Pharmacy Medical

Curriculum vitae

Rohit Gundamaraju, an International Post Graduate Research award Fellow in Gastrointestinal Diseases

Contact information: Ph. No: +919*********

Email: *****.***********@*****.***

*****.***********@****.***.**

Websites

Loop by Frontiers: https://loop.frontiersin.org/people/137023/overview LinkedIn: https://www.linkedin.com/in/rohit-gundamaraju-1895965a/?originalSubdomain=au Research Gate: https://www.researchgate.net/profile/Rohit_Gundamaraju2 Education

Bachelors: Pharmacy

Osmania University, Hyderabad, India (2010)

Masters: M. Pharmacy (Pharmacology)

JNTUH, Hyderabad, India (2012)

PhD: (Medical Sciences)

School of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia Motivation

An enthusiastic, adaptive and fast-learning person with a broad and acute interest in the medicine of new innovative drugs, pathways and mechanisms, I particularly enjoy collaborating with scientists from different disciplines to develop new skills and solve new challenges. My interest greatly lies in oncology and related research.

Objectives

To deliver the results in time dictated targets

To work independently in an environment and be able to demonstrate leadership qualities

To be able to demonstrated capacity to work in a collegiate manner with other staff in the workplace and a demonstrated computer literacy.

To be able to perform multi tasking ability, ability to adapt to harsh environments and attain and required work knowledge, manuscript and analytical skills. Projects handled

PhD: My doctoral research was cracking the hypothesis of what a stressed goblet cell has to do or show. Firstly, the work consisted of a proteomic approach for Winnie (a mouse model of chronic endoplasmic reticular stress) goblet cells to unravel the key players involved in evading programmed cell death and aiding in proliferation. The second part was exploring the molecular mechanisms correlating ERS and apoptosis in colon cancer cells with the aid of chemical inducers and inhibitors of ERS and lastly incorporating unconjugated bilirubin as an ideal anti ER stress agent thereby adding an angle of therapeutics and making it a giant cell biology project. Masters: My masters’ work was divided into two parts obesity and arthritis. One of the ways I have induced obesity was by butter and by hormonal induction (progesterone) which mimics obesity during pregnancy. The arthritis was introduced by a chemical induction via turpentine. Lantana camara, a road side weed was employed by me against these medical conditions which was novel and was published.

Bachelors: The research project in bachelors was a literature search on mesothelioma (a rare lung cancer) which was published as best review paper in University. Research Experience

1. Dec 2012 to Aug 2013- Assistant Professor at ST. Pauls College of Pharmacy Responsibilities:

Was responsible in guiding and teaching undergraduate students.

Involved in research projects for bachelors in Pharmacy.

Involved in college administration.

2. Aug2013 to Jan 2014- Researcher at Sipra Labs

Responsibilities:

Got involved in various research projects like obesity, cancer and arthritis

Designed various projects for under graduates for their thesis. 3. Feb 2014 to June 2015- Researcher at Universiti Malaya (Department of Microbiology, School of Medicine)

Responsibilities:

Dealt with equipments like ECIS (electric cell impedance sensing) for monitoring the activity of virus on cells

Worked on projects like “Effects of dengue virus on vascular damage on various cells”

Involved in manuscript drafting for various projects and review articles for the department and also worked as content writer.

Awards & Grants

1. Young investigator award

2. Bright Spark Research Fellow- Malaysia

3. IPRS Fellow, Australian Post Graduate Award for PhD. Certifications and courses

1. “Introduction to Cancer biology” by Johns Hopkins 2. “Histology- Using microscopy to study anatomy and identify disease” by Open University Skills & Activities

Skills Phytochemicals, Natural Product Drug Discovery, Medicinal Plants, Ethnopharmacology, Atherosclerosis, Plant Extracts, Herbal Medicine, Bioactivity, Renal Disease, Pathophysiology, Treatment, Solid Dispersion, Formulations, Drug Design, Drugs, Low Density Lipoproteins, Docking Studies, Cardiology, Medicinal and Pharmaceutical Chemistry, Natural Product Chemistry, Natural Product Isolation, Phytochemical Analysis, Chromatography, Phytochemical Purification

