line manager: Dr. Huiru Tang) Responsibilities and Duties

• Ph.D. in Analytical Chemistry with 8+ years of work experience

• Advanced knowledge of NMR and mass spectrometry (LC-MS, GC-MS, and lipidomics)

• Advanced knowledge of metabolomics and microbiome-based assays (16S rRNA gene sequencing, genomics, and transcriptomics)

• Experience with cell culture, laboratory mouse model, single bacteria culture, immunohistochemistry, flow cytometry, cell-based luciferase reporter assay, and western blot etc.

• Proficiency in the use of Metabolomics data analysis software (i.e. Topspin, Chenomx, Mnova, MS-DAIL, MZmine, SIMCA-P, MATLAB, and R package etc.)

• Contribute to highly collaborative projects with large sample numbers and many biospecimen types

• Strong scientific writing and presentation skills

• Ability to think critically and demonstrate troubleshooting and problem-solving skills

• Self-motivated, detail-oriented, and willing to accept temporary responsibilities outside of initial job description Peer-Reviewed Publications (Google Scholar Citations: 723) 1. Y. Tian, W. Gui, B. Rimal, E. L. Allman, I. Koo, P. B. Smith, R. G. Nichols, Q. Liu, A. D. Patterson*. “Short- and Long- Term Metabolic Effect of Persistent Organic Pollutants in Immature Mice”. (In preparaion) 2. Y. Tian, W. Gui, B. Rimal, I. Koo, P. B. Smith, R. G. Nichols, J. Cai, Q. Liu, A. D. Patterson*. “Metabolic Impact of Yuan Tian CURRICULUM VITAE Page 2

Persistent Organic Pollutants on Gut Microbiota.” (under review of Nature Metabolism) 3. Y. Tian, W. Gui, I. Koo, P. B. Smith, E. L. Allman, R. G. Nichols, B. Rimal, J. Cai, Q. Liu, A. D. Patterson*. “The microbiome modulating activity of bile acids”. Gut Microbes, 2020, 5: 1-18. (Cited by 2 times). 4. Y. Tian, R. G. Nichols, J. Cai, A. D. Patterson, M. T. Cantorna*. “Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis”. Journal of Nutritional Biochemistry, 2018, 54: 28–34. (Cited by 18 times)

5. Y. Tian, L. Zhang, Y. Wang, H. Tang*.“Age-related topographical metabolic signatures for the rat gastrointestinal contents”. Journal of Proteome Research, 2012, 11: 1397-1411. (Cited by 52 times). 6. Y. Tian, J. Cai, W. Gui, R. G. Nichols, I. Koo, J. Zhang, M. Anitha, A. D. Patterson*. “Berberine directly impacts the gut microbiota to promote intestinal farnesoid X receptor activation”. Drug Metabolism and Disposition, 2019, 47: 86-93.

(Cover paper) (Cited by 14 times).

7. Y. Tian, R. Nichols, P. Roy, W. Gui, P. B. Smith, J. Zhang, Y. Lin, V. Weaver, J. Cai, A. Patterson, M. Cantorna*.

“Prebiotic effects of white button mushroom feeding on succinate and intestinal gluconeogenesis”. Journal of Functional Foods, 2018, 45: 223–232. (Cited by 11 times).

8. Y. Tian#, W. Gui#, P. Smith, I. Koo, I. Murray, M. Cantorna, G. Perdew, A. Patterson*. “Isolation and identification of aryl hydrocarbon receptor modulators in white button mushrooms (Agaricus bisporus)”. Journal of Agricultural and Food Chemistry, 2019, 67: 9286-9294. (Cited by 0 time)

9. Y. Tian#, X. Nie#, S. Xu, Y. Li, T. Huang*, H. Tang*, Y. Wang*. “Integrative metabonomics as potential method for diagnosis of thyroid malignant”. Scientific Reports, 2015, 5: 14869. (Cited by 40 times) 10. Y. Tian#, T. Xu#, J. Huang, L. Zhang, S. Xu, B. Xiong*, Y. Wang*, H. Tang*. “Tissue metabonomic phenotyping for diagnosis and prognosis of human colorectal cancer”. Scientific Reports, 2016, 6: 20790. (Cited by 25 times) 11. S. Xu#, Y. Tian#, Y. Hu, N. Zhang, S. Hu, D. Song, Z. Wu, Y. Wang, Y. Cui, H. Tang*. “Tumor growth affects the metabonomic phenotypes of multiple mouse non-involved organs in an A549 lung cancer xenograft model”. Scientific Reports, 2016, 6: 28057. (Cited by 9 times)

