Chemical Scientist

PRADIP PATIL

***************@*****.***

Mobile No: 082********

Career Summary:

A highly self motivated scientist with deep expertise in synthesis of organic molecules having 11+ year of experience in research and development department from research, pharmaceutical and chemical industries. Professional Qualification:

Post Graduate Diploma in Regulatory Affairs – API (PGDRA-API) from Institute of pharmaceutical management, Boriwali,

Mumbai with 85 % (Grade- A)

M. Sc. in Organic Chemistry (2006-08) from PSGVPM’s science college Shahada Dist: Nandurbar, Maharashtra (North Maharashtra University, Jalgoan, India) with 72%

B.Sc. in Chemistry (2003-2006) from PSGVPM’s science college Shahada Dist: Nandurbar, Maharashtra (North Maharashtra University, Jalgoan, India) with 73% H.S.C. (12th) in Science Feb-2003 from Nashik Board with 75.83% S.S.C. March-2001 from Nashik Board with 77.33%

Work experience: 11+ Years

Currently working as In-charge R and D Lab at Zephyr Synthesis pvt. limited from 5 Aug 2019

Previously working as Senior Executive in RD lab at Raks Pharmaceutical Ltd Dahej Gujarat from 4 Jan 2017 to 2 Aug 2019

Previously working as Jr. Research Scientist in CRD lab at Macleods Pharmaceutical Ltd Sarigam Gujarat from 26 Sep 2014 to Dec 2016

Previously working as Jr. Scientist at Piramal Discovery Solutions Pvt. Ltd. Ahmadabad Gujarat formally known as Oxygen Bioresearch Pvt. Ltd. from 19 July 2012 to 24 Sep 2014

Worked as Research Associate at SRF Ltd Bhiwadi Rajasthan from 21th Nov 2011 to 10 July 2012

Two year of working experience as Research Associate at Jubilant Chemsys NOIDA UP from 16th Nov 2009 to 18th Nov 2011

Experience in API synthesis and process development as research associate at Enaltec Lab Pvt. Ltd. Ambarnath, Mumbai Maharashtra from Oct-2008 to Nov 2009

Job Description in Details:

API PROCESS DEVELOPMENT JOB PROFILE:

Literature search with various scientific software like Sci-finder and Reaxys

Designing and selection of non infringing synthetic route (route scouting) by review of literature and patents

Chemical procurement using SAP system

Feasibility study of selected route with characterization of each and every intermediate by H1 NMR, C13 NMR, LCMS, Mass, IR etc.

Impurity evaluation and their synthesis and characterization as per CMC of product

Optimization and developing new product from lab to pilot scale with process improvement skill

Modification and improvement in existing products and processes as per customer needs and manufacturing department requirements

Preparation of new polymorph of API and study of polymorphism from XRPD data

Monitoring and trouble shooting of plant batches.

Co-ordination to analytical team for the monitoring of reaction by HPLC, GC, etc.

Supporting to RA and IPM department for document required for DMF and patent filing

Audit faced: USFDA, WHO Geneva, Customer audit etc.

Product handled:

API:

Cariprazine Hydrochloride,

D-Penicillamine, Dapagliflozin, Linagliptin

Duloxetin hydrochloride, Montelucast sodium etc.

Chemical:

2-Actylthiophene, Glycienesters Hydrochlorides, methylthioglycolate, Di-para-toluene L/D-tartaric acid etc.

CRO JOB PROFILE

Literature survey and route preparation of organic molecules

Multistage synthesis of novel molecule in mg to gm scale

To carry out experiments & workup on day to day basis

Purification of synthesized compounds using Combi-flash, manual gravity column chromatography

Characterization of organic compounds using IR, H1 NMR, C13 NMR, Mass, LC-MS spectroscopy etc.

Experience in handling of Autoclave reactions, Paar vessel, Microwave reactions in microwave reactor

LNB writing on daily basis

Familiar with documentation for audit

Weekly report preparation of work status

Adequate interpersonal skills to interact effectively with people in other departments

REACTION HANDLE:

Cyanation using KCN, CuCN, NaCN, Zn(CN)2, etc.

Mannich reaction,Wittig reaction,Weinreb reaction, etc.

Coupling reactions like Buchwald reaction, Sonageshira coupling, Stelle coupling, Suzuki coupling, Ulman coupling, etc.

Different protection and de-protection of amines and alchohol

Reduction using LAH, DIBAL, NaCNBH3, NaBH4, H2 Pd/C, raney nickel, NiCl2.6H2O, PtO2 etc.

Halogenations by NIS, NBS, NCS, Select fluor, etc.

Cyclization to prepare purines and pyrimidine derivatives, diamine cyclization, etc.

Butyl lithium reactions, racemic resolution, reductive amination etc. Computer Literacy:

Diploma in Information Technology (C-DAC)

Chemistry software’s- Sci-Finder, Reaxys, Chem-Bio Draw, etc Seminars and Workshop:

National Conference on Development & Analysis of Drugs (DAD-2008) State level seminars on Recent Advancement in Organic Synthetic Reagent

(RAIOSR-2007)

State level seminar on Exploring Horizons in Microbial Biotechnology (EHBT- 2008)

Languages known:

English, Hindi, Marathi and Gujarati

Date of Birth: 20/05/1986

Declaration:

I hereby declare that all the above information is true to the best of my knowledge. PRADIP PATIL

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