Languages English, Hindi, Telugu, Bahsa (known to speak) Scientific

Memberships

Malaysian Society of Physiology and Pharmacology

Malaysian Society of Hypertension

Indian Society of Pharma Research

Cell Stress Society International

American society of Biochemistry and Molecular Biology Publication Highlights

Books

Ravi Chandra Vemuri, Rohit Gundamaraju, Rajeev K. Singla: Volumetric analysis in Oncology. Edited by Wolfgang, 07/2014; LAP Lambert Academic Publishing, ISBN: 978-365-***-**** Other projects handled

1. Endoplasmic reticular stress in the gut: A novel project involving the correlation of endoplasmic reticular stress and cancer spread in the gut involving various inducers and inhibitors of ER stress.

2. Diabetes and renal hypertension: Have dealt with conditions like Goldbaltts disease and hypertension in rats.

3. Treating obesity and arthritis with Lantana camara: This project associated with a wild herb designated to various parts of Asia and its role in the magic cure of obesity and arthritis.

Journal Publications

Gastrointestinal physiology & Pharmacology:

Richard Wilson¥, Rohit Gundamaraju¥, Ravichandra Vemuri, Constanza Angelucci, Dominic Geraghty, Nuri Guven, Rajaraman Eri. Identification of key pro-survival proteins in isolated colonic goblet cells of Winnie, a murine model of spontaneous colitis. Inflam Bowel Dis. (2019). Doi: https://doi.org/10.1093/ibd/izz179. (¥equal first authorship)

Rohit Gundamaraju, Ravichandra Vemuri, Wai Chin Chong, Raj Eri. Bilirubin Attenuates ER Stress-Mediated Inflammation, Escalates Apoptosis and Reduces Proliferation in the LS174T Colonic Epithelial Cell Line. Int J Med Sci. 16(1). 144.

Rohit Gundamaraju, Ravichandra Vemuri, Wai Chin Chong, Raj Eri. Interplay between Survivin and ER stress. Cells. 7(10). E171.

Rohit Gundamaraju, Ravichandra Vemuri, Wai Chin Chong, Dominic Geraghty, Raj Eri. Cell stress signalling cascades regulating cell fate. Curr Pharm Des. 2018. 24(27). 3176- 3183.

Agampodi Promoda Perera, Ruchira Fernando, Tanvi Shinde, Rohit Gundamaraju, Benjamin Southam, Sukhwinder Singh Sohal, Avril A. B. Robertson, Kate Schroder, Dale Kunde, Rajaraman Eri: MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice. Scientific Reports 12/2018; 8(1)., DOI:10.1038/s41598-018-26775-w

Ravichandra Vemuri, Tanvi Shinde, Madhur D Shastri, Promoda Perera, Stephen G Tristram, Christopher Martoni, Rohit Gundamaraju, Kiran D K Ahuja, Madeleine Ball, Rajaraman Eri: A human origin strain Lactobacillus acidophilus DDS-1 exhibits superior in vitro probiotic efficacy in comparison to plant or dairy origin probiotics.

Ravichandra Vemuri, Rohit Gundamaraju, Madhur Shastri, Shakti Shukla, Krishnakumar Kalpurath, Madeleine Ball, Stephen Tristram, Esaki M. Shankar, Kiran D. K. Ahuja, Rajaraman Eri: Gut microbial changes, interactions, and their implications on human lifecycle: an ageing perspective. BioMed Research International 01/2018;

Rajaraman Eri, Ravichandra Vemuri, Rohit Gundamaraju: Editorial: Novel Interventional Targets for Gastrointestinal and Metabolic Disorders. Current Pharmaceutical Design 06/2017; 23(16)., DOI:10.2174/1381612823999170404122838

Ravichandra Vemuri, Rohit Gundamaraju, Rajaraman Eri: Role of Lactic Acid Probiotic Bacteria in IBD. Current pharmaceutical design 02/2017; 23(999)., DOI:10.2174/1381612823666170207100025

