Doctor Tina L. Tekirian

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Talents & Skills: Administrative Executive. Corporate Grant Writer. Highly Valuable Writing Skills/Contributions of Intellect, Intact Linear Skill Logic Set to use for Budget Writing especially for large grant funding; High Assimiliation skills with regard to Integratively assessing Data: My Skill sets include: High end evaluation of Healthy versus Pathophysiologic Tissues at DNA, RNA and protein levels,Histology, Electron Microscopy, Cell Culture, Tissue Preparation, Gross Anatomy, Molecular Genetics (Drosophila and Human), Cloning, and SubCloning.

Collaborations/Awards: Leadership Awards, Keystone Millenium Leadership Award, Keystone Scholar Awards,Gordon Conference Awards, National Pre-Doctoral National Institute of Health (NIH) Awards, National PostDoctoral NIH Award, John Douglas French Foundation Award for Excellence in Research of Alzheimer’s Disease. Leader/Panelist of The Proceedings of The Royal Academy of Sciences International Conference on Resilience. Leader, Nonviolence Course of two weeks duration at The University of Rhode Island Nonviolence Program. Leader, Keystone Millenium Conference. Leader & Participant at Cold Spring Harbor Laboratories, Huntington, New York.

Intelligron Medical, Law, & Ethics Agency 2010-2019.

Greenbaum Cancer Institute Faculty 2009-2010

National Cancer Institute Faculty 2006-2008

U. of Pennsylvania Wharton School of Business: Domestic & International Management Courses, 2003-2004

Faculty Postdoctoral Scholar in Howard Hughes Genetics Department, U. Penn., 2001-2002

Lecture, Johns Hopkins University Kennedy Krieger, Baltimore, Maryland, 2000.

Lecture, Mayo Clinic Jacksonville, Florida, 2000

Bristol-Myers Squibb-Quality Control Analytic Chemist in Robotics, 1991-1992

Johnson & Johnson Company, Milltown NJ Regulatory Affairs 1992-1993.

EDUCATION

Postdoctoral Scholar, The Mass General Hospital, Harvard Medical School, 1998-2001. My Postdoctoral Program Director at The National Institute of Health (NIH) at the time: Dr. Steven Snyder

Doctorate of Classical Anatomy & Neurobiology, Earned on March 28, 1998, At The Sanders Brown Center and NIH Center for Excellent Work Concerning Alzheimer’s Disease Comprehension, University of Kentucky, University of Kentucky, Lexington, Kentucky.

Rutgers University, Double in Major: Biological Sciences and Psychological Sciences, 1989-1992, Mabel Smith Douglass (Women’s College) Scholar. Undergraduate Scholars Thesis: Molecular Brain Studies of Rat Models of Parkinson’s disease and Aggression.

Publications:

1.Advanced signaling networks through proteomics, September 2007 Tina L Tekirian, Stefani N Thomas, Austin J. Yang Expert Rev Proteomics. 2007 Aug;4(4):573-83

Healthful physiology can be distinguished from unhealthful physiology by focusing upon how a given signal transduction pathway is shifted as a function of disease. In order to distinguish between pathways that contribute to normal versus disease biology, it is necessary to identify components that comprise a protein module.

2.Neuronal endosomal/lysosomal membrane destabilization activates caspases and induces abnormal accumulation of the lipid secondary messenger ceramide March 2003 Kristen Ditaranto-Desimone, Mitsuo Saito, Dr TL Tekirian, Austin J. Yang Brain Res Bull. 2003 Feb 15;59(6):523-31. Impairment of endosomal/lysosomal functions are reported as some of the earliest changes in several age-related neurological disorders such as Alzheimer's disease. Dysregulation of the lysosomal system is also accompanied by the accumulation of age-associated pigments and several recent reports have indicated that this age-related lipofuscin accumulation...

3.The Central Role of the Trans-Golgi Network as a Gateway of the Early Secretory Pathway: Physiologic vs Nonphysiologic Protein Transit December 2002 Dr TL Tekirian Exp Cell Res. 2002 Nov 15;281(1):9-18.

The current review focuses upon recent advances concerning the interrelationship between the ER and the trans-Golgi network (ER-TGN), the ER and the nucleus (ER-nucleus), and the ER-ubiquitin-proteasomal pathways at the level of basic cell biology. The overall emphasis of this paper centers upon the high likelihood that measurements of ER-associated...