12. Y. Tian, H. Tang*. “Identification and structure determination of Saccharides in rat feces”. Chinese Journal of Magnetic Resonance, 2012, 29: 361-371. (Cited by 2 times)

13. L. Zhang, Y. Tian, J. Yang, J. Li, H. Tang, Y. Wang*. “Colon ascendens stent peritonitis (CASP) induces excessive inflammation and systemic metabolic dysfunction in a septic rat model”. Journal of Proteome Research, 2018, 17: 680-688.

(Cited by 2 times)

14. K. Belton, Y. Tian, L. Zhang, M. Anitha, P. Smith, G. Perdew, A. Patterson*. “Metabolomics reveals aryl hydrocarbon receptor activation induces liver and mammary gland metabolic dysfunction in lactating mice”. Journal of Proteome Research, 2018, 17: 1375-1382. (Cited by 3 times)

15. Q. Y. Yan, M. Alexander, J. C. Newman, Y. Tian, J. Cai, V. Upadhyay, J. A. Turnbaugh, E. Verdin, K. D. Hall, R. L. Leibel, E. Ravussin, M. Rosenbaum, A. D. Patterson, P. J. Turnbaugh*. “Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells”. Cell, 2020, 181: 1263-1275. (Cited by 4 times) 16. G. Li, C. Xie, S. Lu, R. G. Nichols, Y. Tian, L. Li, D. Patel, Y. Ma, C. N. Brocker, T. Yan, K. W. Krausz, R. Xiang, O. Gavrilova, A. D. Patterson, F. J. Gonzalez*. “Intermittent fasting promotes white adipose browning and decreases obesity by shaping the gut microbiota”. Cell Metabolism, 2017, 26: 672–685. (Cited by 154 times) 17. K. Bittinger, C. Zhao, Y Li, E Ford, E. Friedman, J. Ni, C. Kulkarni, J. Cai, Y. Tian, Q. Liu, A. Patterson, D. Sarkar, S. H. J. Chan, C. Maranas, A. S. Shah, P. Lund, B. Garcia, L. Mattei, J. Gerber, M. Elovitz, A. Kelly, P. DeRusso, D. Kim, C. Hofstaedter, M. Goulian, H. Li, F. Bushman, B. Zemel, G. Wu*. “Bacterial colonization reprograms the neonatal gut metabolome”. Nature Microbiology, 2020, 5: 838-847. (Cited by 1 time) 18. C. Xie, T. Yagai, Y. Luo, X. Liang, T. Chen, Q. Wang, D. Sun, J. Zhao, S. K Ramakrishnan, L. Sun, C. Jiang, X. Xue, Y. Yuan Tian CURRICULUM VITAE Page 3

Tian, K. W Krausz, A. Patterson, Y. Shah, Y. Wu, C. Jiang, F. Gonzalez*. “Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis”. Nature Medicine, 2017, 23: 1298-1308. (Cited by 46 times) 19. J. Cai, J. Zhang, Y. Tian, L. Zhang, E. Hatzakis, K. W. Krausz, P. B. Smith, F. J. Gonzalez, A. D. Patterson*. “Orthogonal comparison of GC−MS and 1H NMR spectroscopy for short chain fatty acid quantitation”. Analytical Chemistry, 2017, 89: 7900−7906. (Cited by 19 times)

20. V. Singh, B. S. Yeoh, A. A. Abokor, R. M. Golonka, Y. Tian, A. D. Patterson, B. Joe, M. Heikenwalder, M. V. Kumar*.

“Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota”. Gut Microbes, 2020, 11: 1077-1091. (Cited by 0 time)

21. A. Dey, J. N. Allen, J. W. Fraser, L. M. Snyder, Y. Tian, L. Zhang, R. F. Paulson, A. D. Patterson, M. T. Cantorna, P. A. Hankey-Giblin*. “Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease”. Frontiers in Immunology, 2018, 9: 513. (Cited by 4 times) 22. L. M. Snyder, K. L. McDaniel, Y. Tian, C. Wei, M. J. Kennett, A. D. Patterson, A. C. Ross, M. T. Cantorna*. “Retinoic acid mediated clearance of Citrobacter rodentium in vitamin A deficient mice requires CD11b+ and T cells”. Frontiers in Immunology, 2019, 9: 3090. (Cited by 4 times)