Wai Chin Chong, Rohit Gundamaraju, Ravichandra Vemuri, Marcus T Scotti, Luciana Scotti: Momordicacharantia: A New Strategic Vision to Improve the Therapy of Endoplasmic Reticulum Stress. Current pharmaceutical design 01/2017; 23(999)., DOI:10.2174/1381612823666170124141104

R.C. Vemuri, R Gundamaraju, T Shinde, R Eri: Therapeutic interventions for gut dysbiosis and related disorders in the elderly: Antibiotics, probiotics or faecal microbiota transplantation?. Beneficial Microbes 12/2016; 8(2):1-15., DOI:10.3920/BM2016.0115

Rohit Gundamaraju, Ravichandra Vemuri, Rajaraman Eri, Hamilton M Ishiki, Ericsson Coy-Barrera, Nagendra Sastry Yarla, Dos Santos SG, Mateus Feitosa Alves, José Maria Barbosa Filho, Margareth F F M Diniz, Marcus T Scotti, Luciana Scotti: Metabolomics as a Functional Tool in Screening Gastro Intestinal Diseases: Where Are We in High Throughput Screening?. Combinatorial chemistry & high throughput screening 12/2016; 20(3)., DOI:10.2174/1386207319666161220122903

Rohit Gundamaraju: Overriding Elements in Colon Cancer Progression: Some Less Known Facts. DOI:10.17140/GOJ-2-124

Rajeev K Singla, Rohit Gundamaraju, Baishakhi Dey, Varadaraj Bhat: Docking Studies and ADMET Profile of Streblusol E, Anti-hepatitis B viral Agent of Streblus Asper. DOI:10.3390/MOL2NET-1-b018

Rohit Gundamaraju, Rajeev K Singla, Ravi Chandra Vemuri, Shamala Devi Sekaran: Functional Correlation of Medicinal Chemistry and Entamoeba histolytica Treatment: An Emphasis on the Past, Present and Future Chemotherapy. Mini Reviews in Medicinal Chemistry 02/2015; 15(3)., DOI:10.2174/138955751503150312121302

Rohit Gundamaraju, Kotla Maheedhar, Kim Kah Hwi: Exploiting the phenomenal anti- ulcerogenic potential of Talinum portulacifolium ethanolic extract whole plant on Albino Rats: The therapeutic potential of Chinese Herb-m ch xiàn kē (Portulacaceae). Pharmacognosy Research 05/2014; 6(3):227-233., DOI:10.4103/0974-8490.132600

Rohit Gundamaraju: Novel antipathy for schistosomiasis–the most lethal ailment of the tropical region. Asian Pacific Journal of Tropical Biomedicine 05/2014; 4(Suppl 1):S43- 5., DOI:10.12980/APJTB.4.2014C831

Rohit Gundamaraju, Ravi Chandra Vemuri: Opisthorchis viverrini (liver fluke) as the lot of baleful parasite of tropical region-A replete synopsis. Asian Pacific Journal of Tropical Disease 02/2014; 4(1):61–66., DOI:10.1016/S2222-1808(14)60316-9

Rohit Gundamaraju, Ravichandra Vemuri: Pathophysiology of Greedy Colon and Diabetes: Role of Atropine in worsening of Diabetes. 01/2014; 4(1):51-54., DOI:10.5005/jp-journals-10018-1096

Rohit Gundamaraju: Evaluation of anti-helmintic activity of Ferula foetida “Hing- A natural Indian spice” aqueous extract. Asian Pacific Journal of Tropical Disease 04/2013; 3(3):189–191., DOI:10.1016/S2222-1808(13)60038-9 Highlighted Publications

Baishakhi De, Koushik Bhandari, Ranjan Mukherjee, Prakash Katakam, Shanta K Adiki, Rohit Gundamaraju, Analava Mitra: PBPK Modeling - A Predictive, Eco-Friendly, Bio- Waiver Tool for Drug Research. Current Drug Discovery Technologies 02/2017; 14(999)., DOI:10.2174/1570163814666170202094922

R Aditya, A Ravi Kiran, D Sai Varma, Ravichandra Vemuri, Rohit Gundamaraju: A review on SIRtuins in diabetes. Current pharmaceutical design 01/2017; 23(16)., DOI:10.2174/1381612823666170125153334

