Address: An der Johanniskirche *, ***** Hannover; Germany

Date of birth: 28.03.1989 Nasywajewsk (Russia; nat. German) Tel.: 017******** Email: adc134@r.postjobfree.com Available from: immediately

Dmitrij Malcev, PhD

Professional experience

10/2015 – 09/2019

Research associate, Medizinische Hochschule Hannover, Hanover, Germany

Design and synthesis of molecular library with inhibitory activity towards the movement protein myosin of malaria parasite. Increase of the inhibitory potency to low nanomolar concentrations in-vitro. Protection of designed molecules by patent ongoing.

Successful explanation and determination of chemo-mechanical properties of the parasitic protein changed by synthetized compounds in-vitro.

Successful in-silico determination of backgrounds for the increased and selective activity of a carbazolic small molecule inhibitor towards the movement protein involved in the cancer progression.

Proactive and successful instruction and managing of three thesises and trainees. 09/2014 – 12/2014

Trainee, Production, Honeywell Specialty Chemicals GmbH, Seelze, Germany

Increase of production system and 40% cost optimization based on statistical, software-supported evaluation of representative experiments.

Leading of laboratory technicians in the evaluation and accomplishment of anaerobic, large-scale industrial production processes. Risk assessments and enhancement of security measures.

Optimization of an innovative, but risk prone scale-up process and successful establishment of an alternative synthesis approach in laboratory scale.

07/2012 – 08/2017

Volunteering Chairman and co-trainer, Sport Club JSV07“ e. V., Hanover, Germany

Coordination and managing of volunteering stuff. Acquisition, development and ongoing maintenance of contacts with sponsors and investor associations in the area of sport and health. Management and moderation of sports events. Organization, lead of meetings, written reporting to tax office and other instances. 02/2013 – 06/2013 und 10/2013 – 11/2013

Scientific Assistant, Leibniz Universität Hannover, Hanover, Germany

Risk assessments, correction of experimental protocols, and instruction of experiments in organic chemistry. Academic education

10/2015 – 09/2019

Leibniz Universität Hannover, Dr. rer. nat. (PhD) (Grade:1.0), Hanover, Germany

PhD thesis: “Design and Synthesis of Allosteric Inhibitors for apicomplexan Movement Machinery”; Supervisor: Prof. Dr. Matthias Preller.

10/2013 – 09/2015

Leibniz Universität Hannover, M.Sc. Wirk- und Naturstoffchemie (Grade:1.8), Hanover, Germany

Organic synthesis, analytic methods, principles of fermentation, characteristics and specificity of natural and pharmaceutical products.

Master thesis: Research on the DIELS-ALDER-Cycloadditions and FRIEDEL-CRAFTS-Reactions Under High Pressure and High Temperature Conditions in Flow-Systems in Presence of Water” Supervisor: Prof. Dr. Andreas Kirschning.

10/2010 - 02/2014

Leibniz Universität Hannover, B. Sc. Chemie (Grade: 1.9), Hanover, Germany

Bachelor thesis: Studies on the Optimization of DIELS-ALDER-Cycloadditions for Chemo- Hyperthermic Cancer Therapy“

Supervisor: Prof. Dr. Andreas Kirschning.

Skills and interests

Languages: German (native), Russian (native), English (fluent), Spanish (basic) IT: MS Office, ChemDraw, Pymol, VMD, Schroedinger, MestreNova, TopSpin, MGL-Tools, MaterialStudio, Origin

Interests:

Martial arts (since 1998); won several German championship medals; top five results at World and European Championships.

Traveling to learn about other cultures and traditions, visit of nearby natural and cultural sights. Further education

11,25/02 und 3,17/03/2016 Training seminar: “Patent Law in Natural Science”

Intellectual Property (IP)

German, European and international proceedings

“Freedom-to-operate”

How to read, write and destroy a patent

Exploration strategy

German Employee Invention Act and Contracts

Agent's job

Cooperation: research - development - patent division 24–28/03/2013 Seminar: “Intercultural Communication”

Outlining of own and foreign cultural standards

Sensibilization of intercultural situations

Development of intercultural communication strategies 4.09.2014 Seminar: Management of Cost, Quality and Ecology in Chemical and Pharmaceutical Industry“

Systems of quality management (DIN/ISO9000ff&GMP, EN45001/17025&GLP

ChemG&REAChV, AMG&AMWHV

International Law and GMP-guidelines (ICH, PIC, FDA)Intellectual Property (IP) Conferences and publications

7/06 – 08/06/2016

HSBDR Retreat, Burg Warberg, Germany

Presentation of progress in design and synthesis of parasitic inhibitors. 16/06 – 17/06/2017

HSBDR Summer School, Burg Warberg, Germany

Presentation about backgrounds of anti-malarial drug research and characterization of the rational approach in the design of active compounds.

4/11/2017

DESY Day Hamburger Nacht des Wissens, Hamburg, Germany

Presentation about general aspects of malaria disease and depiction of the rational approach in development of drugs against malaria inhibition.

30/01 – 31/01/2018

DECHEMA, Advances in Chemical Biology, Frankfurt am Main, Germany

Poster presentation about the studies on the explanation of structure-activity relationship of inhibitory activity of asymmetric, biarylic compounds on the movement machinery of the malaria parasite Plasmodium falciparum.

17/02 – 21/02/2018

Biophysical Society 62nd Annual Meeting, San Francisco, USA

Poster presentation about the benefits of molecular dynamics inclusion in the docking approach for the determination of structure-activity relationships of a selective compound.

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