23. M. T. Cantorna*, Y. D. Lin, J. Arora, S. Bora, Y. Tian, R. G. Nichols, A. D. Patterson. “Vitamin D regulates the microbiota to control the numbers of RORgt/FoxP3+ regulatory T cells in the colon”. Frontiers in Immunology, 2019, 10:1772. (Cited by 5 times)

24. L. Zhang, L. Wang, Y. Hu, Z. Liu, Y. Tian, X. Wu, Y. Zhao, H. Tang, C. Chen, Y. Wang*. “Selective metabolic effects of gold nanorods on normal and cancer cells and their application in anticancer drug screening”. Biomaterials, 2013, 34: 7117-7126. (Cited by 71 times)

25. X. Xiao, B. S. Yeoh, P. Saha, Y. Tian, V. Singh, A. D. Patterson, M. V. Kumar*. “Modulation of urinary siderophores by the diet, gut microbiota and inflammation in mice”. Journal of Nutritional Biochemistry, 2016, 41: 25-33. (Cited by 6 times). 26. L. Zhang, Y. Ye, Y. An, Y. Tian, Y. Wang, H. Tang*. “Systems responses of rats to aflatoxin B1 exposure revealed with metabonomic changes in multiple biological matrices”. Journal of Proteome Research, 2010, 10: 614-623. (Cited by 119 times)

27. F. Chen, D. Coslo, T. Chen, L. Zhang, Y. Tian, P. Smith, A. Patterson, C. Omiecinski*. “Metabolomic approaches reveal the role of CAR in energy metabolism”. Journal of Proteome Research, 2018, 18: 239-251. (Cited by 1 time) 28. L. Zhang, M. Dong, G. Xu, Y. Tian, H. Tang, Y. Wang*. “Metabolomics reveals that dietary ferulic acid and quercetin modulate metabolic homeostasis in rats”. Journal of Agricultural and Food Chemistry, 2018, 66, 1723−1731. (Cited by 13 times)

29. J. Cai, R. Nichols, I. Koo, Z. Kalikow, L. Zhang, Y. Tian, J. Zhang, P. Smith, A Patterson*. “Multi-platform physiologic and metabolic phenotyping reveals microbial toxicity”. mSystem, 2018, 3: e00123-18. (Cited by 3 times) 30. T. D. Hubbard, I. A. Murray, R. G. Nichols, K. Cassel, M. Podolsky, G. Kuzu, Y. Tian, P. Smith, M. J. Kennett, A. D. Patterson, G. H. Perdew*. “Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner”. Journal of Functional Foods, 2017, 37: 685–698. (Cited by 30 times) 31. Q. Liu, J. Cai, R. Nichols, Y. Tian, J. Zhang, P. Smith, Y. Wang, C. Yan, A. Patterson*. “A quantitative HILIC-MS/MS assay of the metabolic response of Huh-7 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin”. Metabolites, 2019, 9: 118.

(Cited by 0 time)

32. L. Zhang, B. Rimal, R. G. Nichols, Y. Tian, P. B. Smith, E. Hatzakis, S. C. Chang, J. L. Butenhoff, J. M. Peters, A. D. Patterson*. “Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice”. Toxicology, 2020, 431: 152365. (Cited by 1 time)

Book Chapters

1. Y. Tian, J. Cai, E. L. Allman, P. B. Smith, A. D. Patterson. “Quantitative analysis of bile acid with UHPLC-MS/MS”. Translational Bioinformatics for Therapeutic Development: Methods and Protocols (Editor: Joseph Markowitz), Yuan Tian CURRICULUM VITAE Page 4

Springer, In press.

2. R. Hu, T. Li, Y. Yang, L. Zhang, Y. Tian*. “NMR-Based Metabolomics in Cancer Research”. Cancer Metabolomics: Technology and Applications (Editor: Shen Hu), Springer, In press. 3. T. K Mal, Y. Tian, A. Patterson. “NMR-based metabolomics”. Translational Bioinformatics for Therapeutic Development: Methods and Protocols (Editor: Joseph Markowitz), Springer, In press.

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