Rajeev K Singla, Koushik Bhandari, Baishakhi De, Bijoy Chandra Ghosh, Prakash Katakam, Dilip Kumar Khushwaha, Rohit Gundamaraju, Gargi Sen, Gargi Saha, Anirban Mitra, Analava Mitra: Chemometrics Based Extraction of Polyphenolics from Fresh Tea Leaves and Processed Tea Showing In- Silico Docking and Anti- oxidative Theronostic Dietary Adjuvant in Alzheimer. Indo Global Journal of Pharmaceutical Sciences 12/2015; 5(3).

Baishakhi De, Koushik Bhandari, Rajeev K Singla, Prakash Katakam, Tanmoy Samanta, Dilip Kumar Kushwaha, Rohit Gundamaraju, Analava Mitra: Chemometrics Optimized Extraction Procedures, Phyto syner gistic Blending, and In vitro Screening of Natural Enzyme Inhibi tors Amongst Leaves of Tulsi, Banyan, and Jamun. Pharmacognosy Magazine 12/2015; 11(44):522-532., DOI:10.4103/0973-1296.172956

Baishakhi De, Koushik Bhandari, Nishant Chakravorty, Ranjan Mukherjee, Rohit Gundamaraju, Rajeev K Singla, Prakash Katakam, Shanta K Adiki, Biswajoy Ghosh, Analava Mitra: Computational pharmacokinetics and in vitro-in vivo correlation of anti- diabetic synergistic phyto-composite blend. 09/2015; 6(11)., DOI:10.4239/wjd.v6.i11.1179

Ravi Chandra Vemuri, Rohit Gundamaraju: Major pathophysiological correlations of rosacea: a complete clinical appraisal.. International journal of medical sciences 06/2015;

Rohit Gundamaraju, Ravi Chandra Vemuri, Lam Sau Kuen, Rishya Manikam, Rajeev K. Singla, Shamala Devi Sekaran, Ramesh Chakrapani: The science of rabies in tropical regions: From epidemiological pandemonium to prevention. Frontiers in Life Science 05/2015; 8(3):1-5., DOI:10.1080/21553769.2015.1041186

Rohit Gundamaraju: Major Pathophysiological Correlations of Rosacea: A Complete Clinical Appraisal. International journal of medical sciences 05/2015; 12(5):387-396., DOI:10.7150/ijms.10608

Arti Mohan, Rohit Gundamaraju: In vitro and in vivo evaluation of fast-dissolving tablets containing solid dispersion of lamotrigine. International Journal of Pharmaceutical Investigation 01/2015; 5(1):57-64., DOI:10.4103/2230-973X.147235

Mohan, R. Gundamaraju: Formulation of immediate release tablets of rabeprazole sodium by using tablet in tablet technology.

Rohit Gundamaraju, Kim Kah Hwi, Rajeev K Singla, Ravi Chandra Vemuri, Sartaj Banu Mulapalli: Antihyperlipidemic potential of Albizia amara (Roxb) Boiv. bark against Triton X-100 induced hyperlipidemic condition in rats. Pharmacognosy Research 10/2014; 6(4)., DOI:10.4103/0974-8490.138237

Rohit Gundamaraju, Ravi Chandra Vemuri, Rajeev K Singla, Rishiya Manikam, Ranga Rao Ambati, Shamla Devi Sekaran: Strophanthus hispidus attenuates the Ischemia- Reperfusion induced myocardial Infarction and reduces mean arterial pressure in renal artery occlusion. Pharmacognosy Magazine 08/2014; 10(39):557-572., DOI:10.4103/0973-1296.139782

Babita Aggarwal, Rajeev K Singla, Mohd Ali, Vijender Singh, John O Igoli, Rohit Gundamaraju, Kah Hwi Kim: Triterpenic and monoterpenic esters from stems of Ichnocarpus frutescens and their drug likeness potential. Medicinal Chemistry Research 08/2014; 24(4)., DOI:10.1007/s00044-014-1227-2