4.Subcellular localization of presenilin 2 endoproteolytic C-terminal fragments Tina L. Tekirian, Dave E. Merriam, Vladimir Marshansky, Wilma Wasco Brain Res Mol Brain Res. 2001 Nov 30;96(1-2):14-20.Mutations in the genes that encode the presenilin 1 and 2 (PS1 and PS2) proteins cause the majority of familial Alzheimer's disease (FAD). Differential cleavage of the presenilins results in a

generation of at least two C-terminal fragments (CTFs). An increase in the smaller of these two CTFs is one of the few changes in presenilin processing…

5. Advancing signaling networks through proteomics

Dr. Tina L. Tekirian Expert Rev Proteomics. 2007 Aug;4(4):573-83.

Healthful physiology can be distinguished from unhealthful physiology by focusing upon how a given signal transduction pathway is shifted as a function of disease. In order to distinguish between pathways that contribute to normal versus disease biology, it is necessary to identify components that comprise a protein module.

6. Neuronal endosomal/lysosomal membrane destabilization activates caspases and induces abnormal accumulation of the lipid secondary messenger ceramide

Kristin-Ditaranto-Desimone, Mitsuo Saito, T.L. Tekirian, A.Y.Yang. Biology, Medicine, Brain Research Bulletin 2003, Impairment of endosomal/lysosomal functions are reported as some of the earliest changes in several age-related neurological disorders such as Alzheimer's disease. Dysregulation of the lysosomal system is also accompanied by the accumulation of age-associated pigments and several recent reports have indicated that this age-related lipofuscin accumulation...

7.Lysosomal Membrane Damage in Soluble Aβ-Mediated Cell Death in Alzheimer's Disease

Kristin-Ditaranto, Tina L. Tekirian, Austin Y. Yang March 2001 Neurobiology of Disease 8(1):19-31 · March 2001

Our previous studies suggest that a failure to degrade aggregated Aβ1-42 in late endosomes or secondary lysosomes is a mechanism that contributes to intracellular accumulation in Alzheimer's disease. In this study, we demonstrate that cultured primary neurons are able to internalize soluble Aβ1-42 from the culture medium and accumulate inside the e...

8.Interactions between calsenilin and the presenilins May 2000

Wilma Wasco, EK-Choi, Nikhat F. Zaidi, T.L. Tekirian, J. D. Buxbaum (data on web)

9.Effects of presenilin 2 in the early secretory pathway May 2000

Tina L. Tekirian, Janice S. Miller, David E. Merriam, Wilma Wasco (data on web)

10. Toxicity of Pyroglutaminated Amyloid β Peptides 3(pE) 40 and 42 Is Similar to That of Aβ1 40 and 42 November 1999 Journal of Neurochemistry Volume 73, Issue 4 Tina L. Tekirian, AY Yang, Charles Glabe, James Geddes

11. N-terminus truncated β-amyloid peptides and C-terminus truncated secreted forms of amyloid precursor protein: Distinct roles in the pathogenesis of Alzheimer's diease

Jim Geddes, T.L. Tekirian, M.P. Mattson. Neurobiol Aging. 1999 Jan-Feb;20(1):75-9; discussion 87.

12. N-terminal Heterogeneity of Parenchymal and Cerebrovascular Aβ Deposits February 1998

T.L. Tekirian, Takaomi C. Saido, William R. Markesbery, Jim Geddes J Neuropathol Exp Neurol. 1998 Jan;57(1):76-94.

13. Comparison of Neuropathologic Criteria for the Diagnosis of Alzheimer’s Disease

Jim Geddes, TL Tekirian, N.S.Soultanian, W.R. Markesbery. Neurobiol Aging. 1997 Jul-Aug;18(4 Suppl):S99-105.

14. Braak Stages III-IV of Alzheimer-Related Neuropathology Are Associated With Mild Memory Loss, Stages V-Vi Are Associated With Dementia: Findings From the Nun Study Jim Geddes, DA Snowdon, N.S. Soultanian, T.L. Tekirian, Kathryn Perez Riley Jon Wesson Ashford, W.R. Markesbery Journal of Neuropathology and Experimental Neurology. 55(5):617, MAY 1996 Issn Print: 0022-3069

15. Carboxy terminal of Beta-amyloid deposits in aged human, canine, and polar bear brains March 1996 TL Tekirian, Gregory M Cole, Michael Russell, Jim Geddes Neurobiol Aging. 1996 Mar-Apr;17(2):249-57.

Additional Skills: Choir, Cantor, Lector, Sacristan, Eucharistic Minister.

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