Assistant Data

Lulu Zhou (M.S. in Biostatistics and Ph.D. in Toxicology)

Los Angeles, California Email: addu9e@r.postjobfree.com Summary: I have extensive experience in developing and evaluating statistical methods in pre-clinical, observational studies and experimental design. I employ strong programming skills in SAS and R to solve problems using sophisticated statistical methods. I am a good team worker with proven self-motivation, ability to build competency in previously unfamiliar areas and work under minimal supervision Educations:

2016-2019 M.S. Biostatistics (GPA: 3.75)

University of Southern California

2011-2014 Ph.D. Toxicology (GPA: NA)

Cranfield University, UK

2006-2011 B.S. Biomedical Science (GPA: 3.68)

Jiangsu University, China

Work and Academic Experience

May 2016-

Dec 2019

M.S. Student and Research Assistant (University of Southern California) Cross-Sectional data analysis to investigate the relation of bisphosphonate use to atherosclerosis in post-menopausal women (M.S. Thesis)

§ Practiced descriptive analysis and checked distribution of all the variables

§ Performed propensity score match and inversed probability weighting procedures and developed weighted linear mixed models at baseline

§ Fitted weighted mixed models and GENMOD models for the on-trial data analysis Prediction of Breast Cancer Survival on Gene Expression Data (Machine Learning)

§ Fitted Lasso and Ridge logistic regressions on breast cancer gene expression data with 1,000 features

§ Tested misclassification error for the selected model Population-based cancer surveillance data analysis for cancer trend and survival at Cancer Registry for LA county

§ Conducted Cox regression analysis and examined proportional hazard assumptions

§ Calculated Age-adjusted cancer incidence rate by race group and graphed cancer trend over different time periods

Jun 2015-

Jun 2018

Postdoctoral Associate (University of Southern California)

§ Led a project to investigate the cross-talk between Nrf2 and NF-kB pathway in response to sulforaphane in vitro

§ Designed and executed analytic techniques to characterize the shifted antioxidant/inflammatory axis with aging

§ Practiced experimental data analysis applying ANOVA and generalized linear regression models

§ Contributed to the grant writing and preparation of reports, journal articles and conference presentations

Clinical Lab Intern (Putuo Hospital, Shanghai)

Jun 2010-

Jun 2011

§ Performed laboratory analyses, including biochemical, microbiological and immunological tests in a clinical laboratory

§ Conducted a project to investigate the association between gene polymorphism of Toll- like Receptor4 Asp299Gly A/G and susceptibility of vascular dementia Teaching Experience

Dec 2012-

Dec 2013

§ Delivered cyto-/geno-toxicology lectures to M.S. students for two semesters in Cranfield University

Aug 2019-

Dec 2019

§ Reviewed lectures, graded homework and led discussions in course ‘Health Behaviour Statistical Method’ in University of Southern California Skills and Certificates

Software/Programming: SAS 9, SAS/Macro, SAS/SQL, SAS/STAT, R, STATA, PASS, Microsoft Word, Excel Statistics: Clinical Trials, Observational Studies, Survival Analysis, Power Analysis, Longitudinal Analysis, Categorical Data Analysis, High-Dimensional Data Analysis, Multivariate Analysis, Bayesian Methods, Mixed Model, Machine Learning, Experimental Design, Simulation, Cross Validation Toxicology: Cell Culture, Flow Cytometry, ELISA, RNA Regulation Assessment, PCR, Confocal Microscopy, Endpoints Genotoxicity and Basic Assays of Cellular and Genetic Toxicity Evaluations Regulations: Drug Development Process, ICH, CDISC

Certifications: SAS Base, SAS Advanced, Human Subjects Research, HIPPA, GCP Publications

§ Zhang, H., Zhou, L., Davies, K.J. and Forman, H.J., Delayed Nrf2-regulated antioxidant gene induction in response to silica nanoparticles." Free Radical Biology and Medicine 108 (2017): 311- 319

§ Zhou, L., et al. "Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells." Redox biology 14 (2018): 35-40

§ Zhou, L., et al. "Multi-walled carbon nanotubes: a cytotoxicity study in relation to functionalization, dose and dispersion." Toxicology In Vitro 42 (2017): 292-298

§ Zhang, H., Zhou, L., Davies, K.J. and Forman, H.J., 2019. Silencing Bach1 alters aging-related changes in the expression of Nrf2-regulated genes in primary human bronchial epithelial cells. Archives of biochemistry and biophysics, p.108074

Nov 2011-

May 2015

Ph.D. Student and Research Assistant (Cranfield University, UK)

§ Conducted preclinical studies investigating oxidative stress, DNA damage, apoptosis, cancerous and inflammatory biomarkers induced by carbon nanotubes in various of cancer cells

§ Performed data analysis to evaluate the potential of carbon nanotubes as drug/gene carriers for cancer therapy at pre-clinical stage

§ Organised weekly toxicology meetings in vitro to train M.S. students

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