Chin Chew Quah, Kah Hwi Kim, Mei Siu Lau, Wee Ric Kim, Swee Hung Cheah, Rohit Gundamaraju: Pigmentation and Dermal Conservative Effects of the Astonishing Algae Sargassum Polycystum and Padina Tenuis on Guinea Pigs, Human Epidermal Melanocytes (HEM) and Chang Cells. African Journal of Traditional, Complementary and Alternative Medicines 06/2014;, DOI:10.4314/ajtcam.v11i4.13

Rohit Gundamaraju, Ravi Chandra Vemuri, Kim Kah Hwi: Are animals a bane for the spread of the deadly malady, the corona virus (MERS)?. Asian Pacific Journal of Tropical Biomedicine 05/2014; 4(Suppl 1):S46-7., DOI:10.12980/APJTB.4.2014C1220

Rohit Gundamaraju: HUNTINGTON’S DISEASE: A PERPLEXING NEUROLOGICAL DISEASE. African Journal of Neurological Sciences 04/2014; 33(1):1.

Ravi Chandra Vemuri, Rudresh Jarecha, Kim Kah Hwi, Rohit Gundamaraju, Aripaka Maruthikanth, Aravindrao Kulkarni, Sundeep Reddy: Importance of Volumetric Measurement Processes in Oncology Imaging Trials for Screening and Evaluation of Tumors as Per Response Evaluation Criteria in Solid Tumors. Asian Pacific journal of cancer prevention: APJCP 03/2014; 15(5):2375-8., DOI:10.7314/APJCP.2014.15.5.2375

R. Gundamaraju, R. Vemuri: Huntington’s disease: A perplexing neurological disease. African Journal of Neurological Sciences 01/2014; 33(1).

R. Gundamaraju, S.B. Mulaplli, C. Ramesh: Evaluation of anti-obesity activity of Lantana camara var linn by progesterone induced obesity on albino mice. International Journal of Pharmacognosy and Phytochemical Research 01/2013; 4(4):113-118.

Rohit Gundamaraju: Evaluation of Anti-Obesity Activity of Lantana camara Var Linn. by Progesterone Induced Obesity on Albino Mice.

Rohit Gundamaraju, T Mohan Verma : EVALUATION OF WOUND HEALING ACTIVITY OF CROSSANDRA INFUNDIBULIFORMIS FLOWER EXTRACT ON ALBINO RATS.

D.V. Atigari, R. Gundamaraju, S. Sabbithi, B.K. Chaitanya, C. Ramesh: Evaluation of antiepileptic activity of methanolic exract of Celastrus paniculatus Willd whole plant in rodents.

Conference Proceedings

Rohit Gundamaraju: Strophanthus Hispidus extract Attenuates the Myocardial Infarction Induced by Ischemia-reperfusion and Reduces of the Renal Hypertension Induced by Renal Artery Occlusion. 6th Scientific Meeting of the Asian-Society-for-Vascular-Biology / 13th; 01/2014

Editorial appointments:

Review Editor- Frontiers in Chemistry

Guest Editor- Current Pharmaceutical Design (Bentham Publications)

Guest Editor- Indo Global Journal of Pharmaceutical Sciences

Associate Editor- Research Journal of Pharmacology and Pharmaco dynamics (A & V Publications)

Associate Editor- VRI Journals

Reviewer- Drug Development Discovery and Therapy (Dove Press)

Reviewer- International Journal of Diabetes in Developing Countries (Springer)

Reviewer- Pharmacognosy Research (Medknow)

Reviewer- Pharmaceutical Biology (Taylor & Francis)

Reviewer- International Journal of Uro-gynecology (Springer)

Reviewer- Journal of Ethnopharmacology (Elsevier)

Reviewer- Science Domain

Reference:

1. Dr.Rajaraman Eri

University of Tasmania

*********.***@****.***.**

2. Dr. Dominic Geraghty

University of Tasmania

*.********@****.***.**

3. Dr. Rajeev K Singla

Mangalam University, India

**************@*****.***

4. Dr. Andrew Bulmer

Griffith University

*.******@********.***.**

5. Dr. Ranga Rao Ambati

Vignan University, India

***********@*****.***

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